BioHarvest Sciences advances CDMO pharma deal to Stage 2, eyes scaled compound production

BioHarvest Sciences CEO Ilan Sobel joined Steve Darling from Proactive to announce a key advancement in the company’s contract development and manufacturing partnership with a Nasdaq-listed pharmaceutical company. The collaboration has now progressed from Stage 1 to Stage 2, marking a critical step forward in validating BioHarvest’s Botanical Synthesis platform for the development of pharmaceutical-grade active compounds. Stage 1 of the contract, which began in early 2024, focused on sourcing the appropriate plant species required to biosynthesize a compound used in an already approved pharmaceutical product. Sobel shared that the BioHarvest R&D team successfully completed this stage by isolating cells from the target plant and then replicating, enhancing, and multiplying those cells in laboratory conditions using its proprietary Botanical Synthesis technology. With Stage 1 successfully completed, Stage 2 is now underway and involves producing a sufficient quantity of biomass for pharmaceutical testing. This phase will also include optimizing the conditions for cultivating plant cells in liquid media to ensure consistent quality and yield. If successful, the project would move into scaled-up production—starting with small and medium volumes, followed by potential commercial-scale manufacturing of the compound. Sobel emphasized the significance of this milestone as further validation of BioHarvest’s Botanical Synthesis platform, which enables sustainable, controlled, and highly efficient production of complex plant-derived compounds without the need to cultivate full plants. “This advancement underscores our ability to address key challenges in pharmaceutical ingredient production and supports our broader goal of scaling up for commercial manufacturing,” Sobel said. As BioHarvest continues to deliver on its innovation roadmap, the CDMO contract signals a growing interest from the pharma industry in plant cell-based biosynthesis as a scalable alternative to traditional agricultural and chemical manufacturing methods. #proactivinvestors #nasdaq #bhst #pharma #biotech #hearthealth #fattyliverdisease #BioHarvestSciences, #IlanSobel, #RevenueGrowth, #NasdaqListing, #PlantBiotech #DrugDevelopment #CDMO #BioreactorTech #PhytoMedicine #ProactiveInvestors #BiotechUpdate #BotanicalSynthesis

Arizona Gold and Silver CEO Mike Stark joined Steve Darling from Proactive to announce the initiation of Phase 2 in the company’s comprehensive metallurgical test program at its Philadelphia Gold-Silver Project, located in northwestern Arizona. This next stage of testing is a critical step in validating the project’s potential for low-cost, heap leach gold recovery. Following the success of Phase 1, which demonstrated gold recoveries ranging from 61% to 73% using column leach tests, Phase 2 aims to optimize and further validate those results. The company has commenced testing on a 415-kilogram bulk sample, incorporating High Pressure Grinding Roll (HPGR) technology—an advanced technique expected to enhance gold recoveries by improving particle liberation. The Phase 2 program will run for 90 days and consist of four parallel column tests: two columns using conventionally crushed material and two using HPGR-crushed material. Each set will be tested at two different crush sizes to assess the impact of particle size and crushing method on gold extraction efficiency. Stark emphasized that this work builds on encouraging geological and drilling results from the Philadelphia property, where widths and grades of mineralization have already demonstrated potential for a commercially viable heap leach operation—comparable to others in the region. “With continued drilling success and now this critical Phase 2 test work underway, we are focused on de-risking the project and positioning Philadelphia as a strong candidate for a large-scale, low-cost gold production operation,” Stark noted. Arizona Gold and Silver's multi-stage metallurgical program is designed to provide the technical foundation required to move the project toward a potential development decision in the future. #proactiveinvestors #arizonagoldandsilverinc #tsxv #azs #otcqb #azasf #GoldExploration #PhiladelphiaProject #MiningNews #JuniorMining #HeapLeach #Metallurgy #ResourceInvesting #GoldStocks #PreciousMetals

