Genes and Your Health Edition | Antisense Oligonucleotide (ASO) Therapeutics for Rare Genetic Disease

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guest: Regis I. Fernandes, M.D. Inflammation commonly occurs as a response to injury or infection but can lead to damage when it develops in healthy tissue. It’s now known that inflammation plays a key role in the development of cardiovascular disease. It produces damage to the endovascular arterial cells allowing plaque to form within the artery leading to stenosis, thereby reducing coronary blood flow. What initiates the inflammatory response as it develops in otherwise healthy arteries? How should we use the hs-CRP in measuring inflammation in cardiovascular disease? Does our management of cardiovascular disease result in a decrease in hs-CRP? These are some of the questions I’ll be asking my guest, Regis I. Fernandes, M.D., a preventive cardiologist from the Mayo Clinic as we discuss “hs-CRP and Cardiovascular Disease”. These talks on Inflammation and Cardiometabolic Disease are sponsored by Novo Nordisk Learn more about this series HERE Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guest: Vinaya Simha, M.B.B.S., M.D. Type 2 Diabetes is a commonly seen condition in a general medical practice. It’s estimated that over 38 million adults have the disease. When we think of diabetes, we think of a metabolic condition with patients who have hyperglycemia, often overweight, and occasionally have renal, eye and/or neurologic complications. But, do we ever think of diabetes as an inflammatory disease? How is inflammation associated with diabetes? What are the mediators of inflammation in diabetics and when we treat diabetes, are we reducing the associated inflammation in addition to lowering blood glucose? These are questions I’ll be asking our guest, Vinaya Simha, M.B.B.S., M.D., from the Division of Endocrinology and Metabolic Disease at the Mayo Clinic as we discuss “Type 2 Diabetes as an Inflammatory Disease”. These talks on Inflammation and Cardiometabolic Disease are sponsored by Novo Nordisk Learn more about this series HERE Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guest: Atul Jain, M.D., M.S. Cardiovascular disease is the leading cause of death for both men and women and it’s responsible for 1 in every 5 deaths. It’s estimated to cost over $250 billion a year, which includes the cost of medical services, medications and lost productivity. Patients with cardiovascular disease are commonly seen in a general medical practice and since it’s such a common health problem, we’re all pretty comfortable managing these patients. But do we know what’s happening pathologically? What’s the role of cholesterol and inflammation in cardiovascular disease?  What causes the inflammation? How do we measure it and most importantly, can we do anything about it? I’ll be asking these questions of our guest, internist Atul Jain, M.D., M.S., from the Division of General Internal Medicine at the Mayo Clinic as we discuss the interplay between cholesterol, inflammation and thrombosis in cardiovascular disease. These talks on Inflammation and Cardiometabolic Disease are sponsored by Novo Nordisk Learn more about this series HERE Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guest: Joselyn R. Lebow, Ph.D., L.P. Unfortunately, mental health problems are common in our youth. A recent study by the CDC found that among adolescents aged 12 to 17, just under 21% had experienced a major depressive episode within the past year. Among high school students, more than 35% reported feeling sad or hopeless, with nearly 20% seriously contemplating suicide and mental health disorders are not limited to our teens. Over 17% of children aged 2 through 8 have had a diagnosis of a mental, behavioral or developmental disorder. Are mental health disorders in our youth increasing? How might depression present in a child or adolescent? How common is suicide in our youth and how often are suicide attempts successful? I’ll be asking these questions and more to my guest in today’s podcast on “Pediatric Mental Health Disorders” as part of our “Back to School” podcast series. My guest is child psychologist Joselyn R. Lebow, Ph.D., L.P., from the Mayo Clinic. To learn more about this series, check it out HERE Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guest: Erick D. Bothun, M.D. It’s estimated that more than 1 in 20 preschool-age children and 1 in 4 school-age children have a vision disorder. Since the eyes are the source of sensory input for much of the learning that takes place in our children, these statistics take on real importance. Vision problems in childhood can result in developmental delays and are often misdiagnosed as learning disabilities. As adults, we’re aware of changes and problems with our vision. Children who have never known clear vision may not realize their vision is impaired. What are the most common eye disorders in children? How many of our pre-school children are receiving vision screening? What are common signs a child may have a vision impairment? These are just some of the questions I’ll asking my guest, Erick D. Bothun, M.D., from the Department of Ophthalmology at the Mayo Clinic. As part of our “Back to School” Series, we’ll be discussing “Pediatric and Adolescent Ophthalmologic Concerns”. To learn more about this series, check it out HERE Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guest: Julie M. Baughn, M.D. Sleep is very important for a child’s physical and mental health and plays a vital role in the development of cognitive and motor skills.  