Episode 188: Marina Walther-Antonio discusses the microbiome’s role in women’s health and cancer

Today we have Dr. Marina Walther-Antonio, a Mayo Clinic researcher who investigates the role of the microbiome in cancer and reproductive health, particularly endometrial and ovarian cancers. According to the World Cancer Research Fund International, endometrial and ovarian cancers are among the top 10 most prevalent cancers in women worldwide, and there are still no standard screenings for early detection. Marina is an assistant professor in the Department of Surgery and the Mayo Clinic Center for Individualized Medicine Microbiome Program. She has a joint appointment in the department of Obstetrics and Gynecology. Today we talk to Marina about how she and her colleagues are utilizing the methodologies of environmental microbiology and technologies used in astrobiology to improve our understanding of endometrial and ovarian cancers. Through her investigations into the microbiome, she and her team are developing early detection tests that will enable clinical interventions before certain cancers develop. Show notes: [00:03:13] Dawn opens our interview asking Marina about the history of her interest in extraterrestrial life. [00:05:49] Dawn mentions that Marina did her undergraduate studies in Portugal at the University of Aveiro, where she majored in biology. Dawn asks why Marina chose biology as her major. [00:06:39] Ken explains that the undergraduate programs at Aveiro University require students to do a year of research outside the university and asks Marina about her experience with this requirement. [00:08:34] Ken explains that while Marina was conducting her internship at NASA Ames Research Center, there were several projects under way at the astrobiology institute, with the one that Marina was assigned to looking at a Mars analogue site in Oregon’s Warner Valley. Ken asks what kind of work Marina did on this project. [00:10:06] Ken asks Marina why after earning a master’s degree in microbiology from Indiana University, she went to Washington State University to earn a Ph.D. in environmental sciences. [00:13:29] Dawn asks about Marina’s Ph.D. research on microbialites, which are microbial structures that can thrive at the bottom of certain freshwater lakes and other extreme environments. [00:16:02] Dawn explains that just as Marina began researching microbial populations, the Mayo Clinic Center for Individualized Medicine created a microbiome program. Dawn asks Marina about the circumstances that led to her joining Mayo. [00:19:05] Dawn mentions that Dr. Claire Fraser, the director of Maryland’s Institute for Genome Sciences pointed out in Episode 32 of STEM-Talk that there are more microbes on a single person’s hands than there are people on Earth, as well as the fact that our gut is home to more than 100 trillion bacteria. Dawn asks Marina to talk about this microbial side of humanity. [00:21:51] Ken mentions that if listeners are interested in learning more about the microbiome and how it affects human health, they should listen to Episodes 20 and 168 with Dr. Alessio Fasano. Ken asks Marina to give a short overview of the microbiome. [00:25:37] Dawn asks Marina how the focus of her research shifted to the role of the microbiome in cancer and reproductive health. [00:29:00] Dawn explains that endometrial and ovarian cancers are among the top 10 most prevalent cancers in women worldwide; with ovarian cancer being the most common gynecological malignancy and the fifth leading cause of death due to cancer in women in the nation. Dawn goes on to explain that in a 2023 paper Marina investigated the area of microbiome that is associated with ovarian cancer to better understand the microbiome’s potential in early detection. Dawn asks Marina to talk about this study and its findings. [00:35:55] Given the small scale and sample size of her initial study, Ken asks Marina what her ideal follow-up study would look like. [00:38:37] Ken mentions that in 2019 Marina published the r...

