Chemical Journeys

In this episode I speak with Prof. Kathrin Fenner, one of the leading academic scientists in the study of chemical biodegradation and environmental persistence.Kathrin and I have a far-reaching conversation covering her background and research interests, challenges and developments in chemical biodegradation research, and implications for policy and society. We have learned an enormous amount about the fate and persistence of chemicals in recent years, and the work of Kathrin and her group has been at the heart of this. Listen to the episode to find out about biodegradation of chemicals in different environmental settings, what factors contribute to persistence, understanding transformation products and pathways, predicting biodegradation for different chemicals and scenarios, and how we can utilise this knowledge toward safer and more sustainable use of chemicals. Works cited:Innovate beyond PFAS | ScienceDesigning Small Molecules for Biodegradability | Chemical ReviewsBridging across OECD 308 and 309 Data in Search of a Robust Biotransformation Indicator | Environmental Science & TechnologyDeveloping a weight-of-evidence methodology for persistence assessment of substances in the environment | IEAMBreaking it down: Unveiling the roles of chemical structure, concentrations and technology on micropollutant biotransformation in wastewater treatment plants - ScienceDirectHigh-Throughput Miniaturized Biotransformation Testing Using Activated Sludge Enables Rapid Chemical Persistence Assessment | Environmental Science & Technology LettersRead-Across of Biotransformation Potential between Activated Sludge and the Terrestrial Environment: Toward Making It Practical and Plausible | ES&TModernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods | Archives of ToxicologyDo biotransformation data from laboratory experiments reflect micropollutant degradation in a large river basin? - ScienceDirectEawag-Soil in enviPath: a new resource for exploring regulatory pesticide soil biodegradation pathways and half-life data - Environmental Science: Processes & ImpactsFAIR and Effective Communication of Data on Chemical Contaminant Biotransformation in the Environment | ES&T LettersConfidently Uncertain: Probabilistic Machine Learning to Predict Soil Biotransformation Half-Lives | ES&TPredicting Micropollutant Removal in Wastewater Treatment Based on Molecular Structure: Benchmark Data and Models | ES&TPersistence Assessment of Chemicals: Trajectories toward New Approach Methodologies (P-NAMs) | ES&TDiscover enviPath.org

In this episode I speak with Joanna Gavins, who is a professor of English Language and Literature at the University of Sheffield.Joanna and I discuss the language we use and how this influences the way we think, feel and act in relation to choices we make, the environment, and chemicals. We start off by discussing the work Joanna has been doing at the Bio-based and Biodegradable Industries Association (BBIA) on how to effectively communicate information about sustainability to consumers. We also delve into our complex relationship with nature, and how this is influenced by language.Our conversation then moves onto chemicals. We do a deep dive into the language surrounding chemicals in modern discourse, and how this influences public perception and emerging policy. We talk about the issue of chemicals in the environment, how this relates to us, and how we might get better at talking - and thinking - about these issues.I hope you will find this discussion as fascinating as I did!Plastic: Unwrapped podcast - Plastic Planet | The University of Sheffield PlayerHuman/Nature podcast | The University of Sheffield PlayerWhite paper: Growing the UK’s Modern Industrial BioeconomyEffective Communication to Advance the Modern Industrial Bioeconomy - reportJust Earth: How a Fairer World Will Save the Planet - Tony JuniperVanished: An Unnatural History of Extinction - Sadiah QureshiEcolinguistics: Language, Ecology and the Stories We Live By – Arran Stibbe

Happy 2026, and welcome to Chemical Journeys Season 2!In this episode, I speak with Dr. Fola Ogungbemi, Senior Expert in Product Compliance at Currenta.Fola and I talk about his career journey so far, from student in ecotoxicology to senior regulatory consultant. We discuss experiences of early career scientists finding their next steps after completing a PhD, adapting to working in different sectors, the importance of staying open for continuous growth and learning, and the value of mentorship and support along the way. Fola also shares some of his personal experiences of relocating to multiple cities, finding friends and community, and his adventures as a DJ. We talk about Fola's journey with the Society of Environmental Toxicology and Chemistry (SETAC), and that part that the organisation has played in his development. Fola also reflects on his Christian Faith and how this shapes his outlook and approach to life.Fola Ogungbemi, PhD | LinkedInDJ with a PhD (@djfolaflo) • Instagram photos and videosSETAC Europe 36th Annual Meeting

