Freely Filtered 042: Nephrin Antibodies Cause Minimal Change Disease. Wait...What?
The Filtrate:
Joel Topf
Jennie Lin
Joshua Waitzman
Nayan Arora
Sophia Ambruso
Special Guest:
Astrid Weins (@AstridWeins) renal pathologist at the Brigham and Woman’s Hospital and Harvard Medical School
Editor:
Nayan Aurora
Show Notes:
Summary of minimal change disease according to the orthodoxy: Light microscopy of renal biopsy specimens from patients with MCD shows minimal to no change; however, electron microscopy reveals the effacement of podocyte foot processes. To add to the conundrum, immunofluorescent staining of biopsy specimens is negative, and no immune complexes are evident.
Minimal change disease and idiopathic FSGS: manifestations of the same disease
New Views of the Glomerulus: Advanced Microscopy for Advanced Diagnosis
Imaging of the Porous Ultrastructure of the Glomerular Epithelial Filtration Slit
Measles in the Nephrotic Syndrome
NEPTUNE: NEPhrotic syndrome sTUdy NEtwork
Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation
Most of these patients have a homozygous truncating mutation (Fin-major mutation) in the nephrin gene (NPHS1), leading to total absence of the major podocyte protein, nephrin. After RTx, these patients develop anti-nephrin antibodies resulting in nephrotic range proteinuria.
Nephrotic syndrome relapse in a boy with COVID-19
Dr. Laurence Beck and the discovery of Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy as published in the NEJM.
Cheer Season 2 now on Netflix
Cloud Cuckoo Land: A Novel by Anthony Doerr
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