Dr. Joseph Mercola - Take Control of Your Health podcast

Obesity Drives Alzheimer's Through Fat Vesicles and Leptin

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  • Obesity increases Alzheimer's risk by altering how fat-derived vesicles communicate with the brain, causing amyloid proteins to misfold and form toxic plaques that damage neurons and impair cognition
  • Specific lipids from obese individuals, including sphingolipids and ceramides, create oxidative stress in brain cells, reduce mitochondrial energy production, and accelerate the formation of sticky amyloid aggregates
  • Excessive fat consumption promotes Alzheimer's development, though balanced, controlled intake at lower concentrations helps inhibit amyloid aggregation and reduce disease risk
  • Leptin resistance from obesity prevents this protective hormone from reaching the brain, disabling the cleanup process that normally breaks down amyloid proteins while worsening inflammation and cognitive decline
  • Cellular health restoration requires eliminating four key factors — excess linoleic acid from vegetable oils, endocrine-disrupting chemicals, electromagnetic fields, and endotoxins in the gut

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