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An increasing number of people are dying from misuse of synthetic opioids. In 2022, the US recorded over 70,000 overdose deaths involving synthetic opioids. The government is spending billions to combat the effects of these super strength drugs. Synthetic opioids, such as Fentanyl, are made in laboratories by using materials derived from the opium poppy. China is a major hub for the production of synthetic opioids, where it then makes its way to North America through Mexican drug cartels. The lab-made drugs can be more deadly than the natural materials, but they are more easily accessible, and prevalence is rising across the world.In West Africa and the Middle East, tramadol is one of the most consumed synthetic drugs. The rise of synthetic opioids in the European market, which are being used as a substitute for a heroin shortage, is fuelling concern that these substances could lead to a rise in drug-related deaths. This week on The Inquiry, we’re asking are synthetic opioids a global problem?Contributors Ric Treble, Forensic chemist and advisor to the Government’s Advisory Council on the Misuse of Drugs Dr Angela Me, Chief of the Research and Trend Analysis Branch from the United Nations Office on Drugs and Crime Ben Westhoff, author of Fentanyl, Inc and investigative journalist Dr Vanda Felbab-Brown is a senior fellow in the Strobe Talbott Center for Security, Strategy, and Technology in the Foreign Policy program at Brookings InstitutionProduction team Presenter: Charmaine Cozier Producers: Vicky Carter and Matt Toulson Researcher: Ajai Singh Editor: Tara McDermott Technical Producer: Cameron Ward Production Co-ordinator: Liam MorreyImage credit: mikroman6 via Getty Images

Six months into Israel’s war in Gaza and with no sign of a ceasefire or breakthrough in securing the release of the 130 hostages, as yet unaccounted for, pressure is mounting on Israel’s Prime Minister Benjamin Netanyahu. There have been widespread protests in Tel Aviv and across Israel. There have been calls both from home and abroad for an early election to be called. And Israel’s greatest ally, the United States has sharpened its rhetoric in the past few weeks over Israel’s conduct of the war, with President Biden now saying that he believes Benjamin Netanyahu is making ‘a mistake’ in his handling of it. For his part, the Israeli Prime Minister looks set to continue with his military offensive and has shown no indication so far that he is willing to step down or call an early election. So, on this week’s Inquiry, we’re asking ‘How secure is Benjamin Netanyahu’s leadership?’Contributors: Professor David Tal, the Yossi Harel Chair in Modern Israel Studies, University of Sussex, UK Natan Sachs, Director of the Centre for Middle East Policy, The Brookings Institution, Washington DC, USA Aaron David Miller, Senior Fellow, Carnegie Endowment for International Peace, Washington DC, USA Professor Tamar Hermann, Senior Research Fellow, The Israel Democracy Institute, JerusalemPresenter: Tanya Beckett Producer: Jill Collins Editor: Tara McDermott Technical Producer: Cameron Ward Production Co-ordinator: Liam MorreyImage credit: Reuters via BBC Images

Multiple Sclerosis (MS) is a neurological disease which can lead to loss of mobility and vision. Almost 3 million people worldwide are affected by it. There is no cure, but attempts are being made to accelerate the healing process with treatments to restore what the disease has damaged.At the same time, scientists have recently discovered a link between MS and a common virus that the majority of us carry in our bodies. It had been known for years that there was a link between Multiple Sclerosis and Epstein-Barr virus (EBV). But then, a study finally proved the link.Now, trials are underway on potential vaccines against EBV and scientists are hopeful that this could be a gateway to preventing MS. This week on the Inquiry we are asking: Are we close to a breakthrough for Multiple Sclerosis?Contributors:Tim Coetzee, Chief Advocacy, Services & Science Officer for the National MS Society, US Tjalf Ziemssen, Professor of Clinical Neuroscience and Head of the Multiple Sclerosis Center and Neuroimmunological Laboratory, University Clinic Carl-Gustav Carus, Germany Jeffrey Huang, Associate Professor of Biology, Georgetown University, US Claire Shannon-Lowe, Associate Professor in Virology, Institute of Immunology and Immunotherapy at the University of Birmingham, UKProduction team: Presenter: Tanya Beckett Producer: Matt Toulson Researcher: Ajai Singh Editor: Tara McDermott Studio Manager: Hal Haines Production Co-ordinator: Liam MorreyImage Credit: Shidlovski\Getty

