Taofeek Owonikoko, MD, PhD on Lung and Thyroid Cancers and Early Phase Drug Development

Description Join Dr. Ralph W. Moss and Ben Moss as they delve into the science of tomatoes and their potent component, lycopene. Uncover the groundbreaking research that positions lycopene as a significant agent against cancer. Discover the fascinating journey of lycopene from the humble tomato to its swift presence in our bloodstream, fueling our body's defense mechanisms. This episode is a compelling look into how nature equips us with powerful tools to combat disease, and offers practical insights on maximizing the benefits of tomatoes in our diet.   Articles Cited in this Episode: Karppi J, Kurl S, Nurmi T, Rissanen TH, Pukkala E, Nyyssönen K. Serum lycopene and the risk of cancer: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study. Ann Epidemiol. 2009 Jul;19(7):512-8. doi: 10.1016/j.annepidem.2009.03.017. Epub 2009 May 13. PMID: 19443241. https://www.sciencedirect.com/science/article/abs/pii/S1047279709001082?via%3Dihub Kim JY, Paik JK, Kim OY, Park HW, Lee JH, Jang Y, Lee JH. Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men. Atherosclerosis. 2011 Mar;215(1):189-95. doi: 10.1016/j.atherosclerosis.2010.11.036. Epub 2010 Dec 9. PMID: 21194693. https://pubmed.ncbi.nlm.nih.gov/21194693/ Zu K, Mucci L, Rosner BA, Clinton SK, Loda M, Stampfer MJ, Giovannucci E. Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era. J Natl Cancer Inst. 2014 Feb;106(2):djt430. doi: 10.1093/jnci/djt430. Epub 2014 Jan 24. PMID: 24463248; PMCID: PMC3952200. https://pubmed.ncbi.nlm.nih.gov/24463248/ Aune D, Keum N, Giovannucci E, Fadnes LT, Boffetta P, Greenwood DC, Tonstad S, Vatten LJ, Riboli E, Norat T. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies. Am J Clin Nutr. 2018 Nov 1;108(5):1069-1091. doi: 10.1093/ajcn/nqy097. PMID: 30475962; PMCID: PMC6250988. https://pubmed.ncbi.nlm.nih.gov/30475962/ Ansari MS, Gupta NP. Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer. Urol Oncol. 2004 Sep-Oct;22(5):415-20. doi: 10.1016/j.urolonc.2004.05.009. PMID: 15464923. https://pubmed.ncbi.nlm.nih.gov/15464923/ Thanks for listening!  

In this pivotal episode, Dr. Moss and his son, Ben, shed light on new insights into Vitamin D's role in cancer prevention, based on data from a study published in 2019. While the original research concluded that Vitamin D had no significant impact on cancer incidence, a meticulous reevaluation of the same data has revealed something crucial: Body Mass Index (BMI) plays a significant role in the effectiveness of Vitamin D supplementation for cancer prevention. Specifically, those with a 'normal' BMI showed a significant reduction in the incidence of advanced and metastatic cancers. Dr. Moss and Ben explore why these game-changing results haven't received the media attention they deserve and what this could mean for natural cancer prevention strategies. Tune in to this eye-opening discussion that presents the science you can't afford to ignore! Program Notes: Primary authors of cited paper: Walter C. Willett Professor of Epidemiology and Nutrition Harvard T.H. Chan School of Public Health https://www.hsph.harvard.edu/profile/walter-c-willett/ Edward L. Giovannucci, D.Sc., M.D. Professor of Nutrition and Epidemiology Harvard T.H. Chan School of Public Health https://connects.catalyst.harvard.edu/Profiles/display/Person/31785 Articles cited in this podcast: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease https://pubmed.ncbi.nlm.nih.gov/30415629/ [Cited 501 times by other papers.] Roni Caryn Rabin. Vitamin D and Fish Oils Are Ineffective for Preventing Cancer and Heart Disease. New York Times, Nov. 10, 2018. VITAL study: an incomplete picture? Eur Rev Med Pharmacol https://pubmed.ncbi.nlm.nih.gov/31002167/ [Cited 8 times.] Gina Kolata. Study Finds Another Condition That Vitamin D Pills Do Not Help New York Times, July 7, 2022: “The first part of VITAL, previously published, found that vitamin D did not prevent cancer or cardiovascular disease in trial participants.” The VITAL Research Group. Effect of Vitamin D3 Supplements on Development of Advanced Cancer: A Secondary Analysis of the VITAL Randomized Clinical Trial.  https://pubmed.ncbi.nlm.nih.gov/33206192/ [Cited 72 times.] Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms. https://pubmed.ncbi.nlm.nih.gov/35406059/ [Cited 31 times.] “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD Recommended Product: 5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 Life Extension Vitamin D3 https://www.amazon.com/gp/product/B0019LPCNO/ref=as_li_tl?ie=UTF8&tag=mosshyh20-20 For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com Thanks for listening!

