Questions Answered on ART Safety and Tolerability in Pregnant People and Transgender Individuals

In this episode, Maunank Shah, MD, PhD, discusses using HIV-ASSIST to optimize treatment for both HIV and hyperlipidemia. Listen as he covers:Hyperlipidemia and cardiovascular disease risk among people living with HIVRecommendations for lipid screening for people living with HIVUsing HIV-ASSIST to support ART treatment decisions for people living with HIV with comorbiditiesHow HIV-ASSIST prioritizes certain ART agents in the setting of hyperlipidemia, including:Deciding between bictegravir, doravirine, dolutegravir, raltegravir, and rilpivirine vs boosted protease inhibitors, including darunavirDeciding between tenofovir disoproxil fumarate and tenofovir alafenamide or abacavirHow HIV-ASSIST incorporates drug‒drug interaction data from the University of Liverpool HIV Drug Interactions Checker and the DHHS guidelines when considering the use of statin therapy with ARTHow HIV-ASSIST further incorporates drug resistance data from the Stanford HIV Drug Resistance DatabaseMaunank Shah, MD, PhD Associate Professor Infectious Diseases Johns Hopkins University Baltimore, Maryland Link to full program: bit.ly/3pwaH2Y

In this episode, Martin Krsak, MD, MSc, FASAM, provides background and context on skin and soft tissue infections. Listen as he gives perspectives on:Epidemiology and clinical outcomesEconomic impactBacterial etiologyImportance of appropriate antimicrobial prescribingClinical presentationSeverity classification and distinction between purulent and nonpurulent infectionsRole of incision and debridement vs antimicrobial managementComplications to be ruled out prior to treatmentFaculty:Martin Krsak, MD, MSc, FASAMAssociate Professor of MedicineDivision of Infectious Diseases University of Colorado School of MedicineDenver, ColoradoLink to full program: CCO: https://bit.ly/3J4mg8hProCE: https://bit.ly/3P0vB4E

In this episode, Marta Boffito, MD, PhD, FRCP, and Michelle Cespedes, MD, MS, discuss initial ART options, including:Recommended first-line ART options for most PWH according to DHHS, IAS-USA, EACS, BHIVA, and WHO guidelines Data for weight gain after ART initiation with different ARV classes and drugsWeight gain disparities by race and gender after ART initiationData from the RESPOND study including risk factors for weight gain and CV event risk with INSTI vs non-INSTI–based ART The impact of INSTIs on CV events in the Swiss HIV Cohort study Recommendations for ART and contraception for PWH of childbearing potential Drug–drug interactions between first-line ART and contraceptive options Guideline-recommended first-line ART options in pregnancy with a discussion of how these regimens differ from those recommended for most PWH Marta Boffito, MD, PhD, FRCP Consultant Physician Clinical Director, HIV, Sexual and Gender Health, Dermatology Chelsea and Westminster Hospital NHS Foundation Trust Imperial College London London, United Kingdom Michelle Cespedes, MD, MS Professor of Medicine Division of Infectious Disease Department of Medicine Icahn School of Medicine at Mount Sinai New York, New York Link to full program: bit.ly/3HPu4Lk

In this episode, Carolyn Chu, MD, MSc, FAAFP, AAHIVS, discusses using HIV-ASSIST to aid in the selection of an ART regimen for PWH coinfected with HBV and HCV. Listen as she covers:How HIV-ASSIST supports ART selection in primary careUpdates to viral hepatitis recommendations including:               CDC HBV screening and testing recommendations             AASLD simplified HCV treatment approach for PWHHIV-ASSIST for managing HIV/HBV coinfections, including ensuring that NRTIs that are effective for both HIV and HBV are included in an ART regimen and alerting the user when an additional HBV treatment is needed HIV-ASSIST for managing HIV/HCV coinfections, including showing how the HIV-ASSIST tool incorporates drug‒drug interaction considerations from the University of Liverpool HIV Drug Interaction CheckerCarolyn Chu, MD, MSc, FAAFP, AAHIVSChief Clinical OfficerNational Clinician Consultation CenterProfessorClinical Family Community MedicineUniversity of California, San FranciscoSan Francisco, CaliforniaLink to full program: bit.ly/3pwaH2Y    

In this episode, Amanda Binkley, PharmD, BCIDP, AAHIVP, and Nimish Patel, PharmD, PhD, AAHIVP, discuss clinically relevant data on long-acting ART from CROI 2023, including:LA CAB + RPV in San Francisco’s Ward 86 Safety Net Clinic Serving Publicly Insured PWHSOLAR: Randomized Switch to LA CAB + RPV From BIC/FTC/TAFAmanda Binkley, PharmD, BCIDP, AAHIVPClinical Pharmacy Specialist Infectious DiseaseDepartment of PharmacyPenn Presbyterian Medical CenterPhiladelphia, PennsylvaniaNimish Patel, PharmD, PhD, AAHIVPProfessorDepartment of Clinical PharmacySkaggs School of Pharmacy & Pharmaceutical SciencesUniversity of CaliforniaLa Jolla, CaliforniaLink to full program: bit.ly/3ZjSFhg

