How a new kind of drug could change the future of Alzheimer’s

In the last few years, artificial intelligence has gone from a novelty to perhaps the most influential technology we’ve ever seen. The people building AI are convinced that it will eradicate disease, turbocharge productivity, and solve climate change. It feels like we’re on the cusp of a profound societal transformation. Fifteen years ago, there was a similar wave of optimism around social media: it was going to connect the world, catalyze social movements and spur innovation. It may have done some of these things. But it also made us lonelier, angrier, and occasionally detached from reality.Few people understand this trajectory better than Maria Ressa. Ressa is a Filipino journalist, and the CEO of a news organization called Rappler. Like many people, she was once a fervent believer in the power of social media. Then she saw how it could be abused. In 2016, she reported on how Rodrigo Duterte, then president of the Philippines, had weaponized Facebook in the election he’d just won. After publishing those stories, Ressa became a target herself, and her inbox was flooded with death threats. In 2021, she won the Nobel Peace Prize.As novel as AI is, it has undoubtedly been shaped by the technologies, the business models, and the CEOs that came before it. And Ressa thinks we’re about to repeat the mistakes we made with social media all over again.

The celebrated Canadian author Alice Munro died on May 13. She was awarded the Nobel Prize for Literature in 2013 as a “master of the contemporary short story,” and the Man Booker International Prize in 2009.On today’s show, members of The Globe newsroom share their reflections on Alice Munro’s life and work, and columnist Marsha Lederman joins to talk about Munro’s impact and legacy.Questions? Comments? Ideas? Email us at [email protected]

As the U.S. election looms, Prime Minister Justin Trudeau’s team is getting ready for both possible outcomes: a Biden re-election and a second Trump term. They are assembling a team of officials to remind American politicians about the importance of free trade across our borders.Adrian Morrow is The Globe’s U.S. correspondent based in Washington, D.C., and he explains who is on this so-called Team Canada, and how their strategy works.Questions? Comments? Ideas? E-mail us at [email protected]

Hydrogen fuel is sometimes called the fuel of the future, and it’s being used in a number of ways around the world. The rail giant CPKC is trialling a new hydrogen train in Alberta, that it hopes can replace diesel-fuelled freight locomotives in delivering goods across the continent.The Globe’s Alberta and energy reporter, Kelly Cyderman, joins us to discuss hydrogen trains, how they work, and how this development might lead toward a greener Canada.Questions? Comments? Ideas? Email us at [email protected]

Canada is in the midst of a primary-care crisis. 6.5 million Canadians don’t have reliable access to a family doctor, and some jurisdictions are turning to nurse practitioners to fill the gap. Alberta recently announced a program that would make it possible for nurse practitioners to receive public funding to establish a practice, although it comes with its conditions and concerns from other organizations.The Globe’s national health reporter, Kelly Grant, walks us through the role nurse practitioners have in providing primary care, how they’re funded, and Alberta’s new plan to address the shortage of primary-care providers.Questions? Comments? Ideas? Email us at [email protected]

The housing affordability problem in Canada continues, and people are desperate for solutions. The federal government is handing out billions of dollars as part of the Apartment Construction Loan Program intending to create more affordable housing. But, a Globe analysis found a disconnect between what’s considered affordable in this program, and what renters can actually afford.The Globe’s real-estate reporter Rachelle Younglai explains why these units aren’t actually attainable to many Canadian renters and looks at the concerns with the program’s definition of affordability.Questions? Comments? Ideas? Email us at [email protected]

After more than a decade, the Trans Mountain pipeline expansion project (TMX) has finally been completed. One of the country’s biggest infrastructure projects is seen as a major win for Albertan oil producers, with nearly 600,000 extra barrels shipped daily, ready for international buyers.But the future ownership of the pipeline remains up in the air. Many of the issues and questions that delayed the project – concerns over its safety and the environment, fights over Indigenous land rights, long-term economic risks – remain.Jeffrey Jones, The Globe’s sustainable finance reporter, explains the ballooning costs of the TMX and why one of Canada’s top exports is creating tension with its future climate targets.Questions? Comments? Ideas? E-mail us at [email protected]

Tension is ratcheting up in the Gaza Strip as the Israeli military descends on the southern city of Rafah. This move has forced hundreds of thousands of Palestinians sheltering there to flee yet again. All of this has been happening this week against the backdrop of ceasefire negotiations between Hamas and the Israeli government and souring relations between Benjamin Netanyahu and U.S. President Joe Biden.The Globe’s Senior International Correspondent Mark MacKinnon brings us up to speed on the many developments, breaks down what happened in the ceasefire talks this week, and what this means for the people in Gaza and the remaining Israeli hostages.Questions? Comments? Ideas? E-mail us at [email protected]

TD Bank has been plagued by concerns about its anti-money-laundering capabilities for over a year. In March 2023, they tried to acquire the U.S. based bank First Horizon Corp. Regulatory issues delayed the acquisition, and in May 2023, the deal fell through.The extent of TD’s anti-money-laundering issues weren’t clear until now, when it’s revealed that TD is involved in a U.S. investigation of a US$653 million money-laundering and drug-trafficking operation. Tim Kiladze, financial reporter and columnist for the Globe, is on the show to talk about TD’s alleged lack of oversight and what this means for the bank – and its customers – going forward.Questions? Comments? Ideas? Email us at [email protected]

175 countries are in the midst of tense discussions around a UN treaty to reduce plastic pollution. The second-last negotiation session wrapped up in Ottawa last week, but there are still significant hurdles to getting it done, including disagreements about whether to include a production cap.Today, The Globe’s environment reporter Wendy Stueck joins to explain what this treaty could change, and how countries are thinking about how to balance our reliance on plastic with its effects on our environment.Questions? Comments? Ideas? Email us at [email protected]