The AMR Studio

Resistance usually comes down to two stories: either a mutation or a plasmid. But in this episode, we explore a third one.In this episode we feature an interview with Professor Stanley Maloy of San Diego State University, a microbial geneticist who was in Uppsala as faculty examiner at Talía Berruga-Fernández's PhD defense. We talk about a career built on bacterial genetics, how cheap sequencing turned evolution into something you can watch happening, and his own antibiotic-resistant infection treated with an experimental drug that did not yet have a name.In the news section, we bring you the two papers behind Talía Berruga-Fernández's thesis, published earlier this year. The first shows that nearly four in ten clinical E. coli isolates can mobilize large sections of their own chromosome, carrying resistance and virulence genes not selected for, while the second finds that E. coli keeps its ability to feed itself only by acquiring working genes from its neighbours. Taken together, these articles suggest that the spread of resistance could be a side effect of a process bacteria depend on for their evolution.Check relevant links in the show notes here ⁠https://www.uu.se/en/centre/uppsala-antibiotic-center/communication/the-amr-studio/episode-64. Follow our updates on social media with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

We hear a lot about the need for new antibiotics. But what about the ones we already have?In this episode, we sit down with Enrico Baraldi to explore the hidden world behind antibiotic markets. You hear how supply chains break, why withdrawals happen, and what it really takes to keep essential drugs available in countries like Sweden. You also get a look at the methods behind this research, the collaborations that make it possible, and some misconceptions that still shape the policy conversation.What happens when economic models, healthcare needs, and global responsibilities collide? This conversation opens that door.On our news section, we first cover a recent publication exploring the factors determining the colonization of the microbiome by antibiotic-resistant E. coli bacteria, and we bring an overview of the much-awaited Global Antibiotic Resistance Surveillance Report for 2025.We wish you a peaceful and rewarding winter break, and see you again in the new year!Check relevant links in the show notes here. ⁠ Follow our updates on ⁠twitter/X & Bluesky⁠ with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

A child in remission. A sudden fever. The antibiotics stop working. In this episode at The AMR Studio we dive into the hidden link between cancer and antibiotic resistance: why cancer patients are especially vulnerable, how antibiotics in oncology affect resistance, and what researchers are doing to change it. In this episode, communications intern Jose Rodriguez Capel, bring us the connection between microbiology, oncology, and patient stories in a powerful way.Check the episode transcript and relevant links in the show notes here https://www.uu.se/en/centre/uppsala-antibiotic-center/communication/the-amr-studio/episode-x13 . Follow our updates on ⁠twitter/X & Bluesky⁠ with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

Happy start of the summer, dear listeners! In this episode before our break, we interview Professor Tove Fall, a veterinarian turned epidemiologist working to unveil the molecular connections determining health and sickness. We learn about her path, how she developed her career to fit her interests and strong skills, and how important study design is. In the news section we cover a recent review about the vaginal microbiota, and a publication from one of our PhD students, who has been working on developing a new kind of inhibitor for metallo beta lactamases. We hope you enjoy this episode!Check relevant links in the show notes here. Follow our updates on ⁠twitter/X & Bluesky⁠ with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

In this episode, we bring you an interview with Professor Elias Arnér from the Karolinska Institute. After a long international career in redox biology, Professor Arnér became CEO of Thioredoxin Systems, the company behind a potential new antibiotic with a novel target and mode of action: EbsArgent. We explore his background, the lessons he has learned, and what makes this new drug candidate so unique. In the news section, Elin brings us a recent article on the resistance and potential collateral sensitivity of Ceftazidime-avibactam to treat P. aeruginosa strains. Eva shares the latest publication at our center, with PhD student Adrián González López’s work on the mechanisms behind FusB-mediated resistance in Staphylococcus aureus. We hope you enjoy this month’s episode, and see you on the next one! Check relevant links in the show notes here. Follow our updates on ⁠twitter/X & Bluesky⁠ with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

