One Day with Jon Bier

He built a company to $1 billion. Watched it drop to $50 million when Covid testing dried up overnight. Then sat down at a dinner in London with David Beckham, no agenda, no pitch, just a conversation about health. Walked out with the co-founder of the fastest-growing supplement brand in history.Jon Bier sits down with Danny Yeung, co-founder and CEO of IM8 and Prenetics, for a conversation about what it actually takes to build a global brand from scratch in under two years. Zero to $220 million in revenue. David Beckham, Aryna Sabalenka, and Giannis Antetokounmpo as equity partners, all inbound, none hunted. A red powder in a category full of green. A public company that turned a Covid collapse into a comeback story Jon calls one of the most impressive he's seen in this space.The celebrity wasn't the brand. The science was the brand. David Beckham was the cherry.In this episode:- How Danny rebuilt from a $50 million market cap to $400 million by betting everything on a supplement brand his own board rejected, and why having super voting rights was the most important structural decision he ever made- Why every major ambassador and athlete partnership came inbound, and what that says about building a product people actually want to be associated with versus one they're paid to pretend they use- The real playbook behind building a global supplement brand in under two years, from clinical trials with Mayo Clinic to F1 helmets to a 50% international revenue split on day oneFind Danny & IM8:- Danny on Instagram: https://www.instagram.com/dannyyeung22/- IM8: https://www.im8health.com- IM8 on Instagram: https://www.instagram.com/im8health/

He grew up in Yugoslavia. Twenty years of communism, crushing poverty, and hunger every single day. He left at 20 with nothing, landed in El Paso, Texas, got a PhD, spent twelve years at Los Alamos National Laboratory, and then co-founded a company that has tested over 500,000 people in 100 countries. He should have been in a wheelchair by now. He cured himself instead. Jon Bier sits down with Dr. Momo Vuyisich, co-founder and Chief Science Officer of Viome, for one of the most genuinely mind-expanding conversations this show has produced. Momo spent six years developing proprietary RNA-based technology that measures tens of thousands of biomarkers in a single test, giving people the kind of precision map of their own biology that has never existed before. No other company in the world has it. Not a university. Not a government lab. Not a competing startup. Just Viome. This isn’t a wellness conversation. It’s a conversation about how medicine actually works, why it is designed the way it is, and what it would look like to actually fix it. In this episode:- Why every chronic disease you have been told is genetic or incurable is almost certainly neither, and what the incentive structure of academic medicine and Big Pharma has to do with that - How Momo cured his own autoimmune condition by removing mammalian foods from his diet, and the molecular mechanism behind it that doctors still won’t acknowledge - Why analyzing RNA is a quantum leap beyond every other microbiome or blood test on the market, and what the airplane analogy reveals about how shallow the competition actually is Find Momo & Viome:- Viome: https://www.viome.com- Viome on Instagram: https://www.instagram.com/viome/

83 million Americans have sleep apnea. Most of them don't know it. And most of the ones who do know it refuse to treat it, because the only solution anyone offered them came with a mask, a hose, and a machine that sounds like a wind tunnel.Jon Bier sits down with Wesley Lones, founder and CEO of Daybreak, the company building the first real alternative to the CPAP for the 80% of sleep apnea sufferers who will never use one. The solution is a custom-fit oral device that looks like a night guard, ships to your door, and works about 90% of the time. The diagnosis happens at home too. No sleep lab. No referral chain. No reason to avoid finding out anymore.This is one of those businesses where the TAM is everyone, the problem is urgent, and the incumbent solution is so bad that people have Facebook support groups for getting diagnosed. Wesley is building into that gap with urgency, discipline, and the kind of founder energy that comes from someone who genuinely believes the problem is solvable.It is.In this episode:- Why 80% of sleep apnea sufferers go undiagnosed and untreated, and why the CPAP being the only known solution is the core reason for that- How Daybreak built a fully at-home pathway from testing to treatment, and why the oral appliance that replaces a CPAP fits in your pocket and ships to your door- What it looks like to build a healthcare company that actually scales, and why the leadership philosophy Wesley is building toward matters as much as the productFind Wesley & Daybreak:- Daybreak: https://www.thedaybreak.com- Daybreak on Instagram: https://www.instagram.com/getdaybreak/

