The mRNA Breakthrough That Changed Medicine Forever with Nobel Laureate Katalin Karikó [Ep. 464]

Get ready to embark on a cosmic journey with Jason Steffen, author of Hidden in the Heavens and one of the brilliant minds behind the groundbreaking Kepler Mission. This live episode of The INTO THE IMPOSSIBLE Podcast promises to be an unmissable masterclass in exoplanet science, filled with awe-inspiring discoveries, behind-the-scenes stories, and lessons that redefine our place in the cosmos. What You’ll Discover: 🚀 The Kepler Mission’s Epic Journey: Learn how a team of visionaries overcame two decades of challenges to launch a space telescope that revolutionized planetary science. 🌍 Earth’s Place in the Universe: What have 5,000+ exoplanets taught us about the possibility of finding Earth-like worlds—and the uniqueness of our own planet? 💡 Breakthroughs That Changed Science Forever: From “hot Jupiters” to the unexpected diversity of planetary systems, explore how Kepler rewrote the rulebook on planetary formation. 👩‍🔬 Inspiration for Aspiring Scientists: Hear Jason’s advice for navigating uncertainty, thriving in collaborative missions, and turning curiosity into impactful discoveries. 🔭 The Future of Exoplanet Research: With the James Webb Space Telescope building on Kepler’s legacy, what’s next in the search for life beyond Earth? Why You Can’t Miss This: This isn’t just a podcast—it’s an educational experience for anyone fascinated by the cosmos, science, or humanity’s eternal quest to answer the biggest questions. Whether you’re a seasoned scientist, a student of the stars, or simply curious about our place in the universe, this episode will leave you inspired and enlightened. Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 Will AI ever surpass human intelligence, discover new laws of physics, and solve the greatest mysteries of our universe?  This week on Into the Impossible, I explore the potential and dangers of artificial intelligence with none other than Max Tegmark!  Max Tegmark is a renowned physicist and machine learning expert who dedicated his career to uncovering the mathematical fabric of reality, proposing that our universe itself might be a vast mathematical structure and that we could be living in a multiverse of endless possibilities. His work goes beyond physics to tackle the transformative power and ethical challenges of artificial intelligence, an area where he believes humanity must tread carefully. In the second part of our fascinating interview, we discuss the development of AI, the impact it will have on science, and our role in all of this.  Tune in to discover if AI will ever surpass human intelligence! Check out the first part of our interview, where we discuss his mathematical universe hypothesis, the search for extraterrestrial life, and AI’s role in science: https://www.youtube.com/watch?v=EFO5lzA_0Og  Key Takeaways:  00:00 Intro 00:28 Is AI limited by embodiment?  10:52 The challenges in AI research  14:53 The role of regulation in AI development  29:53 How AI is going to impact education and science 39:20 Do we need quantum computation for human intelligence?  44:50 Fantastic final four 50:45 Outro Additional resources:  📚 Life 3.0 by Max Tegmark: https://a.co/d/d08r0FJ  ➡️ Follow me on your fav platforms: ✖️ Twitter: https://twitter.com/DrBrianKeating  🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1  📝 Join my mailing list: https://briankeating.com/list  ✍️ Check out my blog: https://briankeating.com/cosmic-musings/  🎙️ Follow my podcast: https://briankeating.com/podcast  Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to follow/subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 What is time? Is it just a ticking clock, or is it something more profound?  In this thought-provoking episode of Into the Impossible, Stephen Wolfram challenges everything we know about time, offering a revolutionary computational perspective that could forever change how we understand the universe. Stephen Wolfram is a computer scientist, physicist, and businessman. He is the founder and CEO of Wolfram Research and the creator of Mathematica, Wolfram Alpha, and Wolfram Language. Over the course of 4 decades, he has pioneered the development & application of computational thinking. He has been responsible for many discoveries, inventions & innovations in science, technology, and business. He argues that time is the inevitable progress of computation in the universe, where simple rules can lead to complex behaviors. This concept, termed computational irreducibility, implies that time has a rigid structure and that our perception of it is limited by our computational capabilities. Wolfram also explores the relationship between time, space, and gravity, suggesting that dark matter might be a feature of the structure of space.  