Optimizing ART With Novel HIV Agents

In this episode, Alexander Wong, MD, FRCPC, discusses how to optimize treatment and engagement in care for individuals with HIV and substance use disorder, including: Barriers to care for persons with substance use disorder Colocating HIV and other services (eg, addiction care medicine, social services) Leveraging a multidisciplinary approach to care Integrating a low-barrier model to foster an environment of open discussion Best practices for opioid agonist therapy implementationConsiderations for cultural dynamics to provide personalized treatment plansImportance of supporting his team members PresenterAlexander Wong, MD, FRCPCAssociate ProfessorDivision of Infectious DiseasesDepartment of MedicineUniversity of SaskatchewanRegina, Saskatchewan, Canada Link to full program:https://bit.ly/3xicSeFGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

In this episode, Jennifer Cocohoba, PharmD, AAHIVP, and David Koren, PharmD, MPH, AAHIVP, FIDSA, cover the most impactful LA ART and LA PrEP clinical studies presented at AIDS 2024, including:The PURPOSE 1 study of twice-yearly lenacapavir injections vs daily oral tenofovir as PrEP in cisgender womenAn open-label extension of HPTN 084 evaluating LA CAB safety during pregnancy48-week data from the IMPAACT 2017/MOCHA study of LA CAB + RPV in adolescents with HIVA substudy of FLAIR evaluating the efficacy, safety, and tolerability of SC self-administration of LA CAB + RPV Presenters:Jennifer Cocohoba, PharmD, AAHIVPProfessor of Clinical PharmacyDepartment of Clinical PharmacyUniversity of California San Francisco School of PharmacySan Francisco, CaliforniaDavid Koren, PharmD, MPH, AAHIVP, FIDSAAdjunct Clinical ProfessorTemple University School of PharmacyClinical Pharmacist SpecialistTemple University Health SystemPhiladelphia, PennsylvaniaTo access all of our new podcast episodes, subscribe to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.  See the full program here.

In this episode, Tristan J. Barber, MA, MD, FRCP, and Glenn J. Treisman, MD, PhD, discuss the importance of screening, diagnosing, and treating PTSD in people with HIV. They illustrate their discussion through a patient case and provide strategies for accomplishing this, sharing their own experiences and approaches to thinking about PTSD, structuring appointments, and integrating care. Presenters:Tristan J. Barber, MA, MD, FRCPConsultant in HIV MedicineRoyal Free London NHS Foundation TrustHonorary Associate ProfessorInstitute for Global HealthUniversity College LondonLondon, United KingdomGlenn J. Treisman, MD, PhDEugene Meyer III Professor of Psychiatry and MedicineJohns Hopkins University School of MedicineBaltimore, MarylandDownloadable slides:https://bit.ly/4dBu929Program:https://bit.ly/3WB2VCO

In this episode, Colleen F. Kelley, MD, MPH, and Jemma Samitpol discuss key considerations to improve the patient experience among transgender persons with HIV, including: Unique circumstances faced by transgender people trying to access HIV care (eg, stigma, discrimination)Best practices to improve access and linkage to HIV careWays to integrate gender-affirming care into HIV careCreating a welcoming and inclusive environmentOffering same-day HIV treatmentAddressing potential drug–drug interactions with gender-affirming hormone therapy (GAHT), including ART and natural remediesUnderstanding and communicating expectations of GAHT (eg, treatment response, timing of effects)Providing information on the safety of gender-affirming surgeriesImportance of providing person-centered care (eg, mental health, substance abuse, housing, harm reduction)Strategies on how to promote a gender-affirming environment (eg, wearing pronoun buttons, staff training)Consequences to the lack of gender recognition lawsHow to “be an ally” for transgender people with HIVPresentersColleen F. Kelley, MD, MPHProfessor of MedicineDivision of Infectious DiseasesDepartment of MedicineCo-Director, Emory Center for AIDS ResearchAssociated Dean for Research, Emory at GradyEmory University School of MedicineAtlanta, GeorgiaKritima Jemma SamitpolTangerine Clinic SupervisorInstitute of HIV Research and InnovationBangkok, ThailandGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast channel on Apple Podcasts, Google Podcasts, or Spotify.

In this episode featuring faculty from the United States and Europe, Aadia I. Rana, MD, and Laurence Slama, MD, PhD, discuss the subtleties of deciding among HIV treatment options in people with adherence challenges.Listen as they debate the potential risks and benefits of long-acting ART in this population, considerations for people with viremia or resistance, recommendations concerning proviral DNA genotyping, and how to interpret guidelines and provide truly patient-centered care. PresentersAadia I. Rana, MD​Professor of Medicine​Division of Infectious Diseases​University of Alabama at Birmingham Heersink School of Medicine​Birmingham, AlabamaLaurence Slama, MD, PhD​Doctor​Department of Infectious Diseases​Hôtel Dieu University Hospital​University Paris Cité​Paris, FranceFollow along with the slides here.See the full program here.Get access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast channel on Apple Podcasts, Google Podcasts, or Spotify.