Nevis Brands CEO John Kueber joined Steve Darling from Proactive to announce the latest milestones in the company’s national expansion strategy. The company has officially launched its flagship cannabis beverage, Major, in the Illinois market and is also rolling out broader distribution of its Happy Apple hemp-derived product in both North and South Carolina. In Illinois, Nevis Brands has secured all necessary state approvals for both product formulation and packaging. Initial production of the Major 100mg 2 oz shots is now complete, and the product is currently available at multiple dispensaries across the Chicago area. The launch lineup includes three popular flavors: Fruit Punch, Blackberry Lemonade, and Blueberry, offering consumers a fast-acting and flavorful THC-infused beverage experience. Meanwhile, the company is also accelerating the growth of its Happy Apple product in the Southeast. Through a new agreement with a top-tier distribution partner in North Carolina, Nevis is expanding its retail footprint to include specialty beer and wine outlets as well as on-premise locations such as bars and entertainment venues across both North and South Carolina. Kueber noted that this regional expansion aligns with the company’s broader goal of making Happy Apple a go-to hemp-derived beverage in traditional retail and hospitality channels. To further support growth, Nevis is actively building out its e-commerce capabilities, leveraging social media influencers and digital platforms to enable direct-to-consumer sales. With demand for cannabis- and hemp-infused beverages continuing to rise, Nevis Brands is positioning itself as a leader in both innovation and market reach within the growing functional beverage category. #proactiveinvestors #nevisbrandsinc #cse #nevi #otcqb #nevif #majorbrand #cannabis #CannabisInvesting #THCDrinks #HappyApple #CannabisStocks #HempTHC #CannabisBeverages #InvestorUpdate #JohnKueber #CannabisNews #CannabisRevenue #DebtReduction #ProactiveInvestors

Delivra Health Brands CEO Gord Davey joined Steve Darling from Proactive to announce a key milestone in the company’s international growth strategy. The company’s Kuwait-based distributor for the Dream Water® brand is set to launch Delivra’s new 60-Count Sleep Gummies across several Middle Eastern markets, with product availability expected by July 2025. This expansion builds on Dream Water®’s existing success in North America, where the sleep aid gummies have gained traction in both Canada and the U.S. markets. The move is a strategic step in Delivra Health’s broader global rollout, which aims to drive growth by leveraging proven products and working closely with experienced local partners. “Our entry into the Middle East with the 60-Count Sleep Gummies underscores our commitment to providing consumers with effective and convenient sleep solutions,” said Davey. “By collaborating with regional distributors who understand the local market dynamics and have a history of delivering strong performance, we are confident this launch will contribute significantly to our international growth.” The new gummy format complements Dream Water®’s existing line of liquid sleep shots, which have already found success in Middle Eastern markets. With growing global demand for non-prescription sleep aids, Delivra Health is positioning Dream Water® as a leading brand for natural, consumer-friendly sleep solutions worldwide. #proactiveinveestors #delivrahealthbrandsinc #tsxv #dhb #otcqb #dhbuf #DreamWater #SleepGummies #NaturalSleepAid #MiddleEastExpansion #GordDavey #GlobalHealthBrands #MelatoninGummies #ProactiveInvestors #HealthInnovation

North Bay Resources CEO Jarad Lazerson joined Steve Darling from Proactive to share a significant milestone in the company’s development of the Fran Gold Project in British Columbia. The company has released a preliminary, non-NI 43-101-compliant resource estimate for the Bullion Alley Zone—an internal figure based on extensive historical drilling and modern 3D modeling. The estimate was generated using Leapfrog Geo + Edge software, a professional-grade 3D modeling tool commonly employed in the mining industry. The analysis incorporated over 18,000 meters of diamond drilling across 104 holes, totaling approximately 50,000 feet of historic data. Lazerson emphasized that while the estimate is not yet compliant with NI 43-101 standards, it provides a transparent and credible basis for strategic conversations with potential investors, joint venture partners, and major mining companies. The internal resource estimate outlines 20 million tons at 0.5 g/t gold in the main Bullion Alley Zone, 43 million tons at an average grade of 0.3 g/t when including the East Zone and an estimated 450,000 ounces of gold across the two zones “These numbers are not certified, but they are meaningful,” Lazerson said. “They give us and the market a clear picture of where we stand and how much value there may be in the ground, especially with current gold prices hovering at historically high levels.” He also pointed to a gap between the main and East zones with no historical drilling, highlighting an exploration opportunity that could further expand the resource base. The company is currently weighing its next steps, including whether to advance toward further drilling, move into preliminary development, or explore financing and M&A opportunities. “This marks a turning point,” Lazerson added. “It’s our way of signaling to the market that North Bay is serious about advancing Fran. We believe there’s a generational opportunity as global demand for gold and strategic metals increases, and we’re positioning ourselves to take advantage of that.” #proactiveinvestors #northbayresourcesinc #otc #nbri #PlatinumConcentrate #NorthBayResources #MiningNews #CaliforniaGold #JaredLazerson #GoldRush #stock #stockmarketnews ResourceEstimate #NorthBayResources #MiningInvestment #JuniorMining #GoldExploration #MiningFinance #MergersAndAcquisitions #GoldPrice #NI43101 #MiningNews #InvestorUpdate