Today Ken interviews his co-host Dr. Dawn Kernagis about her new position as the Director of Scientific Research for DEEP, a UK startup that is pioneering a new era of ocean exploration. For listeners unfamiliar with Dawn’s background, she is a NASA-trained NEEMO Aquanaut, a Fellow of the Explorer's Club Fellow and has been inducted into the Women Divers Hall of Fame. In addition to co-hosting STEM-Talk for the past nine years, Dawn is also a Visiting Research Scientist at IHMC. Dawn’s research over the years has been focused on protecting the brain and nervous system of people working in extreme environments. Prior to joining IHMC, Dawn completed her Ph.D. and Postdoctoral training at Duke University, where she studied the genetics of decompression sickness and mechanisms of oxygen toxicity in divers. In today’s interview, Dawn talks about DEEP’s mission to create subsea stations that will allow humans to live and work permanently underwater. Show notes: [00:03:20] Ken reminds listeners of Dawn’s first STEM-Talk appearance as a guest on Episode 19 where she conducted the interview from the bottom of the ocean floor while she was a member of NASA’s NEEMO Mission 21. [00:04:13] Ken asks Dawn what she was like as a child. [00:05:48] When Ken asks Dawn what she was like as a child, she talks about how she was an annoying kid because she was always asking people questions like, “Why is the sky blue?” [00:06:49] Dawn talks about the different places she lived during her childhood. [00:07:34] Ken mentions that Dawn was inducted into the Women’s Divers Hall of Fame. He asks her how old she was when she first became interested in diving. [00:10:35] Dawn talks about how she wanted to attend the University of North Carolina after high school but ended up at North Carolina State University and then Duke University. [00:12:18] Ken asks Dawn to elaborate on her decision to change her field of study multiple times throughout her collegiate career. What follows is an interesting conversation about the importance of a person following their passion. [00:14:53] Dawn talks about cave diving and how she and her friends used to do deep dives of six and seven hours at a time. Dawn explains how this led to her obsession with ways to protect people who dive into extreme underwater environments. [00:18:28] Ken asks Dawn how she learned that some people have a genetic predisposition to decompression sickness. [00:21:32] The conversation shifts to Dawn’s Ph.D. journey and how Richard Moon, who was a STEM-Talk guest on episode 26, played a significant role in her development. [00:26:14] Ken and Dawn reminisce on the practice of performing academic research in libraries. [00:28:20] Ken points out that despite Dawn’s extensive experience in human physiology with respect to diving, her doctoral work focused on cancer-related research. He asks her to talk about that seemingly odd combination. [00:34:10] Dawn talks about two papers that emerged from this research. One paper addressed how genes with bimodal expression patterns not only define clinically relevant molecular subtypes of ovarian carcinoma, but also provide ideal targets for translation into the clinical laboratory. The other paper looked at precise microarray-based predictions of tumor behavior in breast cancer patients. [00:39:00] Ken asks Dawn to recount the story of how the two of them met. [00:41:52] Ken asks Dawn to discuss the paper she co-wrote with Dom D’Agostino on mitochondrial health and its relationship to potentially preventing oxygen toxicity during exposure to hyperbaric environments. Dawn goes on to talk about some of her other IHMC-related research. [00:43:22] Ken asks Dawn to discuss her acceptance into the Aquanaut Program and her participation during one of NASA’s NEEMO missions. [00:46:04] Ken asks Dawn to reflect on her time on NEEMO Mission 21, and if there are any key takeaways she can discuss.

Today we have Dr. Mari Dezawa, one of the world’s leaders in stem-cell research and regenerative medicine. Mari is a pioneer in this emerging field and is known worldwide for her discovery of MUSE cells, a unique type of stem cell with exciting clinical potential. MUSE is short for Multilineage-Differentiating Stress-Enduring Cells. The discovery of the MUSE cell in humans has many biological and medical implications, and the human body may have a greater regenerative potential than we might have ever imagined. In collaboration with major national and international institutions, Mari and her colleagues are promoting research on MUSE cell-based regenerative medicine for diseases without definitive treatments. She and her team are also exploring the differences in regenerative capacity between less and more complex animals from the viewpoint of the stem-cell system. Mari is a professor and chair of the Division of Stem Cell Biology and Histology at Tohoku University School of Medicine. She has published more than 200 papers and is particularly known for her 2010 paper on the mechanisms of MUSE cells. In 2018, she was appointed a fellow of the U.S. National Academy of Inventors and has been the recipient of numerous awards, including the Japanese Government’s Prize for the Commendation for Science and Technology. Show notes: [00:04:10] Ken opens the interview by mentioning that although Mari was born in Japan, her family moved to the U.S. when she was only eight months old. Ken asks if it is true that Mari finds it difficult to answer the question of where her hometown is. [00:05:23] Ken asks Mari how she handled moving so much as a child. [00:05:52] Ken mentions that Mari’s father was a researcher and asks when she became passionate about research and science. [00:06:58] Ken mentions that Mari attended the Chiba University School of Medicine and asks what inspired her to go to medical school. [00:07:19] Ken explains that after Mari earned her medical