Welcome to “ACR Journals on Air,” the ACR’s newest podcast series featuring interviews, commentary, and analysis on research from our three peer-reviewed journals. Join us each episode for engaging discussions with authors and independent experts about recently published studies, their implications for clinical care, and how they move the field of rheumatology forward. Whether it’s an expert analysis of a manuscript or deep dive with an author – our goal is the same – to understand the impact of the science and bring it from the bench to the bedside
Partnering For New Models of OA Care
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33:19Osteoarthritis is incredibly common, affecting more than 500 million people across the globe. It is a significant cause of pain and disability and carries high healthcare costs and societal burdens. Around the world, there are not enough rheumatology specialists to treat all the patients with OA, and in many countries, OA management is coordinated by primary care internists. However, despite good guidelines recommending first-line evidence-based treatments with muscle strengthening, physical activity, weight loss, and judicious medication management, there are many inconsistencies in OA care delivery. This week, we focus on the manuscript “Effectiveness of a New Service Delivery Model for Management of Knee Osteoarthritis in Primary Care: A Cluster Randomized Controlled Trial” and our guest is Dr. David Hunter, its first author.
A.I. Has Promise in RA
29:18In this week’s episode, we’ll be looking at a paper recently published in “ACR Open Rheumatology” titled: “Machine Learning Applied to Patient-Reported Outcomes to Classify Physician-Derived Measures of Rheumatoid Arthritis Disease Activity“. This study used machine learning tools to investigate whether longitudinal patient-reported outcome data can be a proxy for Clinical Disease Activity Index (CDAI), presenting interesting findings that may impact the practice of rheumatology. Our guest this week is the paper’s first author, Dr. Jeffrey Curtis. Dr. Curtis is the Marguerite Jones Harbert – Gene V. Ball Endowed Professor in Rheumatology and Immunology at the University of Alabama at Birmingham. He has many accolades to his name, including being a prior winner of the Henry Kunkel Young Investigator Award and being a member of the American Society for Clinical Investigation.
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Supporting International Graduates in Rheumatology
34:10This week, we welcome Dr. Ruth Fernandez Ruiz to our show, a physician-scientist and Assistant Professor of Medicine at Weill Cornell Medical College and Hospital for Special Surgery in New York City. Dr. Fernandez Ruiz’s award-winning work focuses on the interplay of genetic variation, type I interferons, and immune dysregulation in lupus. However, her latest study published in “Arthritis & Rheumatology” entitled: Supporting International Medical Graduates in Rheumatology: A Call to Action seeks to understand and draw attention to the challenges and barriers that prevent international medical graduates from coming to the U.S. and practicing medicine in the field of rheumatology.
Sleep Disorders Among Patients with Rheumatoid Arthritis
23:44Dr. Patricia Katz is our guest this week as she presents her latest study “Sleep Disorders among Individuals with Rheumatoid Arthritis”, recently published in “Arthritis Care & Research”. This study focuses on patients with RA who self-report common sleep problems such as obstructive sleep apnea, restless leg syndrome and short sleep and examines the prevalence of these disorders plus their potential negative health implications. Dr. Katz shares with us her methods, findings and conclusions as well as some career advice on writing an academic paper, what she finds most challenging about it, and what the editorial process looks like for “ACR Open Rheumatology” and what they look for while reviewing and editing manuscripts.
The TULIP Study, Three Years On
25:02In this episode, Dr. Shanmugam discusses “A Randomized, Placebo-controlled Phase 3 Extension Trial of Long-term Safety and Tolerability of Anifrolumab in Active Systemic Lupus Erythematosus”, a three-year long-term study designed to understand the safety of anifrolumab in patients with systemic lupus erythematosus (SLE). This study, which was recently published in “Arthritis & Rheumatology”, represents the longest placebo-controlled clinical trial performed in SLE to date. She is joined by our guest, Dr. Richard Furie, Chief of the Division of Rheumatology at Northwell Health in New York and co-author of the paper.
Ticking the Boxes
27:40In this episode, we welcome the lead author of “Deucravacitinib, a Tyrosine Kinase 2 Inhibitor, in Systemic Lupus Erythematosus: A phase 2, Randomized, Double-Blind, Placebo-Controlled Trial” Dr. Eric Morand of Monash University. The objective of this multicenter clinical trial in lupus (recently published in “Arthritis & Rheumatology”) was to assess the efficacy of deucravacitinib in a phase II trial in adult patients with active lupus. Dr. Morand’s methods, results and ultimate conclusions take center stage of our show today.
If you can’t feel it, does it hurt?
32:27Join us this week as we interview the lead author of “Genicular Nerve Block for Pain Management in Patients with Knee Osteoarthritis: A Randomized Placebo-Controlled Trial”, Dr. Michael Shanahan. Dr. Shanahan’s study, most recently published in “Arthritis & Rheumatology” attempts to determine the efficacy of ultrasound-guided genicular nerve block in managing pain in patients with knee osteoarthritis. Dr. Shanahan discusses his team’s methods, results and conclusions of this paper plus some career advice and insights at the top of the show.
Exercise Always Wins: Part 2
32:23This week, our guest is Dr. Grace Lo, first author of “Association Between Walking for Exercise and Symptomatic and Structural Progression in Individuals with Knee Osteoarthritis: Data from the Osteoarthritis Initiative Cohort” And Assistant Professor at Baylor College of Medicine. The objective of her study: To assess the relationship between walking for exercise and symptomatic and structural disease progression in individuals with knee OA. In this episode, she shares her methods and results with us as well as some career advice for our young listeners as well as some motivation to get out there and enjoy a nice walk!
Genetic Autocorrect and Autoimmunity
26:56This week on ‘Journals’, Dr. Shanmugam has invited Dr Joann B Sweasy and Dr. Westley Reeves to discuss a paper with an interesting journey, “A Human MSH6 Germline Variant Associated with Systemic Lupus Erythematosus Induces Lupus-Like Disease in Mice“. In this paper, we discover that the science is always telling us something, regardless of where we believe we’re headed and where we ultimately end up. This lupus study has such a story. Join us as our guests explain the study’s objective, the interesting results, what they did to achieve them and their overall conclusion.
MIS-C Mix Up
24:13In this week’s episode, Dr. Shanmugam welcomes Dr. Mary Beth Son, the senior author and corresponding author of “Treatment of Multisystem Inflammatory Syndrome in Children: Understanding Differences in Results of Comparative Effectiveness Studies.” This study sought to determine whether the application of different MIS-C definitions and differing disease severity in patients participating in two separate comparative cohorts underlay discrepant results. Dr. Jon Hausmann, pediatric rheumatologist and host of “ACR on Air”, joins Dr. Shanmugam and Dr. Son to add to the significant expertise on this episode, with his own in both clinical pediatric and adult rheumatology. Here, Dr. Hausmann shares further insights on integrating the published literature with pediatric treatment of MIS-C.