In this episode, Gregory Huhn, MD, MPHTM, presents a case study of a person with a long HIV treatment history, exploring when and how to consider agents with novel mechanisms of action.Listen as he discusses:The importance of engaging with patients to understand their perspectives and improve their satisfaction with their HIV careOptions in people with multiclass resistanceStudies of agents with novel mechanisms of action:BRIGHTE (fostemsavir)TMB-301/-311 (ibalizumab)CAPELLA (lenacapavir) Faculty​​Gregory Huhn, MD, MPHTM,Interim Chief, Division of Infectious DiseasesSenior Director of HIV ServicesCook County HIV Integrated ProgramsInterim Medical Director, The RMR CORE CenterProfessor, Division of Infectious DiseasesRush University Medical CenterChicago, IllinoisFollow along with the slides.https://bit.ly/4fHmxg5Get access to all of our new podcast episodes. Subscribe to the CCO Infectious Disease podcast on Apple Podcasts, Google Podcasts, or Spotify.    

In this episode, Yvonne Gilleece, MB BCh, BAO, FRCP, uses a case study to illustrate why giving people space and time to engage in HIV care on their terms is key to overcoming potential shame and stigma.She discusses how people can be very vulnerable when engaging in HIV care, and trauma-informed care can help address these vulnerabilities in a safe, respectful way. Listen as she gives her perspectives on:Trauma-informed careOvercoming stigma and shameStaying in care Presenter:Yvonne Gilleece, MB BCh, BAO, FRCPHonorary Clinical Professor and Consultant in HIV Medicine & Sexual HealthBrighton & Sussex Medical School and University Hospitals Sussex NHS Foundation TrustChair of the British HIV AssociationLead for HIV & WomenLead for HIV & HepatitisBrighton, United KingdomContent based on an online CME program supported by an educational grant from Gilead Sciences, Inc.Link to full program:https://bit.ly/3xicSeFGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

In this episode, George Lau, MD, FRCP (Edin, Lond), FHKAM (Med), FHKCP, FAASLD, MBBS (HKU), and a patient discuss opportunities to optimize care for people living with hepatitis B virus (HBV), including: Consequences to poor adherence to antiviral therapyStrategies to promote medication adherence (eg, patient education, setting up routines)The role of routine monitoring to prevent complications related to HBV such as hepatocellular carcinoma  Presenter: George Lau, MD, FRCP (Edin, Lond), FHKAM (Med), FHKCP, FAASLD, MBBS (HKU)Specialist in Gastroenterology & HepatologyChairman and Senior Consultant in Gastroenterology and HepatologyHumanity and Health Medical GroupHong Kong, ChinaContent based on an online CME program supported by an independent educational grant from Gilead Sciences, Inc.Link to full program: https://bit.ly/49TuZ8UGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

In this episode, Gregory Huhn, MD, presents a case study exploring how to optimize oral ART for a person with a long history of different ART regimens.Listen as he discusses:Reasons to consider regimen optimization in the setting of viral suppressionEvidence for INSTIs in the setting of resistanceData on when 2-drug regimens and long-acting regimens may or may not be good optionsFaculty​Gregory Huhn, MDInterim Chief, Division of Infectious DiseasesSenior Director of HIV ServicesCook County HIV Integrated ProgramsInterim Medical Director, The RMR CORE CenterProfessor, Division of Infectious DiseasesRush University Medical CenterChicago, ILFollow along with the slides. https://bit.ly/4fHmxg5Get access to all of our new podcast episodes, subscribe to the CCO Infectious Disease podcast on Apple Podcasts, Google Podcasts, or Spotify.

In this episode, Lucas Hill, PharmD, AAHIVP, BCACP, and Bernadette Jakeman, PharmD, PhC, BCPS, AAHIVP,discuss what pharmacists need to know to provide high-quality HIV care beyond viral suppression, including treatment strategies and tips for addressing and improving patients’ quality of life.Listen as they discuss:Reasons to consider regimen optimization in the setting of viral suppressionEvidence that LA ART may reduce internalized stigma​DHHS recommendations on proviral DNA genotyping​ FacultyLucas Hill, PharmD, AAHIVP, BCACP​HIV Pharmacist Specialist​UC San Diego Owen Clinic​Assistant Clinical Professor​UC San Diego Skaggs School of Pharmacy​San Diego, CaliforniaBernadette Jakeman, PharmD, PhC, BCPS, AAHIVP​|Associate Clinical Professor​Department of Pharmacy Practice and Administrative Sciences​University of New Mexico College of Pharmacy​Albuquerque, New Mexico