For centuries chocolate has had a global appeal, the key ingredient of this confectionery is derived from the dried and fully fermented seed of the Theobroma cacao, whose origins began in northern Amazonia. From this tree, both cocoa solids and cocoa butter can be extracted to form the basis of chocolate. Today, it’s the West African countries of Côte d’Ivoire and Ghana that produce the bulk of the world’s supply of cocoa beans. But in recent years hotter temperatures and shifts in rainfall patterns have impacted cocoa harvests particularly in this region. And now the global price of this key ingredient has roughly doubled since the start of last year, fuelling concern that demand could outweigh supply. Cocoa farming itself is mainly small scale and these farmers are at the bottom end of the value chain when it comes to profits. But whilst many of the major chocolate manufacturers do invest in the industry, with support for improved planting and harvesting techniques, farming sustainably is just one of a number of challenges that these small farmers face. So on this week’s Inquiry, we’re asking ‘Is climate change impacting chocolate production?’ Contributors: Dr Katie Sampeck, British Academy Global Professor of Historical Archaeology, University of Reading, England Philip Antwi-Agyei, Associate Professor, Department of Environmental Science, Kwame Nkrumah University of Science and Technology, Ghana Steffany Bermúdez, Policy Advisor, International Institute for Sustainable Development (IISD), Canada Yunusa Abubakar, Project Manager, International Cocoa Organisation (ICCO), Côte d’IvoirePresenter: Charmaine Cozier Producer: Jill Collins Researcher: Matt Toulson Editor: Tara McDermott Technical Producer: Hal Haines Production Co-ordinator: Liam MorreyImage by grafvision via Getty Images

In February this year, El Salvador's president Nayib Bukele won re-election with nearly 85% of the vote. His flagship policy after he came to power in 2019 has been the mass arrest of thousands of alleged gang members, mainly young men.It is estimated that over 100,000 people are now behind bars as part of his crime crackdown. The round-ups have been hugely popular with El Salvador's people as it has improved security and neighbouring countries are taking note.But critics say following Bukele's approach could threaten democracy, not just in El Salvador but across the continent. So on this week’s Inquiry, we’re asking: Will neighbouring countries follow El Salvador's lead on crime?Contributors: Carlos Dada, director of El Faro, an online newspaper based in El Salvador Katherine Saunders-Hastings, a lecturer in Latin American Studies at the University of London's Institute of the Americas. Will Freeman, Fellow for Latin American Studies at the Council on Foreign Relations, New York. Monica Pachon , a political scientist and professor at the University of the Andes in Bogotá, Colombia.Presenter: David Baker Producer: Farhana Haider Journalism Researcher: Matt Toulson Editor: Tara McDermott Technical Producer: Nicky Edwards Production Co-ordinator: Tim Fernley and Liam MorreyImage Credit: Alex Peña / Stringer via Getty Images

More than half of the world’s population currently lives in cities, and by 2050, the UN estimates that figure will rise to nearly 7 in 10 people. The world is also getting hotter, with heatwaves and wildfires becoming increasingly common. So how can we deal with the dual challenges of increasing urbanisation and extreme weather caused by climate change? Perhaps we should look downwards. For millennia, humans have taken refuge underground from the elements, predators and from war. Even today, bomb shelters exist under major cities like Beijing and Seoul. Many cities across the world have subway systems for easy transportation – and some are integrated seamlessly with below-ground business and shopping centres. But what are the future challenges for urban planners and architects in this subterranean space, and how can we overcome the social stigma against those who live underground? This week on the Inquiry, we ask: is our future underground? Contributors: Martin Dixon, trustee of Subterranea Britannica, a society devoted to the study and investigation of man-made and man-used underground places. Jacques Besner, architect and urban planner; co-founder and general manager of Associated Research Centres for Urban Underground Spaces. Antonia Cornaro co-chair of ITACUS, the International Tunnelling and Underground Space Association's Committee on Underground Space. Professor Clara Irazábal, Director of the Urban Studies and Planning Program at the University of Maryland, USA.Presenter: Tanya Beckett Producer: Ravi Naik Editor: Tara McDermott Researcher: Matt Toulson Production Coordinators : Janet Staples & Liam MorreyPhoto by BEHROUZ MEHRI via Getty Images

