Alexander Disease Research Update

Feedback and questions are welcome!Albee Messing and Abby Olsen discuss the following recent publication:Adult-Onset Alexander Disease Presenting as Atypical Parkinsonism and Autonomic Dysfunction: A Case SeriesJournal of Clinical Medicine, 15, 5677 (2026)Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/Podcasts supported by Daniel's Fight (https://www.danielsfight.org/)#alexanderdisease#alexanderdiseaseresearch  

Feedback and questions are welcome!Albee Messing and Aidan Long discuss the following recent publication: Demonstrating clinical and radiological variability of adult-onset Alexander disease in three siblings                  Journal of the Neurological Sciences 489, 126109 (2026)                  https://pubmed.ncbi.nlm.nih.gov/42501499/Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:          https://alexander-disease.waisman.wisc.edu/donate/Podcasts supported by Daniel's Fight (https://www.danielsfight.org/)#alexanderdisease#alexanderdiseaseresearch  

Feedback and questions are welcome!Albee Messing, Jared Cullen, and Nadine Connor discuss the following recent publication: Behavioral characterization of bulbar sensorimotor function in a rat model of Alexander disease                  Behavioural Brain Research (in press) Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/Podcasts supported by Daniel's Fight (https://www.danielsfight.org/)#alexanderdisease#alexanderdiseaseresearch

Feedback and questions are welcome!Albee Messing and Ylenia Vaia discuss the following recent publication: Neuroradiological patterns and prognostic implications in type I Alexander diseaseMolecular Genetics and Metabolism, 148, 110189 (2026)Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:          https://alexander-disease.waisman.wisc.edu/donate/Podcasts supported by Daniel's Fight (https://www.danielsfight.org/) 

Feedback and questions are welcome!Albee Messing, Dolores Pérez-Sala, and Natasha Snider discuss the following recent publications: Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants.                  Redox Biology 92:104103 (2026)  Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant.                  Free Radical Biology & Medicine (in press)Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/ Podcasts are supported by Daniel's Fight (https://www.danielsfight.com)  

Feedback and questions are welcome!Albee Messing, Annette Bley, and Nadia Kokaly discuss the following recent publication: [01:58]       Description of the Hamburg Alexander Leukodystrophy Cohort-Insights into Practical Classification and the Care Situation. Journal of Clinical Medicine 14, 6918 (2025) [19:00]       Comment: Peer review – please come home. Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/ Podcasts are supported by Daniel's Fight (https://www.danielsfight.com).

Feedback and questions are welcome!Albee Messing, Debra Levin, and Amy Waldman discuss the following recent publications: [01:27]       Language Skills in Patients With Alexander Disease. American Journal of Speech-Language Pathology 35:211-225 (2025) [17:06]       Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease. Annals of Clinical and Translational Neurology (in press) [full text]Send your questions and feedback to:  [email protected] supported by Daniel's Fight. Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:          https://alexander-disease.waisman.wisc.edu/donate/

Feedback and questions are welcome!Albee Messing and Amanda Nagy discuss the following recent publication: [01:42]       Genotype-phenotype correlations of GFAP variants in type I Alexander disease subtypesMolecular Genetics & Metabolism 147, 109689 (2026)Please send questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/

Feedback and questions are welcome!Albee Messing, Tracy Hagemann, and Abby Olsen discuss the following recent publication: [01:45]       Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander DiseaseAnnals of Clinical and Translational Neurology (in press) [full text]Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/

Feedback and questions are welcome!Albee Messing, Mel Feany, and Natasha Snider discuss the following recent publication: Genotype-phenotype association for 14 GFAP variants in Alexander disease. Neurology: Genetics. 11, e200270 (2025) [full text] Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/    1.      Berman RF, Matson MR, Bachman AM, Lin N-H, Coyne S, Frelka A, et al. GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease. eNeuro:(in press) (2025) PMID: 40064497 Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications J Vis Exp, 18, 55655 (2017)STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease Cells, 12, 978 (2023)A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells Stem Cell Reports, 18, 1701-1720 (2023)