degree, she attended Chiba University Graduate School of Medicine for her Ph.D. Ken mentions that while Mari was initially a cardiology resident, she later decided to focus on clinical research and became a stem-cell researcher. Ken asks what led her to shift from cardiology to stem-cell research. [00:08:25] Ken explains that Mari is well-known for her research into the role of stem cells in regeneration and functional recovery of nerve and muscle cells. Ken asks how and when she first became interested in stem cells. [00:09:56] Ken asks Mari to give a brief overview of stem cells and their significance. [00:11:18] Ken mentions that Mari remained at Chiba University as a research associate after earning her Ph.D in 1995. She then took a position as an associate professor at Yokohama City University Graduate School of Medicine before accepting a position at Kyoto University Graduate School of Medicine as an associate professor in 2003. Ken explains that while at Kyoto, Mari developed methods to induce bone marrow stromal cells to generate neuro and skeletal muscle cells, which play a crucial role in tissue repair and regeneration and are widely studied for their potential to serve as therapeutic agents. Ken asks Mari to give a quick primer on the crucial role these cells play in tissue repair. [00:13:25] Ken explains that in 2003, a member of Mari’s technical staff at Kyoto asked her whether they should discard some cultured adult rat and human bone marrow mesenchymal stem cells (MSCs) after she had noticed several strange cell clusters. Ken asks Mari to share what happened next and how this set her on the path to the discovery of Multilineage-Differentiating Stress-Enduring Cells. [00:16:03] Ken asks Mari to elaborate on this story and explain how a mistake led to this incredible discovery. [00:20:48] Ken explains that in 2008 Mari became professor and chair of the Department of Stem Cell Biology and Histology at Tohoku University Graduat...

Today we have our good friend and colleague Dr. Andrew Koutnik on the show. Andrew is a research scientist who studies the influence of nutrition and metabolism on health, disease and performance. He specializes in Type 1 diabetes and works with a wide range of people to improve their metabolic health and athletic performance. Andrew is a visiting research scientist at IHMC and has worked with Harvard, Johns Hopkins, NASA, and the Department of Defense to develop evidence-based strategies for overcoming complex health challenges. He is a graduate of Florida State University and earned his Ph.D. in medical sciences at the University of South Florida, where he worked with another good friend of ours, Dr. Dominic D’Agostino, who has been a previous STEM-Talk guest. Show notes: [00:02:50] Dawn welcomes Andrew to the show and asks him about his website, andrewkoutnik.com, the quote on the site’s homepage “Demystifying complex science to help you thrive in your health journey,” and the tagline “Challenging the status quo of metabolic health, human performance, and the management of type1 diabetes.” [00:05:31] Ken asks Andrew how old he was when he first learned he had Type 1 diabetes. [00:08:32] Dawn asks why Andrew believes his Type 1 diabetes is one of his life’s ultimate assets? [00:12:51] Ken mentions that Andrew grew up in Tallahassee and that despite suffering from childhood obesity, he was relatively athletic as a child. Ken asks Andrew to talk about his childhood. [00:14:20] Dawn asks Andrew to talk about the weight-loss journey he underwent as a teenager. [00:17:25] Dawn shifts gears to ask Andrew about how he got into science, mentioning that when he was younger, he never saw himself becoming a scientist. [00:20:19] Dawn asks if it is true that Andrew was the sort of kid who would constantly asked questions. [00:22:11] Dawn asks Andrew if it is true that after enrolling at Tallahassee Community College, it took him a while to decide on his major. [00:22:58] Ken asks Andrew to talk about the impact that his undergraduate anatomy and physiology class and professor had on his journey. [00:24:44] Ken mentions that after graduating from FSU, Andrew went to the University of South Florida where he worked with Dominic D’Agostino, who is both a previous STEM-Talk guest and a current colleague of Andrew’s. Ken asks Andrew how he met Dom. [00:27:46] Dawn asks Andrew how he came to work in Dom’s lab. [00:29:00] Dawn asks Andrew if his wife is still in touch with her former roommate, who connected Andrew and Dom. [00:29:21] Ken asks Andrew to touch on some of the research he did with Dom while he was pursuing his Ph.D. [00:31:49] Dawn shifts gears to talk about Andrew’s work in metabolic health and Type 1 diabetes. Dawn explains that a study published by the University of North Carolina found only 12 percent of Americans were metabolically healthy. Additionally, researchers from the Friedman School of Nutrition Science and Policy at Tufts University found in 2022 that only 6.8 percent of Americans had good cardiometabolic health. Dawn asks Andrew how he works with people who want to improve their metabolic health. [00:34:19] Ken asks Andrew for his thoughts on the sentiment that a ketogenic diet is hard to sustain. [00:36:55] Ken mentions that  Andrew was part of a review that looked at carbohydrate restriction for diabetes, which is a practice that had been in use since the 1700s. It fell out of favor once insulin was discovered in the 1920s. Ken goes on to explain that carbohydrate restrictive diets, like the ketogenic diet, have regained popularity for the treatment and management of diabetes, weight-loss and a range of other health issues such as migraines, cancer and depression. Ken asks Andrew to first explain the history of carb-restrictive diets as a treatment of diabetes. [00:39:43] Ken asks Andrew to talk more about the aforementioned 2021 review and its argument...

