Ep. 402 Menopausal Gut Health: Latest Research and Insights with Dr. Tim Spector

I am thrilled to have the opportunity to connect with Dr. Tim Spector today. He is a professor of genetic epidemiology at King's College, the director of the Twins UK study, a scientific cofounder at Zoe, and a leading researcher. He is also trained in rheumatology and epidemiology and is the author of Food for Life, his most recent book on nutrition and health. In our conversation today, we unpack the new science on the role of the microbiome, the benefits of diverse food choices, and why Dr. Spector does not support superfoods. We dive into plant-material diversity, fiber, polyphenol-rich foods, fermented foods, and protein, and explore and explore issues surrounding bio-individuality specific to fiber, the impact of antibiotics, the Predict study, the Zoe program, and research on menopausal gut microbiomes. Dr. Spector explains why he does not believe in snacking, the value of digestive rest and intermittent fasting, and why lifestyle is a critical factor in menopause and beyond. We also get into some fascinating upcoming research. I know you will love this insightful discussion with Dr. Spector. IN THIS EPISODE YOU WILL LEARN: What defines a healthy gut microbiome? Dr. Spector explains the concept of the microbiome as a virtual organ Why dietary diversity is essential How fermented foods and plant-based proteins improve gut health Some interesting research on research on how menopause affects the gut microbiome Dr. Spector describes the holistic approach of the ZOE program Why most snacks are unhealthy, and how extending the time between meals can improve gut health Using intermittent fasting to rest the gut and improve overall health How a poor night of sleep can alter food choices the following day The interplay between exercise and gut health Dr. Spector shares some ongoing research on the impact of coffee on the gut microbiome Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Tim Spector On Zoe Instagram ZOE Science & Nutrition podcast

I am honored to have Kristin Kirkpatrick joining me today. She is a registered dietitian, bestselling author, presenter, and dietitian with the Department of Wellness and Preventative Medicine at the Cleveland Clinic.  The fatty liver epidemic now affects one in four people globally. In our discussion today, we explore who is most at risk, the essential functions of the liver, and how factors like COVID, stress, overeating, and alcohol contribute to the problem. We dive into the role of visceral fat, and Kristin shares her go-to labs and tests for assessing metabolic health. We break down why SECO is outdated, why sugar is particularly harmful to the body, and the effects of andropause, menopause, and other hormonal changes. We also tackle the toxic diet culture, under-eating, alcohol, poor sleep, exercise, carb restriction, beneficial supplements, and how nutrigenomics can guide us in navigating bio-individuality. I know you will love this eye-opening conversation with Kristin Kirkpatrick. IN THIS EPISODE YOU WILL LEARN: Why fatty liver is a silent epidemic The connection between fatty liver, type 2 diabetes, and insulin resistance How the COVID-19 infection impacts the liver  How non-alcoholic fatty liver gets diagnosed What are the primary functions of the liver? How ultra-processed foods contribute to sugar intake and impact metabolic health Why we must nourish the body with nutrient-dense foods instead of focusing on calorie restriction How does aging affect metabolic health? Why it is essential to maintain muscle mass during menopause The role of exercise in maintaining metabolic health How nutrigenomics helps in understanding genetic influences  Connect with Cynthia Thurlow   Follow on Twitter, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Kristin Kirkpatrick On her website On social media: @fuelwellwithkrissy

I am delighted and honored today to interview Dr. Lisa Mosconi. She is an Associate Professor of Neuroscience in neurology and radiology at Cornell Medicine and Director of the Women's BRAIN Initiative and the Alzheimer's Prevention Clinic at Weill Cornell Medicine, New York Presbyterian Hospital. She is also a globally acclaimed neuroscientist with a Ph.D. in neuroscience and nuclear medicine and the author of the New York Times bestseller The XX Brain and, more recently, The Menopause Brain. In our conversation, we discuss how women’s brains change during perimenopause and menopause, looking at the significance of puberty, pregnancy, and perimenopause, as well as the lack of medical research on women and medical gaslighting. We explore the concept of bikini medicine and its misconceptions regarding women's health and hormones alongside the crucial roles of hormones like estradiol, progesterone, and testosterone in our neuroendocrine system. Dr. Mosconi also provides insights into evolving menopausal treatments, including lifestyle interventions.  Dr. Mosconi is an esteemed figure in neuroscience and a prominent voice in women's health. I am confident you will gain valuable insights and perspectives from my discussion with her today. IN THIS EPISODE YOU WILL LEARN: How women's brains change during perimenopause and menopause How the lack of information for young girls can lead to medical gaslighting and confusion during perimenopause Dr. Mosconi explains how a simple sugar is used as a tracer to track glucose metabolism in the brain during perimenopause Why brain changes during menopause may lead to mental fatigue and brain fog How the lack of training and research on menopause in medical residency programs leads to a poor understanding among clinicians Why women need to consider their brain and metabolic health during perimenopause Why estrogen is essential after menopause The benefits of HRT for menopausal women How stress impacts hormone production Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Lisa Mosconi On her website On Instagram

