Exploring Approaches to Management for Bronchiectasis

Guest: Donna Gardner, DrPH, RRT, RRT-NPS, FAARC, FCCP Host: Nicola A. Hanania, MD, MS, FCCP Many patients with severe asthma remain uncontrolled despite available biologics, with barriers like referral delays, treatment burden, and frequent dosing often standing in the way of starting and staying on therapy. Joining Dr. Donna Gardner to discuss two-year clinical trial evidence for an ultra-long-acting biologic dosed once every six months and how shared decision-making can help match patients with the right treatment from the start is Dr. Nicola Hanania. Dr. Hanania is the Brown Foundation Professor of Medicine and the Director of Airways Clinical Research Center at Baylor College of Medicine. He is also Chief of the Section of Pulmonary, Critical Care, and Sleep Medicine at Ben Taub Hospital in Houston, Texas. Dr. Gardner is Chief Research and Programs Officer at Allergy & Asthma Network in Fairfax, Virginia. This information is scientific and non-promotional in nature. This educational program was developed by CHEST in collaboration with and sponsored by GSK. This information is not intended to offer recommendations for using this product in a manner inconsistent with its approved labeling. Please consult the Prescribing Information for depemokimab. For GSK to monitor the safety of our products, we encourage healthcare professionals to report adverse events or suspected overdoses to …

Host: Diego Maselli, MD, FCCP Living with severe asthma can mean hospital stays, repeated oral steroid courses, and a long search for the right care, with many eligible patients still facing delays in starting advanced therapies or struggling to stay on them. In this episode of Deep Breaths: Updates from CHEST, Dr. Diego Maselli talks with patient advocate Stephanie Fuller about her journey from uncontrolled asthma to starting biologic therapy. Together, they explore why having ongoing conversations built on knowing the whole patient can help improve outcomes for severe asthma patients. Dr. Diego Maselli is Professor and Chief of the Division of Pulmonary Diseases and Critical Care at UT Health in San Antonio. This information is scientific and non-promotional in nature. This educational program was developed by CHEST in collaboration with and sponsored by GSK.

Host: Brett Bade, MD Guest: Michael Gieske, MD This episode focuses on improving lung cancer screening and early detection by helping primary care providers recognize eligible and high-risk patients, apply current screening guidelines, and engage patients in clear shared decision-making conversations. Speakers will explore why many patients who qualify for low-dose CT scan screening are still not screened. Learn practice strategies to help close preventable gaps in care, including identifying risk during routine visits, addressing patient concerns, ordering appropriate screening, and ensuring follow-up for findings such as pulmonary nodules.

Host: Eric Merrell, MD Guest: Syed Shahzad Mustafa, MD Guest: Glenn Schneider, MD Part of the educational program Bridging Specialties®: Timely Diagnosis and Treatment for Refractory Chronic Cough, this activity explores emerging scientific insights and therapeutic advances shaping the management of refractory chronic cough (RCC). Despite appropriate evaluation and treatment of common etiologies, many patients continue to experience persistent cough consistent with cough hypersensitivity syndrome. Advances in understanding ATP–P2X3 signaling and neural mechanisms have reshaped the conceptual framework for RCC and informed the development of emerging therapies. This activity reviews the neurobiology of cough hypersensitivity, current management gaps, and the evolving therapeutic landscape. Clinicians will gain insight into mechanism-based care strategies and patient-centered counseling considerations in RCC management.

Host: Sandhya Khurana, MD, FCCP Guest: Syed Shahzad Mustafa, MD Guest: Ashley Wilk, DO, DipABLM Part of the educational program Bridging Specialties®: Timely Diagnosis and Treatment for Refractory Chronic Cough, this activity examines the diagnostic challenges associated with refractory chronic cough (RCC) and the importance of coordinated, guideline-directed evaluation across specialties. RCC is frequently characterized by prolonged diagnostic delays, repeated empiric treatments, and fragmented care across specialties. Many patients experience months of persistent symptoms before a structured evaluation is implemented. This activity highlights practical strategies for applying a CHEST guideline-directed diagnostic pathway to improve efficiency, reduce unnecessary repetition, and support timely multidisciplinary coordination. Clinicians will gain tools to streamline evaluation and reduce patient burden.

