Drugging the 'undruggable' cancer proteins & conserving the Bayeux Tapestry | The chemical breakdown podcast

This week, we explore how molecular glues have revolutionized how we treat previously 'undruggable' cancers and explore how modern scientific techniques are teasing apart the mysteries of one of the most iconic historical artefacts with Phillip Broadwith and Neil Withers. A ground-breaking new drug has become the first of its kind to win FDA approval for metastatic pancreatic cancer. Could it mark the beginning of a new era for cancers that have long been considered impossible to target? We'll also uncover the chemistry behind the investigation and conservation of the Bayeux Tapestry. What secrets have scientists already revealed, and what questions about this iconic artefact remain unanswered?   Main stories: https://www.chemistryworld.com/news/us-approves-pancreatic-cancer-treatment-that-targets-undruggable-proteins/4024110.article https://www.chemistryworld.com/features/the-chemistry-helping-to-unravel-the-bayeux-tapestrys-secrets/4024093.article   Headlines: https://www.chemistryworld.com/news/does-the-discovery-of-a-new-coronavirus-upend-the-covid-19-lab-leak-hypothesis/4024170.article https://www.chemistryworld.com/news/uk-funding-agency-to-spend-66-million-on-new-methods-for-engineering-the-mitochondrial-genome/4024165.article https://www.chemistryworld.com/news/chinas-scientific-rise-is-being-driven-by-returning-expertise-especially-chemists/4024149.article https://www.chemistryworld.com/news/growing-confidence-of-africas-chemical-societies-brings-chemistrys-benefits-to-continent/4024137.article  

This week, we discuss a study showing promise in applying CAR-T immunotherapy in bladder cancer tumours and breakdown how scientists have uncovered spectral signatures previously misassigned in carbon materials – with Frankie Macpherson and Mason Wakley. CAR-T therapy has been a game changer for blood cancers, yet solid tumours have been largely resistant to this treatment. We discuss a new study that shows promise in applying this immunotherapy in bladder cancer tumours. And, we discuss why scientists are rethinking how they assign peaks in spectra of carbon-based materials. What does this mean for the technologies that rely on them, and do we need to rethink some long-held assumptions?   Main stories: https://www.chemistryworld.com/news/step-forward-for-car-t-therapy-as-it-shows-promise-in-solid-bladder-tumours/4024034.article https://www.chemistryworld.com/news/chemists-may-be-misassigning-defects-in-carbon-materials-study-suggests/4024018.article   Headlines: https://www.chemistryworld.com/news/copper-chains-more-than-4000-atoms-long-are-the-longest-ever-produced/4024095.article https://www.chemistryworld.com/news/hokkaido-university-graduate-student-dies-after-exposure-to-hydrofluoric-acid/4024098.article https://www.chemistryworld.com/news/sodium-batteries-durability-and-performance-boosted-by-scandium-additive/4024088.article https://www.chemistryworld.com/news/molecular-dyes-outside-of-the-srgb-colour-gamut-present-a-challenge-for-digital-chemistry/4024094.article

In this episode, we discuss the changes to science policy made by the new UK prime minister and breakdown the chemistry behind crumbling concrete in Ireland. On July 21, new UK Prime Minister Andy Burnham abolished the government's department of science and absorbing its functions into the business department. What does this mean for UK research?  And, thousands of Irish buildings are cracking apart, but the culprit may not be what scientists first thought. We discuss the mica crisis and the chemistry behind it.   Main stories: https://www.chemistryworld.com/news/science-department-abolished-as-uks-new-prime-minister-andy-burnham-appoints-first-cabinet/4023895.article https://www.chemistryworld.com/news/why-are-buildings-cracking-up-in-ireland/4023916.article   Headlines: https://www.chemistryworld.com/news/chemistry-can-feel-inaccessible-to-british-asian-students-survey-finds/4024036.article https://www.chemistryworld.com/news/step-forward-for-car-t-therapy-as-it-shows-promise-in-solid-bladder-tumours/4024034.article https://www.chemistryworld.com/news/uranium-complex-smashes-record-for-consecutive-bonds-between-atoms/4024012.article https://www.chemistryworld.com/news/organisations-cant-solve-a-problem-they-cant-measure-industry-framework-aims-to-improve-chemical-hazard-monitoring/4024049.article

In this episode, we breakdown the controversy behind a collection of altered images in the online catalogue of one of the largest laboratory suppliers, and discuss the complexity behind chemical recycling of plastics with Frankie Macpherson and Phillip Broadwith. Multinational laboratory supplier Thermo Fisher Scientific has been criticized after hundreds of doctored images of validation Western blots were found on their online antibody reagent catalogue. We discuss the latest reactions from the scientific community. And, why hasn't chemical recycling been as successful with plastics? We explain some of the reasons behind the industry's contraction and what it means for the future of plastic recycling.   Main stories: https://www.chemistryworld.com/news/thermo-fisher-antibody-data-manipulation-is-a-breach-of-trust-say-researchers/4023854.article https://www.chemistryworld.com/news/chemical-recycling-plants-closing-in-eu-and-us/4023904.article   Headlines: https://www.chemistryworld.com/news/the-genius-narrative-isnt-inspiring-science-biographies-for-children-may-send-a-demotivating-message/4023970.article https://www.chemistryworld.com/news/re-engineered-psychedelic-drug-retains-therapeutic-activity-in-mice-while-limiting-negative-side-effects/4023982.article https://www.chemistryworld.com/news/japan-finalises-joining-the-eus-flagship-research-programme-horizon-europe/4023981.article https://www.chemistryworld.com/news/oral-cholesterol-lowering-peptide-approved-after-a-decade-in-development/4023991.article  