I am delighted to connect with Dr. Darshan Shah today. He is a health and wellness specialist, a board-certified surgeon, a published author, an entrepreneur, and the founder of Next Health, the world's first and largest health optimization clinic.  In our discussion today, we dive into the current state of U.S. healthcare, contrasting how the traditional allopathic model focuses on acute care and disease treatment with a preventative approach. We cover the health of children and teens, mitochondrial dysfunction, the impact of shift work on circadian rhythms, hormonal regulation through HRT and lifestyle changes, looking at Akkermansia, gut physiology, and the implications of ultra-processed foods. We also explore cutting-edge therapies like IV NAD and exosome treatments.  I am sure you will love this enlightening and informative conversation with Dr. Darshan Shah as much as I did. IN THIS EPISODE YOU WILL LEARN: The present state of healthcare in the United States Why we need to be personally responsible for our health How modern lifestyles impact mitochondrial health The impact of shift work on healthcare providers  The interplay between gut health and hormonal changes Why it is essential to address gut health and hormone deficiencies concurrently The health implications of eating ultra-processed foods  Why do we need to track biomarkers regularly? The benefits of novel therapies like IV NAD and exosome therapy Some tips for making simple and nutrient-dense meals Bio: Dr. Drashan Shah Dr. Shah graduated from the accelerated 6-year MD/BS program at the University of Missouri, Kansas City, and earned his medical degree at the age of 21, becoming one of the youngest physicians in the country. He then continued his training in general surgery and trauma in Kern County, California where he performed over 10,000 operations on all body systems. From trauma surgery to reconstructive surgery, Dr. Shah has seen and done it all. He was also prolific in writing many articles published in dozens of academic journals, started a surgical education website, and was an outstanding teacher of fellow medical students and residents. Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Darshan Shah Next Health   On Instagram

I am delighted to reconnect with Dr. Catharine Arnston today. She is the founder, CEO, and Chief Scientific Officer of ENERGYbits. She last joined me on Episode 226 of the podcast.  In our conversation, we dive into the importance of an alkaline lifestyle, looking at how our modern-day lifestyles expose us to toxins while contributing to soil depletion and poor-quality food. We discuss the benefits of spirulina, the effects of mitochondrial dysfunction in perimenopause and menopause, the role of free radicals and antioxidants, and the research currently being done on Me Screen, spirulina, and chlorella. We cover the differences between chlorella and spirulina, explaining how chlorella impacts the immune system and gut microbiome and how it is beneficial for cleansing, toning, healing, and overcoming hangovers. We explain how algae can help us reverse our biological or chronologic age, Catharine shares some tips for aging gracefully, and we also create a mini-course on algae.  I know you will love and appreciate today’s invaluable conversation with Dr. Catharine Arnston. IN THIS EPISODE YOU WILL LEARN: The health benefits of an alkaline lifestyle and how algae helps in maintaining blood PH levels How soil degradation and over-processing impact the quality of our food  Why algae farming is sustainable and beneficial for the environment The nutritional benefits of spirulina and chlorella compared to those of collagen. How the non-stimulant effects of spirulina assist in ATP generation Why mitochondrial health is crucial How aging impacts ATP production How chlorella aids the detoxification process How combining spirulina with chlorella leads to optimum health Catharine shares lifestyle hacks for aging gracefully Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Catharine Arnston ENERGYbits - Use the code CYNTHIATHURLOW for a 20% discount on all ENERGYbits products On Instagram and Facebook Previous Episode Mentioned: Ep. 226 The Incredible Benefits of Algae, Chlorella, and Spirulina with Dr. Catharine Arnston

