The Drug Chat with Dr. Wambui

We've reached the final episode of our dyslipidemia series! In this episode, we explore several additional lipid-lowering therapies, including fibrates, niacin, omega-3 fatty acids, and Evkeeza (evinacumab). Join me as we discuss how these agents fit into the management of dyslipidemia and wrap up our journey through the world of cholesterol and lipid management. Thank you for listening!

Another incredible discovery inside the human body—our built-in recycling system and its surprising role in cholesterol control. What happens when that recycle bin works… or doesn’t? Welcome to the fascinating world of the enzyme PCSK9.

The human body is remarkably efficient—we’re built with a “waste not” mindset, constantly recycling what we can. Bile acid sequestrants tap directly into that system, turning one of our body’s recycling pathways into a powerful tool for lowering cholesterol.

Cholesterol doesn't just come from one place.... so let's treat it with more than one approach. In this episode we discuss a unique class that works in your gut to block cholesterol even before it enters your bloodstream.

Welcome to those that inhibit the "De Novo Synthesis" of cholesterol. We talk about the statins and the new kid on the block Bempedoic acid brand name Nexletol.

Not all cholesterol is created equal. In this episode, we breakdown dyslipidemia, review the major lipoproteins, and work through a patient case where the numbers signal rising ASCVD risk - connecting the dots.

We are at the end of the road of our anti-platelet pathway exploration!!!! We look at 2 different ways of inhibiting the platelets from forming a clot and the different patient populations that these drugs are used. Hooray to the anti-platelets though I'm sure this isn't the end there must be another novel/cutting edge therapy just around the corner that a scientist/discoverer is just about to unveil......

In today's episode I give a gigantic high five to our scientists/discoveres! Figuring out yet another way to stop clot formation by working out the puzzle of how platelets work to form a clot. With that worked out they then make drugs that put a stop 🛑 to this and voila.... no clots are formed.

What a lovely name to pronounce Thienopyridines! Another nugget as to how platelets work to cause clots to form and how this class stops that from happening. Very Sci-Fi how these platelets work.

In the year 1899 (others say 1897) Asprin was marketed by Bayer Pharmaceuticals. Yep and we still use it today talk of super drug. It's used and indicated in many areas but again tunnel vision in this episode where we are specifically interested in how are clots not formed when asprin is around.