The Mexican government has won its appeal to bring a civil lawsuit against a number of American gun companies. Mexico, which has extremely restrictive gun laws, claims that the ‘deliberate’ business practices of these US firms results in the illegal flow of firearms into Mexico, contributing to the gun crime violence in the country. They are now seeking as much as ten billion dollars in compensation. The gun companies, which include some of America’s oldest established names in the firearms business, deny any wrongdoing. Since 2005, these companies have being granted immunity from prosecution under the ‘Protection of Lawful Commerce in Arms Act’. This law protects the firearms manufacturers and dealers from being held liable when crimes have been committed with their products. But Mexico’s argument is that PLCAA, as it’s also known, only applies within the United States and therefore doesn’t protect the companies from liability.It’s a case which is also resonating with other Latin American countries who have been impacted by illegal gun trafficking from the United States. Some of these countries have supported Mexico’s claims in the courts. And they will be watching closely to see if Mexico’s lawsuit, the first by a sovereign state, can set a precedent.So on this week’s Inquiry, we’re asking ‘Can Mexico win its battle with US gun companies?’Contributors: Ioan Grillo, journalist and author focusing on Organised Crime, Mexico Adam Winkler, Cornell Professor of Law, UCLA School of Law, California, USA Robert Spitzer, Distinguished Service Professor Emeritus of Political Science, SUNY Cortland; Adjunct Faculty Member, College of William and Mary School of Law, USA Dr. León Castellanos-Jankiewicz, Senior Researcher, Asser Institute for International and European Law; Academic Supervisor, International Law Clinic on Access to Justice for Gun Violence, University of Amsterdam, The Netherlands. Presenter: Charmaine Cozier Producer: Jill Collins Journalism Researcher: Matt Toulson Editor: Tara McDermott Technical Producer: Cameron Ward Production Co-ordinator: Liam Morrey Image: Reuters via BBC Images

One of the most famous of Egypt’s pyramids, Menkaure’s pyramid on the Giza plateau, is the subject of controversy after the Egyptian authorities announced plans to restore it in what the country’s Head of Antiquities has called “the project of the century” and Egypt’s “gift to the world”. But not everyone believes such a restoration is in keeping with the demands of proper archaeological preservation. The plans met with opposition from archaeologists and Egyptologists both inside and outside the country. The project has now been paused after recommendations from a scientific committee commissioned by the Egyptian authorities.So what’s going on with the pyramids?Presenter: Gary O’Donoghue Producer: Louise Clarke Researcher: Matt Toulson Editor: Tara McDermott Technical producer: Nicky Edwards Production co-ordinator: Liam MorreyContributors: Aidan Dodson, honorary Professor of Egyptology at Bristol university in the UK Dr Jennifer Hellum, senior lecturer in classics and ancient history at the University of Auckland in New Zealand Heba Saleh, Cairo correspondent for the Financial Times Salima Ikram, professor of Egyptology at the American University in CairoPhoto by KHALED ELFIQI/EPA-EFE/REX/Shutterstock via BBC Images

Across the world fertility rates are falling and for the first time Europe is experiencing a sustained population decline. The average fertility rate for the European Union is 1.53 live births per woman. In Italy the fertility rate has remained low for the last thirty years, with an average 1.3 births per woman.Some governments, who are concerned that not enough people are being born to keep their economies functioning in the long term are spending billions on incentives and policies to try and reverse the trend. But even in the Nordic countries, which are noted for some of the best family focused policies, these are proving ineffective against a markedly high drop in fertility rates over the last decade. Society’s attitudes on when or whether to start a family are shifting, so does this mean that we need to change the way we approach the issue or even adapt to a future with fewer people? On this week’s Inquiry, we’re asking ‘Can Europe reverse its falling fertility rates?’Contributors: Anna Rotkirch, Research Director, Population Research Institute, The Family Federation of Finland, Helsinki Michael Herrmann, Senior Advisor on Economics and Demography, United Nations Population Fund (UNFPA), Turkey Arnstein Aassve, Professor of Demography, Political Science Centre, Bocconi University, Milan, Italy Tomas Sobotka, Deputy Director, Vienna Institute of Demography, Austrian Academy of Sciences Presenter: Charmaine Cozier Producer: Jill Collins Journalism Researcher: Matt Toulson Editor: Tara McDermott Technical Producers: Nicky Edwards and Toby James Production Co-ordinator: Liam Morrey Image Credit: PA via BBC Images

In the next two or three years America’s National Aeronautics and Space Administration - NASA - plans to send a mission into space that will land people on the moon for the first time in over a half a century.The mission has already been pushed back and is widely expected to be delayed again.But America is not alone. Both China and India also have ambitions to land people on the lunar surface.Who is next to walk on the moon is driven by geopolitics and a desire to harness the moon’s resources. Different countries, and even the private companies involved, all have different agendas. Who gets there first may even determine the political ideology of any future permanent human settlement. Contributors: Oliver Morton, Senior Editor at The Economist and author of The Moon, A History for the Future Eric Berger, Senior Space Editor at Ars Technica Christopher Newman, Professor of space law and policy at Northumbria University Namrata Goswami, Professor at the Thunderbird School of Global Management at Arizona State UniversityPresenter: Tanya Beckett Producer: Louise Clarke Journalism Researcher: Matt Toulson Editor: Tara McDermott Technical Producer: Richard Hannaford Production Coordinator: Liam MorreyImage: U.S. Flag On The Moon by Encyclopaedia Britannica via Getty Images Credit: NASA Youtube Channel