Theory & Application of CAR-T Therapy

By now, you likely have heard about CAR-T Cell therapy, but what exactly is it? Today, we dive headlong into this topic with Dr. Max Konig. We cover how this therapy works, how CAR-T Cells are made and administered to patients. We discuss the risks associated with this type of therapy, the side effects and their management. Lastly, we’ll discuss the rheumatic diseases amenable to CAR-T therapy, those that are not, the costs and ethics involved and what the future may hold for it in rheumatology. Enjoy! 

Internationally renowned Lyme Disease clinician and researcher, Dr. Allen Steere, joins us for a discussion on Lyme Arthritis. Dr. Steere explains the history of this disease, the historical identification of the borrelia spirochete which causes it, how Lyme Arthritis manifests and presents (including why severity can be vary greatly in patients) and explore the current challenges in its diagnosis. We also cover treatment and antibiotic therapies for the disease, what post-treatment syndromes are, how to treat them and how understanding Lyme Arthritis has improved our knowledge of other diseases, such as rheumatoid arthritis.  

Expert researcher and clinician, Dr. Elana Bernstein, is our guest this week as we dive into lung disease brought on by Systemic Sclerosis (SS). We discuss symptoms, diagnosis, how systemic sclerosis affects the lungs, including pulmonary hypertension and interstitial lung disease. Dr. Bernstein, who has dedicated her career to improving patient outcomes in systemic sclerosis, explains her approach to screening for lung disease, plus the latest research and questions that need to be answered. 

This week, Dr. Hausmann takes on Ultrasound in Rheumatology, exploring its use in the field and diagnosing diseases such as Inflammatory Arthritis, Crystaline Arthropathy and Vasculitis. Dr. Minna Kohler, Founder and Director of the Musculoskeletal Ultrasound Program at Massachusetts General Hospital, joins us as our guest. Dr. Kohler discusses how Ultrasound can help therapeutically, what it's like working in an MSK Ultrasound clinic, plus how one can become trained in the use of Ultrasound, what the patient experience is like, the controversies surrounding the use of Ultrasound in rheumatology and what the future holds for it in our field. 

Join us this week as Jon meets with a truly influential woman in the medical field, Dr. Elizabeth Ang, being one of the first pediatric rheumatologists in the Southeast Asian region to receive pediatric rheumatology training and is the Co-Convenor of the Paediatric Rheumatology Special Interest Group of APLAR (Asia Pacific League of Associations for Rheumatology). Beyond this, and so that children with rheumatic disease in the region have the opportunity to be diagnosed and treated, Dr. Ang trains local doctors and shares her knowledge and experience with them in Cambodia, Vietnam, Indonesia and Myanmar. In this episode she and Dr. Hausmann discuss Singapore’s healthcare system, access to biologics, cultural barriers to treatment and much, much more. 

Bone health may not be first on the mind when discussing rheumatology, however, Dr. Marcy Bolster believes it plays a vital role in caring for ‘the whole patient’. As such, Dr. Bolster’s innovative contributions to the field of Osteoporosis cannot be overstated. She joins us today to discuss the role of the rheumatologist in helping to prevent or treat Osteoporosis, how often it’s under-recognized, plus the services she created to help identify, diagnose and treat the condition among patients.  

When a patient is diagnosed with cancer, treatments that force the immune system into overdrive are given in hopes that it will recognize the cancer and destroy it. Unfortunately, this can mean that various Immune Related Adverse Events (IRAEs) can occur. In rheumatology, our treatments are meant to tame an overactive immune system, creating a unique dilemma. Joining us today is Dr. Laura Cappelli, MD, MHS. Dr. Cappelli explains what these IRAEs really are, how they commonly occur, what risk factors exist in their development, the importance of a multidisciplinary approach to treatment and much, much more. 

April is just around the corner, and so is 2024’s State-of-the-Art Clinical Symposium (SOTA)! This week, we welcome Dr. Sobia Hassan, Chair of the SOTA Planning Committee and Dr. Ibtissam Gad, Chair of the Fellows in Training subcommittee. We discuss the topics and speakers chosen for SOTA and how they were selected, some highlights including discussions on CAR T Cells, CPPD, and Check Point Inhibitors, what’s in store for our Fellows in Training and how you, our listeners, can get involved! If you’ve not yet registered, be sure to visit the ACR’s registration page for all the details you’ll need to plan your trip here: State-of-the-Art Clinical Symposium

Join us this week for an insightful and encouraging discussion with Drs. Mandal and Grant, the founders of The Rheumatology Access Expansion Initiative (RAE). RAE is a project designed to support the Navajo Nation, an underserved community with respect to rheumatic disease. Our guests explain how leveraging the established educational model, Extension for Community Healthcare Outcomes (ECHO), was used to remotely train PCPs among the Navajo in the diagnosis and evidence-based treatment of rheumatoid arthritis (RA). 

Kicking off a new series in conjunction with ARP, we’re spending time with professionals in the field of rheumatology that can, and do, much for our patients. Today, our focus centers on The Occupational Therapist. But how much do we know of our colleagues and their contributions toward our patients? What does an occupational therapist do, with our referrals in hand? We caught up with the founder of Arthritis Life and host of the Arthritis Life Podcast, Cheryl Crow, to answer that question and much more. Cheryl explains to us what happens at an OT visit, what sorts of patients should see an OT, how to manage pain from exercise as well as sharing with us her favorite life hacks and her own personal journey from patient to advocate.