Host: Gerard A. Silvestri MD, MS, Master FCCP Guest: Anurag Singh, MD Guest: Adam H. Fox, MD, MSc Guest: Mariam Alexander, MD, PhD Despite the typically poor prognosis of extensive-stage small cell lung cancer, recent advancements are reshaping clinical perspectives on treatment. New and emerging options show promise for prolonged survival and improved quality of life. Join Drs. Gerard Silvestri, Adam Fox, Mariam Alexander, and Anurag Singh as they discuss how the therapeutic landscape is evolving for these patients. Silvestri is a pulmonologist and the Hillenbrand Professor of Thoracic Oncology at the Medical University of South Carolina. Dr. Fox is a pulmonologist and Assistant Professor of Medicine at the Medical University of South Carolina. Dr. Alexander is a medical oncologist and Assistant Professor of Medicine at the Medical University of South Carolina. Dr. Singh is a Professor of Radiation Oncology and the Director of Radiation Research at the Roswell Park Cancer Center in New York. This program is produced in partnership with the American College of Chest Physicians and is sponsored by AstraZeneca.

Host: Diego Maselli, MD Guest: Monica Kraft, MD, FCCP Guest: Anju T Peters, MD, MSCI, FAAAAI IL-5 is a key driver of Type 2 inflammation in patients with severe asthma, promoting downstream effects like mucus plugging and epithelial barrier dysfunction. Given these impacts, targeted therapy with biologics can play a role in severe asthma management. Join Drs. Diego Maselli, Anju Peters, and Monica Kraft as they explore the impacts of IL-5 and share perspectives on patient selection and shared decision-making for targeted therapies. Dr. Maselli is a Professor of Medicine at the Long School of Medicine at UT Health in San Antonio. Dr. Peters is a Professor of Medicine and Associate Chief of Clinical Research and Practice Innovation at Northwestern Medicine in Chicago. Dr. Kraft is a System Chair of the Samuel Bronfman Department of Medicine and a Professor of Medicine at the Icahn School of Medicine at Mount Sinai Health Systems in New York. This episode of Deep Breaths: Updates from CHEST was supported by a non-promotional, non-CME educational program brought to you by CHEST in collaboration with and sponsored by GSK.

Host: Nathan Falk, MD, MBA, FAAFP Guest: Megan Conroy, MD, MA(Ed), FCCP Patients with chronic obstructive pulmonary disease (COPD) often experience significant delays in diagnosis and treatment due to systemic gaps in management. A recent survey of 400 primary care and pulmonary clinicians uncovered patterns of fragmented care among both specialties. Join Dr. Nate Falk and Dr. Megan Conroy as they dive into the findings and explain how CHEST’s COPD Toolkit can help clinicians address these gaps and provide a coordinated approach to COPD management. Dr. Falk is a board-certified family physician as well as a Professor and Founding Residency Director for Family Medicine at Florida State University in partnership with BayCare Health System. Dr. Conroy is a Chair and Assistant Professor in the Division of Pulmonary, Critical Care, and Sleep Medicine at The Ohio State University. This activity is supported by Regeneron Pharmaceuticals, Inc. and Sanofi.

Host: Angela Birdwell, DO, MA, FCCP Guest: Antonio Anzueto, MD Guest: Susan Corbridge, PhD, APRN, ACNP-BC, FAANP, FCCP, FAAN Although the prevalence of chronic obstructive pulmonary disease (COPD) has decreased in adults aged 18 to 44, it remains elevated in certain patient groups, like women, adults over 65, smokers, and those living in rural areas. This prevalence emphasizes the importance of a patient-centered approach, which is why Dr. Angela Birdwell speaks with Drs. Antonio Anzueto and Susan Corbridge about how open conversations and the First 5 Minutes concept can help personalize the care of COPD patients and lead to better outcomes. Dr. Anzueto is a Professor of Medicine at the South Texas Veterans Health Care System and UT Health San Antonio, and Dr. Corbridge is the Chief Essentials Program Officer at the American Association of Colleges of Nursing and a Professor Emerita at the University of Illinois at Chicago College of Nursing. This non-CME education is brought to you by CHEST, and this program is supported by Regeneron Pharmaceuticals, Inc. and Sanofi.

Guest: Ashwin Basavaraj, MD Host: Christopher Lippincott, MD, MPH From airway clearance techniques and mucoactive therapy—what can clinicians do to manage bronchiectasis exacerbations? To answer this question, Dr. Christopher Lippincott and Dr. Ashwin Basavaraj explore the mechanisms that lead to bronchiectasis and share strategies to manage exacerbations. This program is produced in partnership with the American College of CHEST Physicians, and is sponsored by Insmed Incorporated.