Cholesterol: Overcoming Genetics

For most, reducing LDL-Cholesterol is a straightforward process: diet, exercise, red yeast rice and a statin if necessary. But if high LDL is written into your genes, none of that will move the needle. High Lp(a), measured by a simple blood-test, meant there wasn't much you could do... until researchers discovered PCSK9 inhibitors. Lipfendra, a daily oral medication, is a tool for those with familial hypercholesterolemia. In this episode of Generation Health, host Dante DiMatteo, PharmD, breaks down the latest March 2026 cholesterol guidelines and explores breakthrough treatments like Lipfendra. Learn how cutting-edge lipid science is making it possible to target previously unmovable genetic risk without relying solely on injectable medications. IN THIS EPISODE, YOU'LL LEARN: • How the new tiered LDL targets redefine personal risk levels. • Why LDL-C risk levels are now individualized rather than a single number. • The difference between cholesterol, LDL-C, HDL-C & Lp(a) • How a one-time test can reveal genetic lipid risk. • How LDL-C (and other small particles) were identified as the primary risk factor for heart attack. • Who the FDA approved Lipfendra for, and how to know if it should be considered in conversations with your doctor. We love questions. Comment below or email us: [email protected] CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 00:47 - Cholesterol Basics: LDL and HDL 01:52 - New Personalized Risk Targets 02:06 - Genetic Risk: Lp(a)  02:40 - Lipfendra 04:07 - Who is this for? 04:39 - Lipfendra Study Results 06:16 - Safety Profile 06:55 - Two Common Mistakes 08:34 - Why We Target LDL-C 14:09 - LDL Reduction vs Fewer Heart Attacks 14:39 - The LDL-C Gray Zone 17:06 - Notes on Lipfendra 18:30 - Takeaways SHOW NOTES: 1) Lipfendra Trial (Study) - https://www.nejm.org/doi/10.1056/NEJMoa2511002 2) Oral PCSK9 Safety (Study) - https://pubmed.ncbi.nlm.nih.gov/41206969/ 3) Oral PCSK9 vs Nonstatins (Study) - https://pubmed.ncbi.nlm.nih.gov/42017875/ 4) French PCSK9 Genetics (Study) - https://pubmed.ncbi.nlm.nih.gov/12730697/ 5) Genetic Low PCSK9 (Study) - https://www.nejm.org/doi/full/10.1056/NEJMoa054013 6) Mutation in PCSK9 (Study) - https://pubmed.ncbi.nlm.nih.gov/16909389/ 7) Longterm Lower LDL-C (Study) - https://pubmed.ncbi.nlm.nih.gov/23083789/ 8) PCSK9 Inhib Trial, 2.2 Years (Study) - https://www.nejm.org/doi/full/10.1056/NEJMoa1615664 9) New Lipid Guidelines - https://pubmed.ncbi.nlm.nih.gov/41824552/ 10) Points Not Percents (Study) - https://www.thelancet.com/article/S0140-6736(10)61350-5/fulltext DISCLAIMER:  This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Our FAVORITE Magnesium is available HERE! Shopping for magnesium can feel overwhelming with so many different forms on the shelf. From glycinate and citrate to oxide and L-threonate, every option claims its own distinct health benefits. In this episode, Pharmacist and Clinical Nutritionist Joey DiMatteo cuts through the marketing hype to explain the legitimate formulation science behind each type. Whether you want to support nighttime relaxation, improve digestive regularity, boost cognitive performance, or support cardiovascular health, matching the right form to your specific health goals is essential. Joey breaks down the clinical evidence, practical dosing considerations, key drug interactions, and label reading tips to help you navigate the supplement aisle like a clinician. IN THIS EPISODE, YOU'LL LEARN: • Who should be supplementing magnesium. • How each binding partner alters the benefit and cost of magnesium. • Which forms of magnesium are best for overall daily supplementation. • Why magnesium L-threonate, more than other forms, supports memory, focus, and brain health.    • The evidence behind high-dose magnesium protocols for prevention of migraines (with aura). • How to read the Supplement Facts panel to calculate your actual dose of elemental magnesium.    • Key safety considerations, upper intake limits, and potential drug interactions to discuss with your doctor or pharmacist. We love questions. Comment below or email us: [email protected] CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 00:56 - Magnesium Basics 01:19 - What are Binding Partners? 02:50 - Who needs to supplement? 