Is There Anything GLP-1s Can’t Do?

Writer Pico Iyer stumbled into a lifelong practice of periodic retreat and reflection after he lost nearly everything in a 1990 wildfire that burned his family’s house down. A friend suggested that he recuperate at a Benedictine monastery near Big Sur, California, and the calm he found there was life-altering. He began returning to the oceanside hermitage regularly, and slowing down became a fundamental part of his life and productive career. In this talk from the 2025 Aspen Ideas Festival, Iyer shares what those times of silence have given him, and how he’s learned to navigate tumult while always coming back to peace. Iyer’s latest book is “Aflame: Learning from Silence,” and he’s also the author of “The Half Known Life” and “The Art of Stillness,” among several other books and many essays.

Aspen Ideas to Go teamed up with our friends at the podcast “Life in Seven Songs” for this special episode recorded live at the Aspen Ideas Festival. Host Sophie Bearman interviews NPR host and reporter Mary Louise Kelly about seven songs that tell a story of her life spanning war zones, motherhood, hearing loss, and late-in-life love.

Hope seems like a simple concept, but the feeling can be difficult to hold onto. And when times are difficult and chaos swirls around us, it’s more important than ever. How do we find and practice hope when it’s elusive? Spiritual and religious leaders rely on centuries of experience and wisdom to continually guide people back to hope, and this episode’s discussion from the 2024 Aspen Ideas Festival draws from these experts. Lutheran pastor Nadia Bolz-Weber founded the House for All Sinners and Saints in Denver, and doesn’t shy away from unorthodox methods of ministry. Rabbi Sharon Brous is the founder and leader of IKAR, a nondenominational Jewish congregation in Los Angeles. Humanist chaplain Greg Epstein works with the populations at Harvard University and the Massachusetts Institute of Technology. Union Theological Seminary professor and the former director of the Religion and Society Program at the Aspen Institute, Simran Jeet Singh, introduces and moderates the conversation.

Weight loss and diabetes drugs in the class called GLP-1s have exploded onto the market, starting to put a real dent in the obesity epidemic. And as doctors are gathering more data, it looks like the medications may also provide real benefits for cardiac health, liver disease, kidney function and possibly even addiction and sleep disorders. In this episode, a panel of experts explains how the drugs work, why they’ve been so effective, and how hopeful we might be about other uses. Cedars Sinai cardiologist Martha Gulati joins Nora Volkow, the director of the National Institute on Drug Abuse and Diana Thiara, an obesity expert at UCSF, for a forward-looking conversation about this potentially game-changing medical advancement. Time Magazine health reporter Alice Park moderates the conversation.

Aspen Ideas to Go teamed up with our friends at the podcast “Life in Seven Songs” for this special episode recorded live at the Aspen Ideas Festival. Host Sophie Bearman interviews biographer and historian Walter Isaacson about seven songs that tell a story of his life and upbringing in New Orleans. Isaacson was the president and CEO of the Aspen Institute from 2003 to 2018, and is the author of “Leonardo da Vinci,” “Einstein: His Life and Universe,” and “Elon Musk,” among others. His latest book, “The Greatest Sentence Ever Written,” is out on November 17. “Life in Seven Songs” is a production of The San Francisco Standard.

What does it look like to hope in the face of tough times and undeniable challenges? The speakers in today’s talk might describe true hope as more than a passive platitude, but something closer to a muscle that needs exercise. Krista Tippett, the creator and host of the public radio show “On Being,” reunites with young adult author and MacArthur grantee Jason Reynolds to continue their multi-year conversation about how to find resilience in a world full of obstacles. They explore the relationship between fear and hope, and share experiences of finding light and connection in unexpected places.

Arts institutions carry a responsibility for responding to and driving culture. What does it take to lead these organizations and support diverse groups of artists, audiences, and benefactors? Actress, playwright and professor Anna Deavere Smith leads a frank and deep discussion about the role of museums, foundations, and cultural centers in today’s creative environment. Lonnie G. Bunch III, the head of the Smithsonian Institution, joins Mariko Silver, the CEO of Lincoln Center for the Performing Arts in New York, and Yana Peel, the president of Arts, Culture and Heritage at Chanel.

Leaders who truly inspire and get the best out of people are few and far between. How do they learn to gain trust and rally a group to action? Steve Kerr has been coaching the Golden State Warriors NBA team for 11 years, four of which have been champion seasons. He joins Maryland Governor Wes Moore, who became the first Black person to hold that office after combat in the Army and a career fighting poverty, for a discussion about leading with respect and purpose. CBS co-anchor John Dickerson moderates the conversation.

Following economic news too closely can give you feelings of whiplash and confusion, and may not speak to your personal experience. What economic information should you actually pay attention to, and how should you interpret what you hear? Former economics professor and head of the Federal Reserve Bank of Chicago, Austan Goolsbee, and the CEO of polling and analytics company Gallup, Jon Clifton, break down the economic indicators we come across all the time. They tease apart what’s based on data and reality, what’s missing, and what’s hype and fluff. And how consumers react to economic news, they explain, adds yet another layer of feedback to the equation. Social media influencer and financial advisor Vivian Tu, the founder of advice brand Your Rich BFF, moderates the conversation.

Who would have thought play would be a transformative tool to de-stress and build resilience? Turns out the act, which is different for everyone, is biologically hardwired in our brains. “Everyone has a sense of joyfulness,” says Dr. Stuart Brown, founder of the National Institute for Play. He began studying play science after discovering the perpetrator of a 1960s mass shooting lacked play from the time he was born. Play deprivation can have grave consequences, he found, but joyful engagement fuels happiness and intelligence. He joins a panel of play experts including Cj Hendry, an artist whose large-scale installations often lead people to play, and Heidi Erwin, senior game designer at the New York Times. Sam Sanders, former NPR reporter and producer and host of the podcast, “The Sam Sanders Show,” moderates the conversation.