JAMA Clinical Reviews

Heart failure (HF) affects more than 64 million individuals worldwide, and 20% to 30% of patients with HF and systolic dysfunction have cardiac dyssynchrony due to conduction system disease. JAMA Review author Mihail Chelu, MD, PhD, of Baylor College of Medicine discusses cardiac resynchronization therapy with JAMA Associate Editor David Simel, MD, MHS. Related Content: Cardiac Resynchronization Therapy Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

In the US, approximately 66% of reproductive-aged women have at least 1 modifiable risk factor for adverse pregnancy outcomes. Authors and ob-gyns Kylie Cooper, MD, and Daniel Breitkopf, MD, both from the Mayo Clinic, discuss ways to reduce maternal morbidity and mortality and improve neonatal outcomes with JAMA Senior Editor Karen Lasser, MD, MPH. Related Content: Prepregnancy Care and Counseling

Endometrial cancer accounts for 95% of uterine cancers, which are the fourth most common cancer in women in the US. Author Karen McLean, MD, PhD, of Roswell Park Comprehensive Cancer Center joins JAMA Senior Editor Karen Lasser, MD, MPH, to discuss the current evidence about diagnosis and treatment of endometrial cancer. Related Content: Endometrial Cancer

Explore evidence-based clinical signs, diagnostic accuracy, and practical assessment strategies to optimize care with an in-depth look at the latest information on pediatric concussion. JAMA Review author Sonal N. Shah, MD, MPH, of Boston Children's Hospital, discusses this and more with JAMA Associate Editor David Simel, MD, MHS. Related Content: Does This Child Have a Concussion? Even Mild Concussions Tied to Worse Cognition Later in Life Vestibular/Ocular Motor Screening (VOMS) in Suspected Concussion Balance and Gait Assessment Including Modified BESS Cervical Spine Examination in Suspected Concussion

Absolute iron deficiency with or without anemia affects about 2 billion people worldwide and 14% of adults in the US. Discover causes, diagnosis, and best practices for oral and intravenous iron therapy in adults in this discussion between Michael Auerbach, MD, from Georgetown University School of Medicine, and JAMA Associate Editor Margaret Wheeler, MD. Related Content: Iron Deficiency in Adults

Interview with Thomas Ibounig, MD, author of Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging and Brian T. Feeley, MD, author of Magnetic Resonance Imaging Abnormalities and Incidental Age-Related Changes. Hosted by Eve Rittenberg, MD. Related Content: Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging Magnetic Resonance Imaging Abnormalities and Incidental Age-Related Changes

Resistant hypertension affects about 10% of those treated for hypertension. Managing it involves lowering sodium intake, exercising, losing weight, reducing alcohol consumption, and using optimal diuretics, combination pills, and mineralocorticoid antagonists. Author Michel Azizi, MD, PhD, from Hospital European Georges Pompidou in France discusses this and more with JAMA Associate Editor David L. Simel, MD, MHS. Related Content: Diagnosis and Management of Resistant Hypertension

Peanut allergy affects about 2% of people in the US and most commonly develops in early childhood. Peanut introduction during infancy has led to decreased prevalence of peanut allergy. Author Elissa Abrams, MD, MPH, of the University of Manitoba joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the clinical presentation and methods to diagnose, treat, and decrease the risk of peanut allergy. Related Content: Peanut Allergy

Overweight and obesity may cause 10% of new cancer diagnoses annually in the US. In this JAMA Review in the Translational Science series, author Neil Iyengar, MD, of Emory University discusses the biological pathways that may promote cancer in people with overweight or obesity and potential therapies with JAMA Deputy Editor Mary McDermott, MD. Related Content: Obesity and Cancer

Chronic noninfectious diarrhea affects approximately 6% to 7% of adults in the US and significantly impairs quality of life. Author William Chey, MD, of the University of Michigan joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss strategies for diagnosis and treatment of chronic, noninfectious diarrhea. Related Content: Chronic, Noninfectious Diarrhea