Landmark Trials in Breast Surgery

Here we discuss the landmark trials for Bisphosphonate treatment in early breast cancer. Below are the links to the papers we discuss: NICE guidance - https://www.nice.org.uk/guidance/ng101 Patterson AH et al. NSABP-B34, 2012 – Lancet Oncology - https://www.ncbi.nlm.nih.gov/pubmed/22704583 EBCTCG 2015 - Lancet - https://www.ncbi.nlm.nih.gov/pubmed/26211824 Cochrane review 2017 - Cochrane Database Syst Rev - https://www.ncbi.nlm.nih.gov/pubmed/29082518 Gralow J.R. et al. SWOG SO307 - J Natl Cancer Inst 2020 - https://pubmed.ncbi.nlm.nih.gov/31693129/ Coleman R et al. AZURE - Lancet Oncology 2014 - https://pubmed.ncbi.nlm.nih.gov/25035292/ Gnant M et al. ABCSG-12 - Lancet Oncology 2011 - https://pubmed.ncbi.nlm.nih.gov/21641868/

Here we discuss management of the node positive axilla and cover the indications and evidence behind axillary radiotherapy and de-escalation of axillary surgery. The links to the papers we mention are listed below:  ABS Guidelines, 2011  - https://associationofbreastsurgery.org.uk/media/64197/final-axilla-consensus-statement.pdf Donker M et al, EORTC AMAROS, 2014, Lancet oncology - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291166/ Giuliano A et al. ACOSOG Z0011, 2010 – Annals of Surgery - https://www.ncbi.nlm.nih.gov/pubmed/21304082 Giuliano A et al. ACOSOG Z0011 10 year update, USA, 2017 - JAMA - https://www.ncbi.nlm.nih.gov/pubmed/28898379 POSNOC - https://pubmed.ncbi.nlm.nih.gov/26254841 Hansen NM et al., 2009 – Journal of Clinical Oncology - https://pubmed.ncbi.nlm.nih.gov/19720928/ IBCSG 23-01, 2013+ 2018  Lancet Oncology - ·  2013, https://www.ncbi.nlm.nih.gov/pubmed/23491275, 2018, https://www.ncbi.nlm.nih.gov/pubmed/30196031

We discuss the advent of SLNB and the landmark papers. Below are the links to the paper we discuss.  Veronesi et al, 2003 - New England Journal of Medicine. - https://www.ncbi.nlm.nih.gov/pubmed/12904519 Mansel et al, ALMANAC. 2006 - J Natl Cancer Inst. - https://www.ncbi.nlm.nih.gov/pubmed/16670385 Krag et al. NSABP-32, 2010 - Lancet Oncology - https://www.ncbi.nlm.nih.gov/pubmed/20863759 Boreham et al. Cochrane Review, Cochrane Database Systematic Review, 2017 - https://www.ncbi.nlm.nih.gov/pubmed/28052186 Goyal et al. ALMANAC sub-analysis, 2006 - Breast Cancer Res Treat. - https://www.ncbi.nlm.nih.gov/pubmed/16541308 ASCO Guidelines 2016 - Journal of Clinical Oncology - https://www.ncbi.nlm.nih.gov/pubmed/27937089 Green–top Guidelines - https://associationofbreastsurgery.org.uk/media/64251/z-pregnanty.pdf Huxley N et al., 2012 - Health Technology Assessment, No. 19.2 - https://www.ncbi.nlm.nih.gov/books/NBK269043/

Breast conserving surgery - Margins

Introduction