It’s time for another episode of Ask Me Anything. Dawn and Ken answer listener questions that range from generative AI to whether grip strength is a biomarker for longevity and the potential of ketamine as a treatment for depression. Dawn also gives a brief overview of work she is doing with the deep-sea technology company Deep. As a special treat at the end of today’s episode, Dawn plays a recording of the commencement speech that Ken recently gave at the University of West Florida. As the saying goes, you don’t want to miss it. Show notes: [00:02:18] Ken starts off the episode with a listener question about whether Dawn and Ken read print books or digital, the reason being that a listener recently came across an article that claimed digital screens are rewiring our brains. [00:05:32] A listener asks about a paper titled “Grip Strength An Indispensable Biomarker for Older Adults” which claims that the ability to hang from a bar for 60 seconds for men, and 30 seconds for women, indicates that a person is likely to live longer. The paper claims that a decline in grip strength is associated with adverse health consequences, and the listener asks Ken what advice he has for developing and maintaining grip strength. [00:10:20] A listener asks a question inspired by our recent interview with Dr. Frank Butler. The listener asks if Ken has heard about the FDA approved depression therapy, esketamine, which is a derivative of ketamine and is a long-standing therapy for depression. [00:12:37] A listener asks Ken about a 2023 paper in the journal Age and Aging titled “Higher Dietary Protein Intake is Associated with Sarcopenia in Older British Twins” [00:16:13] A listener asks Ken about “Whisper,” which is a transcription product from OpenAI. The listener explains that OpenAI disclaims that Whisper should not be used in high-risk domains. However, according to a story by the Associated Press titled “Researchers Say an AI Powered Transcription Tool Used in Hospitals Invents Things No One Ever Said,” medical centers have already begun to use the tool to transcribe physician consultations. The listener explains that, according to the article, the use of Whisper in these contexts has led to numerous ‘hallucinations’ from the AI tool and the listener asks Ken what his thoughts are on how tools like Whisper should be integrated into various industries. [00:20:21] A listener asks for Ken’s thoughts on a series of articles by Kevin Roose in The New York Times claiming that there is no reason to learn how to code and program because very soon AI will take over all coding. Mr. Roose also asserts that the time is soon approaching when we need to have discussions on what rights to grant sentient AI. [00:21:57] A listener asks Ken if he concurs with a report from the National Academy of Medicine titled “Generative Artificial Intelligence in Health and Medicine – Opportunities and Responsibilities for Transformative Innovation,” which notes that large language models (LLMs) hold huge promise for patient care and healthcare system workflows, as well as risks. The listener asks if Ken agrees with the report’s claims that two areas in which we could see near term applications of LLMs are patient education and synthesis of information of electronic medical records. [00:23:35] As a follow up question, Ken is asked about the aforementioned report’s discussion of the “digital twin” concept. A digital twin is a computational representation of a patient or disease that could be used to speed up virtual experiments or subgroup analysis of investigational agents that carry risk for real patients. [00:26:26] A listener asks for Ken’s thoughts on a paper published in the journal of Nutrition Health and Aging titled “Effects of Vitamin D3 Omega 3 Fatty Acids and a Simple Home Exercise Program on Change in Physical Activity Among Generally Healthy and Active Older Adults.” The paper claims that among generally healthy,

Today we have the second installment of our interview with Dr. Michael A. Schmidt, the founder, CEO, and Chief Scientific Officer of Sovaris Aerospace, a company focused on assessments and solutions applied to humans in space and extreme environments on Earth. In today’s interview, we talk to Michael about NASA’s plans to send humans to Mars and build permanent colonies on the Moon and Mars. We also talk to Michael about his recent book, “Building a Space-Faring Civilization,” which addresses the challenges of civilian spaceflight and the construction of space settlements. In part one of our interview, Episode 182, we talked with Michael about his pioneering work in the field of precision medicine and how he has used it to improve the cognitive and physical performance of astronauts as well as NBA, NFL players and Special Operations forces. In addition to his work with Sovaris, Michael also is a professor of aerospace medicine at the University of Central Florida