In this episode, I speak with Dr. Watze de Wolf.  Watze has had a long and accomplished career working as a scientist and manager in both industry and regulatory settings, including 15 years working at the European Chemicals Agency (ECHA). We have a wide-ranging discussion about his experiences and observations of how chemicals management has evolved over recent decades, and attempt to provide a diagnosis for the current situation and outlook for the years ahead.  This includes:Watze’s background, career journey and people he worked withThe tension between the uncertainty and complexity of science vs the need for clear and predictable regulationThe importance of communication and meeting your audience where they areContrasting sensitivities and drivers of behaviour in different industriesThe shift away from risk-based approaches, and the rise of persistenceThe importance of dialogue and the value of organisations like the Society of Environmental Toxicology and Chemistry (SETAC)Understanding EU regulations as complex systems Experiences with REACH dossiers, from both industry and regulator perspectivesWhat it’s like for early career scientists at ECHADiscussions and experiences from the ECHA Member State CommitteeThoughts on the Biocidal Products Regulation (BPR)What a new harmonised classification of ethanol means for its ongoing use as a disinfectantThe essential use concept and how it could re-define chemicals management in EuropeImportance of EU Member State participation, and the impact of Brexit on regulatory discussionsRegrettable restrictions and thoughts on the ongoing group-wide restriction of PFASThoughts on the overall direction of travel, broader technological and societal shifts, and the impact on science Watze's website: rMSC.fi – rMSCMember State Committee - ECHATrifluoroacetic Acid in the Environment: Consensus, Gaps, and Next Steps | Environmental Toxicology and Chemistry | Oxford AcademicPersistence Science Interest Group Pushes Forward with Global Collaboration and New InitiativesLiterature review on micro‐ and nanoplastic release from food contact materials during their use | EFSAReflecting on 40 years of regulatory developments in Europe – Peter Fisk — Embark Chemical ConsultingVisit my website for more content and insights www.embarkchemical.com

In this episode I speak with Dr. Steven Brennan, co-founder and CEO of Foresight.Foresight is a software platform that helps organizations to make sense of complex and fast moving chemical regulations, so they can always be ready for what's coming next.Steven and I have a nice conversation that shows how he turned his years of regulatory experience into a software solution that solves a key challenge - how to get access to key insights faster to understand and manage regulatory change. Listen to this conversation if you want to get a look into the world of startups and software as a solution (SaaS) from a chemical regulatory point of view. We also talk about aspects of building and growing a business, and some reflections on life as founders and keeping everything in balance. Our conversation covers:Steven's background and career journeyThe story behind Foresight - identifying an industry need, and developing a solutionFeatures of Foresight - how the tool delivers advanced regulatory insightsApplications and limitations of AI in chemicals regulationREACH Article 129 - Member State safeguard clauseWhat kinds of customers are using Foresight?What process and considerations go into developing new features?Building the company - from startup to commercialisationThe customer buyer journeySteven's work as a co-opted member of the ECHA Socio-Economic Analysis Committee (SEAC)Steven and Chris swap stories about life as foundersFollow the link to find out more about Foresight and start your free trial: Foresight | The future of chemical policy monitoringVisit my website for more content and insights www.embarkchemical.com

