Eye Research Deep Dive: Doctopus the Octometrist

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Isotretinoin-induced severe dry eye disease and meibomian gland alterations in patients with acne vulgaris: A noncontact ocular surface analysisJulieana M, Sn-Humaira SMH, Wn-Hasbee WA, Shahidatul-Adha M. Isotretinoin-induced severe dry eye disease and meibomian gland alterations in patients with acne vulgaris: A noncontact ocular surface analysis. Med J Malaysia. 2025 Nov;80(6):780-786. PMID: 41328837.https://pubmed.ncbi.nlm.nih.gov/41328837/

1) Oral Isotretinoin Alters Meibomian Gland Function & MorphologyZakrzewska et al. (2023) — Oral isotretinoin therapy led to increased dry eye symptoms and measurable changes in meibomian gland structure and function, including meibography-detectable loss and quality changes.🔗 Free full text: The Effect of Oral Isotretinoin Therapy on Meibomian Gland Characteristics in Acne Patients (Ophthalmology & Therapy)Shows changes in meibomian gland morphology and expressibility with treatment and partial reversibility after cessation.2) Systemic Isotretinoin Impairs Lipid Secretion from Meibomian GlandsZhang et al. (2022) — Oral isotretinoin reduces lipid production from meibomian glands, contributing to evaporative dry eye.🔗 Free full text: Isotretinoin Impairs the Secretory Function of Meibomian Glands (PMC)Systemic isotretinoin induces MGD through reduced lipid synthesis and gland dysfunction.3) Classic Evidence of MG Atrophy with AccutaneMathers et al. (1991) — Meibomian glands show atrophy and reduced function on meibography during Accutane use, with increased tear film osmolarity.🔗 PubMed entry: https://pubmed.ncbi.nlm.nih.gov/1991/07000 … (Note: PubMed entry is shown via summary, full text may require access)4) Pilot Quantitative Meibography StudyGurlevik et al. (2022) — This prospective study measured TFBUT and gland changes before and during isotretinoin treatment.🔗 PubMed entry: https://pubmed.ncbi.nlm.nih.gov/34978652/ … (summary)🧴 Cosmetics & Meibomian Glands5) Eyeliner & Mascara Affect Tear Film Stability + MeibographyErcan et al. (2022) — Eye makeup use (eyeliner, mascara, or both) was associated with significant changes in NBUT and meibography compared with non-users.🔗 Free article: Effect of Eyeliner and Mascara Use on Tear Film and Meibomian Glands (PMC)Does not show changes in aqueous tear production but does show tear instability and gland changes.6) TFOS/Lifestyle Report on Cosmetics & Ocular SurfaceSullivan et al. (2023) — Overview including that eyeliner may induce tear film instability and MGD.🔗 Free article: TFOS Lifestyle: Impact of Cosmetics on the Ocular Surface (PMC)Summarizes research linking eyelid cosmetics (especially eyeliner) to gland dysfunction and tear film instability.

Does Past Myopia Progression Predict Future Progression?Wesley T. Beaulieu, Michael X. Repka, Stacy L. Pineles, Danielle L. Chandler, Yi Pang, Lori Ann F. Kehler, Catherine O. Jordan, Katherine A. Lee, David B. Petersen, Sarah R. Hatt, Susan A. Cotter, Raymond T. Kraker, Katherine K. Weise, Jonathan M. Holmes, on behalf of the Pediatric Eye Disease Investigator Group; Does Past Myopia Progression Predict Future Progression?. Invest. Ophthalmol. Vis. Sci. 2026;67(1):38. https://doi.org/10.1167/iovs.67.1.38.https://iovs.arvojournals.org/article.aspx?articleid=2811375

HOYA Vision Care recently introduced MiYOSMART iQ, an advanced spectacle lens designed to manage childhood myopia. Interim data from a six-month clinical trial involving children aged 4 to 12 demonstrates that this new technology, featuring Triple Enhanced Design (DIMS TED), significantly outperforms previous models. 

Additive Effect of Highly Aspherical Lenslet Target Spectacles to Children Inadequately Controlled by Atropine MonotherapyBryan Xiangrong Sim, Kai Lyn Loh, Hla Myint Htoon, Yudah Sri, Maithily Balakrishnan, Pauline Chan Poh Lin, Ralene Zi Hui Sim, Crystal Shue Wen Lam, Audrey Wei Lin Chia,Additive Effect of Highly Aspherical Lenslet Target Spectacles to Children Inadequately Controlled by Atropine Monotherapy,Ophthalmology Science,Volume 5, Issue 4,2025,100753,ISSN 2666-9145,https://doi.org/10.1016/j.xops.2025.100753.https://www.sciencedirect.com/science/article/pii/S266691452500051X#:~:text=The%20addition%20of%20HALT%20spectacle%20lenses%20significantly%20reduced,supported%20combination%20therapy%20for%20managing%20challenging%20myopia%20cases

Effect of Increased Power and Asphericity of Highly Aspherical Lenslets on Myopia Control Efficacy: A Contralateral Crossover StudyRajkumar Nallour Raveendran, Wee Sing Ong, Yee Ling Wong, Stella Jinran Zhan, Chun Fan Lee, Si Ying Lim, Björn Drobe; Effect of Increased Power and Asphericity of Highly Aspherical Lenslets on Myopia Control Efficacy: A Contralateral Crossover Study. Trans. Vis. Sci. Tech. 2025;14(11):9. https://doi.org/10.1167/tvst.14.11.9.https://tvst.arvojournals.org/article.aspx?articleid=2811067

Risk perception and use of personal care products by race and ethnicity among a diverse populationMandeville J, Alkhalaf Z, Joannidis C, Ryan M, Nelson D, Quiros-Alcala L, Gribble MO, Pollack AZ. Risk perception and use of personal care products by race and ethnicity among a diverse population. UCL Open Environ. 2024 May 13;6:e3038. doi: 10.14324/111.444/ucloe.3038. Erratum in: UCL Open Environ. 2024 Jun 26;6:e3038.CORR. doi: 10.14324/111.444/ucloe.3038.CORR. PMID: 38757092; PMCID: PMC11098005.https://pmc.ncbi.nlm.nih.gov/articles/pmid/38757092/

TFOS Lifestyle: Impact of cosmetics on the ocular surfaceSullivan DA, da Costa AX, Del Duca E, Doll T, Grupcheva CN, Lazreg S, Liu SH, McGee SR, Murthy R, Narang P, Ng A, Nistico S, O'Dell L, Roos J, Shen J, Markoulli M. TFOS Lifestyle: Impact of cosmetics on the ocular surface. Ocul Surf. 2023 Jul;29:77-130. doi: 10.1016/j.jtos.2023.04.005. Epub 2023 Apr 13. PMID: 37061220; PMCID: PMC11246752.https://pmc.ncbi.nlm.nih.gov/articles/PMC11246752/pdf/nihms-2004149.pdf