04:01 - Magnesium Glycinate 05:38 - Magnesium Citrate 07:16 - Magnesium Oxide 08:31 - Magnesium L-Threonate 09:50 - Magnesium Malate 10:50 - Magnesium Taurate 11:57 - Simpler Magnesium Forms 12:24 - Magnesium Sulfate 13:10 - Magnesium for Muscle Cramps 13:54 - Magnesium for Migraines 15:04 - Timing 15:56 - How to Read the Label 17:48 - How much magnesium should you take? 19:09 - Summary & Takeaway SHOW NOTES: 1) US Magnesium Deficiencies (Study) - https://pmc.ncbi.nlm.nih.gov/articles/PMC6163803/ 2) Mag Bisglycinate for Sleep (Study) - https://pubmed.ncbi.nlm.nih.gov/40918053/ 3) Mag L-Threonate Cognition & Reaction Time (Study) - https://doi.org/10.3389/fnut.2025.1729164 4) Mag L-Threonate & Adults with Sleep Problems (Study) - https://doi.org/10.1016/j.sleepx.2024.100121 5) Mag L-Threonate & Cognitive Impaired Older Adults (Study) - https://pubmed.ncbi.nlm.nih.gov/26519439/ 6) American Migraine Foundation (Article) - https://americanmigrainefoundation.org/resource-library/magnesium/ 7) Magnesium & Migraines (Study) - https://pubmed.ncbi.nlm.nih.gov/26752497/ DISCLAIMER:  This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Did the FDA just approve BPC-157, or is the internet completely misunderstanding the recent vote? As peptides surge in popularity as "natural biological shortcuts," it is time to look at the real clinical evidence behind these powerful compounds. Peptides are not gentle, natural supplements. They are active drugs that come with real pharmaceutical questions like efficacy, safety, dosing, and long-term risk. Before you buy vials from a shady website, watch this. IN THIS EPISODE, YOU'LL LEARN: • Did the FDA actually approve BPC-157 and other popular peptides? • What is a peptide, and why are they classified as drugs rather than supplements? • How do FDA bulk compounding lists work, and what did the advisory panel actually vote on? • What does current research say about BPC-157, and is there a link to cancer risk? • What are the hidden dangers of the gray market? Would legally compounded peptides be safer? We love questions. Comment below or email us: [email protected] CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 01:25 - What is a peptide? 03:19 - FDA peptide meeting & vote 07:07 - Peptide Analysis Framework 08:16 - BPC-157 09:03 - BPC-157 wasn't evaluated for tendons or joints? 11:24 - Human safety 12:33 - Animal studies 13:00 - Quality concerns 15:07 - What Peptides in Category 1 actually means 16:32 - The bottom line on BPC-157 17:01 - The Real Dangers 18:20 - Wrap up SHOW NOTES: 1) FDA July Meeting (article) https://meto.co/blog/fda-peptide-approval-2026 2) FDA PCAC Meeting Notes (FDA.gov) https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026 3) PCAC Briefing Document (PDF) https://www.fda.gov/media/193343/download 4) US Anti-Doping BPC-157 (Article) https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/ 5) BPC-157 Systematic Review (Study) https://pmc.ncbi.nlm.nih.gov/articles/PMC12313605/ 6) 503A Bulk Drug Regulations (FDA.gov) https://www.fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding 7) Category 2 Bulks List (FDA.gov) https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks?utm_source=gemini#table-2 DISCLAIMER:  This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

PCOS (Polycystic Ovary Syndrome) has, for millions of women, been the catch-all explanation for a host of symptoms like irregular periods, weight gain, acne, facial hair growth, and painful ovarian cysts. While our understanding has grown, the name often served as a distraction, and kept women from understanding the underlying cause. This led to people treating the immediate symptom without correcting the core problem. When The Lancet formally renamed PCOS to Polyendocrine Metabolic Ovarian Syndrome (PMOS), it signaled a massive shift in how clinicians are educating patients: this disease is simply too big for its old name. Joey DiMatteo (PharmD, CCN) breaks down why this rebrand matters far beyond medical terminology. By reframing the condition around metabolic and hormonal complexity, this update shifts the focus from quick symptom management to root-cause treatment. The goal is long-term health rather than just fixing what's broken today. Don't get stuck in the PMOS spiral - Treat it at the source. IN THIS EPISODE, YOU'LL LEARN: • Why is PCOS being renamed to PMOS? • Why erratic periods, weight gain, and acne can all signal one problem. • How to stop the driver of PMOS • Why a birth control prescriptions often misses the full diagnostic picture. • Why follow-through on secondary bloodwork like A1c is vital for systemic health. We love questions. Comment below or email us: [email protected] CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 00:21 - Lancet: PCOS is now PMOS 00:53 - Why is the name changing? 