What happens to the chemicals we use in everyday life once they enter the environment?In this episode, I am joined by Dr. Irene Bramke, Senior Environmental Risk Assessor at AstraZeneca. Irene and I have a detailed discussion about persistence (how long it takes for chemicals to break down in the environment). With recent concerns around plastic pollution, PFAS 'forever chemicals', and broader sustainability goals, the persistence of chemicals in the environment has become one of the most urgent and pressing issues for policymakers and society.Irene and I discuss the science behind persistence, and how it relates to the risks chemicals might pose to people and the environment. We also talk about recent regulatory developments in Europe, and how these are reshaping the future of chemicals management. Our conversation covers:Irene's background and career journeyGrappling with complexity - insights from studying soils in an agrochemicals companyIndustry's participation in regulatory science - then vs nowIssues of environmental relevance in laboratory biodegradation testingThe evolving policy landscape for persistenceNon-degradable chemicals and the legacy P/vP criteriaIn the eye of the beholder - the meaning of word 'persistent'Implications of new policies - the PMT/vPvM hazard classesA troubling outlook - data gaps, transformation products, and questionable impact assessments?Reflections on OECD simulation tests as tools for persistence assessmentsInsights from AstraZeneca's Ecopharmacovigilance programmeThe importance of data quality in monitoring efforts - the CREED approachShifting regulatory paradigms - hazard assessment vs risk assessment, and the need for continuing dialogueCan we get better at assessing persistence? High-throughput and predictive methodsPBT/PMT assessment of active pharmaceutical ingredients - ScienceDirectEnvironmental fate and effects assessment of human pharmaceuticals: lessons learnt from regulatory data | Environmental Sciences EuropeOvercoming challenges and advancing (bio)degradation guidelines: OECD TG309 revisited - ECETOCAstraZeneca - EcoPharmacoVigilance DashboardUsing environmental concentration exposure datasets in environmental assessments: The development of Criteria for Reporting and Evaluating Exposure Datasets (CREED): Integrated Environmental Assessment and ManagementHOMEPAGE - imi-premierModernizing assessment of persistence and transformation products of chemicals – from new tools to implementation (23-October 24, 2025): Overview · HIFIS and Helmholtz Events (Indico)Visit my website for more content and insights www.embarkchemical.com

In this episode I speak with Dr Katherine Santizo, Programme Manager of Cefic's Long-range Research Initiative (LRI). Since 1999, Cefic-LRI has funded over 250 projects (totaling approximately €90 million) to advance the scientific assessment of the safety of chemicals, and to improve understanding of potential health and environmental risks.Tune in to hear first-hand from Katherine about the exciting work that Cefic-LRI does, and how this is helping to deliver progress in chemicals assessment science.Our conversation covers:What is Cefic-LRI? The LRI mission, and what makes it differentHow it works - the LRI process from ideation to publicationsTools and solutions to address key regulatory challengesKatherine's background and career journeyWorking across disciplines - integrating environmental science with human healthReflecting on the 25 year anniversary of Cefic-LRIUpcoming research projects: new approach methodologies (NAMs), mobility and biodegradationOther hot topics in chemicals safety researchCefic-LRI's contribution to persistence assessment scienceCefic-Lri – Long-Range Research InitiativeDetermining the water solubility of difficult-to-test substances: A tutorial review - ScienceDirectCefic-LRI workshop highlights advances in chemical assessments aligned with evolving regulations – Cefic-LriLRI Marks 25 Years of Advancing Chemical Safety Assessments – Cefic-LriCefic-LRI 25th Anniversary Commemorative BookNew funding opportunities for research on NAMs, biodegradation testing and mobility assessment – Cefic-LriECO52 – Bioavailability, complex substances and overall persistence (BCOP): three themes to deliver a step-change in persistence assessments – Cefic-LriDeveloping a weight-of-evidence methodology for persistence assessment of substances in the environment | Earth, Space, and Environmental Chemistry | ChemRxiv | Cambridge Open EngageVisit my website for more content and insights www.embarkchemical.com

In this episode I speak with Dr Anna Zhenova of Green Rose Chemistry.Green Rose Chemistry are a mission-driven consultancy applying the principles of green chemistry to help organisations to develop more sustainable products and processes.Our conversation covers:What does Green Rose Chemistry do?Green chemistry as a grass roots movement - the need for education and champions within organisationsHow different sectors are at varying stages on the green chemistry journeyThe importance of language in communicating sustainabilityExamples of green chemistry solutions - chemical substitution vs functional substitutionReflections on connecting chemical safety with product development and other disciplinesAvoiding tunnel vision and uncovering win-wins - a case with safer solventsWhat is green chemistry? 12 principles, 3 pillarsOn externalities - economic vs moral questionsChemicals in the environment, persistence, transformation products, and mixturesDealing with overwhelm and working within your sphere of influenceHow do green chemists differ from traditional chemistsGreen Rose Chemistry | Sustainable Chemistry ConsultantsBeyond BenignGreen Rose Chemistry | TrainingAdvancing Safer Alternatives Through Functional Substitution | Environmental Science & Technology12 Principles of Green Chemistry - American Chemical SocietyVisit my website for more content and insights www.embarkchemical.com