Tune in to discover the true nature of time. Key Takeaways:  00:00:00 Intro 00:01:06 The true nature of time  00:24:57 The role of computational irreducibility in thermodynamics  00:30:07 The Ruliad and the nature of observers  00:53:40 The role of gravity in the computational universe 01:06:27 Dark matter and the discreteness of space  01:13:06 Paradigm shifts in science and technology 01:20:33 Exploring the cosmic microwave background (CMB)  01:31:47 Outro Additional resources:  ➡️ Check out Stephen Wolfram: 💻 Website: https://www.stephenwolfram.com/  ✖️ Twitter: https://twitter.com/stephen_wolfram ➡️ Follow me on your fav platforms: ✖️ Twitter: https://twitter.com/DrBrianKeating  🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1  📝 Join my mailing list: https://briankeating.com/list  ✍️ Check out my blog: https://briankeating.com/cosmic-musings/  🎙️ Follow my podcast: https://briankeating.com/podcast  Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to follow/subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 Can science, philosophy, and religion work together to address humanity's biggest questions? What lessons can the cosmos teach us about our place in the universe and the future of humanity? And how do we bring back that sense of curiosity that seems to have faded among professionals? Here today to invite us into her daring quest to decode the universe’s secrets is the brilliant Kelsey Johnson. Kelsey is an accomplished astronomer, professor, and science communicator known for her groundbreaking work in astrophysics and her unique approach to blending science with philosophy and existential inquiry. She is a faculty member at the University of Virginia, where she has made significant contributions to the understanding of starburst galaxies, molecular clouds, and magnetic fields in the universe. Kelsey also founded the Dark Skies, Bright Kids program, which introduces rural communities to the wonders of astronomy.  Tune in to learn more about curiosity, the intersection of science and philosophy, and the universe’s mysteries.  Key Takeaways:  00:00:00 Intro 00:13:06 What inspired Kelsey to write Into the Unknown  00:16:23 Why scientists lose their curiosity  00:18:33 Judging a book by its cover 00:24:18 Balancing science and philosophy  00:31:55 The role of religion in understanding science 00:37:21 The cosmic marshmallow test  00:47:04 Dark Skies, Bright Kids 00:50:53 The Fermi paradox and the search for extraterrestrial life 01:00:55 Changing perspectives in cosmology  01:05:48 Starburst galaxies 01:08:03 Molecular clouds and feedback  01:10:38 Magnetic fields  01:12:59 Arthur C Clarke’s three laws 01:19:31 Outro Additional resources:  ➡️ Learn more about Kelsey Johnson:  📚 Get Into the Unknown on Amazon: https://a.co/d/5XW0bmG  ✖️ Follow Kelsey on Twitter: https://x.com/ProfKelsey ➡️ Follow me on your fav platforms: ✖️ Twitter: https://twitter.com/DrBrianKeating  🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1  📝 Join my mailing list: https://briankeating.com/list  ✍️ Check out my blog: https://briankeating.com/cosmic-musings/  🎙️ Follow my podcast: https://briankeating.com/podcast  Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to follow/subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 Simulations today are powerful tools for exploring the mysteries of our universe, but how close can they come to replicating reality? Can we recreate everything through simulations, or are there limits we can’t overcome? And how do today’s powerful simulations shape our understanding of everything from galaxies to climate change? Here today, to answer all of these questions and more, is none other than Andrew Pontzen. Andrew is a cosmologist and professor known for his expertise in using computer simulations to understand the universe. He’s the author of The Universe in a Box, where he unpacks the complexities of cosmic simulations and their surprising limitations. Pontzen’s work is at the cutting edge of how we model and predict phenomena ranging from galaxy formation to climate change, bridging theoretical physics with practical, big-picture questions about reality. As we head toward an era where simulations and AI are central to scientific discovery, these questions are more important than ever.  Tune in to learn about the power and limitations of simulation!  