Exploration Science with Dr. Wendy Hartsock and Dr. Diedra Shorty

In this episode of Exploration Science, CEO and Co-founder of Numaferm, Dr. Christian Schwarz, and peptide manufacturing expert, Dr. Alain Scarso, discuss the peptide therapeutics market and dive into the technology of Numaswitch – a transformative biochemical platform to produce peptides, pepteins, and proteins.

In this episode of Exploration Science, Pepticom co-founders, Dr. Immanuel Lerner and Dr. Amit Michaeli, discuss the advantage of employing biocomputational AI software to optimize peptide drug discovery, reduce development risks, and accelerate time to market.

In this episode of Exploration Science, Dr. James Nowick (University of California, Irvine) and Dr. Nick Truex (University of South Carolina) delve into the complexities of designing, synthesizing, and examining biologically significant peptides. They also share fond memories of their time working together in the lab.

In this episode of ExplorationScience, Dr. Jonathan Steckbeck, the founder and CEO of Peptilogics, discusses the company's approach to peptide drug discovery. Tune into this episode to learn how partnering biology with machine learning is guiding the intelligent navigation of peptide chemical space to develop next-generation therapeutics.

In this episode of Exploration Science, Dr. David Shoultz, Chief Operating Officer & Co-Founder of Monod Bio discusses the next generation of clinical diagnostics and how the company is transforming point of care for patients. Tune in and learn how scientists at Monod Bio are driving diagnostic innovation through de novo protein design and deploying lucCage technology. This platform is based on research conducted by Dr. David Baker and scientists at the University of Washington Institute for Protein Design to generate artificial luciferases with optimized size, stability, substrate specificity, and photophysical properties.

In this episode of Exploration Science, Drs. Ronald Frank (AIMS Scientific Products GmbH) and Christian Behn (CEM) discuss the evolution of SPOT Synthesis to generate peptide libraries. They also correct some misinformation and bring to light the ease and utility of applying SPOT arrays to biological studies.   Watch on YouTube: https://youtu.be/MBJFIygXDRg Correction: The founding of AIMS company was in 1998, not 1989.   See the links and references below for some examples of SPOT applications: AIMS Scientific Products http://www.aims-scientific-products.de/index.php CEM MultiPep: https://cem.com/multipep2 Clemens Schulte, Vladimir Khayenko, Amit Jean Gupta, Hans Michael Maric. Low-cost synthesis of peptide libraries and their use for binding studies via temperature-related intensity change. STAR Protocols. Volume 2, Issue 3, 2021, 100605. https://doi.org/10.1016/j.xpro.2021.100605.  Melder FTI, Lindemann P, Welle A, Trouillet V, Heißler S, Nazaré M, Selbach M. Compound Interaction Screen on a Photoactivatable Cellulose Membrane (CISCM) Identifies Drug Targets. ChemMedChem. 2022 Oct 6;17(19):e202200346. doi: 10.1002/cmdc.202200346. Epub 2022 Sep 20. PMID: 35867055; PMCID: PMC9826412.  Mohammed El-Mowafy, Ursula Bilitewski. Identification of possible Ser/Thr/Tyr phosphorylation sites in the fungal histidine kinase CaNik1p by peptide array technique. Bulletin of Faculty of Pharmacy, Cairo University. Volume 56, Issue 1, 2018, Pages 68-72. https://doi.org/10.1016/j.bfopcu.2018.03.007.  Moreno-Yruela, C., Bæk, M., Vrsanova, AE. et al. Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases. Nat Commun 12, 62 (2021). https://doi.org/10.1038/s41467-020-20250-9.  Meyer et al., Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs. Cell (2018), https://doi.org/10.1016/j.cell.2018.08.019. Rebollo, A., Fliedel, L., Tuffery, P., PEPscan: A Broad-Spectrum Approach for the Characterization of Protein-Binder Interactions? Biomolecules 2022, 12, 178. https://doi.org/10.3390/ Rosie M. Jarrald, Aw W. Liang Alvin, Andrea E. Rawlings, Masayoshi Tanaka, Mina Okochi, and Sarah S. Staniland. Systematic Screening and Deep Analysis of CoPt Binding Peptides Leads to Enhanced CoPt Nanoparticles Using Designed Peptides. Bioconjugate Chemistry 2020 31 (8), 1981-1994. DOI: 10.1021/acs.bioconjchem.0c00348.

In this episode of Exploration Science Dr. Michael Mina, the Chief Scientific Officer of eMed, discusses immunology and the changing landscape of medicine as technology transforms our options for testing and treatment. https://www.emed.com/?hsLang=en

In this episode of Exploration Science, Professor Jennifer Heemstra discusses the biomolecular diversity of peptide nucleic acids, the challenges of our current scientific reward structure, and the opportunity to grow through failure. Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer: https://pubs.acs.org/doi/10.1021/jacs.9b09146 Mentor First Resources: https://mentorfirst.org/

In this episode of Exploration Science, Drs. Gemma Mudd and Kevin McDonnell of Bicycle Therapeutics discuss the Bicycle peptide platform and dive into some of the properties of bicycles that enable the generation of molecules with high affinity, selectivity, and tunable pharmacology. Links: https://www.bicycletherapeutics.com/ Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides DOI: 10.1021/acs.bioconjchem.2c00288 Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors DOI: 10.1158/0008-5472.CAN-18-0238 Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology DOI: 10.1021/acs.jmedchem.2c00505

In this episode of Exploration Science, Professors César de la Fuente from the University of Pennsylvania and Fabien Plisson from CINVESTAV discuss their pursuit of antimicrobial agents and the utility of AI/ML for peptide discovery. Links: Juan CarlosGuido-Patiñoa and FabienPlisson. Profiling hymenopteran venom toxins: Protein families, structural landscape, biological activities, and pharmacological benefits. Toxicon: 10, 14 (2022), 100119. https://doi.org/10.1016/j.toxcx.2022.100119 https://delafuentelab.seas.upenn.edu/research/