Cancer Frontiers (Audio)

Why does glioblastoma often return after treatment? Joe Costello, Ph.D., of UC San Francisco, examines two connected processes underlying this aggressive brain cancer: tumor evolution and the ability of cancer cells to keep dividing. Using three-dimensional sampling across multiple regions of brain tumors, his research investigates small populations of early ancestral cells that appear to survive treatment and may contribute to recurrence. Costello also examines how changes involving the TERT gene help tumor cells maintain their ability to divide. In laboratory and animal experiments, his team tests ways to interfere with proteins that activate TERT, while using artificial intelligence to identify additional potential targets. Although much of this research remains preliminary, it offers new insights into why glioblastoma is difficult to treat and possible directions for future therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40859]

A federally funded clinical trial played a pivotal role in Tom Mugno’s journey after a diagnosis of lymphoma that was not responding to chemotherapy. With guidance from Dr. Joseph Tuscano at ‪UC Davis Health‬, Mugno enrolled in a National Cancer Institute–funded study exploring a novel immunotherapy-based research approach. His experience offers a personal perspective on how clinical research can translate into real-world impact, and celebrates his complete remission. Series: "UC Davis News" [Health and Medicine] [Show ID: 41739]

For people diagnosed with cancer, patient advocacy can play a vital role throughout the treatment process. At UC San Diego’s annual Prostate Cancer Patient Summit, keynote speaker and three-time MLB All-Star David Justice brought visibility and purpose to that message, underscoring the broad reach and lasting importance of speaking up for patients and families. [Health and Medicine] [Show ID: 41648]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Steven Seyedin discusses radiation therapy. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41558]

Pre-cancer and cancer can begin when stressed blood-forming stem cells lose their normal controls. Catriona Jamieson, M.D., Ph.D., UC San Diego, explains how inflammation-linked editing enzymes, repetitive elements in the genome, and stem cell stress shape the progression from myeloproliferative neoplasms to acute myeloid leukemia. Jamieson examines how spaceflight accelerates stem cell aging, how some astronauts mobilize a resilient regenerative stem cell population, and how tumor organoids in space help reveal drug responses by activating the enzyme ADAR1. This work helps explain how cancer starts, why it can return, and how space-based research may speed the development of therapies that stop malignant stem cells before disease advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41473]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Spencer Behr discusses PSMA PET and functional imaging. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41557]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Jonathan Chou discusses targeted therapies. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41563]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. David Oh discusses immunotherapy. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41562]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Stacey Kenfield, ScD, discusses diet and exercise. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41555]

As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Arpita Desai discusses metastatic hormone sensitive prostate cancer. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41560]