Free-Threaded Python's History & uv in Production

How do you plan for the performance of your Python applications? What does a performance budget entail, and where should you spend your resources? This week on the show, we speak with Den Odell about his new book "Fast by Default: Practical Performance Engineering."

What are the key characteristics of complex systems, and what are practical patterns for tackling complex coding problems? Christopher Trudeau is back on the show this week with another batch of PyCoder's Weekly articles and projects.

Why do AI systems silently fail? How can you set up a system that produces results while also reviewing and validating the work? This week on the show, Calvin Hendryx-Parker returns to discuss his recent talk "Orchestrate Agentic AI: Context, Checklists, and No-Miss Reviews."

What bottlenecks were preventing NumPy from scaling on free-threaded Python? Christopher Trudeau is back on the show this week with another batch of PyCoder's Weekly articles and projects.

How can you move from manually writing prompts for an LLM application toward defining them programmatically? This week on the show, Brett Kennedy returns to discuss his new book "Building LLM Applications with DSPy."

Should you understand the entirety of your codebase? How familiar are you with Python's built-in functions? Christopher Trudeau is back on the show this week with another batch of PyCoder's Weekly articles and projects.

Which is more important, the model or the "harness" around an LLM? What are ways to assemble an efficient agentic developer workflow? This week on the show, Ayan Pahwa joins us to discuss harnessing, web scraping, and self-hosting Python applications.

How many attempts have been made to remove Python's Global Interpreter Lock (GIL)? How do they compare to the current approach? Christopher Trudeau is back on the show this week with another batch of PyCoder's Weekly articles and projects.

How can you improve your LLM agent systems through specification enrichment? What are the advantages of having an LLM act as a judge within an agent system? This week on the show, Senior IEEE Member and Quality Engineer Suneet Malhotra joins us to discuss building and evaluating agentic architecture.

How do you avoid the risk of running a Python application locally that could be malicious, break your code, or leak private data? How can you create a sandboxed local environment using WASM and MicroPython? Christopher Trudeau is back on the show this week with another batch of PyCoder's Weekly articles and projects.