Physiological Reviews Podcast

In this episode Editor-in-Chief Dr. Sadis Matalon (University of Alabama Birmingham) interviews author Dr. Sophia N. Karagiannis (King’s College London) about the recently published Review article by Cheung et al. The authors review the latest research into antibody-drug conjugates (ADCs), referred to as “magic bullets” that kill cancer cells with minimal damage to healthy tissue. What are the main obstacles to manufacturing ADCs and can they be used to treat all types of cancer? Listen now to find out.   Anthony Cheung, Yi Liu, Alicia M. Chenoweth, Hanieh Montaseri, Benjamina Esapa, Vijay Chudasama, James R. Baker, David E. Thurston, and Sophia N. Karagiannis Antibody-drug conjugate design and mechanisms of action for cancer treatment: state of the art and beyond Physiological Reviews, published April 20, 2026. DOI: 10.1152/ physrev.00039.2025

In this episode Associate Editor Dr. Hilary Critchley (University of Edinburgh) and Editor-in-Chief Dr. Sadis Matalon (University of Alabama Birmingham) interview author Dr. Serdar Bulun (Northwestern University) about the recently published Review article by Bulun et al. on the critically important topic of uterine fibroids. Listen as we shed light on this underrecognized and under researched topic in women’s health.   Serdar E. Bulun, Ping Yin, JianJun Wei, Azna Zuberi, Takashi Iizuka, Takuma Suzuki, Priyanka Saini, Jyoti Goad, J. Brandon Parker, Mazhar Adli, Thomas Boyer, Debabrata Chakravarti, and Aleksandar Rajkovic Uterine Fibroids Physiological Reviews, published June 13, 2025. DOI: 10.1152/physrev.00010.2024

In this episode Editor-in-Chief Dr. Sadis Matalon (University of Alabama Birmingham) interviews author Dr. Laura Crotty Alexander (University of California, San Diego) about the recently published Review article by Masso-Silva et al. on the impact of e-cigarette vaping on the immune system across the body. We discuss in depth how vaping limits the ability of alveolar macrophages to protect the body from pathogens, and cover the impact of vaping on T cells, the powerhouse cells of adaptive immunity, to respond robustly to tumor antigens. Does vaping impact the rate of tumor growth in cancer patients, particularly breast cancer and prostate cancer? Listen now to learn much more.   Jorge A. Masso-Silva, Alexia Perryman, Sophia Karandashova, Avnee Jaya Kumar, Laura Barnes, Nikita Kasaraneni, and Laura E. Crotty Alexander Impact of e-cigarette vaping on the immune system across the body Physiological Reviews, published January 24, 2026. DOI: 10.1152/physrev.00011.2025

In this episode Associate Editor Dr. George Cotsarelis (University of Pennsylvania) and author Dr. Ralf Paus (University of Manchester) discuss the Review article by Altendorf on male pattern androgenetic alopecia. We uncover the physiology and function of hair in a wide-ranging and engaging conversation. In addition to producing pigmented protein fibers, the “mini organ” that makes our hair shaft not only senses the environment, it chemosenses the environment. According to Dr. Paus, hair can smell, taste, and see! What is the future of hair research? Listen now and find out more about this fascinating topic.   Sabrina Altendorf, Marta Bertolini, Alizée Le Riche, Antonella Tosti, and Ralf Paus Frontiers in the physiology of male pattern androgenetic alopecia: beyond the androgen horizon Physiological Reviews, published September 15, 2025. DOI: 10.1152/physrev.00005.2024

In our latest episode, Associate Editor Dr. John Orlowski (McGill University) interviews Dr. Matthias A Hediger (University of Bern) about the new Review article by Gyimesi et al. published in Physiological Reviews on the intracies of a superfamily of membrane solute carriers that is critically important to our understanding of human health and disease. This extensive Review contains over 3500 citations describing the superfamily of solute carriers the authors refer to as “The SLC-ome.” These SLCs comprise the largest group of membrane transport proteins encoded by the human genome and are responsible for moving numerous solutes and other essential biological compounds in and out of cells. Ready to learn more about how the SLC-ome is essential to mediating the movement of nutrients, electrolytes, metabolites and other molecules, such as pharmacological drugs, across cellular and organellar membranes? Listen now to learn more.   Gergely Gyimesi, Susan Tweedie, Elspeth Bruford, and Matthias A Hediger The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications Physiological Reviews, published September 30, 2025. DOI: 10.1152/physrev.00001.2024

What is the difference between forward and reverse cardio-oncology? In our latest episode, Deputy Editor Dr. Carol Ann Remme (University of Amsterdam) interviews Dr. Rudolf de Boer (Erasmus Medical Center) about the new Review article by Meijers et al. Forward cardio-oncology focuses on cardiotoxicity and cardiac damage due to anti-cancer therapies in patients with prevalent cancer. In contrast, reverse cardio-oncology describes the phenomenon that cancer is more often discovered in patients with prevalent cardiovascular disease. In the more established field of forward cardio-oncology, the focus has been on the diverse array of anti-cancer drugs used to treat different types of cancer that are associated with wide-ranging cardiotoxic effects, such as atrial fibrillation and venous embolism. The developing field of reverse cardio-oncology was launched by initial observations made in clinical registries where the incidence of cancer was common among patients with heart failure. Clinical observations led to the development of murine models of cancer which found the presence of heart failure accelerated tumor growth and considered possible pro-oncogenic factors such as cytokines and extracellular vesicles, along with the microbiome and the immune system. One multifactorial disease is often clinically associated with another multifactorial disease, and underlying physiological mechanisms are complex and multifactorial as well. To learn more, listen now.   Wouter C. Meijers, Joseph Pierre Aboumsallem, Alexander R. Lyon, Javid Moslehi, and Rudolf A. de Boer Forward and reverse cardio-oncology Physiological Reviews, published September 22, 2025. DOI: 10.1152/physrev.00041.2024

What role does inflammation play in atherosclerosis? In our latest episode of The Physiological Reviews Podcast, Dr. Carol Ann Remme talks with authors Dr. Esther Lutgens (Mayo Clinic) and Dr. Claudia Monaco (University of Oxford) about their recent Review on immunotherapy for atherosclerosis. The authors discuss the network of multiple immune cell types and subsets of the innate and adaptive immune system that occupy arteries. In addition, Monaco et al. discuss local inflammation in the arterial wall or plaque compared to systemic inflammation. The authors also discuss atherosclerosis as a process of aging, rather than as a disease. What is the holy grail of safe immunotherapeutic approaches and the future of personalized medicine for atherosclerosis? Listen now to learn more. Claudia Monaco, Coleen A. McNamara, Bram Slütter, Amanda C. Foks, Stefan Bekiranov, Willem J.M. Mulder, Isabel Gonçalves, and Esther Lutgens Immunotherapy for atherosclerosis Physiological Reviews, published May 21, 2025. DOI: 10.1152/physrev.00016.2024

What is cerebral small vessel disease and why is it such a critical area of research? In this episode, Associate Editor Dr. Scott Earley (University of Rochester) interviews author Dr. Anne Joutel (Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM) about the pathogenic diagnosis and molecular basis of cerebral small vessel disease (cSVD). Classified into two categories, cerebral amyloid angiopathy (CAA) and nonamyloid cSVD, cSVD is a major health problem responsible for about 25% of ischemic strokes, the vast majority of spontaneous intracerebral hemorrhage, and about 20% of all dementia cases. What role does the presence of lesions in small vessels play in exacerbating the burden of neurodegenerative diseases such as Alzheimer’s Disease? What is “silent cSVD” and how common is it? Listen now to find out more.   Hugh S. Markus and Anne Joutel The pathogenesis of cerebral small vessel disease and vascular cognitive impairment Physiological Reviews, published February 18, 2025. DOI: 10.1152/physrev.00028.2024

In this episode, Dr. Jan Born (University of Tübingen) interviews his colleague and author Dr. Andreas Nieder (University of Tübingen) about his recent Review in Physiological Reviews on mathematical reasoning that incorporates neurobiology, comparative physiology, and neurophysiology. Mathematical skills can be described as falling into symbolic (arithmetic, number theory) and non-symbolic (set size) representations of numerical quantities. Infants as young as 2 days old can discriminate set size, for example, distinguishing between four dots and eight dots. And then, of course, there is the fascinating concept of zero, which is “rather like the eccentric uncle in the series of numbers,” as Dr. Nieder says. Understanding the concept of zero as the absence of something, represented as a number, is critical to understanding all other numbers. How does all of this work in the brain? Listen and find out.   Andreas Nieder The calculating brain Physiological Reviews, published October 25, 2024. DOI: 10.1152/physrev.00014.2024

In the episode, Dr. Willis K. “Rick” Samson (Saint Louis University School of Medicine) interviews lead author Dr. Eric Lazartigues (Louisiana State University Health Sciences Center) about the recent Review by Chhabra et al. on the latest discoveries related to the role of ACE2 in glucose homeostasis and regulation of metabolism. What are the consequences, in terms of pancreatic function and glucose homeostasis, for ACE2 knockout animals compared to animals used in overexpression studies? Listen as we discuss skeletal muscle effects related to changes in body weight, effects on intestinal absorption and the microbiome, as well as potential clinical applications of ACE2 therapies. What advice does Dr. Lazartigues offer to early career researchers about how to pursue their good ideas? Listen to find out.   Kavaljit H. Chhabra, Robin Shoemaker, Chandana B. Herath, Merlin C. Thomas, Catalin M. Filipeanu, and Eric Lazartigues Molecular Dissection of the Role of ACE2 in Glucose Homeostasis Physiological Reviews, published February 7, 2025. DOI: 10.1152/physrev.00027.2024