Welcome to episode 60th! YES, 60!! Celebrate this rounded number with us and Prof. Till Bachmann in an inspiring interview where we learn Till’s journey, explore how diagnostics are an essential part of managing AMR and infection treatment, and revisit the DOSA project. This multidisciplinary & one-health-focused multi-country endeavor provides solutions to a neglected disease: UTI.In the news section, we cover a recent review looking at the current uses of AI in the field of AMR and how it can help us better tackle different fronts, like diagnostics, surveillance, or antibiotic development. We also bring you the latest publication by the CARe center in Gothenburg, where they show that an AI model can predict successful horizontal gene transfer leading to resistance, and what drives these events.We hope you enjoy this episode!Check relevant links in the show notes here ⁠https://www.uu.se/en/centre/uppsala-antibiotic-center/communication/the-amr-studio/episode-60. Follow our updates on ⁠twitter/X & Bluesky⁠ with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

Welcome to a new episode of The AMR Studio! This month, we bring you an interview with MD Dr. Vance Fowler, co-lead of the Antibacterial Resistance Leadership Group (a.k.a. ARLG). In our chat, we learn how Dr. Fowler came into AMR, the decades-long work they’ve been doing with MRSA research, and the ins and outs of the ARLG. In the news section, we proudly present the recent published paper by our PhD student Valeriia Ladyhina, who has worked on optimizing a pipeline to ease the work to study AMR dynamics in pig farms. We also cover a recent commentary on public involvement for AMR, and an AMR journal collection. Thank you for being with us one more month! Check relevant links in the show notes here . Follow our updates on ⁠twitter/X & Bluesky⁠ with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

Welcome to 2025! We are so happy to be starting one more year with you, our 8th year! On this episode, we bring you the story and work of Dr. Evangelos Mourkas, a veterinarian-turned-computational biologist who loves to also do the field work himself! In this interview, we dive deep into his motivators, reflections, and how campylobacter can be used as a marker for AMR spread.On the news section, we bring you a recent paper looking into the potential risks of probiotics through the lens of AMR, and the latest publication by a previous guest, Alvaro San Millán, exploring the cross-talk between plasmids and the carrier’s chromosome.We hope you enjoy this month’s content and are ready to share an awesome 2025 of learning and exploring new themes!Check relevant links in the show notes here. Follow our updates on ⁠twitter/X & Bluesky⁠ with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

Hitting this November month with a very relevant topic, Global Governance! In this episode, you can listen to an interview with had with Prof. Olivier Rubin, from Roskilde University in Denmark, about the social dimensions of AMR, and how AMR is a so-called “creeping crisis” globally. Olivier has years of experience researching slow-onset crisis such as famine and climate change, and has in the recent years worked intensively in AMR and the similarities and differences with such crises. Tune in to hear his insights!In the news section, we update you on our very very busy month of November, and bring you a really important paper demonstrating the relationship between rifaximin use and daptomicin resistance in Enterococcus.Check relevant links in the show notes here. Follow our updates on ⁠twitter/X & Bluesky⁠ with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

We are finally back from our looooong break! Welcome, to another episode of The AMR studio, now again with co-host Elin Fermer at the mic after her maternity break. We are so thrilled to bring you our conversation with Eva Krockow, a psychologist working with decision making, risk communications, and language. We learn about her interests and path, and what’s on the pipeline for her. On the news, we bring you a recent article looking at if the new generation of large language models AI tools such as chat-GPT could be useful to identify resistance, and the most recent pre-print by our interviewee on the use of metaphors in AMR. We hope you enjoy and are ready for an autumn of goodness, learning and fun at our studio! Check relevant links in the show notes here https://www.uu.se/en/centre/uppsala-antibiotic-center/communication/the-amr-studio/episode-56. Follow our updates on twitter/X with #theAMRstudio hashtag! Theme music by Henrik Niss.