E160 - Ongoing challenges of off-label prescribing

Dhineli Perera sits down with Adam Nelson to discuss updates in the management of hypercholesterolaemia. Adam explains how triglycerides, LDL cholesterol and HDL cholesterol differ in their links to cardiovascular disease. He provides useful tips for checking a lipid profile and highlights other tests that may be helpful when assessing a patient with hypercholesterolaemia. Adam also explains the latest in treatments for reducing LDL cholesterol concentrations and what this means for the role of statins. Read the full article by Adam Nelson and Stephen Nicholls in Australian Prescriber.

Jo Cheah chats with clinical pharmacologist Richard Day about off-label prescribing. Ric explains why off-label prescribing occurs, the barriers to getting new indications added to a drug’s approved label, and the potential risks of off-label prescribing without sufficient evidence. Read the full article by Richard Day in Australian Prescriber.

Justin Coleman sits down with Lee Fong to discuss the changes to the latest version of Therapeutic Guidelines: Dermatology. Lee talks about misconceptions around the use of topical corticosteroids, tailoring treatments to the subtype of acne, and management tips for scabies, sweating disorders, psoriasis and much more.

Dhineli Perera and Andrew McLachlan, Dean of The University of Sydney’s Pharmacy School, talk about the 2022 National Medicines Policy. Andrew gives an overview of the refreshed Policy, what’s changed, and how the Policy can be implemented into practice. Read the full article by Andrew and his colleague, Parisa Aslani, in Australian Prescriber.

Dhineli Perera chats with clinical pharmacologist and fellow podcast host David Liew about Australia's top 10 drugs over the last 2 years. David explains the relationship between the PBAC and the PBS and the different ways the top 10 drugs are presented, and offers some insights into why particular drugs are on the lists. Read the full articles for 2021-22 and 2022-23 in Australian Prescriber.

Laura Beaton speaks to psychiatrist David Castle about enhanced physical health monitoring for people with schizophrenia and the unique challenges to implementing preventive health care in these patients. David discusses modifiable physical health risk factors and how these can be addressed as part of a multidisciplinary holistic approach to care. Read the full article by David and his co-author, Amy Li, in Australian Prescriber.

Jo Cheah speaks with Jodie Austin, a clinical informatics specialist, about using new technologies to deliver health care. The conversation focuses on using digital health to improve prescribing and medication management, through the use of digital dashboards and machine learning. Jodie also outlines the role of the clinician in the developing digital world. Read the full article by Jodie Austin and her co-authors in Australian Prescriber.

Dhineli Perera talks to Geoffrey Sussman, an expert on wound management, about the latest updates in the field. The conversation covers the importance of identifying the cause of a wound and tailoring the treatment accordingly. Geoff also provides useful tips for assessing wounds, the difference between acute and chronic wounds, and best practice for applying wound dressings. Read the full article by Geoffrey Sussman in Australian Prescriber.

Jo Cheah and endocrinologist Benjamin Sly discuss devices for self-monitoring blood glucose concentrations. The conversation covers both capillary (fingerprick) monitoring and continuous blood glucose monitoring, the types of monitoring devices available to patients and their different features. Ben explains how to select the most appropriate device. Read the full article by Benjamin Sly and his co-author Janet Taylor in Australian Prescriber.

SGLT2 inhibitors and GLP-1 receptor agonists now have well-established cardiovascular and renal benefits. What does this mean for their role in the management of type 2 diabetes? Justin Coleman chats with endocrinologist and clinical pharmacologist, Tilenka Thynne, about this and other updates to Therapeutic Guidelines Diabetes.