EP 313 Is Your Immune System Getting in the Way of Conceiving Your Baby? Caryn Johnson
11/26/2024
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41:27
On today’s episode of The Wholesome Fertility Podcast, Caryn Johnson of @_bondlife shares her personal journey through infertility, detailing her struggles with unexplained infertility and the eventual discovery of autoimmune issues affecting her reproductive health. She emphasizes the importance of understanding the immune system's role in fertility and the impact of lifestyle factors such as diet, stress, and environmental toxins. Caryn advocates for women to take charge of their health by educating themselves and seeking out supportive healthcare practitioners. She also discusses her supplement line, Bond, which aims to address these issues holistically. Takeaways
- Caryn's journey began with unexplained infertility.
- She experienced multiple failed IVF attempts.
- The immune system plays a crucial role in fertility.
- Many women with unexplained infertility have underlying immune issues.
- Stress and lifestyle factors significantly impact reproductive health.
- Gut health is linked to fertility and autoimmune conditions.
- Caryn's research led her to create a supplement line, Bond.
- Advocacy and education are essential for women facing infertility.
- Environmental toxins can affect fertility outcomes.
- Women should empower themselves with knowledge about their health.
Check out Michelle’s Latest Book: The Way of Fertility!
https://www.michelleoravitz.com/thewayoffertility
Instagram: @thewholesomelotusfertility Facebook: https://www.facebook.com/thewholesomelotus/ Transcript: Michelle (00:00) Welcome to the podcast, Karin. Caryn Johnson (00:02) Thank you. Thank you for having me. Michelle (00:05) It's so nice to meet you. And I know that you do a lot of amazing work helping women I also know that you have your own story that you can share. And I would love to hear your story and really what got you inspired to do the work that you're doing. Caryn Johnson (00:21) Yeah, absolutely. So I'm here to share really the start of how I got to where I am today. And that really is rooted in finding out that I couldn't get pregnant. So we can start there and then we can get into all of the details together. But my husband and I met when I was young, early 20s. And by the time we got married many years later, we were already most right away to start having a family. There was a piece of me inside that knew that I was gonna have some sort of issue. I don't know, you already mentioned that you do visualizations to me before we started. So, you know, like I just had this feeling whether I manifested it for myself or not. I, you know, we did the full year of trying to get pregnant to no success and then went back to our doctor. Michelle (01:03) Yeah, yeah. Caryn Johnson (01:18) my typical OB-GYN and started the path of IUIs, did four IUIs, had beautiful eggs, each IUI, and reacted to the medicine quite well, but never got a positive from any of those. So we were recommended to move towards IVF. found a reproductive endocrinologist in Chicago, which is where I was located at the time. started the path to IVF and went through the process of an egg retrieval. Ended up seeing similar to what we saw in the IUIs, which was that my reproductive system performed quite well. And I was able, they were able to retrieve just about 30 eggs from one retrieval, which is quite high, borderline too high, but. just shows like the reaction to the medicine and the overall viability of my reproductive system. Of that, I had really normal odds and was able to bank close to 14, I believe, quality grade embryos. So I was really excited to move into implantation because at that point, I just really thought like whatever was unexplained is just kind of, you know, over to the side now. you know, all these things are just working out in my favor. So this is gonna be, you know, it for me, which a lot of women I feel like go into IVF feeling like the IVF center is like the place where you get your baby, which isn't always true. So. I started doing implantations and I started losing babies. Prior to that point, I had never even tested positive in any sort of like regard for a pregnancy test. And I wasn't one of those that, you know, jumped right off birth control, you know, to move into conception. I hadn't been on birth control for many, many, many, many years, you know, prior to this point. But the implantations started failing and My doctor said, this embryo was only attached for two hours, maybe a couple of hours is what they said. I just thought, how on earth, like why on earth would something attach for just a couple of hours and then that be the situation where It just doesn't work out from there. Like what is happening? And you know, got