Ep.2. CRISPRi in the fission yeast – A Discussion with Dr. Ken Ishikawa

In this episode of Genetics in Your World, Sarah Renee Phillips interviews Dr. Christina Cuomo about her paper "Impact of pathogen genetics on clinical phenotypes in a population of Talaromyces marneffei from Vietnam," published in the August 2023 issue of GENETICS. Dr. Cuomo elaborates on the diversity and evolution of a deadly fungal pathogen from southeast Asia and how she and her colleagues used a combination of population genomics and genome-wide association studies to identify evolutionary pattern and process as well as genes influencing patient experiences and health outcomes. Hosted on Acast. See acast.com/privacy for more information.

In this installment of Genetics in Your World, we talk to Dr. Hunter Hill of the University of Montana. He discusses unexpected recent discoveries made while completing his PhD with Dr. Kent Golic at the University of Utah, surrounding new and exciting data about the breakage pattern of chromosomes in Drosophila. He provides advice for others when encountering obstacles during their graduate studies. Check out the paper, "Dicentric chromosome breakage in Drosophila melanogaster is influenced by pericentric heterochromatic and occurs in non-conserved hotspots," published in the June 2023 issue of GENETICS. Hosted on Acast. See acast.com/privacy for more information.

In this installment of Genetics in Your World, we talk to Ting Gong of UC Davis. She discusses the surprising results she found when disrupting meiotic chromosome segregation in C. elegans. Hosted on Acast. See acast.com/privacy for more information.

Join us for a special episode of Genetics in Your World where we interview previous National Institutes of Health (NIH) director Dr. Francis Collins. In this episode, Francis discusses his pathway into science, how he deals with failures in research, and his advice for future scientists. Hosted on Acast. See acast.com/privacy for more information.

“What do penicillin, saccharine, post-it notes, and x-ray machines have in common? They were all the outcome of happy accidents in the laboratory. Listen to Genetics in Your World: Episode 5 to find out how a bad day in the laboratory of Dr. Thomas Merritt turned treasure gold.” Hosted on Acast. See acast.com/privacy for more information.

A new role model for genetics? Tune into this latest episode of Genetics in Your World podcast where Dr. Cao from Caltech shares her team’s development of a new genetically tractable model system in the #nematode Steinernema hermaphroditum! Hosted on Acast. See acast.com/privacy for more information.

A MAP for growth?🙂 Listen to the latest Genetics in your world podcast episode where Dr. King tells us how she developed novel tools to better understand the unreported roles of MT-associated proteins within the nucleus of budding yeast. Hosted on Acast. See acast.com/privacy for more information.

Gene repression with the efficiency and specificity of CRISPR in yeast is no longer a dream! In this episode of Genetics in your world, Dr. Ishikawa tells us about how he and colleagues adapted CRISPR interference for fission yeast, allowing controllable reversible and efficient transcriptional repression. Check out the paper,— “Implementation of dCas9-mediated CRISPRi in the fission yeast Schizosaccharomyces pombe,”—that was published in the February 2021 issue of G3. Hosted on Acast. See acast.com/privacy for more information.

In this episode of Genetics in your world, we speak with Dr. Richard Gomulkiewicz about the evolution of gene drive resistance. With the discovery of CRISPR-Cas systems, scientists realized that they could engineer gene drives for a number of different applications. Using alleles with an “unfair” transmission advantage, we can design gene drives to help eradicate malaria vectors, agricultural pests, or even invasive species. Check out the paper, “Evading resistance to gene drives,”which was published in the February 2021 issue of GENETICS. Hosted on Acast. See acast.com/privacy for more information.

Make sure to check out this paper—Sperm fate is promoted by the mir-44 microRNA family in the Caenorhabditis elegans hermaphrodite germline—that was published in Genetics in Jan 2021. Hosted on Acast. See acast.com/privacy for more information.