He started medical school at 15. Graduated as a doctor at 21. Did over 10,000 surgeries. Then walked away from the operating room to build something he thinks can actually fix healthcare.Jon Bier sits down with Dr. Darshan Shah, board-certified surgeon, founder of Next Health, and one of the most grounded longevity voices in a space that desperately needs grounding. Next Health is now 20 locations and growing, built on a simple premise: don't wait until you're sick to think about your health. Come in when you're healthy and keep it that way.This conversation covers the full arc. The kid who was severely bullied in a New Jersey high school where he was one of two brown kids. The surgeon in his early 20s getting side-eyed in operating rooms. The moment he realized the sick-care system was unfixable and decided to build a parallel one instead. And the new book, Your New Health OS, that makes the case for using AI and personal data to completely rethink how you manage your own health.Dr. Shah is not jaded. That might be the most impressive thing about him.In this episode:- Why the American healthcare system is unfixable from the inside, and why building a parallel system focused on longevity and health optimization is the only real solution- What it looks like to enter medical school at 15, train at the Mayo Clinic, do over 10,000 surgeries, and then pivot entirely to preventive medicine because the operating room is treating the wrong problem- How AI is about to unburden doctors, empower patients, and fundamentally change what it means to take care of your health, including the first fully AI-enabled autonomous surgery that just happenedFind Dr. Shah & Next Health:- Dr. Shah on Instagram: https://www.instagram.com/darshanshahmd/- Dr. Shah's website: https://www.drshah.com- Next Health: https://www.next-health.com- Next Health on Instagram: https://www.instagram.com/nexthealth/

The water filter category hasn't meaningfully changed in forty years. Every pitcher looked the same. Every one was made of plastic. Nobody could tell you what was actually in your water, or what the filter was actually removing.Jon Bier sits down with Brian Keller and Charlie Carlisle, co-founders of Rorra, the brand reimagining water filtration from the ground up, for a conversation about what happens when personal experience turns into a company. Brian's daughter Aurora developed eczema with no known cause shortly after birth. Charlie faced lead contamination in Denver's water supply. They went looking for a solution, couldn't find one they trusted, and spent three years building it themselves in glass and stainless steel, with NSF-certified filtration and an Andrew Huberman partnership to show for it.Before Rorra, they built Love Your Melon into a brand that donated nearly $10 million to pediatric cancer before getting acquired. They know how to build something real. And they think clean water is the most overlooked pillar in the entire wellness conversation.They're probably right.In this episode:- Why the water filtration category is one of the last places in wellness where nobody has built a brand worth talking about, and what it actually takes to change that- The personal stories behind Rorra: two kids with unexplained eczema, one lead contamination problem in Denver, and a combined realization that the solution didn't exist yet- What three years of engineering, design iteration, and filtration research taught two founders who came from hats, and why starting from scratch as a consumer was actually the advantageFind Brian, Charlie & Rorra:- Brian on Instagram: https://www.instagram.com/briandkeller7/- Charlie on Instagram: https://www.instagram.com/charliecarlisle_/- Rorra: https://www.rorra.com- Rorra on Instagram: https://www.instagram.com/rorrawater/Timestamps:0:00 – What's actually in your tap water0:35 – Introducing Brian Keller and Charlie Carile of Aurora4:57 – The personal water problems that led them to start Aurora7:57 – Three years of R&D before ever launching10:17 – Raising their first round with no sales yet17:00 – Eight figures in revenue in year one20:56 – Designing appliances to last decades, not a year26:18 – How they actually use AI (and where they don't)30:42 – Why every city's water problem is different37:27 – How forever chemicals accumulate in the body48:07 – Aurora's vision for a fully integrated water platform

Most people in the wellness space are trying to get from 91 to 100. Nobody's talking about how to get from 0 to 90.Jon Bier sits down with Dr. Jeff Wiegers — double board-certified anesthesiologist, interventional pain specialist, and regenerative medicine expert at BioReset Medical, for a conversation about what it actually means to pursue longevity when most of the market is selling you the shortcut. Jon and Jeff met in Cabo over a $25,000 experimental gene therapy shot. This is the follow-up conversation they should have had before that trip and it's better for it.Peptides. Stem cells. Gene therapy. GLP-1s. Growth hormone. These are the things everyone is talking about and almost nobody is contextualizing correctly. Jeff is one of the rare doctors who will slow down, ask the foundational question, and tell you when the answer is actually just: go outside, eat real food, and sleep.The cutting edge is real. But most people haven't fixed the basics yet.In this episode:Why the peptide boom needs a reality check — what unregulated sourcing actually means, why lead has shown up in tested products, and how to think about trust as the most important factor in this space- The difference between chasing a number and fixing the underlying reason the number is off and why most longevity protocols skip the most important question- What reversible gene therapy, Muse cells, and the next generation of regenerative medicine actually look like and why the delivery method revolution might matter more than the therapies themselvesFind Dr. Wiegers & BioReset: - Dr. Wiegers on Instagram: https://www.instagram.com/jeffwiegers/- BioReset Medical: https://www.bioresetmedical.com- BioReset on Instagram: https://www.instagram.com/bioresetmedical/