immediately, the immediate response was bad odds. You know, this happens, miscarriage happens. Just keep going. You know, one in four, in eight, you you get all the stats and there's definitely a piece of that when you're not working with really good quality embryos. But you know, I was, I knew that everything was genetically great. knew. and had no reason to believe that my body wasn't in working order to, you know, produce a pregnancy. So I just started pushing harder and getting a little bit more more fearful of continuing down the path of losing babies because I just, it hit me so hard. Even the loss of two hours, I mean, I just like, I've never felt sorrow like that. And I didn't, I just didn't feel like myself or really anyone should have to like continue down that path for like the sake of odds. So I started doing my own research and I was at the time experiencing some issues in my digestive system. I also now looking back had a definite cortisol issue. which relates into the picture, but I was a CMO at Vital Proteins at the time, which is that blue tub collagen company. And so I had a high stress level and I knew that something was going on in my digestive system. This was, you know, 2016, 2015, 2016, 2017. So. Michelle (05:39) yeah. Caryn Johnson (05:58) almost prior to when we really started, you know, as a world, as a community talking about the microbiome and gut health. But I sought out a naturopath who ended up doing a blood panel on me and told me that I had, you know, hundreds of food sensitivities, which is a a classic sign of gut dysbiosis, but at the time it wasn't translated back to like an issue in the microbiome. It was treated as like, yes, you have all of these, you have all of these issues with, you know, different foods, just avoid them. And that will be the solve versus, why do you have like, you know, why do you have a hundred things that you can't eat? Michelle (06:42) Hmm. Caryn Johnson (06:46) like watermelon seeds up to your typical gluten, et cetera. So I just started doing my own research online and I found a book called, Is My Body Baby Friendly? It's written by Dr. Alan Beer, who is now deceased, but it's over 700 pages of the science of how the immune system works with your reproductive system, your hormones, et cetera. in order to effectively procreate or in order for conception and implantation to occur. And that's when I realized there was something greater going on in my body outside again of just my reproductive system that we just hadn't figured out yet. So I read the book Front to Back. It's a very science heavy book. So I had to do a lot of like thinking about new terms and figuring and trying to remember what I was learning. At the end of the book, there was a recommendation at the time, there are more doctors now, but at the time for three doctors that practice this type of medicine, which is the field of reproductive immunology. And so, Michelle (08:01) Mm-hmm. Caryn Johnson (08:03) One of those doctors, Dr. Joanne Kwok-Kam of Rosalind Franklin ended up being in my backyard essentially 45 minutes away in the Chicago area. So I took that as a sign that I needed to call and get additional help above and beyond my RE who was doing the IVF. And I called over there and was immediately put on a six month wait list. So proceeded with the next round of IVF because I was already on some hormones. So I was already going through the round. I had at that point only done my own research. So I wasn't really sure what was going on in my body or if I could believe what I had read because my doctors that were helping me with the IVF weren't really like saying that They believed in the immunology side of things. They hadn't seen enough research, et cetera. So I wasn't really getting support on what I was researching. So it was around the holidays, October-ish, when I ended up calling into the clinic and I ended up getting a call right around Thanksgiving that they had a cancellation and I got moved up on the wait list. So I ended up getting into the reproductive immunology clinic many months before they said I would two weeks before my next IVF transfer and that was just an awesome Hail Mary. They did a full ultrasound. So tip to toe thyroid, you know, your whole stomach area inside and outside. And then they do the craziest blood panel that I've ever done. don't know how you can even draw that much blood, but vials and vials of blood to look at immune markers in addition to hormone markers, vitamin markers, and your typical blood panel. And they called me back 48 hours later and said, need to cancel this implantation. You have the highest level of antibodies that we've ever seen. not that we've ever seen, but that we're able to track. So you're past like where the chart goes essentially. So if you proceed with your implantation, it's