AJT Highlights

Description:  Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the November issue of the American Journal of Transplantation. [4:03] Kidney safety net utilization after liver transplant for acute alcohol-associated hepatitis [12:03] Improving diagnostic performance of kidney allograft rejection with a model combining relative fraction and absolute copies of donor-derived cell-free DNA—Results from 5 independent cohorts [19:29] Discovery of endothelial cell antibodies associated with pediatric and adult kidney allograft rejection and assessment of a non-human leukocyte antigen antibody assay [29:01] Urinary single-cell transcriptomics in kidney transplantation: Elucidation of donor-recipient cellular dynamics and fibrogenic stress [37:44] Myeloid-avid mammalian target of rapamycin-inhibiting nanobiologic attenuates allograft fibrosis after lung transplantation

Description: In this specialty podcast, Dr. Sanchez-Fueyo is joined by Dr. Marco A. Olivera-Martinez, Professor at the University of Nebraska Medical Center, for a Spanish-language discussion of an AJT research article and its accompanying editorial examining structural disparities in deceased donor kidney transplantation in Mexico. References Structural disparities in deceased donor kidney transplantation: A nationwide analysis of Mexico’s decentralized organ distribution and allocation system Dying on the waitlist: Mexico’s kidney allocation system as a public health scandal

Description:  Hosts Roz and Dr. Sanchez-Fueyo are joined by Chia-Yu Chiu to discuss the key articles of the October issue of the American Journal of Transplantation. Chia-Yu Chiu is an Assistant Professor of Infectious Disease at the University of Colorado. [3:09] Normothermic regional perfusion in kidney transplants with donors after controlled circulatory death: Functional benefits and safety in older recipients [12:42] Structural disparities in deceased donor kidney transplantation: A nationwide analysis of Mexico’s decentralized organ distribution and allocation system [24:14] Contribution of donor hospital characteristics to deceased donor organ recovery rates [33:20] Effectiveness of respiratory syncytial virus vaccination in solid organ transplant recipients in the United States [44:22] Donor macrophage depletion permits posttransplant tolerance induction in a murine islet transplant model

AJT September 2026 Editors’ Picks Description:  Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the September issue of the American Journal of Transplantation. [2:55] A remote intervention to improve medication nonadherence guided by a marker of risk derived from the electronic health records of adolescent transplant recipients [15:02] On the relative relevance of donor-derived cell-free DNA and urinary chemokines as noninvasive biomarkers for the diagnosis of kidney allograft rejection [28:49] Pre- and post-kidney transplant gnathostomiasis: Clinical manifestations, treatment, and outcomes [34:50] Metabolomic atlas of ischemia-reperfusion injury in human lung transplants: Mitochondrial stress and primary graft dysfunction

Description:  Hosts Roz and Dr. Sanchez-Fueyo are joined by Alessia Giarraputo to discuss the key articles of the August issue of the American Journal of Transplantation. Alessia Giarraputo is a postdoc research fellow at Mass General Hospital and Harvard Medical School [3:38] Donor-reactive clonotypes are overrepresented in the urinary T cell repertoire during kidney transplant rejection and show distinct dynamics in the circulation [13:57] Organ-specific differences in the epidemiology of cytomegalovirus infections in high-risk (cytomegalovirus donor seropositive, recipient seronegative) solid organ transplant recipients with prolonged follow-up: A 10-year experience [22:17] Immune checkpoint inhibitors after liver transplantation: The role of immunosuppressive management [28:34] Expert consensus on the use of immune checkpoint inhibitors in the liver transplant setting: Guidance from the Liver Transplant Committee of the Italian Association for the Study of the Liver (AISF) [33:50] Outcomes of kidney transplants from pediatric donors with acute kidney injury

Description:  Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the July issue of the American Journal of Transplantation. [3:52] Simultaneous quantification of native human and transgenic porcine liver function in a decedent model of extracorporeal cross-circulation [12:11] Pathologic evaluation of pig kidney and heart xenografts: 2024 recommendations from the Banff Xenotransplantation Pathology Working Group [13:36] The use of a centralized normothermic preservation and assessment center to rescue kidneys declined after standard allocation [25:57] Machine perfusion modulates cold-preservation injury in kidney transplantation: IDEAL stage 4 United States population cohort study [37:05] Impaired thymic function is independently associated with an increased risk of posttransplant infections in kidney recipients

Description:  Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the June issue of the American Journal of Transplantation. [3:32] MHC Matchmaker: An in silico based algorithm to analyze cross-species NHP, pig, and human MHC compatibility on the amino acid level [11:50] Wisdom of the Crowd: Ensuring the justness and validity of group decision-making in solid organ transplant [16:39] Inhibition of cytomegalovirus reactivation by ex vivo treatment of human kidneys with the SYN002 immunotoxin [22:20] There is nothing equitable about a wasted organ; eliminating out-of-sequence allocation for 30 days decreases utilization of hard-to-place kidneys

Description:  Hosts Roz and Dr. Sanchez-Fueyo are joined by Somaya Zahran to discuss the key articles of the May issue of the American Journal of Transplantation. Somaya Zahran is a transplant nephrology fellow at the Mayo Clinic in Rochester. [03:06] Sensitization in organ transplantation: Assessment of Risk (STAR) 2025 meeting group report [08:55] The Banff 2024 Kidney Meeting Report: Rejection as a spectrum of phenotypes and focus on differential diagnostic reasoning [22:17] Normothermic versus hypothermic machine perfusion in kidney transplantation: A randomized controlled trial [27:36] Gene-edited pig cardiac xenotransplantation as a bridge to allotransplantation in infants: Progress in a pig-to-baboon model

AJT April 2026 Editors’ Picks Description:  Hosts Roz and Dr. Sanchez-Fueyo are joined by Cesar Berto to discuss the key articles of the April issue of the American Journal of Transplantation. Dr. Cesar Berto is an Assistant Professor at the University of Alabama, Birmingham, in the Division of Infectious Diseases [03:28] Invasive mold infection in heart transplant recipients: A nationwide multicenter matched case–control study between 2008 and 2022 in France [08:50] Pharmacokinetics, lineage identity, and trafficking of ex vivo expanded polyclonal regulatory T cells in a prospective randomized clinical trial of kidney transplant recipients with allograft inflammation [20:55] Transmembrane protein 16F-chloride intracellular channel 1 interaction mediates recipient dendritic cell cross-decoration after transplantation [31:27] Dual costimulation blockade with the CD154-specific fusion protein dazodalibep and belatacept for prophylaxis of kidney allograft rejection [43:52] Costimulatory blockade and infectious risk in solid organ transplantation

In this specialty podcast, Dr. Justin Barr is joined by Dr. Thomas Schlich and Dr. Susan Lederer to discuss the early history of transplant surgery, with Dr. Schlich focusing on the mostly European efforts inaugurating solid organ transplant between 1880 and 1910 whilst Dr. Lederer concentrates on skin, blood, and corneal transplants in early 20th century America.    Justin Barr practices abdominal transplant and advanced hepatobiliary surgery at the Ochsner Clinic Thomas Schlich is the James McGill Professor and Department Chair at McGill University Susan E. Lederer is the Ronald Numbers Professor of History of Medicine and Bioethics at the University of Wisconsin–Madison References: The Origins of Organ Transplantation Flesh and Blood: Organ Transplantation and Blood Transfusion in Twentieth-Century America