In this episode, I speak with Janet Greenwood of TT Environmental. Janet has been working for many years in chemicals safety and regulatory compliance, and runs a community of regulatory professionals (the Chemical Regulations Self Help Group) here in the UK, and a regular newsletter (Chemicals Coffee Time) with over 4000 subscribers across the globe. Janet therefore brings an important perspective from regulatory professionals and small and medium enterprises (SMEs) working 'on the ground' to address regulatory compliance within the chemicals industry.Our conversation covers:Janet's background and the origins of her community and newsletterChemicals Coffee Time - during lockdown and beyondJanet's journey to becoming an environmental consultantEnvironmental permits, sustainability and ISO 14001Top-down procedures vs individual vigilanceSafety Data Sheets (SDS), CLP labels, and the need to keep the end user in the focusDealing with the deluge of regulatory changes in the EU and UKThe impact of new substances of very high concern (SVHCs) Reflections on the evolution and broader impacts of REACHThe shifting chemicals marketplace and shared responsibilityViews on environmental challenges, and the concept of stewardshipTT Environmental Consultancy Yorkshire | EP, IPPC, REACH, COMAH, ADMS & Environmental modelingThe Chemical Regulations Self Help Group – Peer support for REACH, CLP and other chemical regulationsSign up to Chemicals Coffee Time weekly - Chemicals Coffee TimeChemicals Coffee Time Monthly newsletter - LinkedInVisit my website for more content and insights www.embarkchemical.com

In this episode I speak with Professor Thomas Hartung. Prof Hartung is Doerenkamp-Zbinden Chair of Evidence-based Toxicology at Johns Hopkins Bloomberg School of Public Health, and Professor of Pharmacology and Toxicology at the University of Konstanz. He also holds positions as Director of the Center for Alternatives to Animal Testing (CAAT) and Field Chief Editor of the academic journal Frontiers in AI, and was the 2025 recipient of the prestigious Peter Singer Prize. We have a fascinating discussion about the breathtaking developments in AI and animal-free toxicology, and what this means for areas like drug development, chemical regulation, public health, animal testing, research ethics, the exposome, and the future of our society.Our conversation covers:New Approach Methodologies (NAMs): the new automobile?Technological advances in microphysiological systems (MPS) and artificial intelligence (AI)The problems with animal modelsChallenges with validation and regulatory acceptance of NAMsThe importance of education for uptake of NAMsRecent developments on US animal testing policyWhat is happening in the EU? Differences between regions and regulatory systemsHow AI is transforming research, and using it in day-to-day work Implications of AI for quality of scientific publications and risk of biasThe Human Exposome Project: what is it, and how can AI help deliver it?Environmental persistence, the exposome, and the public discourse on chemicalsNAMazing: Déjà Vu at the lab bench - Why animal-free science is the new automobile - ScienceDirectNIH stops funding new projects which focus only on animal testing | Cruelty Free InternationalThe turning point: April 2025 marks historic shift in US animal testing policy | ALTEX - Alternatives to animal experimentationREACH out-numbered! The future of REACH and animal numbers | ALTEX - Alternatives to animal experimentationA systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency | ALTEX - Alternatives to animal experimentationGuidance for Good In Vitro Reporting Standards (GIVReSt) – A draft for stakeholder discussion and background documentation | ALTEX - Alternatives to animal experimentationTop 10 Emerging Technologies of 2024 | World Economic ForumAssessing risk of bias in toxicological studies in the era of artificial intelligence | Archives of ToxicologyIs regulatory science ready for artificial intelligence? | npj Digital MedicineHow AI can deliver the Human Exposome Project | Nature MedicineStockholm Declaration on Chemistry for the FutureVisit my website for more content and insights www.embarkchemical.com