almost definitely gonna end in a miscarriage because your body is gonna fight it off. And at that point I was terrified because that was like the first real something's actually wrong with you that I had heard. Michelle (10:21) wow. Wow. Caryn Johnson (10:50) Everything else was just unexplained, unexplained, unexplained. And I just went into shock. I didn't know what to do. I didn't know who to believe. You know, I had two sets of doctors saying different things. So I proceeded with the implantation and I ended up implanting both a boy and a girl embryo. And then started treatment right away on my immune system through the reproductive immunologist. So what they did was they put me on a series of pretty intense medications to quiet my immune system. And then I did what is called IVIG, which are blood transfusions or infusions that essentially look to wash your blood of the antibodies that are over protecting the immune system. So I went into this protocol and I ended up getting pregnant. It was positive right away. we saw, so the clinic ended up treating me one to three times a week with this IVIG infusion, which they're about two to three hours long based on, they're based on body weight. Michelle (11:50) Mm-hmm. Caryn Johnson (12:14) I was in their office, you know, at least one to two times a week, also for an ultrasound. So I knew by five weeks that both embryos had attached. you know, at that point, my immune markers were even more all over the place. We couldn't get my immune system to a stable level by any means. And I ended up losing the girl embryo at seven weeks. her heartbeat slowed and then ultimately it stopped, which is one of the symptoms or issues when you have an autoimmune issue going into a pregnancy. So, you know, that was so sad and devastating and she was higher up in the womb than the boy embryo. So at that point, It was pretty much 50-50 odds of if she was going to end up coming out and bringing him with her or if she was going to be what's called a vanishing twin, which is when your body reabsorbs the pregnancy for the sake of the other pregnancy, which is really the best case scenario because then you don't lose the other baby. Michelle (13:18) my gosh. Caryn Johnson (13:36) I was put on bed rest. This was the start of my bed rest between six and seven weeks, which continued until I gave birth, basically. I was able to go to work, but that was pretty much it. And I lived in fear that we were going to lose a little boy, but I ended up reabsorbing the girl embryo. So she never came out and we just really aggressively treated my immune system. which held on until 34 weeks when I went into basically how the immune system works during the pregnancy is during the first trimester, there is more inflammation that can be in the body and then it has to subside for the second trimester to continue successfully and then your inflammation increases and that's eventually causes or is part of why you go into labor. But my inflammation and my immune system increased really fast. my water broke early and I ended up having him, you know, early but he was healthy because some of the immune medications included steroids. So he was a little bit bigger than, you know, your typical 34, 35 weaker. But I was able to carry my son and that really started my story of what the heck happened and why is autoimmunity so under researched when it comes to your reproduction and your fertility chances and how can I actually do more now that I have my children here. Michelle (15:06) Mm-hmm. Mm-hmm. Mm-hmm. Caryn Johnson (15:33) to support other women so they don't have to go through this amount of trauma, right? But also this amount of like research and advocacy for themselves because at the end of the day, like we just can't expect that from everyone and we shouldn't. We should be able to support. Yeah, so I'll take a breath there. Michelle (15:40) Mm-hmm. Yeah. Wow, that's incredible story. And I mean, it's it's mind boggling, you know, that, nobody really talks about something that is so prevalent. And I do see that a lot, actually. And it could be the reason why you have unexplained infertility or why transfers don't work. And I speak to Amy Ralph, Amy Ralph, she's a Caryn Johnson (16:19) Yeah. Michelle (16:20) she does the same thing, Chinese medicine. And she talks about this a lot. She says, if you miscarry or you have repeated transfer failures with a good embryo and your doctor doesn't look into like what your lining is doing and how your immune system is working, then go to a different doctor because it's so important to look into that because you could spend so much time. and you can spend so much money and just so many precious years going through so much loss for something that could be treated but can also be prevented. So I'd love to actually get