College of Medicine, one of the few programs in the U.S. that offers a medical residency in aerospace medicine. Show notes: [00:03:00] Dawn picks up our interview from where we left off in part one, discussing the Human Research Program for Civilian Spaceflight. She goes on to mention that Chris Mason at Cornell University has a biobank of 1,500 samples across 22 astronauts and seven missions, and that these samples will lead to deeper insights on the effects of spaceflight on humans. Dawn switches gears to ask Michael about the cognitive and physical challenges of spaceflight over long duration missions. [00:13:03] Following up on the cognitive challenges of long duration spaceflight, Ken mentions that the hippocampus, the primary memory center of the brain, has a relatively low radiation threshold compared to other tissues in the brain. Ken asks Michael to touch on the vulnerability of specialized brain tissues to radiation, particularly in the context of a long duration spaceflight to Mars. [00:21:53] Ken mentions that it is understood that the APOE4/4 genotype is associated with impaired cognitive performance under certain circumstances and an elevated risk of dementia. While it is currently unknown whether APOE4/4 has any correlation of increased risk associated with cognitive impact resultant from environmental exposure due to spaceflight, Ken highlights the concern with sending APOE4/4-positive astronauts on long duration spaceflights without knowing the risks. [00:29:26] Ken notes the worsened cognitive impacts resultant from medical radiation, and while therapeutic radiation is different than radiation experienced by astronauts, these results give some indication of the effects astronauts might experience. [00:33:27] Dawn mentions that we recently had planetary scientist and director of NASA’s Haughton-Mars project, Pascal Lee, on the podcast, who explained his view that since there are so many engineering and biological challenges with going to Mars, we should take a more measured approach to a Mars mission, perhaps even beginning with a roundtrip to Mars rather than landing on our first visit. Dawn asks Michael what his thoughts are on this approach. [00:37:29] Ken shifts the discussion to the subject of one of Mars’ moons, Phobos, and its potential role in a Mars mission. [00:40:30] Dawn pivots to talk about Michael’s Book “Building a Space-Faring Civilization: Advancing the Renaissance of Science, Medicine and Human Performance in Civilian Spaceflight.” Dawn asks Michael to talk about the chapter concerning the question of space radiation from the standpoint of precision medicine. [00:55:12] Dawn asks Michael to talk about the lack of appreciation people have for the fact that a Mars mission would be the most dangerous thing we’ve ever done. [00:59:06] Ken mentions that Michael has worked with a lot of organizations, including Space X, which has a program, the Space X Mars Colonization Program,

Today we have Dr. Michael A. Schmidt, the founder, CEO, and Chief Scientific Officer of Sovaris Aerospace, a company focused on assessments and solutions applied to humans in space and extreme environments on Earth.  Michael is also a professor of aerospace medicine at the University of Central Florida College of Medicine, one of the few programs in the U.S. that offers a medical residency in aerospace medicine. Michael is known for his work pioneering the field of precision medicine. He uses molecular analytics, coupled with physiologic and behavioral assessments, to facilitate human performance and resilience on Earth as well as in the extreme environment of space. His work covers a spectrum from NASA, the NFL, the NBA, U.S. Olympic teams, Nike, SpaceX, Axiom Space, NASCAR, Special Operations, the Naval Submarine Medical Research Lab, the Mayo Clinic, and others. We had a long and fascinating conversation with Michael and decided to break the interview into two parts. This episode focuses on Michael’s background and the cognitive and physical challenges astronauts experience in spaceflight. We also dive into the many ways that precision medicine is facilitating human performance and resilience here on Earth. In part two of our conversation, Michael talks about his work with NASA and SpaceX on the challenges of civilian spaceflight and the future of Mars exploration, including the construction of permanent colonies on the Moon and Mars. You won’t want to miss that conversation. Show notes: [00:03:59] Dawn opens our interview mentioning that Michael grew up in Minnesota in a small farming community, asking if it’s true that he sometimes had to do chores in 20- to 30-degree weather. [00:06:50] Dawn asks if it is true that Michael fell in love with science at a young age, even building telescopes at the age of 11. [00:08:00] Dawn asks Michael what it was that led him to become so fascinated with space specifically. [00:08:58] Dawn asks