Audio long read: Faulty mitochondria cause deadly diseases — fixing them is about to get a lot easier

CRISPR-based gene editing has revolutionized modern biology, but these tools are unable to access the DNA that resides inside mitochondria. Researchers are eager to access and edit this DNA to understand more about the energy production and the mutations that can cause incurable mitochondrial diseases.Because CRISPR can’t help with these problems, researchers have been looking for other ways to precisely edit the mitochrondrial genome. And the past few years have brought some success — if researchers can make editing safe and accurate enough, it could eventually be used to treat, and even cure, these genetic conditions.This is an audio version of our Feature: Faulty mitochondria cause deadly diseases — fixing them is about to get a lot easier Hosted on Acast. See acast.com/privacy for more information.

00:46 Martian ‘micro-lightning’The sounds of ‘micro-lightning’ have been recorded by NASA’s Perseverance rover, ending a long search for the phenomenon on Mars. A lack of suitable equipment has made it difficult to gather evidence of lightning on the red planet, but a team of researchers realized that a microphone on Perseverance should be able to pick up the characteristic sounds of electrical discharges. In total they found 55 such examples, along with signs of electrostatic interference indicative of the phenomenon. They dubbed the electric bursts ‘micro-lightning’, as they are far smaller than the lighting seen on Earth, due to the thin Martian atmosphere. The team believe this finding could help better understand Martian chemistry and how best to design equipment to explore the planet’s surface.Research Article: Chide et al.News and Views: Is there lightning on Mars?11:03 Research HighlightsHow the biology of male seahorses’ brood pouches appears similar to mammalian pregnancy— plus, why Neanderthals’ jaws were so beefy.Research Highlight: The origin of male seahorses’ brood pouchResearch Highlight: Neanderthal DNA reveals how human faces form13:36 The key takeaways from COP30The UN’s climate conference, COP30, came to a close last week in Brazil. Nature reporter Jeff Tollefson tells us what was and wasn’t agreed during the final negotiations.Nature: What happened at COP30? 4 science take-homes from the climate summit22:27 Why women may retract less than menA new analysis suggests that female authors retract fewer medical science papers than their male counterparts. Women are known to be underrepresented in the medical sciences, but even accounting for this an AI-tool revealed that female authors featured on far fewer retracted research articles. Reporter Jenna Ahart has been investigating and told us why this might be, and what it means for research more broadly.Nature: Women seem to retract fewer papers than men — but why?Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

00:45 A molecule that delivers insulin through the skinResearchers have developed a skin-permeable polymer that can deliver insulin into the body, which they say could one day offer an alternative to injections for diabetes management. The skin’s structure presents a formidable barrier to the delivery of large drugs but in this work a team show that their polymer can penetrate though the different layers without causing damage. Insulin attached to this polymer was able to reduce blood glucose levels in animal models for diabetes at a comparable speed to injected insulin. While further research is required on the long-term safety of this strategy, the team hope it could offer a way to non-invasively deliver other large-molecule drugs into the body.Research Article: Wei et al.09:23 Research HighlightsHow extreme drought may be humanity’s biggest challenge after a huge volcanic eruption — plus, turning a bacterium into a factory for a colour-changing pigmentResearch Highlight: Volcano mega-eruptions lead to parched timesResearch Highlight: Dye or die: bacterium forced to make pigment to stay alive11:42 How language lights up the brain, whatever the tongueThe human brain responds in a similar way to both familiar and unfamiliar languages, but there are some key differences, according to new research — a finding that may explain why learning a language can be difficult. A study looking involving 34 people showed that listening to an unfamiliar language triggers similar neural activity to listening to their native tongue. The finding implies that human speech triggers a common reaction in the brain regardless of understanding. However, there were subtle differences when listening to a known language that may help explain how people actually understand words.Research Article: Bhaya-Grossman et al.Neuron: Zhang et alSounds used under CC BY 4.027:18 Briefing ChatSigns that greenhouse-gas emissions may peak around 2030 — plus, evidence of dog breeding by ancient humans.Nature: Global greenhouse-gas emissions are still rising: when will they peak?Nature: How ancient humans bred and traded the first domestic dogsSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Yoshua Bengio, considered by many to be one of the godfathers of AI, has long been at the forefront of machine-learning research . However, his opinions on the technology have shifted in recent years — he joins us to talk about ways to address the risks posed by AI, and his efforts to develop an AI with safety built in from the start. Nature: ‘It keeps me awake at night’: machine-learning pioneer on AI’s threat to humanity Hosted on Acast. See acast.com/privacy for more information.