03:24 - What PMOS really means 05:41 - The metabolic health is the core. 10:04 - Complex Hormone Interplay in PMOS 12:26 - Is there a cure for PMOS? 15:03 - Insulin Resistance 16:48 - How medications factor in 17:52 - Takeaway: Control the Source 21:00 - Show Outro SHOW NOTES: 1) PMOS - The New Name for PCOS (Lancet): https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00717-8/fulltext DISCLAIMER:  This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Testosterone and TRT are having a moment. Public sentiment has radically shifted, often seeing it as an obvious primary intervention for men. Men's health clinics and online stores have made it easy to access. Even the US military is expanding access by checking testosterone levels for all service members 30 years old and older. But is TRT really the best answer for men who are tired or gaining weight? Dante DiMatteo (PharmD) uses a pile of peer-reviewed studies and clinical experience to provide a balanced, fair, and honest answer to the question so many middle-aged men are facing: Why don't I feel like I used to? IN THIS EPISODE, YOU'LL LEARN: • Are online TRT clinics following best practices? • Why automatic testosterone screening is a bad idea. • What is a real Low-T score? • What is the process for diagnosing Low-T? • What factors impact testosterone production? • What do testosterone levels actually signal? We love questions. Comment below or email us: [email protected] CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 00:51 - New Department of War policy on Testosterone 02:38 - Information comes with a catch 03:54 - When is testosterone screening worthwhile? 04:42 - Testosterone is a proxy. 05:51 - Online TRT Clinics vs Guidelines 06:12 - Study findings 06:55 - What 90% of TRT Sites got right 07:26 - What does a real diagnosis look like? 08:31 - One-third of retests return to normal 10:00 - Medications that can lower testosterone 11:25 - What number is actually low? 13:36 - Pete Hegseth's Official Announcement 16:08 - Why TRT seems to work 18:21 - Is TRT dangerous? 20:00 - How does TRT impact fertility? 20:57 - Reasonable TRT results 25:09 - What's most likely causing Testosterone decline 27:28 - TRT will help specific men 28:19 - Where to do before TRT 30:18 - Summary SHOW NOTES: 1) Online Clinic Discrepancies (Study): https://academic.oup.com/jcem/article/111/6/1651/8414025 2) Sec Hegseth Announcement (Video): https://x.com/SecWar/status/2077425458430230838?s=20 3) Testosterone in Healthy Man (Study): https://doi.org/10.1111/j.1365-2265.2012.04432.x 4) Aging Men Testosterone & Function (Study): https://doi.org/10.1530/EJE%2D12%2D0890  5) Endocrine Society Statement: https://www.endocrine.org/news-and-advocacy/news-room/2026/statement-on-testosterone-replacement-therapy 6) Mood & Agression in men on High-dose Testosterone (Study): https://doi.org/10.1001/archpsyc.57.2.133 7) TRAVERSE (Study): https://doi.org/10.1056/NEJMoa2215025 8) Testosterone May Improve Mood & Sexual Function (Study): https://doi.org/10.1136/bmj.i989 DISCLAIMER:  This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Not all sleep aids are created equal. With dozens of options available ranging from natural supplements to prescription medications, finding the solution that will get you to sleep, keep you asleep, and not have unwanted side effects can be a challenge. That's why pharmacist and nutritionist Joey DiMatteo is making it easy by ranking them! He discusses the ones that work, the ones don't, and how to choose based on the particular challenge you're facing. After that, Dante DiMatteo (PharmD) goes over a study directly linking strength in older women to longevity. There are a host of reasons women over 60 should do resistance training, but a 33% reduced risk of mortality has to be one of the best! IN THIS EPISODE, YOU'LL LEARN: • Which sleep aids work best. • How to find the root of your sleep disturbance. • Which prescription sleep aids a pharmacist would never take. • When it's time for a sleep study. • What single factor reduces risk of mortality by 33% in women 63+. We love questions. Comment below or email us: [email protected] CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 00:40 - How we rank sleep aids 01:32 - Alcohol 02:31 - Anti-psychotics (Seroquel) 03:12 - Over-the-counter options 04:14 - Z-drugs (Ambien, Lunesta, Sonata) 05:20 - Benzodiazepine 06:20 - Trazodone 07:31 - Melatonin 09:22 - Supplement Blends 11:31 - Doxepin (low dose) & Ramelteon 12:28 - Dayvigo & Belsomra (orexin receptor antagonist) 13:34 - The only A+ intervention: CBT-I 15:01 - Ranking Recap 15:44 - Takeaway: Find the root problem first. 