The Best Singular Hack To Change EVERYTHING About Your Life : 1543

Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study: Social connections are really good for you. Loneliness kills.It’s the quality of your close relationships that matters.Good close relationships don’t just protect your body, they protect your brain.Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:how relationships improve your physical, mental and emotional health. (More than you know!)how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)what social fitness is and how to practice it. (Yes, it’s a flex.)ways to enliven and energize your relationships. (Energy totally matters.)why casual and work relationships matter more than you think. (A surprisingly big contribution.)You'll Learn:Why loneliness physically harms your body — affecting your brain, immune function, sleep, and pain sensitivityThe likely mechanism behind why relationships improve health: how a good listener helps regulate your stress responseWhat "social fitness" is and why relationships wither from neglect, even without conflictThe four attachment styles and why knowing yours matters before committing to a relationshipWhy intergenerational friendships may be one of the most underused tools for personal growth and happinessResources:    • Visit https://metabolismfixbook.com/ to learn more about JJ Virgin’s new book, The Metabolism Fix, and access the bonus resources she created to go with it. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   Timestamps: 00:00 — Introduction & the Study04:43 — What Makes a Good Life08:47 — How Relationships Heal13:44 — Happiness: Nature vs Nurture17:59 — Measuring Happiness23:56 — Life Stages & Happiness35:34 — Social Fitness44:30 — Energizing Relationships56:14 — Attachment & Childhood1:05:04 — Casual Friends & LegacyThank you to our sponsors!      - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - BodyHealth | Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase. - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Catharine Arnston on Spirulina, Chlorella, Mitochondria, Detox, Brain Energy, and Longevity Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off. Could one of the oldest foods on Earth also be one of the most overlooked tools for mitochondrial health, brain function, detoxification, and longevity? Host Dave Asprey sits down with Catharine Arnston, founder of ENERGYbits and author of Love Your Health to Bits with Algae, to explore the biology of spirulina and chlorella and why these microscopic organisms have been studied for decades as unusually nutrient-dense foods. Catharine explains the major differences between spirulina and chlorella, from how they are grown and processed to how she uses them for completely different purposes. Spirulina contains compounds including phycocyanin and superoxide dismutase that Catharine believes can support mitochondrial function, antioxidant defenses, cellular energy, and brain health, while chlorella is used primarily for binding and removing unwanted compounds such as heavy metals. They also discuss why water quality, sourcing, drying temperature, and processing can dramatically change the final product. The conversation goes deep into mitochondrial biology, including the electron transport chain, ATP production, oxidative stress, free radicals, cytochrome c, superoxide dismutase, and the blue pigment phycocyanin. Dave connects these mechanisms to his own experience rebuilding mitochondrial function and explains why increasing cellular energy without adequate antioxidant defenses may create problems, particularly for people experimenting with advanced longevity interventions such as mitochondrial peptides. Dave and Catharine also explore methylene blue, psychedelics, exercise, brain aging, environmental toxins, nutrient density, food quality, algae farming, sustainable agriculture, and why maintaining mitochondrial function may become increasingly important with age. Catharine, who turns 70 shortly after the recording, also shares the philosophy behind her first book and her belief that aging does not have to mean accepting declining energy and cognitive function. This is essential listening for anyone interested in mitochondria, spirulina, chlorella, cellular energy, brain health, detoxification, oxidative stress, longevity, biohacking, nutrient density, methylene blue, peptides, and maintaining performance as you age. You’ll Learn: Why spirulina and chlorella work differently in the body How spirulina may support mitochondrial energy and antioxidant defenses Why chlorella is commonly used for heavy metal and toxin binding What phycocyanin and superoxide dismutase do inside cells How oxidative stress can disrupt mitochondrial energy production Why Dave cautions against pushing mitochondrial output without adequate cellular protection How algae may support brain health, longevity, and performance as you age  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Catharine Arnston, ENERGYbits, spirulina, chlorella, algae, microalgae, mitochondrial health, mitochondria, cellular energy, ATP production, electron transport chain, oxidative stress, free radicals, superoxide dismutase, SOD, phycocyanin, brain health, detoxification, heavy metals, glyphosate, environmental toxins, methylene blue, MOTS-c, peptides, biohacking, longevity, healthy aging, nutrient density, antioxidant defense, sustainable food Resources:    • Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     Thank you to our sponsors!      - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Timestamps:  00:00 — Show Open 01:25 — Algae Origins & History 06:15 — Sourcing Quality Algae 09:15 — Nutrient Density Crisis 17:15 — Spirulina vs. Chlorella 22:30 — Algae Industry Applications 27:45 — Algae in Your Cells 33:20 — SOD & Brain Health 42:00 — Phycocyanin & Cancer 52:30 — Aging vs. Declining See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Try Longevity Gummies: https://www.timeline.com/partners/dave-aspreyIf you're waking up exhausted, foggy, or inflamed and nothing seems to fix it, the answer might be hiding in your walls. This deep dive walks through how toxic mold and mycotoxins settle into your brain, nerves, and mitochondria, how to properly test your home and body for exposure, and the exact order of operations, environment first, then detox, that actually leads to recovery. Drawing from his own diagnosis with mold-related brain damage, the creator breaks down everything from HVAC contamination to binders and glutathione so you can finally stop chasing symptoms and address the real source.Thank you to our sponsors!Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighNeuronic | Go to www.neuronic.online Code DAVE for $100 offiRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVETimestamps:00:00 — Mold Toxins and My Story02:14 — How Mycotoxins Damage Cells04:09 — Three Sources of Mold05:35 — Track Symptoms by Location07:20 — Fix Environment Before Detox08:53 — Mold Testing Methods10:35 — Remediation and Moisture Control12:47 — Belongings Can Recontaminate14:45 — Why Recovery Varies17:23 — Detox Protocol and BindersConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Back with another all-time classic. Teal's is one of those episodes I keep going back to because it was just that good. Now more than ever, we need to ask ourselves: what is the role of Ego? Do we need to worry about AI killing us? Is there hope for the future of our species?These are just a few of the big questions you’ll tackle in this enlightening and esoteric episode re-run. I’m joined by Teal Swan, a thought leader, bestselling author, and international speaker who is on a mission to reduce human suffering. After a challenging upbringing, Teal emerged with a unique ability to talk about psychology, shadow work, and the nature of our world. Teal shares the unusual and special way she sees the world. We talk about her ESP powers, how to identify a narcissist, and her favorite dimensions. We also get into the divine masculine vs. the divine feminine, the nature of ego, and how to build trust in the world and others. 00:00 — Trailer00:18 — Intro6:12 — Understanding Narcissism13:20 — AI and Spiritual Perception19:30 — Birth Trauma and Memory28:00 — Art and Different Realities35:22 — The Nature of Ego42:50 — Divine Masculine and Feminine50:00 — Hormones and Hope54:05 — Synchronization Workshops1:00:29 — OutroSponsorsButcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighEMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVEResources: • Learn More About Teal's Work At: https://tealswan.com/about-teal/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Michael Leon on Smell Training, Memory, Sleep, Alzheimer’s Risk, and Brain Longevity Your sense of smell may reveal more about your brain health than you realize, and stimulating it while you sleep may improve memory, sleep quality, and cognitive function. **Visit https://memoryair.com/ and use code DAVE15 for 15% off. **Host Dave Asprey sits down with Dr. Michael Leon, Professor Emeritus of Neurobiology and Behavior at UC Irvine and one of the world’s most cited scientists, to explore why smell may be one of the most overlooked tools for brain health and longevity. Dr. Leon explains why the olfactory system has unusually direct access to the brain’s memory and emotional centers, why smell often declines alongside memory after age 60, and why reduced olfactory function has been associated with Alzheimer’s disease, cognitive decline, depression, and increased all-cause mortality. They also discuss how COVID, chronic congestion, pollution, stress, and aging can impair smell without people realizing it. The conversation dives into olfactory enrichment, including research showing major improvements in memory when older adults were exposed to multiple scents during sleep. Dr. Leon explains why novelty matters, how nighttime scent exposure may increase deep sleep and reduce nightmares, and why olfactory stimulation is being studied in dementia, PTSD, depression, and autism. Dave also explores connections between smell, GLP-1 drugs, exercise, rapamycin, spermidine, oxytocin, hormones, mitochondrial function, and other longevity interventions. This is essential listening for anyone interested in memory, sleep, Alzheimer’s