A neuroscience student mixing supplements in his dorm room. A national kendo competitor who became paraplegic at 19 after a snowboarding accident. Best friends. And then, one scuba diving Groupon later — a company.Jon Bier sits down with Kent Yoshimura and Ryan Chen, co-founders of Neuro, for a conversation ten years in the making. Jon was there early. He gave them his first ever angel check. He watched the whole thing — the grinding first seven years on $1.6 million raised while every other DTC brand was burning through $30 million, the Shark Tank appearance that got them zero deals and exploded their sales, the trademark lawsuit that nearly ended everything, the near-billion dollar brand they built without ever compromising the formula.This isn't a success story. It's a story about what success actually looks like when you build it the right way — slowly, stubbornly, and with your friendship completely intact.Jon has been saying it for a decade. This is the episode where everyone else gets to hear why.In this episode:• How Neuro went from clinical trial side income and Craigslist employees to one of TikTok's top-selling brands and why raising less money than everyone else turned out to be the advantage• The Shark Tank story nobody tells: zero deals, a trademark lawsuit, a cold DM to a billionaire, and the moment everything changed• Why Kent and Ryan have never cut a corner on the formula and what it actually means to be a brand-led company in a world that rewards sales-led thinkingFind Kent, Ryan & Neuro:• Kent on Instagram: https://www.instagram.com/kentaro/• Ryan on Instagram: https://www.instagram.com/ryan.ryc/• Neuro: https://www.getneuro.com• Neuro on Instagram: https://www.instagram.com/neurogum/

Sponsored By:→ Neuro | Go to ⁠https://getneuro.com⁠ and use code ONEDAY at checkout for 15% OFF your entire order.You're optimizing your supplement stack. You're tracking your macros. You're sleeping eight hours. And you're washing it all down with water that's sitting in plastic that's been baking on a truck in 100 degree heat for three weeks.Jon Bier sits down with Clara Sieg — co-founder of Loonen and former venture investor — for a conversation about the most overlooked input in the entire wellness conversation. Water. The category that built its entire identity on pictures of waterfalls and asked consumers to just trust them. Clara got pregnant, started paying attention, and found out that no natural source in the US she tested was entirely free of contaminants. So she built something that paired spring sourcing with stainless steel processing, physical membrane filtration, and NSF certification — and put it in glass. Every time.This isn't fear mongering. It's just information and most people don't have it.In this episode:• Why 50% of US tap water tests positive for lead and forever chemicals and why the bottled water sitting in plastic on a hot truck might not be solving the problem you think it is• How Clara went from a panic during pregnancy to six months testing water sources across the US, and why every single one had a footnote• What it actually takes to build a cleaner water brand in the most competitive, public-company-dominated beverage category on the shelf and why being naive enough to start was an advantage.Find Clara & Loonen:• Clara on Instagram: https://www.instagram.com/sieg/• Loonen: https://loonen.com/• Loonen on Instagram: https://www.instagram.com/loonenwater/Timestamps:0:00 — Intro1:12 — Why water is the real foundation of wellness2:15 — How bad is US tap water?4:14 — The bottled water myth: microplastics and leaching7:08 — Jon's $12K arsenic wake-up call9:32 — What plastic bottles actually do to your water12:46 — How Lunan sources and filters its water16:33 — Sponsor: Neurogum17:24 — The spring water myth21:46 — "Pure but proven": NSF and 350+ contaminant testing24:03 — The organic-certification parallel & Clara's mom27:50 — Why this is personal: IVF and fertility29:18 — Building an explosive brand & the bottle design38:06 — The Loon, the name & understated branding42:26 — What's next: single-serve, national rollout, flavors