if Michael ever thought about becoming an astronaut. [00:10:09] Ken asks if it is true that Michael was a big reader as a child. [00:11:21] Dawn asks Michael to talk about his childhood athletic interests. [00:11:55] Dawn asks how it was that a high school quarterback from a small town in Minnesota ended up at university in the United Kingdom. [00:13:38] Ken asks Michael what years he worked at NASA Ames Research Center. [00:14:51] Ken mentions that when Michael was at NASA Ames, he did work collecting molecular and physiologic assessments of humans using NASA’s 20-G centrifuge. Ken asks Michael to talk about the centrifuge and how he used it in his studies of hypergravity. [00:17:49] Ken comments on the fact that pieces of equipment like NASA’s 20-G centrifuge are a precious scientific resource, and when they cease functioning, unfortunately, they are unlikely to be replaced. [00:19:40] Ken and Michael discuss the fact that microgravity, despite being one of the most pressing effects on astronaut health, is the one of the least addressed problems in human spaceflight. [00:21:48] Ken explains that Michael is the founder, CEO and Chief Scientific Officer of a company called Sovaris Aerospace, which is focused on assessments and solutions applied to humans in space and extreme environments on Earth. Ken asks Michael where the idea came from to found this company. [00:24:35] Dawn explains that since the human genome was first sequenced, there has been an acceleration of genome-based technologies that have made it possible to consider a person’s genetic makeup, both in healthcare and optimizing performance. Dawn asks Michael to talk about the work he does applying genomics to human spaceflight. [00:28:52] Dawn asks about Michael’s direction of the molecular profiling and precision medicine efforts for the Golden State Warriors during their record-breaking 73-9 season [00:32:57] Dawn mentions that Michael published a review in the journal Meta...

Our guest today is Dr. Ken Forbus, the Walter P. Murphy Professor of Computer Science and a Professor of Education at Northwestern University. Joining Dr. Ken Ford to co-host today’s interview is Dr. James Allen, who was IHMC’s associate director until he retired a few years ago. James is a founding fellow of the American Association for Artificial Intelligence and a perfect fit for today’s discussion with Dr. Forbus, who, like James, is an AI pioneer.  Back in 2022, James was named a fellow by the Association for Computational Linguistics, an organization that studies computational language processing, another field he helped pioneer. Dr. Forbus also is a Fellow of the Association for the Advancement of Artificial Intelligence and was the inaugural winner of the Herbet A. Simon Prize for Advances in Cognitive Systems. He is well-known for his development of the Structure Mapping Engine. In artificial intelligence and cognitive science, the Structure Mapping Engine is a computer simulation of analogy and similarity comparisons that helped pave the way for computers to reason more like humans. Show Notes: [00:03:07] Ken opens the interview with Dr. Forbus by asking if it is true that he had an unusual hobby for a nerdy kid growing up. [00:04:18] James mentions that Dr. Forbus’ family moved often when he was younger and asks how that affected him. [00:05:18] Ken mentions that when Dr. Forbus was in high school, he filled his free time reading about psychology and cognition before eventually coming across some articles on AI. Ken asks Dr. Forbus to talk about this experience and what happened next. [00:07:49] James asks Dr. Forbus if he remembers the first computer he owned. [00:09:17] Ken asks Dr. Forbus if there was anything, other than its reputation, that led him to attend MIT. [00:10:09] James mentions that for the past few decades, Dr. Forbus has been working on developing “human like” AI systems. While much of AI research and development has been focused on meeting the standard of the Turing test, James asks Dr. Forbus why he is not a fan of the Turing test. [00:12:24] Ken mentions that Dr. Forbus received his Ph.D. from MIT in 1984, the same year that Apple released the first Macintosh, which was rolled out with a famous Super Bowl ad. This computer was the first successful mouse driven personal computer with a graphical interface. Ken asks Dr. Forbus what he remembers about that ad, and what his reaction to it was at the time. [00:13:22] James mentions that 1984 was also the year that Dr. Forbus made his first splash in the AI world with his paper on qualitative process theory. James goes on to explain that at the time, qualitative reasoning regarding quantities was a major problem for AI. In his paper, Dr. Forbus proposed qualitative process theory as a representational framework for common sense physical reasoning, arguing that understanding common sense physical reasoning first required