U.S. Global Investors CEO Frank Holmes joined Steve Darling from Proactive to provide an update on the strong performance of the firm’s War ETF, launched in December 2024. Despite volatile global markets and rising geopolitical tensions, the ETF has demonstrated impressive resilience and has outpaced several other national security-focused investment vehicles. Holmes attributed the ETF's performance to what he described as “smart beta 2.0”—an evolved strategy that focuses on momentum across revenue growth, earnings strength, and free cash flow. Key holdings like Qualcomm and General Dynamics have been standout contributors, supported by global shifts in military priorities and spending patterns. “The strategy is built to identify companies benefitting from real economic trends—not just narratives,” Holmes explained. He emphasized that recent geopolitical developments have served as a strong tailwind for the defense sector. In particular, increased military budgets across Europe—often spurred by U.S. diplomatic pressure—have led to a wave of new defense contracts and infrastructure upgrades. The ETF’s performance is also being driven by a sharp rise in global defense spending, fueled by conflicts and tensions in Ukraine, the Middle East, and the Indian subcontinent, as well as increasing cybersecurity threats from China. Holmes noted that the United States alone is expected to spend close to $3 trillion annually on national defense and related technologies—surpassing previous records. Importantly, Holmes highlighted that the ETF doesn’t only focus on traditional defense contractors. It also includes exposure to high-performance data centers and AI infrastructure, recognizing the critical role of artificial intelligence, secure connectivity, and big data in modern warfare and defense operations. This diversified approach also captures crossover benefits from sectors like healthcare, technology, and cybersecurity. He also pointed to growing investments in Canada and Europe in AI-related infrastructure and 5G mobile networks, positioning the ETF to benefit from parallel technological developments outside of direct military applications. #proactiveinvestors #usglobalinvestorsinc #nasdaq #grow #etf #trip #travel #colombia #WARETF #DefenceSpending #Cybersecurity #Semiconductors #Aerospace #SmartBeta #ETFs #NYSE #FrankHolmes #USGlobalInvestors #AIInvesting #GeopoliticalTensions #MilitaryETF #SmartBeta #Cybersecurity #NATOspending #NYSE #ProactiveInvestors

Oriole Resources PLC (AIM:ORR) CEO Martin Rosser talked with Proactive about the latest drill results from the Mbe Gold Project in Cameroon, which he described as the company’s best since his appointment. The ongoing maiden drilling program has returned 125 gold intersections from just eight holes, translating to an intersection every 21 metres drilled. Rosser emphasised the scale and quality of the results, highlighting that “Mbe eight came back with over 85 metres, I think 86.5 to be precise,” including a particularly strong section of 39.4 metres at two grams per tonne. He added that these intersections start close to surface, supporting the potential for open-pit mining. To date, over 60% of the drilling program has been completed, but only one-third of the results have been reported, suggesting more updates to come. Rosser confirmed that 16 more holes remain to be reported, with the JORC exploration target expected in Q3, followed by a maiden mineral resource estimate in Q4. In addition to ongoing analysis at Mbe South, Rosser mentioned plans to launch the first drilling program at Mbe North, indicating further upside potential. For more updates from Oriole Resources and other mining sector news, visit Proactive’s YouTube channel. Don’t forget to like this video, subscribe, and turn on notifications so you never miss a story. #OrioleResources #GoldExploration #CameroonMining #MbeGoldProject #DrillingResults #JuniorMining #MineralExploration #GoldInvesting #NaturalResources #MiningUpdates

