Methusalem Podcast

In this episode of the Methusalem Podcast, Dr. Karl Pfleger, a longevity biotech investor, analyst, and founder of AgingBiotech.info, brings an engineer's lens to the science of aging. We explore why he splits the field into two camps, slowing aging versus rejuvenation, where "replacement" approaches fit in, and why he argues that aging has to be tackled as many problems at once rather than one. We talk about thymus rejuvenation, get his clear-eyed take on whether biological clocks are ready for prime time, and hear Karl's perspective on longevity funding.

In this episode of the Methusalem Podcast, I discuss with Niklas Anzinger, founder and CEO of Infinita City, the story behind Próspera, a special economic zone on the island of Roatán, Honduras. Niklas shares his journey from public policy and the Berlin startup scene to building a jurisdiction designed to accelerate biotech and longevity innovation.We cover how Próspera operates as a startup city with its own regulatory framework, why Niklas believes FDA-style regulatory monopolies are the biggest bottleneck in longevity research rather than the science itself, and how Próspera's insurance-based regulatory model offers a market-driven alternative. We also discuss biotech companies already operating on-site.If you're a founder or researcher interested in launching a biotech company in this unique regulatory environment, check out the BioHub Startup Accelerator at luma.com/BioHub2026.For more information on Infinita City and everything happening at Prospera, visit the homepage at infinita.city.

Can we actually turn back the clock of aging? In this episode, I’m joined by Dr. Daniel Ives, CEO of Shift Bioscience, to unpack the science of partial epigenetic reprogramming—the technology that might one day reverse aging itself. We dive into epigenetic clocks, Yamanaka factors, and how Shift plans to make the oldest mouse ever.

In this episode of the Methusalem Podcast, Dr. Aubrey de Grey, one of the most influential voices in longevity science, shares his vision for defeating aging through an engineering approach. We explore the origins of the SENS framework, strategies to repair age-related damage, and the biggest hurdles to progress in the field. Aubrey discusses the future of rejuvenation trials, the role of artificial intelligence in biology, and how we might achieve robust mouse rejuvenation within this decade.

In this episode I continue my discussion with Dr. Bill Andrews and we discuss the role of telomeres for longevity and strategies to activate telomerase and slow telomere shortening.

In this episode, I explore the inspiring journey of Dr. Bill Andrews, a pioneer in aging research and telomerase science. We dive into how his passion for endurance running shaped his mindset, leading him to become an accomplished ultramarathoner, and how his groundbreaking work in telomerase therapy made him a thought leader in the field of longevity.