In this episode, we reflect on the lessons learned and the impacts of the Seveso chemical disaster of 1976, and discuss the latest membrane materials that could slash the energy required to refine crude oil with Jamie Durrani and Mason Wakley. Fifty years ago, a major accident at an Italian chemical plant released a cloud of dioxin that spread across 18 square kilometres, exposing 35,000 residents to the toxin. We discuss the legacy of Seveso and its impact on chemical regulation. And, a new method of separating hydrocarbons using membranes could replace fractional distillation in crude oil refineries, slashing energy costs. But what does this mean for a world trying to move beyond fossil fuels altogether?   Main stories: https://www.chemistryworld.com/features/seveso-disaster-at-50-how-italys-dioxin-catastrophe-transformed-chemical-safety/4023734.articledisaster https://www.chemistryworld.com/news/a-materials-breakthrough-membranes-to-separate-crude-oil-could-slash-energy-costs/4023811.article   Headlines: https://www.chemistryworld.com/news/losing-an-entire-generation-of-scientific-talent-top-us-universities-accepted-15-fewer-phds/4023877.article https://www.chemistryworld.com/news/stfcs-160-million-cost-cutting-plan-prompts-concern-over-future-access-to-key-uk-research-facilities/4023862.article https://www.chemistryworld.com/news/german-research-funder-issues-warning-over-threats-to-academic-freedom/4023880.article https://www.chemistryworld.com/news/thermo-fisher-antibody-data-manipulation-is-a-breach-of-trust-say-researchers/4023854.article  

In this episode, we bring the latest from the recent temporary reopening of the Strait of Hormuz, and discuss the presence of potential explosives at the historic Antarctic bases of explorers Ernest Shackleton and Robert Scott with Phillip Broadwith and Frances Briggs. The US and Iran have recently signed a form of agreement to temporarily reopen the Strait of Hormuz for shipping. But will this be enough to ease costs of resources, or has too much damage already been done? And, representatives from New Zealand have warned about the possible presence of explosive materials inside the Antarctic Laboratories left behind by explorers Robert Scott and Ernest Shakleton. We explain the chemistry underpinning the substances. 

This week, we discuss the latest challenges facing US science outlined by president of the US National Academy of Sciences Marcia McNutt in her outgoing address as well as the unique chemistry underpinning wool's incredible properties with Neil Withers and Rebecca Trager. Marcia McNutt gave her final address as president of the US National Academy of Sciences earlier this month, warning of turmoil for science in the wake of further proposals by the White House to restrict funding. We discuss highlights from the event.  And, how does the chemical composition of wool contribute to its material properties? We explore this staple fabric and its uses beyond clothing.

This week, we look back at how far click chemistry has come in the last 25 years and discuss the strange bonding behaviour of some of the largest elements on the periodic table with Mason Wakley and Frances Briggs. It started as a review paper in 2001 that has since been cited almost 20,000 times, becoming one of the most influential chemistry papers ever written. Click chemistry has revolutionised the way we build molecules. But what defines a click reaction, and what does the future hold? And, new research has revealed experimental evidence of how covalent bonding affects the 5f orbital in early actinides. We discuss the challenges of studying these elements.

This week, we discuss the latest milestone in quantum computational modelling and reveal the common laboratory item causing strange readings in microplastics research with Frankie Macpherson and Patrick Walter. A new hybrid workflow involving two IBM quantum computers and two powerful supercomputers has allowed researchers to model a protein–ligand system containing up to a record 12,635 atoms. What does this mean for the future of quantum computing? And, a recent study has found an unsuspecting source of contamination in microplastics research, distorting measurements of atmospheric pollution. We discuss the underlying cause.

This week, we are celebrating Chemistry World's Battery Week with a special battery-themed episode! We discuss the race between cathode materials for electric vehicles and a new photocatalyst capable of turning plastic waste into hydrogen and value-added chemicals, with Neil Withers and Patrick Walter. A race between competing battery cathode materials is heating up, the winner of which will shape the future of electric vehicles. But which will come out on top? And, we discuss a new photocatalyst that could change the way we recycle plastics and battery acid, demonstrating how waste streams could be transformed into resources. We explore what this could mean for building a truly circular economy. To register for more Battery Week activities, check out:  https://www.chemistryworld.com/collections/energy-storage-and-batteries