00:45 A coronal mass ejection from a distant starResearchers have detected what they say is the strongest evidence yet of a coronal mass ejection (CME) coming from a star other than our Sun. CMEs are massive bursts of fast-moving plasma that can be detected thanks to the characteristic radio signal they produce. However, despite decades of searching, these signals have only been identified from the Sun. Now a team has identified a similar signal coming from a distant star in the Milky Way. They hope their discovery will lead to better understanding of the impact these colossal events might have on the atmospheres of exoplanets, and their chances of being habitable.Research Article: Callingham et al.12:28 Research HighlightsVideo footage of a devastating earthquake provides a first-of-its-kind glimpse of a dramatic ground rupture — plus, a flock of comets seen outside our Solar System.Research Highlight: Single video camera tells the story of deadly Myanmar quakeResearch Highlight: A host of ‘exocomets’ swarms a distant star14:29 The rare genetic variants that may increase the risk of ADHDAttention-deficit/Hyperactivity disorder (ADHD) is a condition that affects around 1 in 20 young people, but its underlying causes are not fully understood. Now, a team of researchers show that three rare genetic variants are implicated in an increased risk of ADHD, which may play a role in the neurons involved in dopamine signalling. While this work provides a better understanding of the complex genetics at play, the authors caution more research is needed to unpick the complex interplay other factors involved in ADHD.Research Article: Demontis et al.18:41 Briefing ChatA high-resolution digital map for Roman roads, and how speaking more than one language could slow brain ageing.Nature: ‘Google Maps’ for Roman roads reveals vast extent of ancient networkNature: Want a younger brain? Learn another languageSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

00:45 The debate around NanotyrannusA hotly debated species of dinosaur, assumed by many to be a juvenile T. rex, is actually a separate species, according to new research. Nanotyrannus was a dinosaur anatomically similar to T. rex, but about a tenth of the size, leading many to argue it was a young version of the iconic species. However, examination of the limb bones of a well-preserved Nanotyrannus fossil suggests it was close to finishing its growth and so would never become as large as a T. rex, leading the authors to argue that it is, in fact, a different species.Research Article: Zanno and NapoliNews and Views: T. rex debate settled: contested fossils are smaller rival species, not juvenilesNews: ‘Teenage T. rex’ fossil is actually a different speciesVideo: Hotly debated dinosaur is not a tiny T. rex after all08:46 Research HighlightsAn artificial ‘neuron’ could pave the way to build a brain-inspired computer — plus, how bats buck the trend by hunting prey their own size.Research Highlight: Artificial brains with less drainResearch Highlight: By the time you hear these bats, it’s too late11:19 A less invasive way to prevent breast cancerAn ‘anti-hormone’ therapy has shown promise in halting the onset of hallmarks associated with breast cancer, in a small trial. Breast cancer is a leading cause of death in women worldwide, but preventative measures, such as mastectomies, are invasive. A new study examined the efficacy of a treatment that blocks progesterone, a hormone thought to play an important role in breast cancer progression. The therapy reduced both specific clinical markers of breast cancer and the number of cells that can become cancerous. Larger, longer trials are needed to show that this treatment could ultimately become part of a breast cancer prevention strategy, but the team think that this work shows the promise of this approach.Research Article: Simões et al.18:41 Briefing ChatA new approach to speed up CRIPSR therapies reaching clinical trials, and how vocal cords could be healed using a tiny 3D printer.Nature: Personalized gene editing helped one baby: can it be rolled out widely?Nature: World’s smallest 3D bioprinter could rebuild tissue during surgerySubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