Dr. Ralph W. Moss and his son Ben dive into the multifaceted world of the avocado. This superfood, known for its creamy texture and health benefits, has recently been at the center of some unexpected scientific findings. While it offers undeniable health advantages for many, there might be potential concerns for others. Join them as they explore the data, breaking down its implications, and help you determine what this means for you or your loved ones. Articles Cited in this Episode: Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. Cancer Causes Control. https://pubmed.ncbi.nlm.nih.gov/21984307/ Prospective Study of Avocado Consumption and Cancer Risk in U.S. Men and Women. https://pubmed.ncbi.nlm.nih.gov/36490225/ “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD Recommended Product: 5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com Thanks for listening!

Join Dr. Moss and his son, Ben, as they crack open the topic of nuts and their role in cancer prevention and overall health. Learn about the numerous scientific studies indicating the positive effects of nuts on metabolism, cardiovascular health, and cancer-fighting properties. They discuss potential hazards, and why moderation is key to getting the most out of this nutrient packed food. Find out about the benefits of incorporating nuts into a cancer-fighting diet, and learn how these tiny powerhouses can make a big impact on your health. Are you ready to discover how these tiny powerhouses can make a big impact on your health? Tune in now. Program Notes: For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com 5 Defenders Mushroom Blend “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD For Dr. Moss’ recommended products list, please visit https://www.themossreport.com/recommended-products/ Articles on nuts, cancer and health The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. Meta-analysis of the association between nut consumption and the risks of cancer incidence and cancer-specific mortality. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies. Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. Cited co-author of the first paper in ASN Dagfinn Aune https://twitter.com/AuneDagfinn Penny Kris-Etherton - Penn State https://hhd.psu.edu/contact/penny-kris-etherton  

Join Dr. Moss and Ben as they delve into the unexpected benefits of coffee in the battle against cancer. Learn about Dr. Moss' unique blend, a carefully crafted recipe that enriches your daily cup with polyphenols, cafestol, kahweol, cocoa, chicory, and Ceylon cinnamon. Discover the science that shows how this potent combination serves as a prebiotic, aids metabolism, and how it may help in your fight against cancer. Tune in as we unveil the health-boosting secrets hiding in your coffee cup and learn how to transform it into an anti-cancer superfood powerhouse!  Program Notes: For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com 5  Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD For Dr. Moss’ recommended products list, please visit https://www.themossreport.com/recommended-products/ Anthony's Organic Ceylon Cinnamon Powder  Anthony's Organic Roasted Chicory Root Granules  Anthony's Organic Cocoa Powder Rainforest Blend Ground Coffee   Articles  Coffee Drinking and Risk of Lung Cancer—A Meta-Analysis https://aacrjournals.org/cebp/article/25/6/951/282888/Coffee- Drinking-and-Risk-of-Lung-Cancer-A-Meta Coffee Consumption and Lung Cancer Risk: A Prospective Cohort Study in Khon Kaen Thailand  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771955/ A Decade of Research on Coffee as an Anticarcinogenic Beverage https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460369/ Coffee and cancer risk: A meta-analysis of prospective observational studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036059/ Associations of coffee and tea consumption with lung cancer risk https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460087/