I am honored to reconnect with Dave Asprey today! He is the renowned father of biohacking and a New York Times bestselling author.  Dave would like a world where we all have enough free time and peace to be at full power! In this episode, he and I have a no-nonsense conversation about his newest book, Smarter Not Harder, which is my favorite of all his books! We dive into the impact of the pandemic, the art and science of environment, the laziness principle, homeostasis, and the concept behind “slope with the curve” thinking. We discuss anti-nutrients, the biohacking pathway, REHIIT training, and various other cellular hacks, including hypoxification and specialized breathing, and how trauma pertains to becoming a more efficient human. I also ask Dave about his favorite supplements. I hope you enjoy listening to today’s conversation with Dave Asprey as much as I did recording it!    IN THIS EPISODE YOU WILL LEARN: Why Dave chose to write his latest book now. How Dave’s book can help you achieve homeostasis. The 5 goals in Dave’s book that he recommends for people focus on, one at a time. A fundamental mistake that people in the world of health and fitness often make.  How the “slope with the curve” biology works. How you can save energy with biohacking. The benefits of REHIT (Reduced Energy High-Intensity Interval Training). Some foods that can negatively impact our health. Dave shares his thoughts on dairy. Using hypoxification as a cellular biohack. Dave sheds some light on his favorite supplements. The role of trauma resolution. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Connect with Dave Asprey On his website  Danger Coffee    To open an Upgrade Labs, go to www.ownanupgradelabs.com Books mentioned Men Are from Mars Women Are from Venus by John Gray Dave’s new book, Smarter Not Harder is available from most bookstores.

I am thrilled to have Jim Kwik joining me on the podcast today.  Jim is an advocate for brain health. He is recognized widely as a global expert in memory improvement, brain optimization, and accelerated learning. He is also a New York Times bestselling author, keynote speaker, and the host of the acclaimed Kwik Brain Podcast.  In our conversation, we dive into digital dementia, exploring how our heavy dependence on technology affects our memories, learning styles, visualization, teaching methods, and lifestyle choices. We touch on the role of the reticular activating system (RAS) in learning, looking at how to foster a curious mindset. We also cover information overload, the benefits of the Pomodoro Technique for brain breaks, common middle-age concerns, and the role of nootropics. Jim has kindly offered to give a few books away to our listeners. To participate, take a screenshot of the podcast featuring Jim and me and identify something you learned on social media, explaining how you will apply it to boost your brain health. Jim and his team will select a handful of listeners to receive an autographed copy of his book, Limitless- one of my favorites.  This discussion with Jim Kwik is invaluable, and I know you will enjoy it! IN THIS EPISODE YOU WILL LEARN: What is digital dementia? Why handwriting notes is better than digital note-taking Jim shares a whole-brain note-taking method that combines logical left-brain and holistic right-brain thinking The benefits of visualization for learning and retaining information Why you need to forget what you already know to learn something new Why we need to stay curious and engage in lifelong learning How taking regular breaks helps us to avoid information overload and maintain focus Jim explains the Pomodoro Technique How genetics and lifestyle impact brain health The benefits of meditation, diet, and exercise Why Jim is passionate about the aging brain Bio:  Jim Kwik is an internationally acclaimed authority in the realm of brain optimization. With over 30 years of experience, Jim has dedicated his life to helping people tap into their brain’s full potential. From overcoming learning challenges after a childhood brain injury, Jim embarked on a journey with the mission to leave no brain behind. Through his teachings, Jim inspires others to unlock their innate genius, empowering them to live a life of greater power, productivity, and purpose. Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Jim Kwik On his website Instagram Twitter Facebook YouTube Kwik Brain Podcast Limitless is available on the Limitless website.

I am thrilled to reconnect with Kylie Larson today. Kylie is truly an exceptional individual. She is a Brendon Bouchard-trained coach, host of the Far from Perfect Podcast, content creator, and founder of Lift to Get Lean.  In our discussion today, we dive into the role of compassion, particularly during perimenopause and menopause, and explore the concepts of surrender and trusting your body. We discuss why women are more concerned about the number on the scale than their body composition, explain why data is simply data, and how resistance to change can affect our ability to manage perimenopause and menopause. We cover macros, misinformation, and metabolic flexibility and look into the value of maintenance and how to reverse diet. Kylie also shares some of her favorite resources, books, and tools.  I was honored to reconnect with Kylie, and I know you will love this conversation with her as much as I did. IN THIS EPISODE YOU WILL LEARN: The role of compassion in perimenopause and menopause How struggling to accept body changes can lead to self-criticism and stress The benefits of resting and mindful exercising Why body composition is more important than the number on the scale Why we need to be flexible about our health goals The value of nutrient-dense foods for maintaining muscle mass  Misconceptions surrounding macros How to maintain balance in your diet and lifestyle Why getting enough sleep is essential Making informed decisions about your food choices Kylie’s favorite books and resources Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Kylie Larson On Instagram The Far from Perfect podcast Book mentioned: Think Again by Adam Grant