Key Takeaways:  00:00 Intro 00:44 Is it possible to simulate reality?  04:49 Early simulation experiments  10:30 Fluid dynamics and weather simulations  13:51 Judging a book by its cover  16:01 End of the universe 19:13 Cosmic microwave background and spinning universes 24:11 Verification and validation 27:34 Big Bang controversy and the JWST 31:35 Galaxy simulations  42:23 Multiverse and quantum computing  48:58 Ethics and energy impact of high-performance computing 55:34 Outro Additional resources:  ➡️ Learn more about Andrew:  📚 Get The Universe in a Box: https://a.co/d/2V7vuFR  ✖️ Follow Andrew on Twitter: https://x.com/apontzen ➡️ Follow me on your fav platforms: ✖️ Twitter: https://twitter.com/DrBrianKeating  🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1  📝 Join my mailing list: https://briankeating.com/list  ✍️ Check out my blog: https://briankeating.com/cosmic-musings/  🎙️ Follow my podcast: https://briankeating.com/podcast  Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to follow/subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 Is reality fundamentally mathematical? Is our universe just one of many? And will we ever discover extraterrestrial life?  This week on Into the Impossible, I sit down with renowned physicist and machine learning expert Max Tegmark to discuss some of the most fundamental questions of our time! Tegmark has dedicated his career to uncovering the mathematical fabric of reality, proposing that our universe itself might be a vast mathematical structure and that we could be living in a multiverse of endless possibilities. His work goes beyond physics to tackle the transformative power and ethical challenges of artificial intelligence, an area where he believes humanity must tread carefully. In the first part of this mind-bending interview, we discuss his mathematical universe hypothesis, the search for extraterrestrial life, and AI’s role in science. Tune in! Key Takeaways:  00:00 Intro 00:49 The multiverse and mathematical structures  02:33 Theory of inflation and the multiverse 06:52 Levels of multiverses and mathematical structures  11:19 Quantum mechanics and classical mechanics 14:21 The relationship between theory and experiment   21:48 The search for extraterrestrial life  37:15 UFOs and military surveillance technology  41:19 Outro Additional resources:  📚 Our Mathematical Universe by Max Tegmark: https://a.co/d/03qjhLD  ➡️ Follow me on your fav platforms: ✖️ Twitter: https://twitter.com/DrBrianKeating  🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1  📝 Join my mailing list: https://briankeating.com/list  ✍️ Check out my blog: https://briankeating.com/cosmic-musings/  🎙️ Follow my podcast: https://briankeating.com/podcast  Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to follow/subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 What if the secret to saving millions of lives was hidden for years—overlooked, dismissed, and even rejected? That’s the story behind the groundbreaking mRNA technology used in COVID-19 vaccines. Today’s remarkable guest, Dr. Katalin Karikó—a Nobel laureate whose persistence and vision changed the course of medical history—shares how she overcame countless setbacks to drive one of the biggest breakthroughs in modern medicine. Discover how a humble butcher’s daughter from Hungary developed the foundation for the COVID-19 vaccine and why mRNA could hold the key to curing cancer and other deadly diseases. Tune in to learn more about the mRNA revolution that almost didn’t happen! Key Takeaways:  00:00:00 Intro 00:01:06 Origin of the Hungarian phrase “Marslahok” 00:02:11 Judging a book by its cover 00:05:40 The definition of life and extraterrestrial life  00:09:28 Katalin’s early life and scientific curiosity  00:18:00 Understanding RNA and mRNA 00:24:43 Development of the COVID vaccine 00:28:44 The COVID vaccine controversy  00:35:41 Overcoming adversity and advice for young scientists  00:54:10 The future of mRNA research and dealing with pandemics  01:01:08 What was Katalin wrong about? 01:02:15 Outro Additional resources:  📚 Get “Breaking Through: My Life in Science” by Dr. Katalin Karikó: https://a.co/d/cZjaFCw  ➡️ Follow me on your fav platforms: ✖️ Twitter: https://twitter.com/DrBrianKeating  🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1  📝 Join my mailing list: https://briankeating.com/list  ✍️ Check out my blog: https://briankeating.com/cosmic-musings/  🎙️ Follow my podcast: https://briankeating.com/podcast  Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to follow/subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 Is Earth truly one of a kind?  