Overcoming EGFR-TKI resistance: Emerging therapies and biomarker strategies in NSCLC Module 1: Beyond EGFR: Addressing actionable drug resistance mechanisms

touchCLINICAL PERSPECTIVES for touchONCOLOGY and touchRESPIRATORY In this module, Professors Jänne and Girard explore the challenges of resistance to EGFR-targeted therapies in non-small cell lung cancer. They discuss how mechanisms such as MET and HER2 amplification drive resistance to first-line osimertinib, review emerging targeted strategies to overcome these barriers, and highlight the importance of biomarker testing and managing treatment side effects when shaping second-line options for patients. Course director Prof. Pasi Jänne, Dana-Farber Cancer Institute, Boston, MA, USA The clinical expert Prof. Nicholas Girard, Institut Curie, Paris, France This touchPODCAST is for HCPs only. This activity is funded by an educational grant from AstraZeneca Ltd.  This medical education is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website:   add url

touchEXPERT FOCUS for touchONCOLOGY Listen to insights from Prof. Jean-Pascal Machiels on optimizing the use of immunotherapy in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) and the potential future role of immunotherapy in resectable locally advanced HNSCC. The expert: Prof. Jean-Pascal Machiels, Cliniques universitaires Saint-Luc, Brussels, Belgium This touchPODCAST is for HCPs outside of the UK. This activity is funded by an independent medical education grant from Merck Sharp & Dohme LLC. The activity is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website: www.touchONCOLOGY.com

touchIN CONVERSATION for touchCARDIOLOGY and touchENDOCRINOLOGY Listen to two experts as they discuss the diagnosis, treatment and how to support patients with FCS. They cover how to recognize key clinical signs and symptoms, strategies to help manage symptoms, reduce triglyceride levels and prevent complications. They  also share key insights from their experience with novel targeted therapies for FCS. The expert(s) Professor Antonio Gallo, Sorbonne University Hospital Pitié-Salpêtrière, Paris, France Dr Vikesh Singh, Johns Hopkins University School of Medicine, Baltimore, MD, USA This touchPODCAST is for HCPs in the USA and Europe only. This activity is funded by an independent medical education grant from Arrowhead Pharmaceuticals, Inc. This activity is jointly provided by USF Health and touchIME.  touchIME is an EBAC® accredited provider. For further information visit our websites: https://touchcardioime.org/fcs-unmasked/ and https://touchendocrinologyime.org/fcs-unmasked/

touchEXPERT FOCUS for touchHAEMATOLOGY Prof. Lucia de Franceschi, a leading expert in sickle cell disease, examines the clinical manifestations and burden of the condition, reviews current and emerging treatments and offers guidance on comprehensive lifespan care that addresses complications, quality of life, and disparities, while highlighting the essential role of multidisciplinary support. The experts Prof. Lucia de Franceschi, University of Verona, Italy This touchPODCAST is for HCPs outside of the UK. This activity is funded by an independent medical education grant from Agios Pharmaceuticals, Inc. The activity is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website: www.touchHAEMATOLOGY.com

touchEXPERT FOCUS for touchENDOCRINOLOGY, touchCARDIO and touchNEUROLOGY Listen to a series of short expert interviews on timely diagnosis and individualized care for Fabry disease, using genetic and clinical insights. Our faculty discuss strategies to reduce diagnostic delays, identify clinically relevant genetic variants and tailor treatment based on each patient's genotype–phenotype correlations. The experts Dr Raphael Schiffmann, Texas Christian University, Fort Worth, TX, USA Ms Dawn Laney, Emory Genetic Clinical Trials Center, Atlanta, GA, USA Dr Ozlem Goker-Alpan, Lysosomal Disorders Research and Treatment Center (LDRTC), Fairfax, VA, USA This touchPODCAST is for HCPs outside of the UK. This activity is funded by an independent medical education grant from Amicus Therapeutics Inc. This activity is jointly provided by USF Health and touchIME. For further information visit our websites:  www.touchENDOCRINOLOGY.com www.touchCARDIO.com and www.touchNEUROLOGY.com