16:39 - Muscular Strength & Mortality in women 63-99 17:12 - How the study was designed 18:24 - Findings of the study 21:34 - Grip strength is a proxy, not a goal. 23:18 - Takeaway: Exercise is safe & effective 24:54 - Show Outro SHOW NOTES: 1) Muscular Strength & Mortality (Study): • https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845052 DISCLAIMER:  This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Nearly 80 percent of adults over 65 take at least one dietary supplement, and 60 percent of all adults use them daily. But does every bottle contain what the label claims? In this episode of Generation Health, pharmacist and nutritionist Joey DiMatteo breaks down the reality of FDA supplement regulation. He evaluates the American College of Physicians' push for stricter laws, analyzes quality studies on popular supplements, and shares a 5-question checklist you should ask before taking any pill in your cabinet. IN THIS EPISODE, YOU'LL LEARN: • The FDA Reality: What "Good Manufacturing Practices" cover and how supplement rules differ from drug approvals. • Label Accuracy: What recent testing reveals about melatonin gummies, immune formulas, and weight-loss products. • The ACP Proposal: The push for mandatory FDA registration, premarket reviews, and USP quality standards, and more... • The 5-Question Framework: A practical checklist to evaluate any supplement for safety, dosing, and drug interactions. We love questions. Comment below or email us: [email protected] CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 00:40 - Why the American College of Physicians claims supplements are under-regulated. 02:07 - What recent JAMA research reveals about modern supplement consumption trends. 03:40 - How FDA oversight actually works for dietary supplements. 04:42 - Difference between supplements and medications 06:52 - Are products being mislabeled? 08:40 - FDA Warning Analysis 09:23 - New England Journal of Medicine Analysis 10:41 - What does the ACP want to change regarding supplements? 14:05 - 5-questions to ask about every supplement yout take. 16:55 - The Bottom Line: Regulation should raise quality without limiting access. SHOW NOTES: 1) American College of Physicians position paper: • https://www.acpjournals.org/doi/10.7326/ANNALS-26-01119 2) 2026 JAMA Network Open supplement-use analysis: • https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2850245 3) CGMPs for Supplements:  • https://www.fda.gov/food/guidance-regulation-food-and-dietary-supplements/current-good-manufacturing-practices-cgmps-food-and-dietary-supplements 4) FDA dietary-supplement regulation Q&A: • https://www.fda.gov/food/information-consumers-using-dietary-supplements/questions-and-answers-dietary-supplements 5) Immune-support product analysis: • https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2794987 6) Weight-loss product analysis: • https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818120 7) Melatonin gummy analysis: • https://jamanetwork.com/journals/jama/fullarticle/2804077 8) Unapproved Rx in Supplements:  • https://pubmed.ncbi.nlm.nih.gov/30646238/ 9) Supplement-related emergency visits: • https://pmc.ncbi.nlm.nih.gov/articles/PMC6196363/ DISCLAIMER:  This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

We're celebrating our 100th episode by answering YOUR questions! Joey DiMatteo (PharmD CCN) and Dante DiMatteo (PharmD) answer questions about a wide variety of concerns like supplement interactions, vitamin dosage changes, medication timing, petroleum based supplements and more. They bring their years of experience as practicing pharmacists to bear with honest, direct answers to common family medicine questions! IN THIS EPISODE, YOU'LL LEARN: • How natural supplements can interact with medications. • Does it matter what time of day you take prescribed medication? • Do medicines like Provigil drain nutrients from our bodies? • Are "whole-food" supplements better than other high-quality natural supplements? ... and more! We love questions. Comment below or email us: [email protected] CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 01:54 - Using CoQ10 with Xarelto07:30 - Concerns when reducing D3 and B12 supplementation12:40 - Can you change the time at which you take your medications?19:47 - What nutrients does Provigil deplete from our bodies?28:15 - Are whole food fermented vitamins better for you?38:03 - Show Outro DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Is AI ready to take you from fat to fit? That's what researchers hoped to answer in a recent clinical study. Looking at three different models of ChatGPT, professional trainers analyzed 12 week training programs the AI provided based on hypothetical users. Dante DiMatteo, a human personal trainer, digs through the data to show what worked and where having an experienced human to guide is a good idea.  