prevention, brain aging, smell training, dementia, PTSD, autism, longevity, neuroplasticity, biohacking, and protecting cognitive function as you age. You’ll Learn: -Why your sense of smell often declines alongside memory -How smell connects directly to the brain’s memory and emotional centers -Why poor olfactory function is associated with Alzheimer’s risk and mortality -How chronic congestion may affect memory and brain health -What COVID-related smell loss may mean for long-term cognitive health -How olfactory enrichment can stimulate memory centers while you sleep -Why one study reported a 226% improvement in memory in healthy older adults -How scent exposure may increase deep sleep and reduce nightmares -Why novelty and rotating scents appear to matter for neuroplasticity -How smell training is being studied in dementia, depression, PTSD, and autism -Why several longevity interventions are also associated with improved olfaction -How GLP-1 drugs may affect smell, food enjoyment, memory, and emotion -Why professional wine tasters may offer clues about protecting the aging brain  Thank you to our sponsors!         - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.comDAVE and using code DAVE at checkout. - LMNT | Right now, grab any LMNT drink mix and they'll throw in a free sample pack. Go to drinklmnt.com/dave to get yours. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Michael Leon, smell training, olfactory enrichment, sense of smell, memory improvement, brain aging, Alzheimer’s disease, dementia, deep sleep, nightmares, PTSD, autism, depression, COVID smell loss, olfactory system, neuroplasticity, MemoryAir, essential oils, cognitive decline, all-cause mortality, GLP-1, rapamycin, spermidine, oxytocin, longevity, brain health, sleep optimization, memory loss, olfactory stimulation  Resources:    • Visit https://memoryair.com/ and use code DAVE15 for 15% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     Timestamps:  00:00 — Smell and Your Brain 01:25 — Intro 06:52 — Why Smell Goes Unnoticed 10:59 — Making MemoryAir 15:46 — Smell and Dementia 20:00 — Smell Predicts Lifespan 25:32 — Testing Your Sense of Smell 28:33 — Autism and Olfactory Therapy 36:23 — Biohacking Your Nose 42:50 — GLP-1 and Olfaction 45:55 — PTSD, Nightmares, and Sleep See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

**Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!**At 53, Josh Duhamel says he feels better than he did in his 30s. Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age. Josh shares why he started TRT in his early 40s, what changed once he began tracking his hormones, and why he decided to build a health company around hormone optimization. They also discuss injectable testosterone, GLP-1s, peptide quality, hair loss treatments, stem cells, and the importance of medical guidance when experimenting with longevity tools. The conversation also gets into cognitive performance, including Josh's past struggles with forgetting lines, his interest in nootropics, and Dave's experience with Modafinil and Aniracetam. Josh explains why having a newborn and a toddler at 53 has made longevity more personal, while Dave and Josh explore the connection between physical health, spirituality, breathwork, psychedelics, and mental performance. This is essential listening for anyone interested in testosterone, TRT, peptides, nootropics, brain health, GLP-1s, healthy aging, fatherhood, hormone optimization, and longevity. You'll Learn: Why Josh started testosterone therapy in his early 40s How TRT changed his energy, strength, joints, and motivation Why testosterone levels should be individualized How injectable, oral, and topical testosterone differ Why peptide sourcing matters How GLP-1s can affect muscle and body composition What Josh has tried for hair loss Why brain performance became a major concern for him Which nootropics come up for memory, focus, and mental stamina Why becoming a father later in life changed how Josh thinks about longevity How breathwork, psychedelics, and spirituality fit into the conversation Thank you to our sponsors!      - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY. - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Josh Duhamel, Gatlan Health, testosterone therapy, TRT, low testosterone, hormone optimization, injectable testosterone, testosterone cream, oral testosterone, peptides, peptide therapy, GLP-1, healthy aging, longevity, nootropics, Modafinil, Aniracetam, Dihexa, brain health, cognitive performance, hair loss, stem cells, fatherhood, men over 50, energy, muscle, strength, bloodwork, hormone testing, psychedelics, breathwork, spirituality Resources:    • Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     Timestamps:  00:00 – Trailer 01:15 – Intro 07:16 – Alcohol & Hangover Hacks 13:24 – Spirituality & Health 19:36 – Hormone Therapy for Women 24:45 – Inside Gatlan's Model 30:35 – Potty Training Secrets 38:39 – North Dakota & Fargo 43:57 – Hollywood's Beauty Secrets 50:19 – Acting Career & Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Carolina Reis de Oliveira on Reversing Skin Age, Menopause, GLP-1 Skin, and the Science of Senescent Cells Your skin is likely biologically older than you are, but new research suggests some of that aging may be reversible. **For Dave’s listeners only, visit oneskin.co/Dave  for exclusive early access to the OS-01 Face Rich Cream!