In this episode, Christine Katlama, MD, and Babafemi Taiwo, MBBS, discuss optimizing ART for people with HIV who are treatment experienced or failing a current ART regimen, including:Recycling agents from the NRTI, NNRTI, INSTI, and PI classes in salvage ART regimensMaintaining NRTIs in second-line and salvage ART regimens, including the use of 3TC, TFV, and ABCART regimen simplificationWhen to perform genotypic resistance testing, including for PWH who have been off ARTWhen to perform DNA genotyping for archived resistance testingConsidering LA CAB + RPV with prior NNRTI exposure, ART resistance, or past adherence concerns with oral ARTUsing boosted DRV + DTG in salvage regimensSwitching from boosted PIs to INSTIs in PWH receiving second-line therapySecond-line regimens with LA CAB + RPV failure Christine Katlama, MD Professor Sorbonne University APHP Paris Head, HIV/Hepatitis Clinical and Research Unit Department of Infectious Diseases Paris, France Babafemi Taiwo, MBBS Gene Stollerman Professor of Medicine Chief, Division of Infectious Diseases Northwestern University Feinberg School of Medicine Chicago, Illinois Link to full program: https://bit.ly/3Z44Gq3

In this episode, Sonya Krishnan, MD, MHS, discusses using HIV-ASSIST to aid in the selection of an ART regimen for a virologically suppressed PWH who is planning a pregnancy. Listen as she covers:How to input patient specific factors into the HIV-ASSIST toolDiscussion of available education sheets to review the data and recommendations for her current ART regimen in pregnancyAn explanation of why some regimens are ranked lower because of adherence factors such as increased pill burden or dosing frequencyGuidelines informing the HIV-ASSIST output, including DHHS and IAS-USA, and the frequency with which updates are incorporatedHow to use the HIV-ASSIST output to guide regimen selection in pregnancyUse of the HIV-ASSIST tool in shared decision-making and patient counselingSonya Krishnan, MD, MHSAssistant ProfessorDivision of Infectious DiseasesJohns Hopkins UniversityBaltimore, MarylandLink to full program: bit.ly/3pwaH2Y

In this episode, Ian Frank, MD, discusses long-acting HIV treatment with cabotegravir plus rilpivirine for people with HIV, including:Efficacy data with every-8-week dosingReal-world use in people with viremia Initiation and continuation strategiesVirologic failure dataSafety information Presenter:Ian Frank, MDAssociate ChiefDivision of Infectious DiseasesProfessor of MedicineUniversity of PennsylvaniaPhiladelphia, PennsylvaniaTo download the slides: https://bit.ly/3HX1GGn To view the full online program: https://bit.ly/3ZjSFhg 

In this episode, Patrick W. G. Mallon, MB, BCh, PhD, FRACP, FRCPI, discusses new data on COVID-19 presented at ECCMID 2023, including:Treatment in special populationsREDPINE: remdesivir in people with renal impairment hospitalized for COVID-19 pneumoniaRemdesivir and readmission for COVID-19 in immunocompromised patientsMolnupiravir vs nirmatrelvir plus ritonavir for COVID-19 with hematologic malignancyManagement of patients with severe diseaseRECOVERY: higher-dose vs standard-dose corticosteroids for hospitalized patients with COVID-19Real-world study of tocilizumab vs baricitinib for severe COVID-19Novel antiviralsEnsitrelvirBemnifosbuvir Novel vaccinesNB2155AZD2816/AZD1222qNIV/CoV2373GRT-R910NVX-CoV2373 in people with HIVFaculty:  Patrick W. G. Mallon, MB, BCh, PhD, FRACP, FRCPIProfessor of Microbial DiseasesCentre for Experimental Pathogen Host ResearchUniversity College DublinDublin, IrelandContent based on an online CME/CE program supported by independent educational grants from Gilead Sciences, Inc. and Novavax.  Link to full program: bit.ly/3niXGJ6Link to downloadable slides: bit.ly/3LUFejG

In this episode, Renslow Sherer, MD, and Trinh P. Vu, PharmD, BCIDP, discuss strategies for managing ambulatory patients with acute or previous COVID-19 infection, including:Current COVID-19 landscapeRapid antigen tests and PCR testsRisk stratification of patients who have a positive SARS-CoV-2 testAntiviral treatment (nirmatrelvir + ritonavir, remdesivir, and molnupiravir)Long COVIDPresenters:Renslow Sherer, MDDirector, International HIV Training CenterProfessor of MedicineSection of Infectious Diseases and Global HealthDepartment of MedicineUniversity of ChicagoChicago, IllinoisTrinh P. Vu, PharmD, BCIDPClinical Pharmacy Specialist in Infectious DiseasesDepartment of Pharmaceutical ServicesEmory University Hospital MidtownAtlanta, GeorgiaTo download the slides: bit.ly/3oHKC09To view the full online program: bit.ly/4201xcO