#377 — The Future of Psychedelic Medicine 2

Sam Harris discusses the result of the 2024 presidential election, the lessons that the Democratic Party should draw from it, and the implications of a second Trump term. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Mark Cuban about the 2024 presidential election. They discuss Trump’s ethics, his apparent political indestructibility, election denialism, the influence of Elon Musk, the strengths and weaknesses of the Harris campaign, the mystery of the southern border, Trump’s immigration and deportation policies, Elon’s trafficking in the “great replacement theory,” Trump’s economic policy, Harris’s tax and healthcare proposals, the effect of tariffs, the U.S. supply chain, the problem of wealth inequality, a proposed tax on unrealized capital gains, support for Israel, a return to normal politics, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris speaks with Nate Silver about cultural attitudes toward risk and the state of American politics. They discuss the erosion of trust in liberal institutions, polling and political narratives, different camps of cultural elites, the influence of Silicon Valley, Peter Thiel, Elon Musk, Sam Bankman-Fried and the fall of FTX, Gell-Mann amnesia, Christopher Rufo, why Kamala Harris can’t admit to having changed her views, a problem with strict utilitarianism, AI and existential risk, what people misunderstand about election forecasting, which news events have affected the 2024 race, how current polls might be misleading, public vs. private polling, undecided and marginal voters, Gen Z, the gender divide, the likelihood that Trump won’t accept the election results if he loses, election integrity in the swing states, the chance of a landslide, the prospect of public unrest, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris speaks with Sara Imari Walker about a scientific understanding of life. They discuss the contributions of physics to this topic, Erwin Schrödinger, the inadequacy of standard definitions of life, the prospect of "artificial" life, the role of information, constructor theory, assembly theory, the space of all possible structures, a "block universe," the existence of abstract objects like numbers, the Fermi paradox, the likelihood of life elsewhere in the universe, experiments that could decide how likely life is to emerge, the possibility of a Great Filter, the number of Earth-like worlds, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris speaks with Ambassador Rahm Emanuel about the state of world order and American politics. They discuss the mystery of Japan’s economic health, U.S. competition with China, possible conflict over Taiwan and the Philippines, the significance of the South China Sea, the history of the Japan-U.S. friendship, how the Democratic Party lost its way, immigration, whether Vice President Harris needs a “Sister Souljah moment,” whether she should explain her changes of position better than she has, the standing of Israel in the eyes of the world, antisemitism, the Abraham Accords, Hamas, the West Bank, the influence of the religious right in Israel, a possible war with Iran, Netanyahu and Israeli security, a two-state solution, whether a Harris administration would reliably support Israel, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris speaks with Yuval Noah Harari about his new book, Nexus, and its application to current crises. They discuss humanity’s capacity for self-destruction, democracy and dictatorship as information networks, the “naive view of information,” the advantages of fiction over truth, trust in institutions, self-correction in a democracy, truth vs. power, truth vs. order, the suicide of conservatism, fixing social media, algorithms as editorial choices, efficiency vs. inefficiency, threats to democracy, the authoritarian character of Trump’s candidacy, the need for patriotism and nationalism, Israeli politics, the peaceful transfer of power, Putin and the war in Ukraine, the vulnerability of world order, the killing of Hassan Nasrallah, antisemitism and anti-colonialism, religious fanaticism among Israelis, the status of Arabs in Israeli society, biblical and post-biblical Judaism, whether a wider war in the Middle East is necessary, the danger of spirituality without ethics, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris speaks with Nick Bostrom about ongoing progress in artificial intelligence. They discuss the twin concerns about the failure of alignment and the failure to make progress, why smart people don’t perceive the risk of superintelligent AI, the governance risk, path dependence and "knotty problems," the idea of a solved world, Keynes’s predictions about human productivity, the uncanny valley of utopia, the replacement of human labor and other activities, meaning and purpose, digital isolation and plugging into something like the Matrix, pure hedonism, the asymmetry between pleasure and pain, increasingly subtle distinctions in experience, artificial purpose, altering human values at the level of the brain, ethical changes in the absence of extreme suffering, our cosmic endowment, longtermism, problems with consequentialism, the ethical conundrum of dealing with small probabilities of large outcomes, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris speaks with Barton Gellman about election integrity and the safeguarding of American democracy. They discuss the war games he's run to test our response to an authoritarian president, using federal troops against American citizens, the difference between laws and norms, state powers to resist the federal government, voter identification and election integrity, political control over election certifications, the Bush-Gore election, the Electoral Count Reform Act, the prospect of public unrest after the November election, January 6th, George Soros, the "good people on both sides" calumny against Trump, what happens to Trump and Trumpism if Harris wins in November, the presidential debate with Harris, the authoritarian potential of a second Trump term, Project 2025, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris talks about the recent assassination attempt on Donald Trump, the cesspool of X, Tucker Carlson’s conversation with Darryl Cooper, freedom of speech, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris speaks with Richard Dawkins about his new book The Genetic Book of the Dead, the genome as a palimpsest, what scientists of the future may do with genetic information, genotypes and phenotypes, embryology and epigenetics, why the Lamarckian theory of acquired characteristics couldn't be true, how environmental selection pressure works, why evolution is hard to think about, human dependence on material culture, the future of genetic enhancement of human beings, viral DNA, symbiotic bacteria, AI and the future of scholarship, resurrecting extinct species, the problem of free speech in the UK, the problem of political Islam and antisemitism in the UK, reflections on Dan Dennett, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.