1. Computers to Find Big Molecules

On episode 8 of Under the Surface, we’re joined by The Molecular Assassin, Arijit Basu. Arijit describes his journey from India to the US via a transformative sabbatical in Israel. Landing in the Langer lab at MIT and then finding his industrial legs, Arijit turns to computational toxicology as a way to ensure that drug hunters enable the concept of Safety by Design as a core tenant for how they’re navigating chemical space. He doesn’t discuss how he got his cool nickname though, so if that’s what you’re after, you will be out of luck. This episode was recorded live in Montreal at our 2024 UGM.

This next episode of Under the Surface has us speaking to crystallographer Eric Larson. In episode 7, as you’ll hear, Eric’s a little nervous about having his thoughts committed to ‘perpetuity.’ But, as you’ll also hear, he does a great job. As our first second structural biologist on the show, he tells us about how he got into the field, the very real logistical challenges of working in industry, and his evocative description of what it feels like to peek ‘behind the veil’ and be the first on the planet to observe the structure of a previously unknown protein. It’s a magical episode This episode was recorded live in Montreal at our 2024 UGM.

Check out the next episode of our podcast, Under the Surface! In episode 6, Revolutionizing Nanoscale Visualization, we talk to Nanome CEO and co-founder Steve McCloskey. In a virtual rollercoaster of a conversation, he shares Nanome’s scrappy beginnings, the challenge and excitement of bringing new ways of interacting with models to the science community, and paints a vivid picture of an exciting element of the future of molecular modeling.  It’s Reality Jim, but not as we know it… Interested in giving this a test drive?  Contact [email protected] to set up a demo with Nanome.

In episode 5, Farm to Pharma, we talk to Dr. Dan McKay about his career in the pharmaceutical industry (he grew up on a Farm! See what we did there … ?). As a pioneer in the applied use of quantum mechanics, Dan describes his break into the industry from academia, his realization of the critical importance of water in understanding ‘what’s going on’, and offers some pointed observations on the applicability of artificial intelligence and machine learning in drug discovery. Throughout our time with him, Dan’s stories paint a vivid and exciting picture of what it means to support a modern discovery effort. Also, in a first for Under the Surface, we ask something of you, our audience. Can you help us, help Dan?

Welcome to the last episode of the year for our podcast, Under the Surface! In this episode, A CHRIStmas Carol, we conjure up some jovial spirits of the past as our Super Senior co-host Dave grills his colleagues on the founding, early years, and development of the Chemical Computing Group. As you’ll hear, Dave manages to make Research Group Leader, Anna Lin, and his regular co-host, Chris Williams, feel deeply uncomfortable and encourages them to step out of their inherent Canadian humility and embrace the fact that they contributed to the building of a thing that is still going strong - 30 years on! Reminiscences are shared, the field is reflected upon, and famous Canadians are listed. It is, dear listener, a roller coaster of an emotional ride.  

In episode 3, Instructions for a Life in Science, we talk to Dr. Vanita Sood about her experiences as a drug hunter. Vanita candidly shares her career journey, reflecting back on the choices she made, the opportunities and challenges she navigated, and the transformational science she drove.  She describes her recent transition from a large pharma company to a startup environment and the critical considerations she’s had to deal with. Throughout we talk about AI in discovery, the science of serendipity, and Mary Oliver the naturist and poet. Vanita expounds the spirit of paying attention, being astonished, and sharing this enthusiasm with others.. Strap in folks.

Check out the next episode of our podcast, Under the Surface! In episode 2, Fun with Pharmacophores, we talk to Dr. Scott Rowland about pharmacophore-based techniques and their role in understanding receptor–ligand interactions, and ultimately, how they contribute to the design of new drugs. Recently retired, following decades in the pharmaceutical industry, Scott tells us about his journey through the field and his deep appreciation for collaborative science. Scott hasn’t completely hung up his abacus just yet though, and he tells us about his recent consultative adventures too! How have we managed to fit all of this in one episode? It’s a mystery.

In episode 1 of our yet-to-win award podcast, we talk to Dr. Sandeep Kumar, Distinguished Research Fellow in Biotherapeutics at Boehringer Ingelheim about how he uses computers to help develop and deliver biopharmaceuticals and his thoughts on the increasing importance of computational methods in drug discovery.  It gets controversial at times, so, you know, just a warning on that. See more: Computational Antibody Discovery: State of the Art: https://www.antibodysociety.org/computational-antibody-discovery-state-of-the-art/

What's this all about, you ask? In today's inaugural episode of our sure-to-be award-winning podcast, we'll cover the who, what, and why we decided to create this podcast.  As well as preview industry topics we'll be covering in future episodes. This is not your average science podcast - Welcome to Under the Surface. For more information on Chemical Computing Group, head to: https://www.chemcomp.com/.