Dr. Ralph W. Moss and son Ben discuss how a walk in the woods may help manage symptoms and improve quality of life. Delve into the science behind how forest bathing and aromatherapy can reduce stress, improve mood, and ease pain.  Program Notes: Recommended Product NOW Woodland Walk essential oil https://www.nowfoods.com/products/essential-oils/woodland-walk-oil-blend   For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com   5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD For Dr. Moss’ recommended products list, please visit https://www.themossreport.com/recommended-products/ How to use reed diffusers https://www.harlemcandlecompany.com/blogs/journal/how-to-use-reed-diffusers-everything-you-need-to-know Tips on diluting essential oils with carrier oils https://essentials.banyantree.com/blogs/blog/how-to-dilute-essential-oils#:~:text=Is%20dilution%20always%20necessary%3F,and%20model%20of%20diffuser%20differs The Tisserand Academy (of Aromatherapy) of Robert and Hana Tisserand https://roberttisserand.com/ Articles cited: Aromatherapy as an adjuvant treatment in cancer care--a descriptive systematic review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746639/ Efficacy of Essential Oils in Relieving Cancer Pain: A Systematic Review and Meta-Analysis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138439/ Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteins. https://journals.sagepub.com/doi/10.1177/039463200802100113?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Effects of forest environment (Shinrin-yoku/Forest bathing) on health promotion and disease prevention -the Establishment of "Forest Medicine" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665958/ Enhancing Cytotoxicity of Tamoxifen Using Geranium Oil. Evid Based Complement https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942665/ A Randomized Controlled Trial for the Effectiveness of Aromatherapy in Decreasing Salivary Gland Damage following Radioactive Iodine Therapy for Differentiated Thyroid Cancer. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155074/ The physiological effects of Shinrin-yoku (taking in the forest atmosphere or forest bathing): evidence from field experiments in 24 forests across Japan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793346/ Anti-inflammatory and anti-cancer activities of essential oils and their biological constituents. https://www.dustri.com/nc/article-response-page.html?artId=8281&doi= Olfactory stimulation modulates the blood glucose level in rats. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820856/

Description Dr. Ralph W. Moss and son Ben discuss the science behind the health benefits of chocolate and how this delightful indulgence, often considered a guilty pleasure, can play a vital role in our overall well being. Program Notes: For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com 5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 Mushroom Hot Chocolate with 5 Defenders https://shop.realmushrooms.com/products/organic-mushroom-hot-chocolate-mix?ref=391 5 Defenders Chocolate (seasonal item - October-April) https://shop.realmushrooms.com/products/mushroom-chocolate-bar “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD Olive Oil From the Raw https://www.olivefromtheraw.com/?aff=2 “A study of over 1,000,000 people shows that daily consumption of 2 Tbsp of high quality, extra virgin olive oil that contain polyphenols, results in a 30-40% decrease in cancer incidents.” – Ralph W. Moss, PhD For Dr. Moss’ recommended products list, please visit https://www.themossreport.com/recommended-products/ Articles cited: Effect of chocolate on older patients with cancer in palliative care: a randomized controlled study https://pubmed.ncbi.nlm.nih.gov/34980096/ Cocoa, chocolate, and cardiovascular disease https://pubmed.ncbi.nlm.nih.gov/19701098/ Cocoa and chocolate in human health and disease https://pubmed.ncbi.nlm.nih.gov/21470061/ Chocolate consumption and all-cause and cause-specific mortality in a US population: a post hoc analysis of the PLCO cancer screening trial https://pubmed.ncbi.nlm.nih.gov/34329196/ Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/35294962/ https://www.consumerlab.com/  