your input on what you've discovered and how the gut relates to it but maybe other things that you've noticed or learned for the listeners. Caryn Johnson (16:59) Absolutely. Yeah, absolutely. And I think what you're saying is just incredibly important. Like the immune system, I feel like is the secret starting point to a lot of issues. And what's happening in medicine right now is a lot of women are walking away with an unexplained infertility diagnosis, but they're accepting that as a diagnosis, right? When it's not, it's just, it's not an answer. And if you look underneath kind of that answer, you see a lot of crazy statistics, such as over 65 % of women who have unexplained infertility actually have an issue in their immune system. And then similarly over 60 % have an issue in their metabolic system. So blood sugar, insulin, know, early signs of PCOS, et cetera. And then. Michelle (18:05) You Caryn Johnson (18:10) When you look, you see that there are deep, deep nutrient deficiencies happening in this group of women as well. So you're looking at vitamin D deficiencies, vitamin B deficiencies, magnesium, omegas. All of these start with modulations that occur in the immune system as well. So when you think about it on a deeper level and from the research that I've done, Michelle (18:23) Mm-hmm. Mm-hmm, yeah. Caryn Johnson (18:39) you're looking at something that's happened to you before it's affecting your hormones and triggering one of these other issues in your reproductive system. So like for instance, not only do I have, you know, autoimmune infertility, I do carry PCOS and adenomyosis as well. And for me, and based on the research that I've done, those are secondary factors. to my immune system modulating and creating an overly inflammatory environment in my body, which then produced those issues. So we're not going up far enough in the chain of our bodies as to understanding our full systems. And again, it kind of goes back to like what's happening in medicine, which is that our doctors are Classically trained in our reproductive organs, right? So they know our uterus they know our ovaries they understand how those work, but we need to get into you know, a new phase where we have Practitioners that understand how all of the systems are working together in our body Including our immune system and our endocrine system because they do have such a big and almost starting impact Michelle (19:57) Mm-hmm. Yeah. Caryn Johnson (20:07) on what's happening with our fertility. Michelle (20:10) yeah, I completely agree. And I also I'm wondering, like, what have you seen? Because I think that when you talked about the food sensitivities, you were saying that it's okay, I'm allergic to so many things, or I'm sensitive to so many things, but why? So like, what are the things that you've seen that cause it to begin with? Caryn Johnson (20:28) Yeah. Yeah. So there are a couple of things that I see as a starting factors. One is overall stress. So if you can't keep your stress in check, you can't keep your cortisol levels in check, then your adrenal function will not perform in the rest of your hormones will not function correctly, which then trickles into some of these other problems. and then you get into other factors like what you're putting in your body. the nutrition that you have or you don't have. They're saying the American diet is still between 60 and 80 % processed food. So we're putting still mostly junk into our systems that's modulating and creating these environments that we don't want. Number three is dysbiosis of the gut, right? Which is a huge factor in Michelle (21:13) Mm-hmm. Yeah. Caryn Johnson (21:31) overall well-being and then your chances at fertility because what happens is that if your gut is in dysbiosis, your mucosal lining is disrupted and all of the toxins that are supposed to be in this like, think of it like pipe in your body, piped to get to the outside are now permeating that pipe and moving into your system and causing again, these major inflammation issues. these, this uproar of immune response that is hard to counteract. You know, once you have that level of bacteria and then toxins that are entering the bloodstream. And then the last kind of reason that you would be kind of in this situation is just based on what's going on in your environment. So are you living in a city, you know, that a lot of people in Detroit, for instance, there's a bigger rate of infertility there versus, you know, your non-city residents. It's also based on the toxins that enter your home. So are you getting rid of your plastics? Are you looking at the cleaning supplies you're using, the makeup you're putting on your face? It seems simple, but this toxic overload, again, Michelle (22:52) Mm-hmm. Caryn Johnson (22:55) creates this inflammatory response, which