The Lab Report

Dr. Nasha Winters is a naturopathic physician with a deeply powerful story. Diagnosed with stage IV cancer at age 19 and given just a few months to live, she embarked on a relentless journey to self-education and integrative healing that ultimately saved her life. Now a leading expert in metabolic oncology, Dr. Nasha is passionate in her mission to transform healthcare by addressing underlying metabolic dysfunction that fuels not only cancer, but virtually all chronic diseases. Dr. Nasha Winters has a message of empowerment for cancer patients: by understanding and correcting the terrain of the body rather than merely attacking the tumor, we can shift from a disease-centered model to one rooted in true healing and prevention for everyone. This message will resonate not only in cancer, but also for anyone wanting to treat or prevent chronic disease. Today on The Lab Report: 3:45 Meet Dr. Nasha Winters and hear what a metabolic approach to cancer looks like 7:10 Nasha’s inspiring story 15:55 Fasting, ketosis, various diets in cancer 18:55 Ketosis and ketone bodies 24:10 Working with traditional oncology 29:10 Cachexia, sarcopenia, and fasting 34:00 Specialty testing in cancer patients 36:30 Facing mortality, past trauma, and taking control 41:10 Practical steps on where to start – diagnosis/prevention 45:30 Tend the terrain, connecting farming and medicine 48:30 Nasha’s current state 51:00 The Fireball Additional Resources: drnasha.com Tend the Terrain Substack The Metabolic Approach to Cancer Mistletoe and the Emerging Future of Integrative Oncology Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Maggie Awad, NP is the founder of Elevate Performance Medicine and a leading functional sports medicine nurse practitioner. Drawing on her work with elite professional athletes, Maggie breaks down how an optimized microbiome and personalized nutrition can fuel energy production, decrease inflammation, and support recovery. This holistic approach allows athletes to train harder, bounce back faster, and sustain peak performance without burnout or injury. Whether you're a competitive athlete, weekend warrior, or high-performer chasing longevity in your sport or career, Maggie Awad shifts the paradigm from symptom management to true root-cause optimization. Today on The Lab Report: 5:15 Meet Maggie Awad and learn what “Functional Sport Medicine” means 8:10 Why did Maggie choose this specialty 10:45 Common health issues among all athletes 12:30 Gut health and stool testing 17:20 Overtraining and the importance of sleep and recovery 18:50 Nutritional deficiencies in athletes – glycine tangent 20:50 Hormone optimization and supplementation 23:00 Maggie’s patient population and practice 25 :40 The Fireball   Additional Resources: Elevate Performance Medicine Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.See omnystudio.com/listener for privacy information.

Celebrate the magic of the season with our special Christmas episode as we unwrap the 5 Love Languages and explore why love truly is the greatest gift of all. Whether it’s words that warm the heart, thoughtful acts of kindness, actual Christmas gifts, quality time with family and friends, or a comforting touch, we’ll help you discover how to give – and receive- love in ways that matter most. Cozy up, tune in, and get ready to spread a little more love this season. Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

The gut microbiome is more than just bacteria. It encompasses all organisms and genetic material including yeast, viruses, and archaea. It is a common belief that yeast in the GI tract needs to be eradicated. But not so fast. In this episode, we focus on the mycobiome. We examine the dual roles of commensal and pathogenic yeast species within the GI tract, exploring how they influence immune signaling, metabolic function, and mucosal integrity. We also discuss emerging evidence linking fungal dysbiosis to conditions such as Inflammatory Bowel Disease, cancer, and systemic inflammation. If you’re interested in the clinical science behind how yeast can support health – or contribute to disease - this episode explores a topic often overlooked in longevity medicine. Today on The Lab Report: 4:00 The Gut Mycobiome – needs a new name 6:40 Yeast vs. Bacteria 9:00 Development of the commensal mycobiome 11:00 The important role of yeast & their metabolites 15:25 Candida and Malassezia 18:45 Saccharomyces 21:05 Dietary influences and fermented foods 23:30 Question of the Day If yeast grows out in culture on the GI Effects, what next? Additional Resources: GI Effects Stool Profile Microbiomix  Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

The Thanksgiving holiday is more than just family, friends, food, and football. It is an opportunity to be reminded of the importance of gratitude. Although being thankful seems like just a nice moral platitude, gratitude interventions are shown to have surprisingly important clinical implications for our health.   On today’s episode, we talk Thanksgiving ‘fun facts,’ gratitude interventions, and strategies to combat holiday season stress and weight gain.   Today on The Lab Report:  3:10 Fun facts about Thanksgiving  7:35 Gratitude interventions and health  11:15 Strategies to prevent holiday weight gain  14:30 Keto, Vegan, Carnivore, Omnivore holiday dinner menus  16:45 Kitchen Cook-cophany!  Subscribe, Rate, & Review The Lab Report  Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.  Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].   And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.   To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.   Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.  See omnystudio.com/listener for privacy information.