touchCASES for touchONCOLOGY Listen to three experts as they discuss how patient and disease characteristics may inform treatment selection in recurrent/metastatic nasopharyngeal carcinoma (R/M NPC). They will discuss the cases of three patients which will cover first-line and second-line treatments as well as key considerations for their treatment plans in their patients' cases. The experts: Dr Nabil Saba, Winship Cancer Institute, Emory University, Atlanta, GA, USA Dr Victoria Villaflor, Chao Family Comprehensive Cancer Center, UCI Health, Orange, CA, USA This activity is for HCPs in the USA only This activity is funded by an independent medical education grant from Coherus Biosciences. This activity is jointly provided by USF Health and touchIME. For further information visit our website: https://touchoncologyime.org/treatment-selection-in-r-m-npc/  

touchEXPERT FOCUS for touchHAEMATOLOGY and touchONCOLOGY Listen to a series of short expert interviews on the role of B-cell maturation antigen (BCMA)-directed therapies in relapsed/refractory multiple myeloma (RRMM). The faculty discuss patient selection, treatment tailoring and strategies to manage side effects, providing practical guidance for integrating BCMA-targeting approaches into care. The experts Prof. Jesús San Miguel, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain Prof. Pieter Sonneveld, Erasmus University Medical Center, Rotterdam, The Netherlands Dr Francesca Gay, University of Torino, Italy This touchPODCAST is for HCPs outside of the USA. This activity is funded by an independent medical education grant from GSK. This activity is provided by touchIME. touchIME is an EBAC® accredited provider. For further information visit our websites: www.touchHAEMATOLOGY.com and www.touchONCOLOGY.com 

touchEXPERT FOCUS for touchOPHTHALMOLOGY Listen to a series of short interviews with leading experts on phacoemulsification in cataract surgery. The faculty discuss optimizing fluidics and ultrasound energy, ophthalmic viscosurgical device selection, and integrating technological advances in phacoemulsification into clinical practice. The experts: Dr Ike K Ahmed, Prism Eye Institute, Toronto, ON, Canada; John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA Dr David F Chang, University of California, San Francisco, CA, USA; Altos Eye Physicians, Los Altos, CA, USA Dr Jennifer Loh, Loh Ophthalmology Associates, Miami, FL, USA This touchPODCAST is for HCPs in the USA, Latin America and Canada only. This activity is funded by an independent medical education grant from Alcon Vision, LLC and Johnson & Johnson Surgical Vision, Inc. The activity is jointly provided by USF Health and touchIME. For further information visit our website: https://touchophthalmologyime.org/phacoemulsification-cataract-surgery/    

touchEXPERT FOCUS for touchOPHTHALMOLOGY Listen to a series of interviews with Prof. Elias Traboulsi on the clinical presentation, diagnosis and management of patients with Stargardt disease. Prof. Traboulsi shares key clinical characteristics and retinal imaging results indicative of Stargardt disease, discusses the right tools to use to accurately and promptly diagnose the condition, and reviews supportive care strategies to maximize patients’ functional vision and improve their wellbeing.  The expert: Prof. Elias Traboulsi, Cleveland Clinic, Cleveland, OH, USA This touchPODCAST is for HCPs in the USA only. This activity is funded by an independent medical education grant from Alkeus Pharmaceuticals, Inc. The activity is jointly provided by USF Health and touchIME. For further information visit our website: www.touchOPHTHALMOLOGY.com

touchTALKS for touchENDOCRINOLOGY  Listen to Prof. Jennifer Sherr, as she discusses key updates on the prevention and management of DKA. The discussion covers the clinical features and aetiology of DKA, its impact on people living with diabetes, the underlying metabolic pathways, risk factors, common triggers, and the pillars of management. Prof. Sherr also explores strategies for prevention and early intervention plus the advantages, drawbacks and recent developments in ketone monitoring. The experts Prof. Jennifer Sherr, Yale School of Medicine, New Haven, CT, US This touchPODCAST is for HCPs outside of the UK only. This activity is funded by an independent medical education grant from Abbott Diabetes Care Inc. This activity is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider.  For further information visit our website:  www.touchENDOCRINOLOGY.com