CCO Infectious Disease Podcast podcast

Hepatitis Delta in Focus: Episode 1 of Answering the Questions on Screening, Diagnosis, and Treatment

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In this episode, Maria Buti, MD, and Richard H. Davis, PA-C, address key considerations when screening, diagnosing, and treating patients with hepatitis delta virus (HDV), such as:

  • Barriers to screening 
  • HDV screening based on patient risk factors 
  • Universal screening for all patients with positive hepatitis B surface antigen (HBsAg)
  • Reflex testing 
  • Availability of commercial testing
  • Monitoring suggestions in HBsAg positive and HDV antibody positive patients with negative HDV RNA
  • Limitations to evaluating advanced fibrosis in patients with HDV
  • Data on novel HDV therapies (eg, bulevirtide and lonafarnib)
  • Extending HDV therapy (eg, peginterferon) based on treatment response
  • Stopping rules (eg, HDV RNA negativity, HBsAg loss) for discontinuing HDV therapy


Maria Buti, MD
Professor of Medicine
Hospital Universitario Vall d’Hebron
Barcelona, Spain

Richard H. Davis, PA-C
Senior PA
University of Florida
UF Health
Gainesville, Florida

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