Dr. Ralph W. Moss and son Ben discuss the healing and preventive properties of the readily available, inexpensive and delicious, humble little parsley plant.   Join us for another fascinating journey as we dive 'Beyond the Garnish' into the remarkable world of parsley and its component, Apigenin. This humble herb, often relegated to the sidelines of our plates, holds an impressive secret - the potential to significantly impact the fight against cancer. Program Notes: For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com 5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD Olive Oil From the Raw https://www.olivefromtheraw.com/?aff=2 “A study of over 1,000,000 people shows that daily consumption of 2 Tbsp of high quality, extra virgin olive oil that contain polyphenols, results in a 30-40% decrease in cancer incidents.” – Ralph W. Moss, PhD For Dr. Moss’ recommended products list, please visit https://www.themossreport.com/recommended-products/ The full scope of research on apigenin and cancer: https://pubmed.ncbi.nlm.nih.gov/?term=apigenin+cancer The Indian review article: Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models https://pubmed.ncbi.nlm.nih.gov/35752426/ The German clinical trial: Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703843/ Recommended parsley intake: Approximately 0.79 tablespoons or 2.37 teaspoons of chopped fresh parsley would provide 10 mg of apigenin. TAKE about one tablespoon OR THE EQUIVALENT AMT. OF DRIED PARSLEY (SEE BELOW) TWICE PER DAY. For 0.69 grams of dried parsley flakes: 0.69 grams / 0.8 grams per teaspoon ≈ 0.86 teaspoons So, approximately one teaspoon 0.86 teaspoons of dried parsley flakes would provide 10 mg of apigenin. OR TAKE THIS TWICE PER DAY. NOTE: PATIENTS IN THE GERMAN STUDY ALSO RECEIVED EGCG (GREEN TEA) AT THE SAME TIME. Based on the average amount of EGCG in one gram of Japanese Sencha green tea leaves (47.3 milligrams), and assuming that you're using one teaspoon (about 2.5 grams) of tea leaves to brew 6 ounces of tea, you can expect to get around 118.25 milligrams of EGCG in your cup of tea. A short bibliography on apigenin and cancer: Shukla S, Gupta S. Apigenin: a promising molecule for cancer prevention. Pharm Res. 2010;27(6):962-978. Salehi B, Venditti A, Sharifi-Rad M, et al. The therapeutic potential of apigenin. Int J Mol Sci. 2019;20(6):1305. Chen AY, Chen YC. A review of the dietary flavonoid, apigenin, on cancer prevention and treatment. Curr Med Chem. 2013;20(19):2570-2581. Fang J, Xia C, Cao Z, Zheng JZ, Reed E, Jiang BH. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J. 2005;19(3):342-353. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674. Kim BR, Seo HS, Ku JM, et al. Apigenin inhibits cancer stem cell-like phenotypes in human glioblastoma cells via suppression of c-Met signaling. Phytother Res. 2016;30(5): 800-807. Lu L, Sun T, Chen X, et al. Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through the AKT/GSK-3β/Snail signaling pathway. Oncol Rep. 2016;35(1):369-374. Lu Z, Xu S, ER P, et al. Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3-derived sphere-forming cells. Mol Med Rep. 2015;11(4): 2850-2856. Wang J, Wu J, Zhang X, et al. Apigenin suppresses the growth of colorectal cancer cells by targeting Twist-mediated epithelial-mesenchymal transition. Mol Med Rep. 2018;17(5): 7305-7310. Yao J, Zhao L, Zhao Q, et al. Apigenin inhibits ovarian cancer stem cell-like properties through the modulation of the Twist1/TGF-β1/Smad3 pathway. Oncol Rep. 2016;36(1): 512-520. For Dr. Moss’ Red, Green, and Green Tea Smoothie recipes, visit The Moss Report. These smoothie recipes are just some examples of how you can incorporate natural compounds with potential health benefits into your diet.

Description Dr. Ralph W. Moss and son Ben discuss the potential health benefits of fasting from dawn to dusk, a practice commonly observed during Ramadan, and how it may aid in cancer prevention and overall well-being. Program Notes: For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com 5 Defenders Mushroom Blend “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD Olive Oil From the Raw  “A study of over 1,000,000 people shows that daily consumption of 2 Tbsp of high quality, extra virgin olive oil that contain polyphenols, results in a 30-40% decrease in cancer incidents.” – Ralph W. Moss, PhD For Dr. Moss’ recommended products list, please visit https://www.themossreport.com/recommended-products/ Five scientific articles: Dawn-to-dusk dry fasting induces anti-atherosclerotic, anti-inflammatory, and anti-tumorigenic proteome in peripheral blood mononuclear cells in subjects with metabolic syndrome The impact of dawn to sunset fasting on immune system and its clinical significance in COVID-19 pandemic Impact of Time-Restricted Feeding and Dawn-to-Sunset Fasting on Circadian Rhythm, Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome Fasting and cancer: molecular mechanisms and clinical application Dr. Bernstein's Diabetes Solution: The Complete Guide to Achieving Normal Blood Sugars  

Dr. Ralph W. Moss and son Ben talk about the Budwig Diet, flaxseeds and flaxseed oil as a healing agent for cancer. Is it just a fad? Does it reduce tumor size? Hear what Dr. Moss has to say about this natural remedy. Program Notes: For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com 5 Defenders Mushroom Blend  A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable. – Ralph W. Moss, PhD Olive Oil From the Raw   A study of over 1,000,000 people shows that daily consumption of 2 Tbsp of high quality, extra virgin olive oil that contain polyphenols, results in a 30-40% decrease in cancer incidents. – Ralph W. Moss, PhD For Dr. Moss’ recommended products list, please visit https://www.themossreport.com/recomme... Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery A pilot study comparing the effect of flaxseed, aromatase inhibitor, and the combination on breast tumor biomarkers  The Effect of Flaxseed in Breast Cancer: A Literature Review  Budwig Diet for Cancer: Flax or Fiction by Ralph W. Moss PhD  Budwig Diet for Cancer: Flax or Fiction Video by Ralph W. Moss PhD Book: Fats That Heal, Fats That Kill: The Complete Guide to Fats, Oils, Cholesterol and Human Health  Olive Oil & Cancer - Scientists study 1,000,000+ people, with astounding results.