Encore: How to Build a Moonshot Factory

Astro Teller, Alphabet’s Captain of Moonshots, joins us for a conversation about the importance of failure, workplace culture in a moonshot factory, and not throwing away your shot.We Meet: Astro Teller is the Captain of Moonshots at X, Alphabet's Moonshot FactoryCredits:This episode of SHIFT was produced by Jennifer Strong with help from Emma Cillekens. It was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco.This episode originally ran in April 2025.

AMD provides high-performance computing power that runs everything from your gaming console and personal laptop, to the giant supercomputers and AI systems that power the cloud. Its head of AI discusses the move from sequential to massively parallel processing, and the company's strategy to embed AI from big cloud machines to tiny client devices.We Meet:  AMD’s SVP for AI Vamsi BoppanaCredits:This episode of SHIFT was produced by Jennifer Strong with help from Emma Cillekens. It was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco.

We explore how one group is using AI to help people talk, listen and understand in large groups, in hopes of counteracting forces that have undermined our ability to communicate online, in the latest installment of our oral history project.We Meet:  Yasmin Green, CEO of Jigsaw, an incubator within Google Credits:This episode of SHIFT was produced by Jennifer Strong with help from Emma Cillekens. It was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco.

What do you think it would be like to lead AI efforts and the overall digital transformation of the CIA? This week, we find out as we dive into a world of espionage and secrets in the latest installment of our oral history project. We Meet:  Retired Deputy CIA Director for Digital Innovation Jennifer Ewbank Credits:This episode of SHIFT was produced by Jennifer Strong with help from Emma Cillekens. It was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco.

How we build products, why we build them, and what we think they’re for have always changed, but these days developers and engineers who love things like product roadmaps might find the current AI scene a little disorienting. That’s because there often isn’t a roadmap. If there is? It’s constantly changing.This week, we meet the CTO of IBM Research and she tells us about the current landscape and what she imagines for the future. This episode was recorded at TEDAI in Vienna, Austria. We Meet:  IBM Research CTO Anna Topol Credits:This episode of SHIFT was produced by Jennifer Strong with help from Emma Cillekens, and special thanks to Dajana Doskoc and Alina Nikoloau at TEDAI Vienna. It was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco.

Agentic AI is one of the hottest topics going in tech circles, but if pinning down exactly what we’re talking about feels a bit like a moving target, it’s not your imagination. What agents are capable of doing is changing almost as quickly as what people want to do with them. We Meet:  VP of Agentic AI at AWS Swami Sivasubramanian Credits:This episode of SHIFT was produced by Jennifer Strong with help from Emma Cillekens, and special thanks to Dajana Doskoc and Alina Nikoloau at TEDAI Vienna. It was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco.

What’s an astronaut’s time worth? Answering that question is not a perfect science, but at more than $100,000 an hour (not counting salary - that's just to keep one alive) on the International Space Station, it’s safe to say it’s more than you want to pay for bagging up trash. This week, we take a field trip in New York City to see some space robots that could help with this problem. We Meet:  Icarus Robotics CEO Ethan Barajas Icarus Robotics CTO Jamie Palmer  Credits:This episode of SHIFT was produced by Jennifer Strong with help from Emma Cillekens. It was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco.

Might a lack of legacy healthcare tech infrastructure in rural communities offer an advantage over mature markets? A  founder makes the case in the latest installment of our oral history project.We Meet:  Homeward Co-Founder & President Amar Kendale Credits:This episode of SHIFT was produced by Jennifer Strong with help from Emma Cillekens. It was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco.

You've likely heard that artificial intelligence is gobbling up electricity and drinking water, and causing a global race to build more energy capacity. Have you ever stopped to consider why? Or what we’re doing to bring compute power and sustainability closer together?This episode was recorded in front of a live audience at TechBBQ, the largest tech conference in the Nordics. It's held each year in Copenhagen, Denmark.We Meet:  Caspar Høgh, Co-Founding Partner Noon Ventures Yasser Nour, CTO & Co-Founder Lotus MicrosystemsRuben Bryon, CEO & Co-Founder DatacrunchCredits:This episode of SHIFT was produced by Jennifer Strong and Emma Cillekens, and it was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco. 

EU AI Act architect and lead author Gabriele Mazzini shares his experience drafting the law. He also talks about his concerns with implementation and its potential impact on European competitiveness, and how that led him to quit his job, in the latest installment of our oral history project.This episode was recorded at TEDAI in Vienna and originally ran in 2024.We Meet:MIT Media Lab Research Affiliate & MIT Connection Science Fellow Gabriele MazziniCredits:This episode of SHIFT was produced by Jennifer Strong and Emma Cillekens, and it was mixed by Garret Lang, with original music from him and Jacob Gorski. Art by Meg Marco.