Gut motility may be the most important and least discussed aspect of health. One vital part of gut motility is the Migrating Motor Complex. The Migrating Motor Complex (MMC) is the gut’s “street sweeper,” clearing food and bacteria to maintain intestinal homeostasis between meals. In this episode, we review its physiology, regulatory mechanisms, and clinical relevance – from SIBO to functional GI disorders – highlighting why this cyclical motility pattern matters for patient care. Today you’ll meet the migrating motor complex: your gut’s built-in street sweeper that clocks in when you’re not eating. This behind-the-scenes cleaning cycle is essential to GI health! Today on The Lab Report: 3:20 Gut motility – peristalsis and segmentation 5:45 Migrating Motor Complex (MMC) 8:40 Motilin, serotonin, and the vagus nerve 11:15 Acidification of the small intestine and Motilin 13:25 Signaling the vagus nerve 16:20 MMC’s role in SIBO/IMO 17:50 Prokinetics and meal spacing 22:00 Question of the Day What is the relationship between PPI’s and MMC? Additional Resources: SIBO Breath Test GI Effects Stool Profile Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

The microbiome continues to be viewed as a cornerstone of health, whether we are discussing the gastrointestinal tract, cardiovascular risk, immune dysfunction, and even cognitive health. One major contributions of the microbiome to our global health is in the production of short-chain fatty acids. Primary among these products is a compound known as n-butyrate. N-butyrate has profound roles, not only in our gut, but throughout our entire body. What are all the impacts of n-butyrate, and how do we foster an adequate supply of it? These are but some of the questions we discuss on today’s Lab Report. In this episode, we continue our spree on the importance of gut health. We cover food sources that are important for microbiome health, particularly for fermentation of short-chain fatty acids. We also cover how butyrate impacts the gut, the immune system, and much more. With all the profound roles of n-butyrate, it begs the question: is it the greatest of all the things made by our microbiome? Today on The Lab Report: 5:30 Gut microbiome production of SCFA’s (short-chain fatty acids) 6:30 Food sources of n-butyrate 8:00 Let’s Google It: The entomology of ‘butyrate’ 9:00 Butyrogenic species: What bacteria produce butyrate? 10:45 How butyrate is used throughout the body 13:00 Logical Speculation: n-butyrate, autoimmunity, and fiber 15:45 The gut-brain axis and appetite are influenced by butyrate 20:30 Skeletal muscle also responds to butyrate 23:30 Foods to eat to promote butyrate 26:00 N-Butyrate supplementation: mixed studies?   Additional Resources: GI Effects Stool Profile Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Based on recent research, the term ‘dysbiosis’ is no longer a simple black-and-white diagnosis of a gut imbalance. The scientific understanding of a healthy microbiome is evolving. It’s no longer just about the laundry list of organisms present, but rather about their functionality for health and disease. In today’s episode, we unpack the term ‘dysbiosis.’ Join us to rethink what it means to have a healthy microbiome, the utility of novel algorithmic scoring, and how a deeper understanding of this complex ecosystem is opening doors to more targeted diagnostics and therapeutics.   Today on The Lab Report: 4:30 Healthy microbiome vs. Dysbiosis 8:00 Defining terms 10:10 Dysbiosis scoring algorithms 15:40 Functional approach to dysbiosis 16:30 Rethinking pathogens 19:25 The microbiome is reactionary – root cause is important! 23:15 Should we even be using the word “dysbiosis”? 24:25 Whole genome sequencing and gut functionality 28:00 Adaptability of the microbiome Additional Resources: GI Effects Stool Profile Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Like Hippocrates said, “All Disease Begins in the Gut.” Here in functional/personalized medicine, stool testing is an important tool to help get to the root cause of chronic conditions or to optimize health. Given its vital role in clinical practice, choosing the right stool test becomes paramount and being mindful of the information you are seeking is key. In today’s episode, we're taking the conversation deeper, refocusing on why studying the microbiome is so critical. This episode redefines the clinical utility of Genova's stool tests, giving you the insights you need to make informed decisions and get better results for your patients. Today on The Lab Report: 4:55 Stool testing - High-level why’s 8:00 Clinical guide to basic gut function 11:00 Inflammation biomarker overload 13:30 Measuring maldigestion/malabsorption 16:15 Gut metabolites – direct vs. Next-Gen Sequencing 20:10 Infection – bacterial culture 24:45 Finding parasites Additional Resources: GI Effects Stool Profile Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Heat Shock Proteins (HSPs) are often called molecular chaperones. These crucial proteins spring into action when cells are under threat from environmental stressors, toxins, inflammation, and oxidative stress. Join us as we uncover how heat shock proteins function as the cell’s microscopic repair crew. Discover how this fundamental biological mechanism not only protects our cells from daily stresses but also holds promising clues to treating age-related illnesses like cancer and neurodegenerative diseases. Today on The Lab Report: 3:50 Heat shock proteins and cellular health 8:05 Types of cellular stress 9:30 Specific functions of HSPs 11:00 Metaphors are fun 13:05 How were these discovered? 14:00 Different than cold shock proteins 16:00 Clinical associations in disease 19:15 Naturally increasing your HSPs 21:25 Drug development and implications Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.