The American Academy of Pediatrics estimates that up to 50% of children and 40% of adolescents have problems with their sleep, which may manifest as issues in school, mood disorders as well as relationship problems with others. What kind of sleep problems do children and adolescents commonly experience? When should we suspect impaired sleep is causing problems and do children and adolescents have some of the same sleep disorders as adults? I’ll be asking these questions and more as we explore “Pediatric and Adolescent Sleep Medicine” as part of our “Back to School” series of podcasts. My guest is Julie M. Baughn, M.D., a pulmonologist and sleep specialist at the Mayo Clinic. To learn more about this series, check it out HERE Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guests: Sahil Khanna, M.B.B.S., M.S., and Sherief Shawki, M.B., B.Ch., M.D. Diverticulosis is quite common. Its prevalence varies with age from fewer than 20% at age 40 to 60% by age 60. It's far more common in the left colon and tends to be progressive with both the number and size of the diverticula, both increasing with age. There are potential complications of diverticulosis, with diverticulitis being most common. This also tends to increase in prevalence with age and appears to be increasing with time. Can diverticulitis be prevented? What’s the best way to manage a patient with acute diverticulitis and when is surgery indicated? I’ll be asking these questions and more to my guests, Sahil Khanna, M.B.B.S., M.S., from the Division of Gastroenterology and Hepatology and Sherief Shawki, M.B., B.Ch., M.D., from the Division of Colorectal Surgery at the Mayo Clinic. The topic for this podcast is diverticular disease. Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guest: David B. Soma, M.D. Participation in sports in children and adolescents is extremely common and its popularity is increasing. Although sports play an important role in promoting health and developing interpersonal relationships, its estimated that injuries related to playing sports is quite common, especially musculoskeletal injuries. The literature describes prevalence rates ranging from 34 to 65%. This leads to lost school days and significant health care costs. Which sports carry the greatest risk of injury? Are there any differences in injuries in girls vs. boys? Can sports injuries be prevented and are the benefits of participation in sports worth the risk of serious injury? We’ll discuss these issues and more as part of our “Back to School” podcast series. The topic for this podcast is “Pediatric and Adolescent Sports Injuries” and my guest is David B. Soma, M.D., from the Department of Pediatric and Adolescent Medicine at the Mayo Clinic. To learn more about this series, check it out HERE Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Brought to you by: Mayo Clinic Talks Host: Nicole Nfonoyim-Hara Guests: Semirra L. Bayan, M.D., and Katie M. Van Abel, M.D. On this episode of the RISE for Equity podcast, host Nicole Nfonoyim-Hara is joined by Semirra L. Bayan, M.D., and Katie M. Van Abel, M.D., to discuss diversifying the physician workforce. Dr. Van Abel and Dr. Bayan share about the important role of pathway programs to lift up marginalized and underserved communities, and innovative strategies for cultivating diversity, equity, and inclusion in medical training and careers.   Learn more at https://mcpress.mayoclinic.org/rise-for-equity/    Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.    “Equity is about pulling up more chairs at a table.  There's just more chairs at the table. We're not taking chairs away from other people. And the importance of lifting everybody up and creating community truly makes all of us better people.” – Dr. Bayan “One thought has been really important for me throughout this process, and that is to remain curious; to not just assume you know everything about a problem, to learn as we go, and to allow the people that we're working with to teach us so that we can do better for the next group of students or individuals.”  -Dr. Van Abel

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guest: Angela C. Mattke, M.D. Providing good nutrition and developing healthy eating habits is extremely important for our children. It sets a pattern and can impact their health throughout their adult life. However, this goal has many challenges. Parents must battle effective media marketing for unhealthy foods, deal with ever available and convenient fast-food options and struggle with time constraints in their busy families. How healthy are the diets of our children? How can parents manage their own busy schedules and still prepare healthy meals and what’s our role as health care clinicians in promoting healthy nutrition in our children. This podcast in our “Back to School” series will focus on these questions as we discuss “Pediatric and Adolescent Diet and Nutrition”. My guest is Angela C. Mattke, M.D., a pediatrician from the Division of Community Pediatrics and Adolescent Medicine at the Mayo Clinic. To learn more about this series, check it out HERE Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.