modulates your immune system. So those are really the four categories that kind of put you in this place. And then it kind of gets into epigenetics, which is like, you know, you've created this new world for yourself that your body has become. And, you know, is it going to be like that or are you going to be able to get yourself out of it? Michelle (23:23) Yeah. my God. It's so important and it's true. We hear all the different factors and actually those toxins and the endocrine disruptors can be found in food, I mean, through pesticides and that can also impact your gut dysbiosis. so it's just, it's like an entangled web and it really is like a reflection of how we're living today and what's allowed in this country, which Caryn Johnson (23:38) Yeah. Yeah. Michelle (23:50) I'm starting to get more and more frustrated with, you know, the fact that other countries are protecting their citizens more from chemicals and pesticides and things that are harming not only our health and chronic disease, also future. it's, it's unbelievable. And for that reason, I often tell people just go gluten free. It's not that. Caryn Johnson (23:58) Yeah. Gosh, get me started on glyphosate. It's so sad. Mm-hmm. Michelle (24:16) It's not that wheat is bad. And actually, as a matter of fact, a lot of people don't have those same responses if they go to Spain or Italy, even though it's not considered GMO, they have genetically modified it over the years. So there's so many aspects. So sometimes I'm just like, just remove it, And I see people feeling a lot better. Caryn Johnson (24:26) Right. Yeah. Michelle (24:41) just from that, and especially with autoimmune conditions, actually that like going gluten free can really help. That's what I've seen. Caryn Johnson (24:50) Yeah, no, definitely. It's just our food source is really sad. And it's just, it's so hard to pinpoint at the end of the day because no one really has the exact answer. But I just like, you see the data, like women who are eating on a Mediterranean diet have a lower risk of endometriosis. Michelle (24:55) Yeah. Mm-hmm. Caryn Johnson (25:15) women who have like vitamin sources through green leafy vegetables don't have as much PMS. So like the correlations are there. It's just like, how do we get people to make better decisions for their body and understand like, don't be me, don't make bad decisions and then get into a position where you can't have the life that you wanted or dreamed of, or you have to fight so hard for it because Michelle (25:16) Right. Yes. Mm-hmm. Caryn Johnson (25:43) of choices you made earlier in your life from lack of knowledge, you know? Michelle (25:47) Right. Yeah, totally. And then I also look at the nervous system, which is what you're, I feel like it's really linked to the cortisol issue, like the high stress, because we're constantly being bombarded with too much information. Really, I think too much information that our nervous system is able to translate. And I think that takes a trickle down effect into our bodies. I'm very big on like mind body because of that, you know, like that, that's one aspect, but of course, I mean, there's so many Caryn Johnson (26:02) Mm-hmm. Yeah. Michelle (26:16) Like I said, it's like a web and every single piece matters. And that's what you were talking about before with medicine, looking at the body as a whole, as a functioning system, rather than just one part. Caryn Johnson (26:21) you Right, right. And just going back to your comment on cortisol, you know, a lot of it does start with cortisol because if you put yourself into too high of a cortisol state, your body doesn't produce enough hormones. It basically triggers all of your other hormones to act inappropriately. It goes into your progesterone receptor. Michelle (27:00) Mm-hmm. Yeah. Caryn Johnson (27:00) pretends it's progesterone and then it goes on your thyroid and says slow down, slow down. Your body doesn't have enough energy for this and your thyroid slows. So it's really like easy to dismiss like, yeah, I'm so stressed but I don't have to be stressed today and to understanding like if your body is in a constant state of stress, like the impact it can truly have on your system and on your hormones because Michelle (27:27) Mm-hmm. Caryn Johnson (27:30) I guess also people think of like cortisol is like over here and then estrogen and progesterone as like over here because they work through different axes of the body, right? But it's all related because if you knock one off, you're messing with the others. So I just, I wish people ultimately would understand that cortisol is a huge starting factor to their fertility journey as well. Michelle (27:38) Mm-hmm. Right. Yes. Caryn Johnson (27:57)More episodes from "The Wholesome Fertility Podcast"
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