00:47 How bowhead whales live so longResearchers have uncovered a protein that enhances DNA repair and may explain how bowhead whales can live more than 200 years. The protein, cold-induced RNA-binding protein, was shown to enhance repair of double stranded DNA breaks, a particularly troublesome kind of damage. The team showed that this protein could also extend the lives of Drosophila flies and enhance repair in human cells. More needs to be understood about how this protein works, but the researchers hope that it could, one day, help prevent cancer and ageing in humans.Research Article: Firsanov et al.News: This whale lives for centuries: its secret could help to extend human lifespan11:22 Research HighlightsA precise way to grow crystals, with lasers — plus, the specialist organ that allows stinkbugs to protect their eggs from wasps.Research Highlight: How to grow crystals when and where you want themResearch Highlight: Stinkbug ‘ear’ actually hosts parasite-fighting fungi13:31 An antivenom against a broad range of snakebitesResearchers have used ‘nanobodies’ to create an antivenom that works against 17 snake species’ venom. Snakebites kill millions each year, so getting the right antivenom can be life or death. But they are difficult to produce and often are very specific. Now, using nanobodies from llamas, researchers created an antivenom against a broad range of snake species’ venom. The new antivenom can now even be produced without the llamas, and the team hope it will pave the way for a more universal antivenom.Research Article: Ahmadi et al.Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Advice on how to get good sleep is everywhere, with the market for sleep aids worth more than US$100 billion annually. However, scientists warn that online hacks and pricey tools aren’t always effective, and suggest that lessons learnt about the workings of a network of biological clocks found in the human body could ultimately lead to improved sleep.This is an audio version of our Feature: How to get the best night’s sleep: what the science says Hosted on Acast. See acast.com/privacy for more information.

00:48 How hunger, hormones and aggression interact in mouse brainsResearchers have uncovered the neural mechanisms that underlie an aggressive behaviour in mice prompted by hunger and hormonal state. Virgin female mice can become aggressive towards mouse pups when they are food deprived, but it seems that the relevant amounts of pregnancy hormones, oestrogen and progesterone, also played a role. By investigating the neurons involved, neuroscientists showed how hunger and hormones are integrated by the brain to lead to aggressive behaviour. This could help researchers understand more about how multiple stimuli are interpreted by the brain, something much harder to study than single stimulus effects.Research Article: Cao et al.09:35 Research HighlightsThe overlooked environmental costs of wastewater treatment facilities — plus, an ancient communal hunting system that lasted well into the eighteenth century.Research Highlight: Wastewater treatment produces surprising amounts of greenhouse gasesResearch Highlight: Andean peoples hunted and gathered long after they embraced farming11:53 What generative AI could mean for higher educationAround the world, universities and students are scrambling to adapt to the use of generative AI tools such as ChatGPT. And while there is optimism that these tools could improve education, there are also concerns about the ways they could stifle independent, critical thought. We hear about the studies trying to unpick the potential impact of this new technology.News Feature: Universities are embracing AI: will students get smarter or stop thinking?21:26 Briefing ChatA blood test for Alzheimer’s, and what should be the next ‘test’ for AI after the Turing test?Nature: Blood tests are now approved for Alzheimer’s: how accurate are they?Nature: AI language models killed the Turing test: do we even need a replacement?Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

00:46 A multi-variant avian flu vaccine that could enhance pandemic preparednessA vaccine capable of protecting against multiple strains of avian influenza virus might be a step closer, according to new research. The H5 subtype of avian influenza viruses has spilled over into mammals and is particularly concerning to researchers because of the risk that one of its variants may evolve to cause a pandemic. But because there are multiple variants of these viruses, it has been hard to pre-prepare vaccines. Now, a team has used information on how H5 viruses changed over time to design a vaccine that in animal studies provided protection against different H5 variants. They hope their approach could be applied to create stockpiles of a vaccine that could be used in the event of a pandemic, regardless of the variant that causes it.Research Article: Kok et al.10:53 Research HighlightsMaking muon beams without a huge particle accelerator — plus, the bats hunting migrating birds in mid-air.Research Highlight: Portable muon beam could accelerate archaeology scansResearch Highlight: European bats capture migrating birds and eat them on the wing13:34 Briefing ChatA new search engine that can sift through the staggering volumes of biological data, and the multiple failings revealed by an assessment of 25 years of carbon offsetting data.Nature: ‘Google for DNA’ brings order to biology’s big dataThe Guardian: Carbon offsets fail to cut global heating due to ‘intractable’ systemic problems, study says​​​​​​​Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.