Genflow Biosciences PLC (LSE:GENF, OTCQB:GENFF) CEO Dr Eric Leire talked with Proactive's Stephen Gunnion about the company’s latest milestone—a successful £0.5 million fundraising to support a gene therapy trial in ageing dogs using SIRT6. Dr Leire explained that the funding was secured via a share subscription from a US-based longevity fund, with shares issued at market price and without a discount—what he described as a clear “vote of confidence in the company and its therapies.” Dr Leire explained that the funding was secured via a share subscription from a US-based longevity fund, with shares issued at market price and without a discount—what he described as a clear “vote of confidence in the company and its therapies.” The trial aims to demonstrate proof of concept in dogs, replicating promising results previously seen in mice. “It worked like magic in mice. We reasonably think that it will work likewise in dogs,” Leire stated. Unlike mice, however, dogs share environmental conditions with humans, making them a more relevant model for translation into human therapies. Leire also highlighted the commercial potential of targeting animal health, as it offers a shorter regulatory pathway compared to human applications. He confirmed that the trial has reached a key milestone: the randomisation of 24 senior dogs, aged over ten years, into four arms, including one control group and three treatment groups using different SIRT6 delivery methods. He also addressed ethical considerations, stating that the therapy does not involve genetic modification, and described the use of non-integrating gene therapy approaches, including naked DNA and AAV vectors. Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel and enable notifications for future content. #GenflowBiosciences #GeneTherapy #SIRT6 #DogAgingTrial #LongevityResearch #BiotechFunding #AnimalHealth #AntiAging #Biotechnology #ClinicalTrials #LifeSciences #InvestingInBiotech #SeniorDogs

Caledonia Mining Corporation PLC chief executive Mark Learmonth talked with Proactive's Stephen Gunnion about the company’s strong first-quarter performance, driven by a rise in both gold production and gold prices. Learmonth highlighted that Caledonia sold approximately 19,000 ounces of gold in the quarter, up from 17,500 ounces in Q1 2024, and achieved a gold price of just under $2,900 per ounce. This led to gross profit nearly doubling from $14 million to $27 million, and earnings per share increasing from $0.07 to $0.45. The company is investing $41 million in capital expenditure this year, with $34 million allocated to sustaining operations at the Blanket mine. Projects include a new tailings facility, underground development to improve flexibility, and engineering upgrades for efficiency, such as converting the main winder to lower power consumption. Learmonth stated, “To some extent, we're using the higher gold price to invest for the extended life of mine and to build in more and more efficiency and robustness.” On safety, changes in senior personnel have led to visible management presence underground and proactive incident prevention strategies. Updates were also provided on Bilboes and Motapa, where Caledonia is revisiting feasibility approaches, continuing exploration, and exploring small-scale, high-return opportunities. Visit Proactive's YouTube channel for more videos, and don’t forget to give the video a like, subscribe to the channel, and enable notifications for future content. #CaledoniaMining #GoldMining #MarkLearmonth #ZimbabweMining #MiningStocks #GoldInvestment #Q1Results #MiningCapex #GoldProduction #BilboesProject #MotapaExploration #MiningUpdates #ProactiveInvestors

American Rare Earths CEO Chris Gibbs joined Steve Darling from Proactive to announce new assay results from the company’s ongoing mapping and channel sampling program at the Cowboy State Mine area of the Halleck Creek Rare Earths Project in Wyoming. The results further confirm the project's potential to become a major U.S.-based source of critical minerals. Gibbs shared that a total of 106 channel samples were collected across the Red Mountain area, a key target within the Halleck Creek project. Assay results revealed elevated levels of rare earth mineralization, with one standout sample grading 1.37% Total Rare Earth Oxide (TREO). Across the Red Mountain Pluton — the rare earth-bearing lithology — TREO grades ranged from 711 parts per million (ppm) to 13,651 ppm, with an average of 3,661 ppm. Notably, the company reported that magnet rare earth oxides, which are essential for high-performance magnets used in electric vehicles and wind turbines, account for approximately 28% of the total rare earth content. Heavy rare earth oxides, which are typically rarer and more valuable, represent about 13%. Fifteen of the collected samples exceeded 4,500 ppm TREO, further underscoring the presence of elevated-grade zones within the Red Mountain system. The company is currently incorporating the new channel sampling data into an updated geological model and mineral resource estimate for the CSM area. These updates will inform the ongoing mine planning process and play a key role in the upcoming Pre-Feasibility Study, which remains on track for completion in late 2025. #proactiveinvestors #americanrareearthslimited #asx #arr #otcqx #arrnf #adr #amrry #wyomingrareinc #AmericanRareEarths #HalleckCreek #CowboyStateMine #CriticalMinerals #Neodymium #Praseodymium #Yttrium #Dysprosium #MiningUpdate #PFS #ChannelSampling #ProactiveInvestors