Between the Signals

In our wide-ranging conversation with Professor Chris Shaw, we had enoughmaterial for a bonus episode. Join Dr Sarah Mizielinska and Professor ChrisShaw as they take a closer look at the different stages of clinical trials, fromearly preclinical work to testing in patients. They also explore the evolvingrole of animals in research, and how advances in stem cell technology arehelping scientists reduce reliance on animal models when developing newtherapies. Learn more:  📚 UK DRI website: www.ukdri.ac.uk 🔬 UK DRI at King's: https://www.ukdri.ac.uk/centres/kings... 📧 Newsletter: tinyurl.com/ukdri-newsletter  Find us on: bsky, LinkedIn and YouTube

Welcome to the third episode of Between the Signals, a podcast brought to you by the UK Dementia Research Institute at King’s College London. In this episode, we explore how fundamental research gets turned into medicine.  Join Dr Sarah Mizielinska as she speaks with Professor Chris Shaw, whose experience as a clinician and medical doctor has driven his scientific research. His work focuses on gene discoveries in a hereditary form of motor neuron disease (MND) and how to translate that knowledge into developing treatments for neurodegenerative conditions such as MNDand frontotemporal dementia (FTD). Hear more on the latest cutting-edge research happening at the UK DRI, from understanding how molecules move around cells to developing new gene therapies.  Whether you're living with one of these conditions, are a carer, researcher, or simply curious about neuroscience, this conversation provides insights into these complex conditions and hope for new treatments on the horizon.  Episode 3 definitionsProgranulinProgranulin is a secreted, multifunctional protein encoded by the GRN gene. Loss-of-function mutations in the Progranulin gene are a major cause of frontotemporal dementia.Glial CellsGlial cells or glia are non-neuronal cells in the brain and spinal cord. They provide structural support, insulation, immune defence, and nutrients/oxygen for neurons.Chromosome A chromosome is a package of DNA containing part or all of the genetic material of an organism. Humans have 23 pairs of chromosomes containing all our genetic information.MutationMutations in the context of neurodegeneration refer to changes in the DNA that can affect how a protein is made, where in the cell it is located or how it behaves. In neurodegenerative conditions mutations often lead to protein accumulation or loss of function.Genetic risk factorGenetic risk factors are inherited variations or mutations in DNA that increase a person's risk of developing a disease. These factors are often identified through family history, and they are not a guarantee that a person will get sick. Environmental factors also play a key role.PathologyPathology is the study of disease. In the context of research, it can also refer to the typical manifestation of an illness. For example, the pathology of frontotemporal dementia includes the shrinking of specific brain regions (frontal and temporal lobe).TherapeuticsThe word therapeutic(s) refers to a treatment, therapy or drug in the context of disease research. In this episode the therapeutic discussed is the delivery of a missing protein to the brain with the help of a virus.For more detailed information about any of the conditions mentioned, visit:  Frontotemporal dementia: https://www.ukdri.ac.uk/conditions/frontotemporal-dementia Motor neuron disease: https://www.ukdri.ac.uk/conditions/mo... Learn more:  📚 UK DRI website: www.ukdri.ac.uk 🔬 UK DRI at King's: https://www.ukdri.ac.uk/centres/kings... 📧 Newsletter: tinyurl.com/ukdri-newsletter  Find us on: bsky, LinkedIn and YouTube

Welcome to the second episode of Between the Signals, a podcast brought to you by the UK Dementia Research Institute at King’s College London. In this episode, we explore what neurodegeneration and dementia are and discuss the similarities and differences between Alzheimer’s disease, Parkinson’s and motor neuron disease.  Join Dr Asma Bashir and Dr Sarah Mizielinska as they speak with Dr Sarah Marzi, whose research focuses how environmental factors contribute the development of conditions such as Parkinson’s. Hear more on the latest cutting-edge research happening at the UK DRI, from understanding how molecules move around cells to developing new gene therapies.  Whether you're living with one of these conditions, a carer, researcher, or simply curious about neuroscience, this conversation provides insights into these complex conditions and hope for new treatments on the horizon.  For more detailed information about any of the conditions mentioned, visit: Alzheimer’s disease: https://www.ukdri.ac.uk/conditions/alzheimers-disease Parkinson’s: https://www.ukdri.ac.uk/conditions/parkinsons-disease Frontotemporal dementia: https://www.ukdri.ac.uk/conditions/frontotemporal-dementia Motor neuron disease: https://www.ukdri.ac.uk/conditions/mo...   Learn more:  📚 UK DRI website: www.ukdri.ac.uk  🔬 UK DRI at King's: https://www.ukdri.ac.uk/centres/kings...  📧 Newsletter: tinyurl.com/ukdri-newsletter  Learn more:  📚 UK DRI website: www.ukdri.ac.uk 🔬 UK DRI at King's: https://www.ukdri.ac.uk/centres/kings... 📧 Newsletter: tinyurl.com/ukdri-newsletter  Find us on: bsky, LinkedIn and YouTube

Listen to the UK DRI’s new podcast Between the Signals. In the first episode called "What is Motor Neuron Disease?” Dr Asma Bashir and Dr Sarah Marzi speak with expert Dr Sarah Mizielinska to understand more about Motor Neuron Disease (MND).  Scientists at UK DRI at King’s are working toward a better understanding of the condition and the development of much-needed, effective treatments. For more information, visit: Motor neuron disease/ALS | UK DRIDisclaimer: Actor Bruce Willis was diagnosed with frontotemporal dementia (FTD) in 2023. FTD is a neurodegenerative condition that affects the frontotemporal lobe of the brain and it is believed to be part of a disease spectrum with ALS/MND.Learn more:  📚 UK DRI website: www.ukdri.ac.uk 🔬 UK DRI at King's: https://www.ukdri.ac.uk/centres/kings... 📧 Newsletter: tinyurl.com/ukdri-newsletter  Find us on: bsky, LinkedIn and YouTube