understanding of processes and their effects and limits. James asks Dr. Forbus to give an overview of this paper and its significance. [00:18:10] Ken asks Dr. Forbus how it was that he ended up marrying one of his collaborators on the Structure Mapping Engine project, Dedre Gentner. [00:19:14] James explains that Dedre’s Structure Mapping Theory explains how people understand and reason about relationships between different situations, which is central to human cognition. James asks Dr. Forbus how Dedre’s theory was foundational for the Structure Mapping Engine (SME). [00:25:19] Ken mentions how SME has gone through a number of changes and improvements over the years, as documented in Dr. Forbus’ 2016 paper “Extending SME to handle large scale cognitive modeling.” Ken asks, as a cognitive model, what evidence Dr. Forbus has used to argue for the psychological and cognitive plausibility of SME. [00:30:00] Ken explains that many AI systems rely on deep learning,

Today we have planetary scientist Dr. Pascal Lee and STEM-Talk host Dr. Ken Ford in a wide-ranging conversation about NASA’s ambitions to return humans to the Moon as a stepping stone to sending astronauts to Mars. Pascal is making his third appearance on STEM-Talk. Much of his research focuses on asteroids, impact craters, and the future human exploration of Mars. Pascal and Ken have a lively discussion about the growing momentum for space exploration. Pascal is a researcher at the SETI Institute, a not-for-profit NASA program focused on searching for extraterrestrial intelligence in an effort to understand and explain the origin and nature of life in the universe. He also is the co-founder and chairman of the Mars Institute, and director of the Haughton-Mars Project at NASA Ames Research Center. Last year, Pascal received significant news coverage for his discovery of a giant volcano along with a possible sheet of buried glacier ice in the eastern part of Mars' Tharsis volcanic province. This was the first geological find of this magnitude since the other major volcanos on Mars were discovered back in the 1970s. Show notes: [00:03:06] Ken welcomes Pascal back to STEM-Talk and starts our interview by mentioning the developments in space exploration over the past few years, including civilian space missions, NASA’s Artemis program which aims to send humans back to the moon, and commitments to a manned mission to Mars. Given Pascal’s career in advancement of space exploration, Ken asks if Pascal is excited by these recent developments. [00:04:43] Ken explains that for a couple of decades Pascal has spent his summers visiting Devon Island in the Canadian arctic archipelago, which is the largest uninhabited land on Earth. When Pascal was last on STEM-Talk, his annual trip to Devon Island was cancelled due to COVID-19. Devon Island has unique geological characteristics that are in some ways similar to those on Mars. Since 2001, Devon Isalnd has been the home of the Haughton Mars Project (HMP). Ken asks Pascal to talk about the advances in this project since his last appearance on STEM-Talk. [00:07:59] Ken mentions that while much conversation has been centered on a human trip to Mars, a mission to return humans to the Moon and establish a permanent base is a more immediately feasible goal in the short term. Ken asks Pascal to talk about the importance and significance of such a mission. [00:12:06] On the topic of a Moon base, Ken explains that NASA’s Artemis project aims to send humans to the south pole of the Moon. Pascal has written a paper on that topic titled “An Off-Polar Site Option for the NASA Artemis Space Camp.” Ken asks Pascal what he sees as the primary weakness in the south pole location. [00:20:25] Ken agrees with Pascal’s perspective on sending humans to the lunar south pole, and the two discuss the problems with focusing human space exploration on romantic ideas such as “living off the land.” [00:22:24] Ken follows up on the previous questions by mentioning that in Pascal’s aforementioned paper, he suggests setting up a lunar base at the floor of the Clavius crater. Ken asks Pascal to talk about Clavius and why it is a potentially good permanent location for a moon base. [00:27:56] Ken asks Pascal how confident he and the community at large is in the Sophia finding of water. [00:29:00] Ken notes that contemporary interest in human space exploration appears tied to current geopolitical issues, much like the first space race between the US and USSR. Today, interest in space travel is closely linked with relations between the US and China. Ken asks Pascal to discuss this and how he believes the US should view this current situation. [00:35:43] Ken asks Pascal what he knows about the China’s current plans for a lunar mission. [00:34:36] Ken talks about a meeting at IHMC that addressed power-beaming to the lunar surface. [00:39:01] Ken notes that there is a lot of talk the...