This question has fascinated humans for decades, and with today's advanced technology, we're finally able to explore it scientifically. In this episode, renowned astrophysicist Josh Winn joins us to discuss the fascinating world of exoplanets, planetary systems, and the quest to discover other habitable planets. Josh shares the latest breakthroughs in exoplanet research, from unexpected discoveries like hot Jupiters to the ongoing efforts to detect Earth-like planets around distant stars. He also explores the challenges of studying planets light-years away and the exciting future missions that could reveal more about the universe beyond our solar system.  Tune in to learn more about exoplanets and life beyond our solar system! Key Takeaways:  00:00:00 Intro 00:00:34 Rare Earth Hypothesis  00:06:04 The role of stars in exoplanet habitability  00:13:23 Judging a book by its cover  00:16:50 Could aliens detect Tokyo?  00:19:42 The Habitable Worlds Observatory  00:22:06 Methods for detecting exoplanets  00:25:21 The lazy method  00:30:03 Avi Loeb and Oumuamua 00:36:08 The nuts and bolts of Josh's work  00:44:29 The role of technology in detecting exoplanets  00:52:48 Why should young people be interested in exoplanets? 00:57:22 Outro Additional resources:  📚 Get The Little Book of Exoplanets by Josh Winn: https://a.co/d/9PK4XFV  ➡️ Follow me on your fav platforms: ✖️ Twitter: https://twitter.com/DrBrianKeating  🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1  📝 Join my mailing list: https://briankeating.com/list  ✍️ Check out my blog: https://briankeating.com/cosmic-musings/  🎙️ Follow my podcast: https://briankeating.com/podcast  Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to follow/subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 Have you ever looked up at the night sky and wondered if your eyes were enough to capture all it has to offer? Spoiler alert: They’re not! While our eyes are absolutely amazing, they are also full of flaws. Nearsightedness, astigmatism, and even pesky floaters! But did you know these same flaws are mirrored in the world’s most advanced telescopes? In this episode, I discuss common eye deficiencies and explain how they affect our ability to observe the stars. I compare them to the optical imperfections in telescopes, such as chromatic and spherical aberration.  Tune in to learn more about nature’s first telescopes!  This episode is part 2 of a series where we’ll uncover even more intriguing insights about the connections between our eyes and telescopes, so stay tuned! Check out part 1: https://youtu.be/lSbyohV1XSE Key Takeaways:  00:00 Intro  01:29 Deficiencies of the human eye 05:42 Deficiencies in telescopes  13:59 Conclusion  15:37 Outro Additional resources:  ➡️ Follow me on your fav platforms: ✖️ Twitter: https://twitter.com/DrBrianKeating  🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1  📝 Join my mailing list: https://briankeating.com/list  ✍️ Check out my blog: https://briankeating.com/cosmic-musings/  🎙️ Follow my podcast: https://briankeating.com/podcast  Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to follow/subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices

What are the leading theories of everything, and are we any closer to discovering the one true theory of everything? In this 90-minute summit, some of the world’s top physicists—Max Tegmark, James Beacham, Stephon Alexander—go beyond the hype to explore the very heart of physics.  Einstein began the monumental task of unifying quantum mechanics with general relativity, but will we ever succeed in unifying all the forces of the universe? Can it be done? If so, when? Join us for this thought-provoking discussion and find out! Key Takeaways:  00:00:00 Intro  00:00:45 What is a theory of everything? 00:05:25 State of the field and personal perspectives  00:20:42 Experimental challenges  00:34:13 Mathematical foundations, the multiverse, and theoretical beauty  01:05:12 Where do we go from here? 01:14:23 Audience questions 01:25:35 Outro Additional resources:  ➡️ Follow me on your fav platforms: ✖️ Twitter: https://x.com/DrBrianKeating 🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1 📝 Join my mailing list: https://briankeating.com/list ✍️ Check out my blog: https://briankeating.com/cosmic-musings/ 🎙️ Follow my podcast: https://briankeating.com/podcast ✨ Member's only playlist: https://www.youtube.com/playlist?list=UUMOmXH_moPhfkqCk6S3b9RWuw Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices