Audio long read: Hope, despair and CRISPR — the race to save one woman’s life

This series was originally broadcast in 2020.Science and politics are not easy bedfellows - "Stick to the science" is a three part series which aims to find out why.In this episode we're asking how politics shapes the life of a working scientist. Be it through funding agendas, cultural lobbies or personal bias, there's a myriad of ways in which politics can shape the game; influencing the direction and quality of research, But what does this mean for the objective ideals of science?This episode was produced by Nick Petrić Howe, with editing from Noah Baker and Benjamin Thompson. it featured contributions from many people, including: Mayana Zatz, Shobita Parthasarathy, Michael Erard, Peg AtKisson, Susannah Gal, Allen Rostron, Mark Rosenberg, and Alice Bell. Further ReadingBrazil’s budget cuts threaten more than 80,000 science scholarshipsMove to reallocate funds from scientific institutions in São PauloBacklash to “Shrimps on a treadmill”Explanation of the Dickey AmendmentAfter over 20 years the CDC can now fund gun violence researchSpirometer use “race-correction” softwareBlack researchers less likely to get funding from the National Institutes of Health in the USBlack researchers may get less funding from the National Institutes of Health due to topic choiceBlack researchers fill fewer academic roles in the UKClinical trials use mostly white participantsThe Received Wisdom Podcast, with Shobita Parthasarathy Hosted on Acast. See acast.com/privacy for more information.

This series was originally broadcast in 2020.Science and politics are not easy bedfellows - "Stick to the science" is a three part series which aims to find out why.In this episode we delve into the past, and uncover the complicated relationship between science, politics and power. Along the way, we come up against some pretty big questions: what is science? Should science be apolitical? And where does Nature fit in?This episode was produced by Nick Petrić Howe, with editing from Noah Baker and Benjamin Thompson. it featured contributions from many researchers, including: Shobita Parthasarathy, Alice Bell, Dan Sarewitz, Anna Jay, Melinda Baldwin, Magdelena Skipper, Steven Shapin, David Edgerton, Deborah Blum, Bruce Lewenstein and Chiara Ambrosio. Quotes from social media were read by: Shamini Bundell, Flora Graham, Dan Fox, Edie Edmundson and Bredan Maher. And excerpts from Nature were read by Jen Musgreave.Further ReadingHistory of Education in the UKNature’s HistoryNature’s Mission statementNature editorial on covering politicsMaking “Nature”, by Melinda BaldwinNever Pure: Historical Studies of Science as if It Was Produced by People with Bodies, Situated in Time, Space, Culture, and Society, and Struggling for Credibility and Authority, by Steven ShapinDavid Edgerton’s writing on the history of science and politics in the GuardianThe received wisdom podcast with Shobita Parthasarathy Hosted on Acast. See acast.com/privacy for more information.

00:48 Rebuilding mental health after the floodsResearchers have been investigating the best ways to help people deal with trauma in the wake of a climate disaster. In April and May devastating floods surged across Rio Grande do Sul in the South of Brazil, affecting two million people and killing hundreds. As people try to put their lives back together scientists have been conducting surveys and investigating how to make sure that any mental health issues don’t become persistent. We hear from some of the affected people and researchers in the region.This story was supported by the Pulitzer Center.News Feature: How to recover when a climate disaster destroys your city 13:48 Research HighlightsA new way to make ultra-heavy elements, and how some plankton swim by blowing up like a balloon.Research Highlight: Atomic smash-ups hold promise of record-breaking elementsResearch Highlight: This plankton balloons in size to soar upwards through the water16:54 What are your thoughts on the US election?Nature has conducted a poll of its readers to get a sense of what is on researchers’ minds in the run up to the US election. Overwhelmingly, the survey respondents identified as researchers and reported that they supported Vice President Harris (86%). Many also voiced concerns about a possible victory for former President Trump, saying that they would consider changing where they would live if he wins. Reporter Jeff Tollefson tells us more about the results and what the election means for US science.News: The US election is monumental for science, say Nature readers — here’s why27:07 Briefing ChatThe possible benefits of ‘poo milkshakes’ for newborns, and how Tardigrades can withstand incredibly high levels of radiation.Nature: ‘Poo milkshake’ boosts the microbiome of c-section babiesNature: New species of tardigrade reveals secrets of radiation-resisting powersSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

By the end of 2024 up to two billion people will have gone to the polls, in a pivotal year of elections around the globe. This is giving political scientists the chance to dive into each election in detail but also to compare the differing voting systems involved.They hope understanding the advantages and drawbacks of the systems will help highlight whether some are more likely to promote democratic resilience or to stave off corrosive partisanship.This is an audio version of our Feature: Which is the fairest electoral system? Mega-election year sparks debate Hosted on Acast. See acast.com/privacy for more information.

00:48 The hidden cities of UzbekistanResearchers have uncovered the scale of two ancient cities buried high in the mountains of Uzbekistan. The cities were thought to be there, but their extent was unknown, so the team used drone-mounted LiDAR equipment to reveal what was hidden beneath the ground. The survey surprised researchers by showing one of the cities was six times bigger than expected. The two cities, called Tashbulak and Tugunbulak, were nestled in the heart of Central Asia’s medieval Silk Road, suggesting that highland areas played an important role in trade of the era.Research Article: Frachetti et al.Video: Uncovering a lost mountain metropolis09:32 Research HighlightsHow children's’ movements resemble water vapour, and why coastal waters may be a lot dirtier than we thought.Research Highlight: Kids in the classroom flow like water vapourResearch Highlight: Sewage lurks in coastal waters — often unnoticed by widely used test12:06 Watermarking AI-generated textA team at Google Deepmind has demonstrated a way to add a digital watermark to AI-generated text that can be detected by computers. As AI-generated content becomes more pervasive, there are fears that it will be impossible to tell it apart from content made by humans. To tackle this, the new method subtly biases the word choices made by a Large Language Model in a statistically detectable pattern. Despite the changes to word choice, a test of 20 million live chat interactions revealed that users did not notice a drop in quality compared to unwatermarked text.Research Article: Dathathri et al.News: DeepMind deploys invisible ‘watermark’ on AI-written text22:38 Briefing ChatWhat one researcher found after repeatedly scanning her own brain to see how it responded to birth-control pills, and how high-altitude tree planting could offer refuge to an imperilled butterfly species.Nature: How does the brain react to birth control? A researcher scanned herself 75 times to find outNature: Mexican forest ‘relocated’ in attempt to save iconic monarch butterfliesSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:46 An unusual γ-ray producing microquasarA type of binary-system known as a microquasar has been found to be firing out γ-rays at high energy-levels, which may make it a candidate to be a long-theorized natural particle-accelerator known as a PeVatron. These objects are thought to be a source of galactic cosmic rays, the origins of which are currently a mystery.Understanding how this microquasar works could also help researchers learn more about full-sized quasars — monstrous objects centred around supermassive black holes, which are too distant to study easily.Research Article: Alfaro et al.News and Views: High-altitude particle detector spots a second Galactic microquasar09:27 Research HighlightsThe comb jellies caught fusing their bodies, and an ancient burial site reveals that Classical accounts of Scythian culture appear to be true.Research Highlight: Two comb jellies fuse their bodies and then act as oneResearch Highlight: Evidence of dead people posed on dead horses found in ancient tomb12:08 A ‘smart’ insulin-molecule that could lower hypoglycaemia riskResearchers have developed a modified insulin-molecule that varies its level of activity depending on blood-glucose levels. It’s hoped that this ‘smart’ insulin could one day help those with diabetes regulate their blood sugar more easily.Many people with diabetes rely on regular insulin injections, but because blood-sugar levels can be difficult to predict it can be hard to select the correct dose. This can lead to hypoglycaemia — a life-threateningly low level of glucose. To overcome this, a team created a modified form of insulin with a switch that activates the molecule when glucose levels are high, and deactivates it when levels are low. This insulin-molecule was effective at maintaining correct blood glucose in animal models, and may eventually help lessen diabetes-related complications in humans.Research Article: Hoeg-Jensen et al.News and Views: Smart insulin switches itself off in response to low blood sugar20:33 Briefing ChatAncient DNA confirms that infamous lions hunted humans and a variety of game, and a new technique can sequence a cell’s DNA and pinpoint its proteins, without cracking it open.Nature: Famed lions’ full diet revealed by DNA — and humans were among their preyNature: ‘Phenomenal’ tool sequences DNA and tracks proteins — without cracking cells open Hosted on Acast. See acast.com/privacy for more information.

00:55 Graphene TongueResearchers have developed a graphene ‘tongue’ that uses AI to tell the subtle differences between drinks. Graphene has long been sought after as a chemical sensor, but tiny variations between devices have meant that it couldn’t be used very reliably. The team behind the ‘tongue’ got around this problem by training an AI to tell the difference between similar liquids regardless of variations between graphene devices. They hope that their work shows that it’s possible to use ‘imperfect’ chemical sensors to get accurate readings and that the ‘tongue’ will be able to help detect problems with food.Research Article: Pannone et al.09:22 Research HighlightsA 3D-printed optical microscope that can image biological samples with ultrahigh resolution, and how newly-hatched sea turtles dig their way up to the beach.Research Highlight: A ‘Swiss army knife’ microscope that doesn’t break the bankResearch Highlight: Baby sea turtles ‘swim’ up from buried nests to the open air11:32 How migrating salmon move nutrients and contaminants at a continental scaleStudies of migrating Pacific salmon have revealed that these animals transport thousands of tonnes of nutrients and kilograms of contaminants from the ocean to freshwater ecosystems. It’s been known that as the fish return to their freshwater spawning grounds from the sea they bring with them both nutrients and contaminants, but the impact of each has largely been studied separately. A new study combines datasets to estimate that over 40 years, the levels of nutrients these fish carry have increased at a proportionally higher rate than the contaminants, but the toxins could nevertheless be present at concerning levels to the animals that eat them.Research Article: Brandt et al.News and Views: Salmon’s moveable feast of nutrients with a side order of contaminants23:19 Nobel NewsFlora Graham from the Nature Briefing joins us to talk about the winners of this year’s science Nobel Prizes.News: Medicine Nobel awarded for gene-regulating ‘microRNAs’News: Physics Nobel scooped by machine-learning pioneers News: Chemistry Nobel goes to developers of AlphaFold AI that predicts protein structuresSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

00:46 Physicists spot new types of high-energy radiation in thunderstormsPhysicists have identified new forms of γ-ray radiation created inside thunderclouds, and shown that levels of γ-ray production are much higher on Earth than previously thought.Scientists already knew about two types of γ-ray phenomena in thunderclouds — glows that last as long as a minute and high-intensity flashes that come and go in only a few millionths of a second. Now, researchers have identified that these both occur more frequently than expected, and that previously undetected γ-ray types exist, including flickering flashes that share characteristics of the other two types of radiation.The researchers hope that understanding more about these mysterious phenomena could help explain what initiates lightning, which often follows these γ-ray events.Research Article: Østgaard et al. Research Article: Marisaldi et al. Nature: Mysterious form of high-energy radiation spotted in thunderstorms10:00 Research HighlightsAncient arrowheads reveal that Europe's oldest battle likely featured warriors from far afield, and why the dwarf planet Ceres’s frozen ocean has deep impurities.Research Highlight: Bronze Age clash was Europe’s oldest known interregional battle Research Highlight: A dwarf planet has dirty depths, model suggests12:09 A complete wiring diagram of the fruit fly brainResearchers have published the most complete wiring diagram, or ‘connectome’ of the fruit fly’s brain, which includes nearly 140,000 neurons and 54.5 million connections between nerve cells.The map, made from the brain of a single female fruit fly (Drosophila melanogaster), reveals over 8,400 neuron types in the brain, and has enabled scientists to learn more about the brain and how it controls aspects of fruit fly behaviour.The FlyWire connectome: neuronal wiring diagram of a complete fly brainNature: Largest brain map ever reveals fruit fly's neurons in exquisite detail22:16 Briefing ChatHow researchers created an elusive single-electron bond between carbon atoms, and why bigger chatbots get over-confident when answering questions.Nature: Carbon bond that uses only one electron seen for first time: ‘It will be in the textbooks’Nature: Bigger AI chatbots more inclined to spew nonsense — and people don't always realizeSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

The world's fastest supercomputer, known as Frontier, is located at the Leadership Computing Facility at Oak Ridge National Laboratory in Tennessee. This machine churns through data at record speed, outpacing 100,000 laptops working simultaneously.With nearly 50,000 processors, Frontier was designed to push the bounds of human knowledge. It's being used to create open-source large language models to compete with commercial AI systems, simulate proteins for drug development, help improve aeroplane engine design, and more.This is an audio version of our Feature: A day in the life of the world’s fastest supercomputer Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:46 Unravelling why children with Down’s syndrome are at a higher risk of leukaemiaChildren with Down’s syndrome have a 150-fold increased risk of developing leukaemia than those without the condition. Now, an in-depth investigation has revealed that changes to genome structures in fetal liver stem-cells appear to be playing a key role in this increase.Down’s syndrome is characterised by cells having an extra copy of chromosome 21. The team behind this work saw that in liver stem-cells — one of the main places blood is produced in a growing fetus — this extra copy results in changes in how DNA is packaged in a nucleus, opening up areas that are prone to mutation, including those known to be important in leukaemia development.The researchers hope their work will be an important step in understanding and reducing this risk in children with Down’s syndrome.Research Article: Marderstein et al. News and Views: Childhood leukaemia in Down’s syndrome primed by blood-cell bias11:47 Research HighlightsHow taking pints of beer off the table lowers alcohol consumption, and a small lizard’s ‘scuba gear’ helps it stay submerged.Research Highlight: A small fix to cut beer intake: downsize the pintResearch Highlight: This ‘scuba diving’ lizard has a self-made air supply14:12 Briefing ChatHow tiny crustaceans use ‘smell’ to find their home cave, and how atomic bomb X-rays could deflect an asteroid away from a deadly Earth impact.Science: In the dark ocean, these tiny creatures can smell their way homeNature: Scientists successfully ‘nuke asteroid’ — in a lab mock-upSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.