Today we have JP Errico, a scientist and inventor whose work focuses on neuroimmunology and the many ways it impacts cellular metabolism, inflammation, mental health and how we age. He recently joined IHMC as a Senior Research Scientist. JP is particularly known for his research on vagus-nerve stimulation and is the author of the book, The Vagus-Immune Connection: Harness Your Vagus Nerve to Manage Stress, Prevent Immune Dysregulation, and Avoid Chronic Disease. He also is the co-host of the podcast, The Health Upgrade. JP has more than 250 patents and is the founder of ElectroCore, a company that specializes in neuromodulation and noninvasive vagus-nerve stimulation. He has an undergraduate degree in aeronautical engineering from the Massachusetts Institute of Technology and worked at Lincoln Laboratories. JP also holds graduate degrees in both law and mechanical/materials engineering from Duke University. Show notes: [00:03:08] Tim opens our interview mentioning that as a child JP was focused on both sports and academics. [00:04:50] Tim talks about how hard it is to find quality math and science education today similar to what JP experienced at his high school. [00:05:16] Tim asks JP what it was that led him to pursue an undergraduate degree at MIT. [00:05:53] Tim asks if it was always JP’s plan to go into aeronautical engineering. [00:07:22] Tim mentions that as a kid, JP would scour bookstores and libraries for textbooks on physics and quantum mechanics and asks JP if there were any books that particularly inspired him. [00:10:12] Ken mentions that after MIT, JP went to Duke University where he pursued mechanical engineering and also went to law school. Given this workload, Ken asks if JP ever had any free time while studying at Duke. [00:13:26] Tim mentions that while JP was in law school, he got a job at a patent firm. After obtaining his law degree, JP’s uncle called and offered JP an opportunity. [00:17:42] Tim explains that JP’s career has focused on neuroimmunology, or the study of how the nervous system and immune system interact. Neuroimmunology affects a wide range of health factors including inflammation, mental health and aging. Tim also explains that JP has recently authored a book on neuroimmunology titled “The Vagus Immune Connection: Harness Your Vagus Nerve to Manage Stress, Prevent Immune Dysregulation and Avoid Chronic Disease.” Tim asks JP to touch on the key features of neuroimmunology that people should be aware of. [00:21:59] Tim asks JP to touch on the epigenetic factors regarding neuroimmunology. [00:25:01] Since JP brought up Dr. Kevin Tracey’s work, Ken mentions that Kevin was recently interviewed on STEM-Talk episode 172 and encourages listeners to listen to that episode for more context on the vagus nerve and neuroimmunology. [00:25:48] JP talks about how he stumbled upon the idea of how stimulating a nerve may have the same clinical benefit that sometimes occurs as a result of cutting a nerve. [00:28:16] Tim talks about the unintended consequences he observed as surgeon when he cut a patient’s vagus nerve. [00:30:50] Ken mentions that another area where JP has had impact with respect to stimulating the vagus nerve is the treatment of asthma and asks JP to talk about his findings in this area. [00:40:10] Tim notes that after JP knew that non-invasive approaches to vagus-nerve stimulation were possible, he went on to optimize a delivery device. These efforts resulted in a device called gamaCore. Tim asks JP to talk about this device and how it works. [00:43:27] Tim asks JP to talk about what it feels like for patients to have their vagus nerve stimulated. [00:44:50] Ken asks if JP thinks that his and others’ work in vagus-nerve stimulation inspired the development of similar devices for orthopedic pain, where the device is implanted near the nerve on the knee or other area experiencing pain.