Sponsored By:→ Neuro | Go to ⁠https://getneuro.com⁠ and use code ONEDAY at checkout for 15% OFF your entire order.Every single grocery store aisle has been disrupted by better-for-you brands. Every one — except the aisle where the fastest-growing demographic in America shops for nutrition.Jon Bier sits down with Jess Haghani — founder and CEO of Lucille Health — for a conversation about what happens when you spot a gap so obvious it feels impossible that no one has filled it yet. Jess watched her grandmother, Lucille, come home from heart surgery and get handed the same ultra-processed nutrition shakes that haven't meaningfully changed since the 1970s. Products people hide in their basements. Products they're embarrassed to let their grandkids see. A $6 billion category with zero dignity, zero innovation, and no real competition.So she left KKR, went to Harvard Business School, and built the brand she knew had to exist.This episode is a little different. Jess hasn't built a nine-figure business yet. But Jon believes she will and this conversation is why.In this episode:• Why less than 1% of food and beverage innovation is happening for older adults, despite them being the fastest-growing consumer demographic in the world — and why that gap is finally closing• The real story behind Lucille: how watching her 92-year-old grandmother hide a nutrition shake in her basement became the founding moment of a brand built around dignity• What it looks like to take on Abbott and Nestlé with no money, no formulation experience, and no playbook and why that might actually be the advantageFind Jess & Lucille:• Jess on Instagram: https://www.instagram.com/jesshaghani/• Lucille Health: https://www.lucillehealth.com• Lucille on Instagram: https://www.instagram.com/lucillehealth/Timestamps:0:00 - Intro1:21 - Jon's personal experience with his dad's hospital nutrition2:04 - Why do hospitals still serve such poor nutrition products?7:43 - The corruption of big incumbents like Abbott and Nestle9:59 - How big is the older adult nutrition market?11:01 - Why has this category never been disrupted?11:38 - The shame and stigma around products like Ensure and Boost15:25 - Jess's background: London, real estate, KKR, HBS17:02 - The story of Lucille, Jess's 92-year-old grandmother19:51 - Assembling the team and figuring it out step by step25:00 - Should founders pay themselves a salary?31:04 - The broader vision: beyond beverages, full category disruption37:23 - The 70+ demographic has the highest retention rate43:18 - Jon's confidence in Lucille Health's future

Sponsored By:→ Neuro | Go to ⁠https://getneuro.com⁠ and use code ONEDAY at checkout for 15% OFF your entire order.DescriptionHe licensed technology from Oxford, sold it to Navy SEALs and the US Department of Defense, brought the price from $30 a shot to $5, and is now stocking shelves at Chevron and Equinox. This is what it looks like to create a new category from scratch and refuse to stop.Jon Bier sits down with Michael Brandt — Stanford CS grad, 2:35 marathoner, and co-founder and CEO of Ketone-IQ — for one of the most genuinely nerdy, genuinely exciting conversations about building a brand that didn't exist before. Jon helped launch Ketone-IQ early on and didn't invest. He'll tell you that himself. This is the conversation where he probably fully processes that decision.Ketones aren't a trend. They're a nutritional primitive — a new macronutrient. The kind of thing you can't speed-run. And Michael Brandt is the rare founder who built his entire business philosophy around that truth.The category is coming. They just got here first.In this episode:• Why creating a new category is a decade-long bet — and why that's exactly the right bet if you want to build something fundamental instead of fast• How Ketone-IQ went from a $6M DoD contract and $30-a-shot margins to nationwide grocery stores and a near-half-billion-dollar valuation• What Jon and Michael actually talk about when they talk about celebrity deals, brand equity, and why the brands nobody can name are the real cautionary taleFind Michael & Ketone-IQ:• Michael on Instagram: https://www.instagram.com/michaeldbrandt/• Ketone-IQ: https://ketone.com• Ketone-IQ on IG:https://www.instagram.com/ketone/Timestamps:0:00 - Building a New Category From Scratch: Why It's Harder (and Bigger) Than Anything Else1:18 - How Ketone IQ Started: Oxford, the Military, and $30-a-Shot Pro Athletes4:01 - What Ketones Actually Do and Why Michael Got Obsessed7:08 - The DoD Relationship: Research, Procurement, and On-Base Retail8:02 - The Early Positioning Problem: Ketones ≠ the Keto Diet10:22 - Why Sampling Is Everything for a Product You Actually Feel13:36 - Jon Bier's Regret: Why He Didn't Invest (And Why the Odds Were Against It)15:18 - How Marathon Running Gave Michael the Belief to Do the Impossible21:25 - The First Sign of Real Momentum: People Who Tried It Couldn't Stop23:17 - "We're Not Selling Ketones — We're Selling a Feeling"25:03 - Grün, Element, and How to Win Without a Product People Can Feel29:27 - Trend Proof vs. Trend Dependent: Why Ketones Are a Nutritional Primitive32:43 - How Jon Bier Spots Winners (And Why Most Brands Fail Because They're Too Early)35:26 - How to Cannibalize Yourself Before a Competitor Does39:10 - The Jake Paul and Jeff Wu Connection (and the Antifund Story)41:43 - What the Rogan Partnership Actually Means for a Brand45:40 - Why DTC Alone Is Dead and Retail Is the Startup Within the Startup49:08 - Why the Brands That Won DTC Stopped Innovating53:26 - How Celebrity Ambassadors Unlock Retail Doors56:03 - What Retailers Actually Want to Hear (It's Not About the Product)1:00:07 - Why Big Companies Destroy the Brands They Buy1:02:50 - Where Ketone IQ Is Now and What the Exit Math Looks Like1:05:10 - What Michael Would Actually Do With the Money