Building a Metabolically Healthy Mind and Body - Discussion between Dr. Mercola and Dr. Casey Means

Emerging research shows that human egg cells resist mitochondrial aging, challenging the idea that menopause is irreversible Scientists have successfully reactivated dormant ovarian follicles in women with premature ovarian insufficiency using stem cell strategies and metabolic interventions Mitochondrial health, not egg depletion, may be the key to reversing menopause symptoms and restoring reproductive function Hormones like DHEA, T3, and progesterone, along with nutrients like vitamin A and E, are being studied for their role in rejuvenating ovaries These findings suggest menopause may be a reversible metabolic state — not a permanent shutdown

A new JAMA Network Open study found that cutting down social media use to roughly 30 minutes per day had measurable effects on mental health, reducing anxiety by about 16%, depression by about 25%, and insomnia symptoms by 15% Loneliness scores did not change much, which shows that social media can be a lifeline for connection as well as a source of stress Earlier randomized trials from the University of Bath and others also found that a one-week break from platforms like TikTok, Instagram, and Facebook improved wellbeing, depression, and anxiety A short reset is not a cure for depression or anxiety, and does not replace therapy, medication, or crisis care. Still, it can be a realistic experiment that helps you see how specific apps affect your mood, sleep, and focus If you already struggle with your mental health, or if you rely on online communities for support, it makes sense to plan your week carefully and to talk with a trusted health professional about how this kind of experiment fits into your overall care

Fluoridated water has shaped U.S. dental policy since the 1940s, when officials began adding fluoride to public water supplies in an effort to reduce childhood cavities.1 As of 2022, the U.S. Centers for Disease Control and Prevention (CDC) reported that 72.3% of Americans on community water systems (about 62.8% of the entire population) received fluoridated water,2 making systemic exposure nearly unavoidable. Mounting evidence now shows that fluoride offers little measurable benefit for dental health while introducing significant risks, particularly for children. Many countries, including Germany, Sweden, and the Netherlands, have already abandoned water fluoridation.3 In the U.S., Utah and Florida recently became the first states to ban the practice, and similar bills are emerging elsewhere.4 However, in places where fluoride is not added to tap water, fluoride supplements are prescribed for infants and children. Recently, the U.S. Food and Drug Administration (FDA) announced it is taking action to restrict the use of these prescription fluoride supplements, following a directive from the Make America Healthy Again (MAHA) Commission to reassess their safety and effectiveness.5

Your gut's nervous system directly influences whether you tolerate foods or react to them, making it a key factor in food sensitivities and allergy risk A tiny nerve messenger called the vasoactive intestinal peptide (VIP) tells your gut stem cells how to rebuild the intestinal lining; when VIP drops, your gut produces too many tuft cells that trigger allergy like inflammation Everyday exposures — like microplastics, seed oils, and emulsifiers found in processed foods — damage tight junction proteins, weaken your gut barrier, and increase the flow of irritants into your bloodstream Low vitamin D, disrupted sleep, and high stress interfere with your gut's ability to maintain barrier integrity and calm immune activity, raising your vulnerability to allergic reactions You can lower your allergy risk by supporting mitochondrial function, removing gut damaging triggers, restoring healthy carbs in the right order, and improving the nerve-gut connection that regulates intestinal healing

About 24.2% of U.S. men today screen positive for erectile dysfunction (ED), while global rates range from 3% to 76.5%, showing it's a common health problem that affects men of all ages A 2025 study in the American Journal of Clinical and Experimental Urology found that ED is influenced by genes that also raise risk for obesity, diabetes, heart disease, and addiction, tying erection problems to long-term heart health ED is usually multifactorial, with vascular, neurogenic, hormonal, and psychogenic forms, and is strongly associated with conditions like heart disease, obesity, sleep apnea, and depression, making it a powerful early warning sign that something deeper is wrong While drugs like Viagra can temporarily improve erections, they don't work for everyone and may be unsafe for men taking heart and lung medications Instead of relying solely on pills, addressing root causes with a heart-focused check-up, a metabolic-friendly diet, pelvic floor training, restorative sleep, enough sunlight and mindful supplementation can help restore sexual function without more drugs

Nearly 1 in 5 urinary tract infections (UTIs) are caused by E. coli strains that originated in contaminated meat, confirming what earlier research has shown Poultry is the main source of these dangerous bacteria, with chicken and turkey accounting for more than 74% of meat-linked UTI cases, while all retail meats showed high contamination levels These bacteria, known as extraintestinal pathogenic E. coli (ExPEC), survive processing and cooking to enter your body, where they colonize your urinary tract and can spread to your bloodstream Overuse of antibiotics in concentrated animal feeding operations (CAFOs) fuels the growth of drug-resistant E. coli, creating infections that are harder to treat and more likely to require hospitalization You can protect yourself by avoiding CAFO meats, choosing grass fed and regeneratively raised options, improving food and personal hygiene, and supporting urinary health with methylene blue, cranberries, and D-mannose

A 2025 analysis of over 13,500 knee MRI scans revealed that men have more anterior cruciate ligament (ACL) tears overall, including ACL plus meniscus combinations, contrary to earlier data focused on female athletes Men under 40 were more likely to have trauma-driven medial collateral ligament (MCL) and meniscus injuries, while women over 40 had a higher rate of degenerative MCL and meniscus damage These patterns suggest trauma dominates in male injuries, while age-linked tissue breakdown plays a bigger role in older female patients These results can aid clinicians and radiologists in recognizing patterns of injury so they can tailor imaging protocols, risk assessments, and early intervention strategies for patients Researchers say these gender-specific patterns may change the screening, prevention, and rehabilitation for knee injury across lifespans

Cold weather worsens arthritis symptoms by thickening joint fluid, slowing blood flow, and tightening muscles, which amplifies pain and stiffness Drops in barometric pressure cause tendons and muscles to expand, adding extra pressure to already inflamed joints and increasing discomfort Reduced sunlight during winter lowers vitamin D levels, weakening bones and increasing inflammation, while inactivity further restricts circulation Eliminating seed oils, boosting vitamin K2, optimizing vitamin D, and sipping warm bone broth help reduce inflammation, strengthen cartilage, and restore flexibility Daily movement, heat therapy, and sunlight exposure keep joints lubricated, improve circulation, and help you stay active and pain-free all winter long

Low-fat protein after exercise delivers amino acids into your bloodstream faster, giving your muscles a stronger signal to repair and grow High-fat meals slow digestion and weaken your muscle-building response, even when the total amount of protein is the same A stronger and faster leucine surge from lean protein helps activate muscle repair more effectively, improving your recovery window Higher daily protein intake — around 0.8 grams per pound of ideal body weight — supports better muscle gain, fat loss, bone strength, and metabolic stability Simplifying your post-workout meal and choosing low-LA, low-fat protein sources help you recover more quickly and get better results from every training session

Metformin is a widely prescribed Type 2 diabetes drug that works by lowering liver glucose production and improve insulin sensitivity A 16-week Rutgers trial in 72 adults found that metformin dulled exercise benefits, reducing the usual improvements in aerobic fitness Long-term risks for prolonged metformin use include vitamin B12 deficiency, rare lactic acidosis, and hypoglycemia Skipping breakfast, not getting enough sleep, consuming too much alcohol, and social isolation can greatly disturb glucose regulation and increase the risk of developing diabetes over time Lifestyle strategies such as consistent movement, and a bioenergetic, nutrient-dense diet can support insulin sensitivity. Berberine may also help to slowly wean you off metformin medication