What is quantum computing and how will it improve healthcare? What are the latest innovations in cell and gene therapy? How are human eating habits affected by our evolution? Health Science Radio is a podcast that answers these questions and more, exploring tomorrow’s medicine today. We talk with University of Colorado Anschutz Medical Campus researchers who are devoted to solving the most persistent challenges in health science.
New Therapy Quiets Brain’s ‘False Alarms,’ Aims to Cure Chronic Pain
33:35This episode features a discussion about new and exciting neuroscience-based treatments that are aimed toward recovery from chronic pain. Our guest is Dr. Yoni Ashar, an assistant professor of medicine at the University of Colorado School of Medicine, who shares the promising findings of a study that used pain reprocessing therapy, or PRT, for a sizeable group of chronic back pain sufferers. Dr. Ashar explains how PRT works and how it could offer a pathway to helping to relieve other common chronic pain, including migraine headaches.
CU Anschutz Harnesses Technology and Innovation to Speed Drug Discovery
29:56In this episode of CU Anschutz 360, Daniel LaBarbera, PhD, director of the Center for Drug Discovery, talks about harnessing technology and innovation to speed the development of new therapies. He discusses robotic automation, quantum computing and building bridges over the ‘valley of death.’
From Childhood Fascination to Life-Changing Research
32:44In this episode of CU Anschutz 360, Angelo D’Alessandro, PhD, shares his fascination with blood science and how it led him into biochemistry, molecular genetics and metabolomics. A steadfast collaborator, D’Alessandro explains why multidisciplinary research is so important to science, especially in the area of personalized medicine.
CU Anschutz Takes Lead in Unraveling the Mysteries of Long COVID
27:24This episode of CU Anschutz 360 focuses on the research into long COVID taking place at the University of Colorado Anschutz Medical Campus. An important study involving CU Anschutz researchers ties into RECOVER, a national initiative seeking to uncover the long-term effects of COVID and develop treatments for long COVID patients. Kristine Erlandson, MD, an associate professor of medicine and infectious disease at the CU School of Medicine, shares insights into the study that developed a scoring system to help learn which adults, out of a cohort of nearly 10,000, may have long COVID.
CAR T-Cell Pioneer Takes Aim at Where No Campus Has Gone Before
28:00In this episode of the CU Anschutz 360 podcast, Terry Fry, MD, the inaugural executive director and Charles C. Gates Endowed Chair of the Gates Institute, explains how the institute is heading toward new frontiers of targeted cell and gene therapies for cancers and other rare diseases. Fry talks about the latest advances in chimeric antigen receptor (CAR T) cell therapies, which he helped pioneer at the National Institutes of Health. He talks about how the Gates Institute, which connects and centralizes campus resources into a seamless translational pathway, offers an incredible opportunity to help patients facing serious health issues. Thomas Flaig, MD, CU Anschutz vice chancellor for research, co-hosts the discussion.
At CU Anschutz, the Future of AI Is Here
34:00In this episode of the CU Anschutz 360 podcast, Casey Greene, PhD, the founding chair of the Department of Biomedical Informatics at the University of Colorado School of Medicine, offers insights into the rapid development of artificial intelligence and its implications for advancements in research and healthcare. He discusses ethical issues around AI, the rise of biobanks and personalized medicine, using technology to improve patient care, a general skepticism about the effectiveness of AI in medical care, and the peculiar, AI-related connection between chihuahuas and blueberry muffins. He also addresses the buzz around ChatGPT and large language models. Thomas Flaig, MD, CU Anschutz vice chancellor for research, co-hosts the discussion.
COMBAT Seeks to Solve Military's Clinical Challenges, Translate Science for Civilian Communities
30:00This episode of CU Anschutz 360 focuses on the Center for Combat and Battlefield Research at the University of Colorado Anschutz Medical Campus. Launched in January 2019, the COMBAT Center conducts research that impacts clinical patient care, battlefield casualty and trauma care, and critical, large-scale societal issues including mental health. Using multidisciplinary and collaborative teams, the center conducts clinically relevant, translational research to get newly discovered treatments and devices into the hands of first responders and clinicians. The COMBAT Center is directed by Dr. Vik Bebarta, a colonel in the US Air Force Reserve and a researcher on the forefront of the toughest clinical challenges for civilian and military care. Thomas Flaig, MD, vice chancellor for research, co-hosts the discussion.
Seeing a Regressive Form of Down Syndrome From All Sides
26:54This episode of CU Anschutz 360 focuses on the mysterious and debilitating condition known as Down Syndrome Regression Disorder. DSRD is a severe neurological condition with symptoms such as loss of speech, inability to perform activities of daily life, hallucinations, delusions and insomnia. Scientists at the University of Colorado Anschutz Medical Campus, including Joaquin Espinosa, PhD, executive director of the Linda Crnic Institute for Down Syndrome, are teaming with Children’s Hospital Los Angeles researchers on the first-of-its-kind investigation into the causes and potential treatments for DSRD. Thomas Flaig, MD, vice chancellor for research, co-hosts the discussion.
CAR T-Cell Therapy Transforming Science and Cancer Patient Outcomes at CU Anschutz
24:46This episode of CU Anschutz 360 focuses on a promising breakthrough therapy for patients with large B-cell lymphoma, an aggressive subtype of the disease. The clinical trial was led by Manali Kamdar, MD, clinical director of the lymphoma program in the Division of Hematology at the University of Colorado School of Medicine. In the trial for relapsed patients or patients who didn’t respond to treatment initially, CAR T-cell therapy with lisocabtagene maraleucel showed significant improvement in keeping patients in remission when compared to the standard-of-care, which consisted of chemotherapy followed by stem cell transplantation. Thomas Flaig, MD, vice chancellor for research, co-hosts the discussion.
OCD ruled Moksha Patel's life until a rare surgical procedure changed everything
39:18Moksha Patel is a successful senior instructor at CU School of Medicine. He has been dealing with severe OCD his whole life. When he came to CU Anschutz as a fellow in hospital medicine, his advisors intervened. After a year of clearing insurance and procedural hurdles, Patel underwent deep brain stimulation - an invasive surgery that delivers currents to the brain through generators in the chest. He and Rachel Davis, MD, talk about the procedure and how it happened.