IN THIS EPISODE, YOU'LL LEARN: • Where AI excelled at creating a program, and where it still lags. • How to spot mistakes & unsafe suggestions in any training program. • How to construct a prompt that will deliver excellent results for anyone looking to start exercising, regardless of starting point or end goal. • What is the "roman chair" and why does Josiah want one? Subscribe to join a community of health-conscious individuals seeking clinical clarity. We love questions. Comment below or email us: [email protected] CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 02:13 - AI Training Study 05:54 - Blinding of the study 08:28 - Where the AI Failed 11:39 - Individualization 12:26 - Safety and Injury Prevention 13:52 - Additional Studies 16:14 - How Dante uses AI 19:00 - Brainstorming Ideas 23:09 - Chat GPT exercise ad 28:51 - Additional AI banter 33:24 - How can a normal person use this information? 38:46 - Show Outro SHOW NOTES: 1) Comparative evaluation of ChatGPT versions in training program design • https://pmc.ncbi.nlm.nih.gov/articles/PMC12797729/ DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

There's been a major paradigm shift in how and why to use a probiotic. We explain why the old view of probiotics—tools to "recolonize" the gut with new bacteria—is outdated. Instead, the latest science shows that we use probiotics to gain specific, temporary physiological responses. Using data from 70+ randomized controlled trials, we look at why strain specificity matters far more than just a massive CFU count on a label. We identify conditions (Diarrhea, C-diff, IBS, etc) where probiotics help, outline the 4 pillars of an effective probiotic, and evaluate who actually needs a probiotic (and who doesn't). Plus, we share a major announcement: a complete reformulation of our legacy flagship Probiotic Essentials! IN THIS EPISODE, YOU'LL LEARN: • The New Probiotic Paradigm: Why the goal isn't to permanent-colonize your gut, but to trigger targeted physiological and immune responses. • Why Strain Matters: How understanding the specific strain prevents you from buying ineffective supplements. • The Antibiotic Shield: How clinical data proves early probiotic intervention can drop antibiotic-associated diarrhea (AAD) rates by 37–38%. • Who It's For (and Who It's Not): The clinical reality of who benefits most from supplementation, and who should avoid them entirely. • The 4 Pillars of Efficacy: How to evaluate Strain, CFU Count, Shelf Stability, and Delivery Systems so active bacteria actually survive your stomach acid. • The Evolution of Essentials: How we have radically upgraded our 15-year-old legacy formula into the new Probiotic Advanced Essentials. CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook -  https://facebook.com/askjoedimatteo  Instagram - https://tinyurl.com/5n6kfwhs YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 01:34 - What are Probiotics? 03:10 - What do probiotics do? 10:09 - Why does the exact species matter? 12:37 - What is the research supporting Probiotics? 13:05 - Antibiotic-associated diarrhea 14:45 - C-diff 18:16 - IBS 19:54 - Immune Support 21:58 - Downstream benefits of Probiotics 22:39 - What makes a good probiotic? 27:40 - Who should take probiotics? 32:47 - Introducing Probiotic Advanced Essentials CITATIONS: 1) Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis. • https://bmjopen.bmj.com/content/11/8/e043054 2) Early use of probiotics significantly reduces the incidence of antibiotic-associated diarrhea (AAD) in adults without increasing adverse events. • https://journals.lww.com/jcge/fulltext/2021/07000/probiotics_for_the_prevention_of.4.aspx 3) Probiotics help protect against intestinal and colonic injury caused by Staphylococcus aureus. • https://pubmed.ncbi.nlm.nih.gov/21963346/ 4) Probiotic Bifidobacterium lactis NCC2818 modulates immune response in individuals with seasonal allergic rhinitis. • https://pubmed.ncbi.nlm.nih.gov/23299716/ 5) Early dietary supplementation with Bifidobacterium lactis NCC2818 boosts systemic antibodies. • https://pubmed.ncbi.nlm.nih.gov/23473077/ 6) Commercial probiotic strains show strong in vitro inhibition of Clostridium difficile and Clostridium perfringens. • https://pubmed.ncbi.nlm.nih.gov/23471038/ 7) Lactobacillus plantarum & flax-seed oil exhibit anti-inflammatory and immunoregulatory effects against E. coli. • https://pubmed.ncbi.nlm.nih.gov/23465779/ 8) Lactobacillus rhamnosus Lcr35 provides dose-dependent immunomodulation of human dendritic cells. • https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018735 9) Saccharomyces boulardii stimulates sIgA production and enhances phagocytic immune systems. • https://pubmed.ncbi.nlm.nih.gov/11021572/ DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.