Today I am honored to connect with a friend and fellow nurse practitioner, Marcelle Pick! Marcelle is passionate about transforming how women experience healthcare through an integrative approach. She has successfully treated thousands of women through her unique approach to wellness. Marcelle is currently a faculty member of The Institute of Functional Medicine and has served as a Medical Advisor to Healthy Living Magazine. She has written countless articles and multiple books, including Is It Me or My Hormones? I always think of Marcelle as a pioneer in the women’s health/nurse practitioner space. In this episode, we dive into her background and the impact of the Women’s Health Initiative. We discuss the limitations of the traditional allopathic model regarding hormones, common misconceptions about adrenal health, perimenopause, and menopause, adverse childhood events and adrenal health, how lifestyle affects our sex hormones, fibroids, endometriosis, PMS, PMDD, and contraception for perimenopause. We speak about endocrine disruptors, mold, and micro toxins. We also get into ways to think about hormone replacement therapy and ways to address intimacy and low libido. I love connecting with other nurses and nurse practitioners! I hope you will love today’s conversation with Marcelle as much as I did! IN THIS EPISODE YOU WILL LEARN: Marcelle was part of the first all-women practice in the country. How the Women’s Health Initiative has impacted health care for women. The limitations of the traditional allopathic model, particularly in terms of perimenopause, menopause, and hormones. The less common labs that Marcelle likes to look at for her patients. Marcelle shares her approach to unraveling the symptoms of perimenopause. Some unique ways in which Marcelle deals with problems like fibroids and endometriosis. How childhood trauma could lead to adrenal and autoimmune issues, weight-loss resistance, and various other health problems. Many of the things Marcelle recommended for treating PMS and PMDD back in the day (1985) have now become the standard of care. Contraceptive options for women in perimenopause. The impact of stress on adrenal function during perimenopause and menopause. Marcelle dives into liver health and detoxification, chemicals and other factors that could impact our health, and changes we can make to avoid problems and feel better. What Marcelle does to help women with low libido. Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia’s website Connect with Marcelle Pick On her website    On Facebook and Instagram All of Marcelle’s books are available on Amazon

I am thrilled to be doing a two-part series on progesterone with Dr. Lindsey Berkson. Dr. Berkson is a peer-reviewed researcher, bestselling author, educator, nutritional gastroenterology and hormonal thought leader, and an inventor and formulator of nutraceuticals and pharmaceuticals.  In the first part of our series today, we address common misconceptions about hormones and provide an overview of the anatomy and physiology of progesterone, including lesser-known production sites outside the ovaries and adrenal glands. We examine the limitations of current medical training, the influence of the Women’s Health Initiative, and shifts in prescribing practices. We also explore the effects of chronic stress, ultra-processed foods, and toxins, discussing practical steps to mitigate exposure. You will also learn about essential cofactors for progesterone production, including zinc, iodine, magnesium, vitamin B6, and vitamin A, along with strategies for optimizing digestion. This enlightening series on progesterone with Dr. Lindsey Berkson has many valuable insights, and I know you will gain a lot from it. IN THIS EPISODE YOU WILL LEARN: Why progesterone is an essential hormone  How did progesterone become misunderstood?  How progesterone has contributed to human evolution Dr. Berkson debunks the common myths surrounding progesterone  How hormones function as signaling molecules The importance of progesterone receptors in the brain, heart, and lungs The role progesterone plays in protecting the lungs How modern lifestyle factors affect hormone levels Why you need to filter all your water, including shower water How eating organic foods can help reduce exposure to endocrine disruptors Connect with Cynthia Thurlow   Follow on Twitter, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Lindsey Berkson On her website Find Dr. Berkson’s books on Amazon