**Host Dave Asprey sits down with Carolina Reis de Oliveira, PhD, CEO and co-founder of OneSkin. Carolina holds a PhD in stem cell biology and tissue engineering, is a co-inventor of five patents, and has co-authored numerous scientific publications. She and her team are studying skin longevity by targeting one of the central drivers of aging: the accumulation of senescent cells.  They break down why skin loses its ability to hold water as you age, and why that process can accelerate dramatically during perimenopause and menopause. Carolina explains the skin's "brick and mortar" barrier system, how declining estrogen affects collagen, ceramides, cholesterol, hyaluronic acid, and elastin, and why simply sealing moisture into your skin with occlusive products does not solve the underlying biology. They also explore why GLP-1 users can experience loose or sagging skin after rapid weight loss and what may help preserve skin structure over time. Carolina reveals how her team screened hundreds of peptides to develop OS-01, a senomorphic peptide designed to reduce the damaging signals produced by senescent "zombie" cells while supporting healthier skin function. In their research, OS-01 reduced markers of cellular senescence and inflammation, increased collagen production, and was associated with a 2.5-year reduction in measured biological skin age. She also explains why more peptides are not necessarily better, why some GHK-Cu formulations may fail to perform, and why peptide stability, concentration, delivery, and formulation matter. The conversation also covers why the skin around your eyes may biologically age decades faster than your cheeks, whether topical collagen really works, why cholesterol is essential for a healthy skin barrier, how over-moisturizing and "slugging" can backfire, and how damaged skin may contribute to systemic inflammation. Carolina also shares clinical data on OneSkin's new OS-01 Rich moisturizer, including improvements in hydration, firmness, fine lines, wrinkles, collagen, hyaluronic acid, and elastin. This is essential listening for anyone serious about skin longevity, anti-aging, menopause, GLP-1 weight loss, collagen, senescent cells, peptides, biological age testing, inflammation, hydration, hair and skin health, and maintaining younger-looking skin as you age. You'll Learn: -Why menopause can rapidly accelerate dry, thin, and crepey skin -How your skin's natural barrier holds water and why it breaks down with age -Why GLP-1 weight loss can make loose and sagging skin more noticeable -How senescent "zombie" cells accelerate inflammation and collagen loss -How OS-01 was associated with a 2.5-year reduction in biological skin age -Why skin around your eyes may be biologically much older than skin on your cheeks -Why topical collagen is different from collagen amino acids and collagen-producing signals -How cholesterol, ceramides, fatty acids, and hyaluronic acid support skin hydration -Why some GHK-Cu peptide products may not perform as expected -How over-moisturizing, face masks, Vaseline, and "slugging" can disrupt the skin barrier -How scientists measure the biological age of skin with epigenetic clocks -Why healthier skin may help lower inflammation throughout the body  Thank you to our sponsors!      - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Calroy | Go to calroy.com/dave for your discount. - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Carolina Reis de Oliveira, OneSkin, OS-01, skin longevity, skin biological age, skin age reversal, senescent cells, zombie cells, menopause skin, perimenopause skin, GLP-1 weight loss, loose skin, crepey skin, skin hydration, skin barrier, collagen production, hyaluronic acid, elastin, ceramides, cholesterol skin, GHK-Cu, copper peptide, peptides, epigenetic skin clock, MoClock, fine lines, wrinkles, skin firmness, slugging, topical collagen Resources:    • OneSkin | Get Early Access To OS-01 Rich Cream: oneskin.co/Dave   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     Timestamps:  00:00 — Trailer 01:33 — Meet Carolina & OneSkin 04:31 — Skin Hydration Decline 11:46 — How the Peptide Hydrates Skin 18:20 — Zombie Cells Explained 23:32 — Discovering Peptide OS-01 32:44 — Measuring Biological Skin Age 39:00 — Skincare Philosophy for Men 43:32 — Body Lotion & Inflammation 50:09 — New Rich Cream Data See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Try Longevity Gummies: https://www.timeline.com/partners/dave-aspreyThis video walks you through the complete biological timeline of a 36-hour sugar fast, from insulin dropping and liver glycogen draining to fat burning, ketone production, lower inflammation, and sharper mental clarity. You’ll see how quickly your metabolism can start switching back to the fuel system it was built to use.Thank you to our sponsors!Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighBrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power BundleiRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE00:00 – Sugar's Deadly Toll01:31 – Insulin's Hidden Damage02:52 – The Glycogen Reserve04:12 – Liver Fuel Runs Low05:29 – Reversing Insulin Resistance07:30 – Brain's Fuel Problem07:53 – Ketones: Backup Fuel09:24 – The Hormonal Reset10:46 – Visible Physical ChangesConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sea Squirt Plasmalogens Show Brain And Aging Benefits In Old Mice Aged mice given purified plasmalogen supplements showed better memory performance, healthier synaptic structure, lower neuroinflammation, and increased signaling tied to neurite growth and synapse development, with treated mice even growing thicker, darker, glossier hair. Plasmalogens are specialized lipids concentrated in cell membranes and the brain that tend to decline with age and neurodegenerative disease, making them an intriguing target for cognitive longevity. Host Dave Asprey breaks down why membrane composition matters for brain signaling, mitochondrial function, and inflammation, while stressing that this remains mouse research from 2022 and does not mean eating sea squirts or taking an unproven plasmalogen supplement will reproduce the same effects in humans. Sources: https://www.sciencedaily.com/releases/2026/09/260902234518.htm https://doi.org/10.3389/fmolb.2022.815320 ~~ Apple Watch Series 12 Adds More HRV Data, Readiness Scoring, And Health Age Apple Watch Series 12 pushes deeper into health tracking with heart rate measurements every five seconds, substantially more frequent HRV sampling, a new daily Readiness score, and a Longevity section in the Health app featuring Health Age. Apple is also expanding its health ecosystem with daytime vitals, movement assessments, menopause tracking, and Quest Diagnostics lab ordering for more than fifty biomarkers. Host Dave Asprey explains why higher-frequency wearable data can become useful for spotting changes in stress, recovery, sleep, and illness, but warns against letting algorithmic scores override your own baseline, symptoms, and real-world performance. Source: https://www.apple.com/newsroom/2026/09/introducing-apple-watch-series-12-with-the-all-new-health-sensing-system/ ~~ FDA Moves To Accelerate Botanical Drug Development The FDA has opened a formal request for input on how to accelerate botanical drug development, including better clinical trial designs, stronger quality standards, improved standardization of complex plant mixtures, and expanded use of real-world evidence. The agency is also working with the European Medicines Agency on regulatory considerations for herbal and botanical medicines, potentially creating a clearer path for standardized plant-derived therapies to move beyond vague supplement claims and into more rigorous clinical testing. Host Dave Asprey breaks down why this could strengthen the evidence behind compounds like berberine, saffron, medicinal mushrooms, and flavanols, while also warning that more pharmaceutical-style regulation could increase costs and reduce access. Source: https://www.healthmanagement.com/insights/weekly-roundup-v2/september-9-2026/ ~~ Persistent Adolescent Cannabis Use Linked To Long-Term IQ And Cognitive Decline A long-running New Zealand birth cohort found that people with persistent cannabis dependence beginning in adolescence showed significant cognitive decline by age thirty-eight, including losses in IQ, memory, processing speed, attention, and executive function. The most persistent users showed an average decline of roughly eight IQ points, while adult-onset users did not show the same pattern, pointing toward adolescence as a potentially important developmental vulnerability window. Host Dave Asprey explains why this 2012 observational study cannot prove cannabis caused every cognitive change, but argues that dose, frequency, age of exposure, and brain development all matter when evaluating cannabis for performance, health, or therapeutic use. Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC3479587/ ~~ Pterostilbene Helps Mouse Muscle Cells Burn More Fat Through PPAR-Delta Researchers testing pterostilbene, a polyphenol found in blueberries and grapes, found that it reduced intracellular fat accumulation and increased fatty acid oxidation in cultured mouse muscle cells. Rather than directly activating PPAR-delta, pterostilbene appeared to slow its breakdown, leaving more of the protein available to regulate genes involved in fat metabolism and potentially offering a new mechanistic target for myosteatosis and metabolic dysfunction. Host Dave Asprey explains why the PPAR-delta mechanism is interesting for metabolic health, but draws a clear line between promising cell research and human outcomes, emphasizing that resistance training, walking, muscle mass, and mitochondrial health still have far stronger evidence than taking blueberry extracts to reduce muscle fat. Sources: https://www.sciencedaily.com/releases/2026/09/260903064219.htm https://doi.org/10.1016/j.fbio.2026.109519 https://www.reddit.com/r/Biohackers/comments/1w8flq4/compound_in_blueberries_may_help_muscle_cells/ ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want emerging research on brain aging, wearables, botanical medicine, cannabis, metabolic health, and supplements translated into what matters for human biology. Host Dave Asprey separates promising mechanisms from premature hype and explains how to evaluate new health research through the lens of evidence quality, dose, biological context, and measurable outcomes. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: plasmalogens aging, plasmalogens brain health, sea squirt plasmalogens, cognitive longevity, neuroinflammation, synaptic health, Apple Watch Series 12, Apple Watch HRV, Apple Watch Readiness score, Apple Health Age, biological age tracking, wearable health data, Quest Diagnostics Apple Health, FDA botanical drugs, botanical medicine regulation, standardized botanical extracts, berberine research, medicinal mushrooms, cannabis IQ decline, adolescent cannabis brain development, cannabis cognitive decline, marijuana memory, pterostilbene fat metabolism, pterostilbene PPAR delta, blueberries metabolism, intramuscular fat, myosteatosis, metabolic flexibility, longevity news 2026, biohacking news 2026 Thank you to our sponsors!  - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Intro 00:24 – Sea Squirt Anti-Aging Lipids 01:39 – Apple Watch Series 12 03:38 – FDA Botanical Drug Push 05:25 – Cannabis & Brain Health 06:47 – Blueberry Fat Metabolism 08:33 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Karan Rajan on Fiber Fermentation, Sodium Myths, and What Your Poop Reveals About Disease Risk Your poop is more predictive than almost any other health signal, and you are flushing that data away every single day without a second look. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Karan Rajan, a practicing NHS gastrointestinal surgeon, best-selling author, and Chief Science Officer at Throne, who has built a following of over 12 million people by making gut science accessible and actionable. He has spent his career removing colon cancers, treating digestive disease, and now studies how gut bacteria drive nearly every system in the body, from hormone metabolism to brain optimization. They break down why fibermaxxing can backfire without the right mix of fast, medium, and slow fermenting fibers, and why generic "eat more fiber" advice ignores what your gut bacteria actually need. The conversation covers protein absorption limits and how much your body can really use, the truth about saturated fat and metabolism, and why the sodium-to-potassium ratio matters more than sodium alone. They also dig into fasting and the gut's natural cleaning cycle, the estrobolome and testobolome and their role in hormone balance and longevity, and how AI is starting to reshape personalized health data, supplements, and functional medicine. Dr. Rajan shares some of the strangest objects he has surgically removed from patients, and explains what your poop's color, shape, and consistency reveal about liver function, inflammation, and disease risk long before symptoms show up anywhere else. This is essential listening for anyone serious about biohacking, gut health, human performance, longevity, mitochondria function, nootropics, ketosis, carnivore and fiber-based diets, sleep optimization, anti-aging, and hacking your metabolism from the inside out. You'll Learn: Why fibermaxxing can cause bloating instead of better gut health The real difference between fast, medium, and slow fermenting fibers How much protein your gut can actually absorb and digest Why low sodium may be more dangerous than high sodium for most people How fasting triggers your gut's natural cleaning cycle, the migrating motor complex What your poop's color and consistency can reveal about liver and metabolic health How gut bacteria influence hormone metabolism through the estrobolome and testobolome Where AI and functional medicine are headed in personalized gut health tracking  Thank you to our sponsors!      - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. - Caldera + Lab | Go to calroy.com/dave for the research, a discount, and a 45-day money back guarantee. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Karan Rajan, gut surgeon, fibermaxxing, gut microbiome, Bristol stool chart, poop health, Throne, fermentation geography, soluble fiber, insoluble fiber, prebiotics, inulin, oxalates, estrobolome, testobolome, migrating motor complex, sodium potassium ratio, saturated fat, ghee, collagen, protein absorption, keto, carnivore, fasting, gut bacteria, flatulence science  Resources:   • Dr. Karan's Newsletter: https://drkaran.kit.com • Learn more about Throne - https://www.thronescience.com/• Check Out Dr. Karan’s YouTube: https://www.youtube.com/c/DrKaran • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    Timestamps:  00:00 – Trailer 00:55 – Meet Dr. Karan Rajan 04:04 – Kellogg's History & Farts 11:53 – Throne Poop Tracking 19:35 – Poop Colors & Wild Stories 28:02 – Worst Foods & Saturated Fat 36:26 – Fiber Fermentation Geography 46:57 – Sodium & Salt Myths 59:03 – Keto, Carnivore & Fasting 01:04:45 – AI, Misinformation & Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.