The Meta Health podcast simplifies the science of health, nutrition and metabolism by sparking your imagination through creative storytelling and visualization. You'll gain a deep understanding of your body to help you make informed and personalized lifestyle choices. The host, Dr.Ronesh Sinha, is a physician, author, speaker, and teacher who runs a lifestyle clinic focused on reversing insulin resistance in diverse ethnic groups, and designs wellness programs for top Silicon Valley companies.
#25 - The Critical Pentose Phosphate Pathway and Erythritol
32:33The pentose phosphate pathway, which I refer to as P3, is one of my favorite metabolic pathways and one that gets far less attention than glycolysis, gluconeogenesis, and Krebs, yet plays such a key role in our body. In this episode we go over the following: Brief refresher on glycolysis and coenzymes using James Bond storytelling Deeper dive into oxidation, reduction, and free radicals (aka reactive oxygen species or ROS) Understanding and remembering the key functions of P3 How P3 is tied to obesity, insulin resistance, heart disease, and cancer How erythritol is tied to P3 and the fallacy of a study linking it to heart disease
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#23 - Holistic Hypocrisy and Supplement Scams
55:51Call it holistic, functional, metabolic, integrative, longevity, or whatever, but this episode expresses some of my concerns about the direction of what I refer to as the rising "alt health" movement. Interestingly, I'm part of both alt health and mainstream medicine, so I'll share my take from both sides. I'll discuss: The story of "Dr.Bob," a fictional alt health practitioner whose practice is rife with hypocrisy and questionable practices The story of "Diane," a fictional patient anecdote based on patient and audience feedback, who is going bankrupt purchasing alt health services. How the supplement industry is morphing into its own version of "Big Pharma" Defending mainstream doctors, an unfortunate target of the alt health movement Blindspots and potential harms of alt health messaging Some thoughts on how alt health and mainstream medicine can collaborate better
#22 - Lipids Part 2: Cholesterol Numbers and Heart Disease Risk
34:24In this episode we will tie together cholesterol metabolism using the boat vehicular model from Part 1, and understanding your own cholesterol results in greater depth. My free cholesterol e-book here summarizes key numbers and concepts discussed in this episode. We'll discuss the following: Review of lipid boats and cholesterol metabolism Understanding the impact of lifestyle on blood vessel health Key characteristics of lipid particles driving heart disease Overlooked cholesterol numbers that matter most Hidden heart disease risks you need to prioritize
# 21 - Lipids Part 1: Metabolic Trafficking using Cars and Boats
31:57Lipid (cholesterol) physiology is complicated, but essential for you to understand as part of metabolism, health, and longevity. Let's simplify lipids (and glucose) using cars, boats, and traffic. This sets the foundation for future episodes where I discuss the practical implications of lipids and heart disease risk. We'll discuss the following: The vehicular metabolic traffic model Quick review of glucose and insulin metabolism Introducing lipoprotein boats Understanding glucose cars and lipid boats together What we mean by "fat-burner" and "sugar-burner"
#20 - Glucose Variability: An Essential Metabolic Metric
28:01Glucose variability (GV) is an important metric that expands upon the current limited application of fasting blood glucose and hemoglobin A1C. In this episode we'll discuss: The limitations of A1C and fasting blood glucose What is GV and why it matters? How GV is related to inflammation and chronic disease Glucose dipping and its connection to weight gain Defining an optimal range for GV
#19 - Rethinking Hemoglobin A1C and Are You Truly Prediabetic?
26:24The hemoglobin A1C is a useful, yet imperfect glycemic marker which we'll explore further in this episode where we discuss: The origins of the glycohemoglobin test (aka A1C) The flaws of A1C testing and why you may not be prediabetic Insulin resistant markers that should accompany A1C testing The impact of ethnicity on A1C testing An exciting new metric that may be superior to the A1C test
#18 - Multiethnic Metabolism and Heart Disease Risk
42:06There are significant ethnicity-specific differences in metabolism and heart disease risk that are not often discussed. In this episode we cover: A brief overview of insulin resistance (IR) and the renin angiotensin system (aka RAS) How IR and RAS present in major ethnic groups like African Americans, Asians (including South Asians), Hispanics, etc. My simplistic model for categorizing IR to better explain ethnic risk Ethnic-specific lifestyle changes to improve metabolism and reduce heart disease risk
#17 - Blood Pressure, Body Fat, and Sodium
33:51I'm going to explain the interaction between blood pressure, body fat, and sodium by explaining the all important RAAS (renin-angiotensin-aldosterone system). Understanding this system can help you optimize blood pressure, heart, and overall vascular health. We'll discuss the following: Understanding how RAAS works How body fat interacts with RAAS Why sodium is not the root cause of high blood pressure The connection between insulin resistance and RAAS Lifestyle measures to effectively reduce blood pressure
#16 - Getting Your Body to Burn Fat
41:29Understanding the mechanism behind how your body stores and burns fat (aka lipolysis) will help you incorporate lifestyle strategies to help you lose excess body fat. In this episode we discuss: The science of burning body fat Different types of body fat based on color and location Teaching your body to burn excess fat through thermogenesis Multiple lifestyle strategies to enhance fat loss